{"id":"https://openalex.org/W114422769","doi":"https://doi.org/10.1002/cpt1970115630","title":"Role of corticosteroids in the treatment of circulatory collapse states","display_name":"Role of corticosteroids in the treatment of circulatory collapse states","publication_year":1970,"publication_date":"1970-09-01","ids":{"openalex":"https://openalex.org/W114422769","doi":"https://doi.org/10.1002/cpt1970115630","mag":"114422769","pmid":"https://pubmed.ncbi.nlm.nih.gov/4917089"},"language":"en","primary_location":{"id":"doi:10.1002/cpt1970115630","doi":"https://doi.org/10.1002/cpt1970115630","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt1970115630","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110287816","display_name":"Allan M. Lefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allan M. Lefer","raw_affiliation_strings":["Department of Physiology, University of Virginia School of Medicine, Charlottesville, Va"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Virginia School of Medicine, Charlottesville, Va","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021644068","display_name":"Richard L. Verrier","orcid":"https://orcid.org/0000-0001-5602-6793","observed_orcids":["https://orcid.org/0000-0001-5602-6793"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard L. Verrier","raw_affiliation_strings":["Department of Physiology, University of Virginia School of Medicine, Charlottesville, Va"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Virginia School of Medicine, Charlottesville, Va","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":4.1703,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.92216557,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"11","issue":"5","first_page":"630","last_page":"655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/shock","display_name":"shock","score":0.8659999966621399},{"id":"https://openalex.org/keywords/circulatory-collapse","display_name":"cardiovascular collapse","score":0.8230000138282776},{"id":"https://openalex.org/keywords/adrenal-insufficiency","display_name":"adrenal insufficiency","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.9089999794960022},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.968999981880188},{"id":"https://openalex.org/keywords/shock-treatment","display_name":"shock treatment","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.7991553544998169},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.7308816909790039},{"id":"https://openalex.org/C2776371345","wikidata":"https://www.wikidata.org/wiki/Q5121708","display_name":"Circulatory collapse","level":2,"score":0.7256805300712585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7202147245407104},{"id":"https://openalex.org/C2778129406","wikidata":"https://www.wikidata.org/wiki/Q2507454","display_name":"Adrenal insufficiency","level":2,"score":0.5824277400970459},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5406927466392517},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5064321756362915},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.48119932413101196},{"id":"https://openalex.org/C3019758011","wikidata":"https://www.wikidata.org/wiki/Q1055456","display_name":"Adrenal cortex hormones","level":2,"score":0.4150247871875763},{"id":"https://openalex.org/C3018799218","wikidata":"https://www.wikidata.org/wiki/Q188193","display_name":"Organ system","level":3,"score":0.4137290418148041},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2747487425804138},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1642189919948578}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000309","descriptor_name":"Adrenal Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000315","descriptor_name":"Adrenalectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012769","descriptor_name":"Shock","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012771","descriptor_name":"Shock, Hemorrhagic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012773","descriptor_name":"Shock, Surgical","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014688","descriptor_name":"Venoms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cpt1970115630","doi":"https://doi.org/10.1002/cpt1970115630","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cpt1970115630","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology & Therapeutics","raw_type":"journal-article"},{"id":"pmid:4917089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4917089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099648110","https://openalex.org/W1991948866","https://openalex.org/W2318637069","https://openalex.org/W2088684938","https://openalex.org/W272486695","https://openalex.org/W2413931701","https://openalex.org/W2397509777","https://openalex.org/W3146293149","https://openalex.org/W60869985","https://openalex.org/W2469394025"],"abstract_inverted_index":{"Corticosteroids":[0],"are":[1,92],"hormones":[2],"which":[3,157],"exert":[4,27,159],"effects":[5,29,38,89,162,179],"on":[6,30],"virtually":[7],"every":[8],"organ":[9],"and":[10,12,20,105,151],"tissue":[11],"thereby":[13,80],"play":[14],"a":[15,56,99,123,170],"key":[16],"role":[17],"in":[18,77,102,108,119,140,145,163,173],"preserving":[19],"maintaining":[21],"homeostasis.":[22],"154":[23],"In":[24],"particular,":[25],"corticosteroids":[26,73,91,114,158],"prominent":[28,57,100],"the":[31,40,68,120,146,148,177,181],"cardiovascular":[32,53,88,161],"system.":[33],"65,":[34],"66":[35],"The":[36,87,130],"circulatory":[37,128,178],"of":[39,59,84,90,93,110,122,125,127,133,142,156,180],"orticosteroids":[41],"have":[42,74,115],"been":[43,66,75,116],"under":[44],"investigation":[45,83],"since":[46],"1849":[47],"when":[48],"Addison":[49],"2":[50],"recognized":[51],"that":[52,72],"collapse":[54],"was":[55],"feature":[58,101],"adrenal":[60,111],"insufficiency.":[61],"However,":[62],"it":[63],"has":[64],"only":[65],"within":[67],"last":[69],"twenty":[70],"years":[71],"available":[76],"pure":[78],"form,":[79],"permitting":[81],"an":[82],"their":[85,160],"effects.":[86],"considerable":[94],"interest":[95],"because":[96],"hypotension":[97],"is":[98],"adrenocortical":[103],"insufficiency,":[104],"hypertension":[106],"occurs":[107],"hypersecretion":[109],"corticosteroids.":[112,182],"Furthermore,":[113],"widely":[117],"used":[118],"treatment":[121],"variety":[124],"states":[126],"shock.":[129],"particular":[131],"emphasis":[132],"this":[134],"review":[135],"will":[136],"be":[137],"to":[138],"discuss,":[139],"terms":[141],"recent":[143],"developments":[144],"field,":[147],"basic":[149],"physiologic":[150],"pharmacologic":[152],"mechanisms":[153],"by":[154],"means":[155],"shock":[164],"states.":[165],"Several":[166],"new":[167],"findings":[168],"necessitate":[169],"significant":[171],"shift":[172],"our":[174],"thinking":[175],"about":[176]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}