{"id":"https://openalex.org/W1146200217","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.1042.6","title":"Quantitative Assessment of the Coupling of Theoretical Fibroblast and Cardiomyocyte Models","display_name":"Quantitative Assessment of the Coupling of Theoretical Fibroblast and Cardiomyocyte Models","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1146200217","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.1042.6","mag":"1146200217"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.1042.6","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.1042.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.1042.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100708315","display_name":"Fusheng Liu","orcid":"https://orcid.org/0000-0002-2969-2675","observed_orcids":["https://orcid.org/0000-0002-2969-2675"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fusheng Liu","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China","1--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"1--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100399575","display_name":"Pengfei Wang","orcid":"https://orcid.org/0000-0002-9081-3683","observed_orcids":["https://orcid.org/0000-0002-9081-3683","https://orcid.org/0009-0004-6886-1090"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Wang","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China","1--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"1--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432902","display_name":"Feng Xu","orcid":"https://orcid.org/0000-0002-4670-3727","observed_orcids":["https://orcid.org/0000-0002-4670-3727","https://orcid.org/0009-0001-8046-8361"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Xu","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China","1--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"1--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102018858","display_name":"Tianjian Lu","orcid":"https://orcid.org/0000-0003-4894-3190","observed_orcids":["https://orcid.org/0000-0003-4894-3190"]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianjian Lu","raw_affiliation_strings":["<!--<label><sup>1</sup></label>--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China","1--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>1</sup></label>--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"1--> Bioinspired Engineering and Biomechanics Center Xi'an Jaitong University Xi'an China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108355922","display_name":"Elliot L. Elson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliot Elson","raw_affiliation_strings":["<!--<label><sup>2</sup></label>--> Biochemistry and Molecular Biophysics Washington University St. Louis MO United States","2--> Biochemistry and Molecular Biophysics Washington University St. Louis MO United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>2</sup></label>--> Biochemistry and Molecular Biophysics Washington University St. Louis MO United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"2--> Biochemistry and Molecular Biophysics Washington University St. Louis MO United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039100833","display_name":"Tetsuro Wakatsuki","orcid":"https://orcid.org/0000-0002-2175-1132","observed_orcids":["https://orcid.org/0000-0002-2175-1132"]},"institutions":[{"id":"https://openalex.org/I4210166000","display_name":"Invivo Sciences (United States)","ror":"https://ror.org/05wfxya04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210166000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tetsuro Wakatsuki","raw_affiliation_strings":["<!--<label><sup>3</sup></label>--> InvivoSciences LLC. Madison WI United States","3--> InvivoSciences LLC. Madison WI United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>3</sup></label>--> InvivoSciences LLC. Madison WI United States","institution_ids":["https://openalex.org/I4210166000"]},{"raw_affiliation_string":"3--> InvivoSciences LLC. Madison WI United States","institution_ids":["https://openalex.org/I4210166000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091520233","display_name":"Guy M. Genin","orcid":"https://orcid.org/0000-0003-3612-4729","observed_orcids":["https://orcid.org/0000-0003-3612-4729"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guy Genin","raw_affiliation_strings":["<!--<label><sup>4</sup></label>--> Mechanical and Aerospace Engineering Washington University St. Louis MO United States","4--> Mechanical and Aerospace Engineering Washington University St. Louis MO United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>4</sup></label>--> Mechanical and Aerospace Engineering Washington University St. Louis MO United States","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"4--> Mechanical and Aerospace Engineering Washington University St. Louis MO United States","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076010626","display_name":"Brian E. Carlson","orcid":"https://orcid.org/0000-0002-1353-5907","observed_orcids":["https://orcid.org/0000-0002-1353-5907"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Carlson","raw_affiliation_strings":["<!--<label><sup>5</sup></label>--> Molecular and Integrative Physiology University of Michigan Ann Arbor MI United States","5--> Molecular and Integrative Physiology University of Michigan Ann Arbor MI United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--<label><sup>5</sup></label>--> Molecular and Integrative Physiology University of Michigan Ann Arbor MI United States","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"5--> Molecular and Integrative Physiology University of Michigan Ann Arbor MI United States","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0202334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/engineered-heart-tissue","display_name":"engineered heart tissue","score":0.9879999756813049},{"id":"https://openalex.org/keywords/transient-outward-potassium-current","display_name":"transient outward potassium current","score":0.9300000071525574},{"id":"https://openalex.org/keywords/slow-delayed-rectifier-potassium-current","display_name":"slow delayed rectifier potassium current","score":0.859000027179718},{"id":"https://openalex.org/keywords/human-cardiomyocytes","display_name":"human cardiomyocytes","score":0.6800000071525574},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.8430277109146118},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.6705865859985352},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6024147272109985},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5487974882125854},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.524550199508667},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.46746304631233215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41586899757385254},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3831493854522705},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.35383063554763794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3134538531303406},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.263389527797699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20595577359199524},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.16702404618263245},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10414043068885803},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.1042.6","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.1042.6","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.1042.6","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G695438355","display_name":"THE EFFECTS OF MYOFIBROBLASTS ON ELECTROMECHANICAL FUNCTION OF MODEL HEART TISSUE","funder_award_id":"R01HL109505","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405370641","https://openalex.org/W4392985003","https://openalex.org/W2170126521","https://openalex.org/W2089413167","https://openalex.org/W7037292328","https://openalex.org/W2949931550","https://openalex.org/W3184363598","https://openalex.org/W3043687198","https://openalex.org/W1984718859","https://openalex.org/W1985041911"],"abstract_inverted_index":{"Methodologies":[0],"for":[1,78],"creating":[2],"engineered":[3],"heart":[4,24],"tissue":[5,25,37],"(EHT)":[6],"constructs":[7],"by":[8,45,152,206],"co\u2010culturing":[9],"cardiomyocytes":[10,82,191],"and":[11,41,51,64,67,110,147],"fibroblasts":[12,189],"are":[13,57],"currently":[14],"used":[15],"as":[16,199],"an":[17,46,200],"in":[18,168,172,201],"vitro":[19,202],"platform":[20],"to":[21,83,109,115,143,180],"understand":[22],"native":[23,36],"function.":[26],"However":[27],"a":[28,98,144,169],"careful":[29],"evaluation":[30],"of":[31,62,81,100,103,118,135,188],"how":[32,79],"closely":[33],"EHTs":[34,198],"mimic":[35],"is":[38,97,107,113,150,160,165,178],"still":[39],"needed":[40],"can":[42],"be":[43,194],"facilitated":[44],"approach":[47],"combining":[48],"both":[49],"theoretical":[50,55],"experimental":[52],"analysis.":[53],"These":[54],"analyses":[56],"previously":[58],"developed":[59],"computational":[60],"models":[61,72],"cardiomyocyte":[63,86,104,120,146,177],"fibroblast":[65,84,106,136],"electrophysiology":[66,137],"ion":[68],"handling.":[69],"In":[70,126],"these":[71],"contrasting":[73],"results":[74,140],"have":[75],"been":[76],"shown":[77],"coupling":[80],"affects":[85],"action":[87],"potential":[88],"duration":[89],"(APD).":[90],"Here":[91],"we":[92,128],"show":[93],"that":[94,130,148],"this":[95,163],"result":[96],"function":[99],"the":[101,105,116,119,175,186],"type":[102],"coupled":[108,142,179],"more":[111],"specifically":[112],"linked":[114],"magnitude":[117],"transient":[121],"outward":[122],"K":[123,158],"+":[124,159],"current.":[125],"addition,":[127],"observe":[129],"two":[131,181],"very":[132],"different":[133],"formulations":[134],"yield":[138],"similar":[139],"when":[141,154,174,196],"human":[145,176],"APD":[149,173],"increased":[151],"~20%":[153],"slow":[155],"delayed":[156],"rectifier":[157],"blocked":[161],"but":[162],"increase":[164],"eliminated":[166],"resulting":[167],"~6%":[170],"decrease":[171],"fibroblasts.":[182],"This":[183],"finding":[184],"suggests":[185],"influence":[187],"on":[190],"should":[192],"not":[193],"ignored":[195],"using":[197],"testing":[203],"platform.":[204],"Supported":[205],"NIH":[207],"R01":[208],"HL109505":[209],"03.":[210]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}