{"id":"https://openalex.org/W1147904152","doi":null,"title":"Hydrogen Bond Shaping of Membrane Protein Structure","display_name":"Hydrogen Bond Shaping of Membrane Protein Structure","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1147904152","mag":"1147904152"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt7k03d6pn","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7k03d6pn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017731648","display_name":"Zheng Cao","orcid":"https://orcid.org/0000-0002-9147-5540","observed_orcids":["https://orcid.org/0000-0002-9147-5540"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zheng Cao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9147-5540","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017731648"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.6980000138282776},{"id":"https://openalex.org/keywords/membrane-protein-structure","display_name":"membrane protein structure","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bacteriorhodopsin","display_name":"bacteriorhodopsin","score":0.9490000009536743},{"id":"https://openalex.org/keywords/ca2-atpase","display_name":"Ca2+-ATPase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/helix-distortion","display_name":"helix distortion","score":0.5559999942779541},{"id":"https://openalex.org/keywords/phi-values","display_name":"phi-values","score":0.6809999942779541},{"id":"https://openalex.org/keywords/protein-unfolding","display_name":"protein unfolding","score":0.4909999966621399},{"id":"https://openalex.org/keywords/voltage-sensing-domain","display_name":"voltage-sensing domain","score":0.5339999794960022},{"id":"https://openalex.org/keywords/voltage-gated-potassium-channels","display_name":"voltage-gated potassium channels","score":0.8289999961853027},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.5540000200271606},{"id":"https://openalex.org/keywords/structural-evolution","display_name":"structural evolution","score":0.3050000071525574}],"concepts":[{"id":"https://openalex.org/C189542057","wikidata":"https://www.wikidata.org/wiki/Q242310","display_name":"Bacteriorhodopsin","level":3,"score":0.8838738203048706},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.817655086517334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6959044337272644},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5419169068336487},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.5188942551612854},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.505763053894043},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.49377140402793884},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.4792187809944153},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.44780173897743225},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.4183003008365631},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.364254891872406},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33082178235054016},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.22612729668617249},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09821465611457825},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08159232139587402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07486540079116821},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt7k03d6pn","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7k03d6pn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:qt7k03d6pn","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/7k03d6pn","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cao, Zheng. (2013). Hydrogen Bond Shaping of Membrane Protein Structure. UCLA: Chemistry 0153. Retrieved from: http://www.escholarship.org/uc/item/7k03d6pn","raw_type":"dissertation"},{"id":"mag:1147904152","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt7k03d6pn/qt7k03d6pn.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1499122356","https://openalex.org/W1537290919","https://openalex.org/W1545242444","https://openalex.org/W1971692809","https://openalex.org/W1971739197","https://openalex.org/W1974129871","https://openalex.org/W1977222497","https://openalex.org/W1988326881","https://openalex.org/W1993858793","https://openalex.org/W1997263768","https://openalex.org/W2009973554","https://openalex.org/W2010182484","https://openalex.org/W2011165993","https://openalex.org/W2012670872","https://openalex.org/W2015448723","https://openalex.org/W2022309859","https://openalex.org/W2031798762","https://openalex.org/W2041256732","https://openalex.org/W2053230248","https://openalex.org/W2054137332","https://openalex.org/W2071586286","https://openalex.org/W2073629943","https://openalex.org/W2074889347","https://openalex.org/W2075758496","https://openalex.org/W2080656986","https://openalex.org/W2081238461","https://openalex.org/W2084558544","https://openalex.org/W2086942533","https://openalex.org/W2090764181","https://openalex.org/W2094113671","https://openalex.org/W2117975224","https://openalex.org/W2127395373","https://openalex.org/W2129073213","https://openalex.org/W2133935241","https://openalex.org/W2136676634","https://openalex.org/W2142722662","https://openalex.org/W2143015200","https://openalex.org/W2149192805","https://openalex.org/W2152033204","https://openalex.org/W2155149840","https://openalex.org/W2950046166","https://openalex.org/W3005251832"],"related_works":["https://openalex.org/W2127395373","https://openalex.org/W2041256732","https://openalex.org/W2129073213","https://openalex.org/W2734471036","https://openalex.org/W1982581985","https://openalex.org/W2140145336","https://openalex.org/W2093389151","https://openalex.org/W7099887027","https://openalex.org/W1993232582","https://openalex.org/W2062016903"],"abstract_inverted_index":{"The":[0,21],"intricate":[1],"functions":[2],"of":[3,101,121,134,167,194,273,294,326],"membrane":[4,88,264,301],"proteins":[5,315],"would":[6],"not":[7,107,190],"be":[8,32,48,143,180,334],"possible":[9],"without":[10],"bends":[11],"or":[12],"breaks":[13],"that":[14,61,98,130,137,236,305,321,343],"are":[15,24,64],"remarkably":[16],"common":[17],"in":[18,34,262,299,330,342],"transmembrane":[19,82,157,328],"helices.":[20,40],"frequent":[22],"distortions":[23,46,63],"nevertheless":[25],"surprising":[26],"because":[27,175],"backbone":[28,169,176,296,309,338],"hydrogen":[29,68,153,172,177,196,205,212,226,237,259,297,310,339],"bonds":[30,154,178,298],"should":[31],"strong":[33],"an":[35],"apolar":[36],"environment,":[37],"potentially":[38],"rigidifying":[39],"It":[41],"is":[42],"therefore":[43,199],"mysterious":[44],"how":[45,74,152],"can":[47,333],"generated":[49],"by":[50,66,85,117,182,243],"evolutions.":[51],"Through":[52],"my":[53],"studies":[54],"on":[55,145,268,316],"bacteriorhodopsin":[56,102,123],"and":[57,92,170,184,224,253,287],"Ca2+-ATPase,":[58],"I":[59,111,159,198,214,234,266,284,303,319],"found":[60,97,235,304,320],"helix":[62,83,329],"facilitated":[65],"shifting":[67],"bonding":[69,238],"partners.":[70],"My":[71,127],"results":[72],"explained":[73],"evolution":[75],"has":[76,94,307],"been":[77,96,139],"able":[78],"to":[79,124,164,186,201,218,245,313],"liberally":[80],"exploit":[81],"bending":[84],"for":[86,211,291],"optimizing":[87],"protein":[89,332],"structure,":[90],"function":[91],"dynamics.It":[93],"recently":[95],"the":[99,119,131,146,192,203,220,225,250,269,274,295,322,337],"stability":[100],"assessed":[103],"through":[104],"unfolding":[105],"did":[106],"achieve":[108],"equilibrium.":[109],"Here":[110],"made":[112],"a":[113,161,263,327],"new":[114],"equilibrium":[115,204],"test":[116],"measuring":[118],"transition":[120],"folded":[122,147],"unfolded":[125],"bacterioopsin.":[126],"result":[128],"suggests":[129],"energetic":[132],"effects":[133],"most":[135],"mutations":[136],"have":[138],"studied":[140],"before":[141],"may":[142,155,189],"focused":[144,267],"state.":[148],"To":[149],"further":[150],"investigate":[151],"shape":[156],"helices,":[158],"sought":[160],"non-perturbing":[162],"method":[163],"measure":[165,258],"strengths":[166,261,341],"both":[168],"side-chain":[171,195],"bond":[173,227,260,311,340],"strengths,":[174],"cannot":[179],"probed":[181],"mutation":[183],"mutagenesis":[185],"remove":[187],"side-chains":[188],"mimic":[191],"breaking":[193],"bonds.":[197,213],"decided":[200],"employ":[202],"/":[206],"deuterium":[207],"fractionation":[208],"factors":[209],"(phi-value)":[210],"used":[215],"model":[216],"compounds":[217],"study":[219],"relationship":[221],"between":[222],"phi-value":[223],"free":[228,289],"energy.":[229],"By":[230,278],"applying":[231],"this":[232,300,331],"relationship,":[233],"stabilizes":[239],"enzyme":[240],"intermediate":[241],"state":[242,252],"up":[244],"4":[246],"kcal/mol":[247],"more":[248],"than":[249],"resting":[251],"marginally":[254],"favor":[255],"soluble-protein":[256],"unfolding.To":[257],"protein,":[265],"isolated":[270],"voltage-sensor":[271],"domain":[272],"voltage-dependent":[275],"potassium-selective":[276],"channel.":[277],"utilizing":[279],"its":[280],"2D":[281],"NMR":[282],"spectrum,":[283],"obtained":[285],"phi-values":[286],"thus":[288],"energies":[290],"70":[292],"%":[293],"protein.":[302],"it":[306],"similar":[308],"strength":[312],"water-soluble":[314],"average.":[317],"Moreover,":[318],"flexible":[323],"(dynamic)":[324],"point":[325],"predicted":[335],"from":[336],"helix.":[344]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2016-06-24T00:00:00"}
