{"id":"https://openalex.org/W114646072","doi":null,"title":"Site-Specific Structure and Dynamics of Polyglutamine-Containing Amyloid Fibrils and the Caveolin Scaffolding Domain by Magic Angle Spinning Solid-State NMR","display_name":"Site-Specific Structure and Dynamics of Polyglutamine-Containing Amyloid Fibrils and the Caveolin Scaffolding Domain by Magic Angle Spinning Solid-State NMR","publication_year":2014,"publication_date":"2014-12-11","ids":{"openalex":"https://openalex.org/W114646072","mag":"114646072"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:23846","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/23846/1/HOOP_etd3.pdf","pdf_url":"http://d-scholarship.pitt.edu/23846/1/HOOP_etd3.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/23846/1/HOOP_etd3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055702476","display_name":"Cody L. Hoop","orcid":"https://orcid.org/0000-0003-4441-8321","observed_orcids":["https://orcid.org/0000-0003-4441-8321"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Cody L. Hoop","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4441-8321","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055702476"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00323389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.10740000009536743,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyglutamine","display_name":"polyglutamine","score":0.8529999852180481},{"id":"https://openalex.org/keywords/amyloid-fibrils","display_name":"amyloid fibrils","score":0.9430000185966492},{"id":"https://openalex.org/keywords/huntingtin","display_name":"huntingtin","score":0.7139999866485596},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.8880000114440918},{"id":"https://openalex.org/keywords/huntingtin-exon-1","display_name":"huntingtin exon 1","score":0.7170000076293945},{"id":"https://openalex.org/keywords/polyproline","display_name":"polyproline","score":0.6589999794960022},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9340000152587891},{"id":"https://openalex.org/keywords/caveolin-scaffolding-domain","display_name":"caveolin scaffolding domain","score":0.9800000190734863},{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":0.9559999704360962},{"id":"https://openalex.org/keywords/membrane-protein-structure","display_name":"membrane protein structure","score":0.6330000162124634},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.7457022666931152},{"id":"https://openalex.org/C153202636","wikidata":"https://www.wikidata.org/wiki/Q7557802","display_name":"Solid-state nuclear magnetic resonance","level":2,"score":0.6291210651397705},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6267149448394775},{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.5904826521873474},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5766187906265259},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.5477933883666992},{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.5405023097991943},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4989752769470215},{"id":"https://openalex.org/C84935128","wikidata":"https://www.wikidata.org/wiki/Q1884060","display_name":"Magic angle spinning","level":3,"score":0.46847668290138245},{"id":"https://openalex.org/C125501631","wikidata":"https://www.wikidata.org/wiki/Q1587185","display_name":"Biological membrane","level":3,"score":0.4502675533294678},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.44170430302619934},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.4355713725090027},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.42075857520103455},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.4147648215293884},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.34641045331954956},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3401463031768799},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2363463044166565},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.22748929262161255},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.10817098617553711},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09076389670372009},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.08777433633804321},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:23846","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/23846/1/HOOP_etd3.pdf","pdf_url":"http://d-scholarship.pitt.edu/23846/1/HOOP_etd3.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:114646072","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/23846/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:23846","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/23846/1/HOOP_etd3.pdf","pdf_url":"http://d-scholarship.pitt.edu/23846/1/HOOP_etd3.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3336669051","display_name":"Mechanisms of amyloid nucleation","funder_award_id":"R01GM099718","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8243880418","display_name":"Structures and Properties of Polyglutamine Proteins and Their Aggregates","funder_award_id":"R01AG019322","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W114646072.pdf","grobid_xml":"https://content.openalex.org/works/W114646072.grobid-xml"},"referenced_works_count":203,"referenced_works":["https://openalex.org/W4561113","https://openalex.org/W63866321","https://openalex.org/W1498088837","https://openalex.org/W1547490339","https://openalex.org/W1552415503","https://openalex.org/W1589545251","https://openalex.org/W1606337626","https://openalex.org/W1963537123","https://openalex.org/W1965331176","https://openalex.org/W1966457778","https://openalex.org/W1966910457","https://openalex.org/W1966949741","https://openalex.org/W1968622506","https://openalex.org/W1969787762","https://openalex.org/W1970232844","https://openalex.org/W1970456057","https://openalex.org/W1972121821","https://openalex.org/W1972434016","https://openalex.org/W1974390195","https://openalex.org/W1974586979","https://openalex.org/W1974607424","https://openalex.org/W1975932182","https://openalex.org/W1976073965","https://openalex.org/W1977792099","https://openalex.org/W1978015101","https://openalex.org/W1978279440","https://openalex.org/W1978672495","https://openalex.org/W1978794287","https://openalex.org/W1981396716","https://openalex.org/W1981969349","https://openalex.org/W1982138826","https://openalex.org/W1982752783","https://openalex.org/W1984560450","https://openalex.org/W1984640820","https://openalex.org/W1985474993","https://openalex.org/W1989142184","https://openalex.org/W1989661323","https://openalex.org/W1991898882","https://openalex.org/W1991930121","https://openalex.org/W1993201479","https://openalex.org/W1994277766","https://openalex.org/W1994612850","https://openalex.org/W1995747923","https://openalex.org/W1996565611","https://openalex.org/W2000408345","https://openalex.org/W2000532420","https://openalex.org/W2000904062","https://openalex.org/W2001299940","https://openalex.org/W2001682320","https://openalex.org/W2001997725","https://openalex.org/W2002869713","https://openalex.org/W2003715450","https://openalex.org/W2004077282","https://openalex.org/W2004098528","https://openalex.org/W2006506278","https://openalex.org/W2006914704","https://openalex.org/W2008307658","https://openalex.org/W2009480358","https://openalex.org/W2010227081","https://openalex.org/W2010614834","https://openalex.org/W2012762365","https://openalex.org/W2012850328","https://openalex.org/W2014479354","https://openalex.org/W2014668312","https://openalex.org/W2015214742","https://openalex.org/W2015795135","https://openalex.org/W2017579710","https://openalex.org/W2017684135","https://openalex.org/W2018143845","https://openalex.org/W2018459217","https://openalex.org/W2020078414","https://openalex.org/W2020086703","https://openalex.org/W2020251399","https://openalex.org/W2021330026","https://openalex.org/W2023072399","https://openalex.org/W2023218382","https://openalex.org/W2023338599","https://openalex.org/W2027105865","https://openalex.org/W2028168451","https://openalex.org/W2029984090","https://openalex.org/W2030727312","https://openalex.org/W2031427361","https://openalex.org/W2032255653","https://openalex.org/W2032379027","https://openalex.org/W2033575799","https://openalex.org/W2034160988","https://openalex.org/W2034329419","https://openalex.org/W2036548578","https://openalex.org/W2036563840","https://openalex.org/W2037751823","https://openalex.org/W2038147123","https://openalex.org/W2038277098","https://openalex.org/W2039877652","https://openalex.org/W2041432176","https://openalex.org/W2042159816","https://openalex.org/W2042197472","https://openalex.org/W2042204511","https://openalex.org/W2042442392","https://openalex.org/W2042521416","https://openalex.org/W2043864366","https://openalex.org/W2044053438","https://openalex.org/W2044628667","https://openalex.org/W2046000642","https://openalex.org/W2046132401","https://openalex.org/W2046703224","https://openalex.org/W2046760198","https://openalex.org/W2048043626","https://openalex.org/W2049022748","https://openalex.org/W2049185462","https://openalex.org/W2049791243","https://openalex.org/W2051577979","https://openalex.org/W2051858905","https://openalex.org/W2053460134","https://openalex.org/W2054118905","https://openalex.org/W2055501963","https://openalex.org/W2056702184","https://openalex.org/W2059195182","https://openalex.org/W2059266062","https://openalex.org/W2060802640","https://openalex.org/W2061051947","https://openalex.org/W2061740577","https://openalex.org/W2062044517","https://openalex.org/W2062315382","https://openalex.org/W2062682951","https://openalex.org/W2064922129","https://openalex.org/W2065145701","https://openalex.org/W2065591719","https://openalex.org/W2067297186","https://openalex.org/W2067680463","https://openalex.org/W2069452881","https://openalex.org/W2069607465","https://openalex.org/W2070017758","https://openalex.org/W2072613948","https://openalex.org/W2073295365","https://openalex.org/W2073922528","https://openalex.org/W2074703430","https://openalex.org/W2075793654","https://openalex.org/W2075796682","https://openalex.org/W2077569857","https://openalex.org/W2077903973","https://openalex.org/W2079002615","https://openalex.org/W2081606553","https://openalex.org/W2083482072","https://openalex.org/W2083914866","https://openalex.org/W2084889102","https://openalex.org/W2085705066","https://openalex.org/W2085899859","https://openalex.org/W2088628021","https://openalex.org/W2088661320","https://openalex.org/W2088848851","https://openalex.org/W2089888763","https://openalex.org/W2090786642","https://openalex.org/W2091089938","https://openalex.org/W2091196473","https://openalex.org/W2091386390","https://openalex.org/W2095480781","https://openalex.org/W2095710767","https://openalex.org/W2099114485","https://openalex.org/W2099724367","https://openalex.org/W2101235425","https://openalex.org/W2101817300","https://openalex.org/W2104332287","https://openalex.org/W2105459766","https://openalex.org/W2106658644","https://openalex.org/W2107735396","https://openalex.org/W2109459193","https://openalex.org/W2110863368","https://openalex.org/W2112418305","https://openalex.org/W2113403117","https://openalex.org/W2113671566","https://openalex.org/W2117178889","https://openalex.org/W2119152368","https://openalex.org/W2119951313","https://openalex.org/W2121053757","https://openalex.org/W2122294662","https://openalex.org/W2125054419","https://openalex.org/W2125625416","https://openalex.org/W2126055383","https://openalex.org/W2126877059","https://openalex.org/W2127886370","https://openalex.org/W2128674001","https://openalex.org/W2128963767","https://openalex.org/W2131926693","https://openalex.org/W2132954592","https://openalex.org/W2134783787","https://openalex.org/W2138619586","https://openalex.org/W2141583055","https://openalex.org/W2143617069","https://openalex.org/W2144166008","https://openalex.org/W2146656482","https://openalex.org/W2147282851","https://openalex.org/W2148521301","https://openalex.org/W2153187042","https://openalex.org/W2156478040","https://openalex.org/W2157295729","https://openalex.org/W2165186407","https://openalex.org/W2169707043","https://openalex.org/W2169821755","https://openalex.org/W2248411869","https://openalex.org/W2270457622","https://openalex.org/W2313044108","https://openalex.org/W2318414036","https://openalex.org/W2328556202"],"related_works":["https://openalex.org/W2043740558","https://openalex.org/W4393425594","https://openalex.org/W2426994386","https://openalex.org/W2041037769","https://openalex.org/W2318414036","https://openalex.org/W2104332287","https://openalex.org/W2885338037","https://openalex.org/W1601157919","https://openalex.org/W1831094025","https://openalex.org/W1919435895"],"abstract_inverted_index":{"Protein":[0],"assemblies":[1],"and":[2,10,43,51,114,118,146,151,188,194,206,216,228],"membrane":[3,52,166],"associations":[4],"play":[5],"important":[6],"roles":[7],"in":[8,28,92,155,184,191,235,253],"health":[9],"disease.":[11],"Structural":[12],"studies":[13,39],"of":[14,40,67,87,96,105,148,162,200,225,231,248,251],"these":[15],"biological":[16,45],"complexes":[17],"are":[18,22,56,165,219],"thus":[19],"vital,":[20],"but":[21],"often":[23],"unfeasible":[24],"by":[25,81],"conventional":[26],"tools":[27],"structural":[29,38,65],"biology.":[30],"Solid-state":[31],"NMR":[32],"(ssNMR)":[33],"has":[34],"made":[35],"possible":[36],"atomic-level":[37],"large,":[41],"insoluble,":[42],"non-crystalline":[44],"systems,":[46],"such":[47],"as":[48],"amyloid":[49],"fibrils":[50,55],"proteins.":[53,167],"Amyloid":[54],"associated":[57,174],"with":[58,175],"at":[59],"least":[60],"20":[61],"human":[62,163],"diseases,":[63],"making":[64],"aspects":[66],"their":[68,73],"formation":[69],"crucial":[70],"to":[71,127,142,208,221],"understanding":[72,247],"aggregation":[74,113],"pathways.":[75],"Huntington\u2019s":[76],"disease":[77],"(HD)":[78],"is":[79,170,189,202],"caused":[80],"an":[82],"expansion":[83],"beyond":[84],"a":[85,123,171,236,244],"threshold":[86],"the":[88,93,97,106,111,121,128,149,185,210,226,232,249],"polyglutamine":[89],"(polyQ)":[90],"domain":[91,198],"Exon":[94,107],"1":[95,108],"huntingtin":[98],"protein":[99,172],"(htt).":[100],"The":[101,196],"17-residue":[102],"N-terminal":[103],"segment":[104,125],"(httNT)":[109],"initiates":[110],"fibril":[112,131],"helps":[115],"stabilize":[116],"oligomers":[117],"fibrils.":[119,158],"On":[120],"contrary,":[122],"polyPro":[124],"C-terminal":[126],"polyQ":[129,150],"reduces":[130],"aggregation.":[132],"In":[133,212],"this":[134,213],"thesis,":[135,214],"magic-angle":[136],"spinning":[137],"(MAS)":[138],"ssNMR":[139,218],"was":[140],"used":[141,220],"elucidate":[143,222],"atomic-resolution":[144],"structure":[145,224],"dynamics":[147],"its":[152,229],"flanking":[153],"domains":[154],"polyQ-containing":[156],"amyloid-like":[157],"More":[159],"than":[160],"25%":[161],"proteins":[164],"Caveolin-1":[168],"(Cav1)":[169],"found":[173],"cholesterol-rich":[176,237],"membranes":[177],"that":[178],"forms":[179],"caveolae,":[180],"curved":[181],"cave-like":[182],"invaginations":[183],"plasma":[186],"membrane,":[187],"implicated":[190],"muscular":[192],"diseases":[193],"cancers.":[195],"caveolin-scaffolding":[197],"(CSD)":[199],"Cav1":[201],"responsible":[203],"for":[204,243],"cholesterol-recognition":[205],"oligomerization":[207],"form":[209],"caveolae.":[211],"MAS":[215],"static":[217],"molecular":[223],"CSD":[227,252],"perturbation":[230],"lipid":[233,238],"bilayer":[234],"environment.":[239],"These":[240],"results":[241],"allow":[242],"more":[245],"thorough":[246],"role":[250],"caveolae":[254],"formation.":[255]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}
