{"id":"https://openalex.org/W114401722","doi":null,"title":"Mutant ubiquitin and the proteasome in Alzheimer's disease","display_name":"Mutant ubiquitin and the proteasome in Alzheimer's disease","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W114401722","mag":"114401722"},"language":"en","primary_location":{"id":"pmh:oai:dare.uva.nl:openaire/f66c6bc0-02c0-4cac-93cf-8edf36e942d5","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/mutant-ubiquitin-and-the-proteasome-in-alzheimers-disease(f66c6bc0-02c0-4cac-93cf-8edf36e942d5).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"de Vrij, F M S 2005, 'Mutant ubiquitin and the proteasome in Alzheimer's disease', Doctor of Philosophy, Universiteit van Amsterdam.","raw_type":"info:eu-repo/semantics/other"},"volume":null,"type":"other","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://handle.uba.uva.nl/personal/pure/en/publications/mutant-ubiquitin-and-the-proteasome-in-alzheimers-disease(f66c6bc0-02c0-4cac-93cf-8edf36e942d5).html","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004639920","display_name":"Femke M. S. de Vrij","orcid":"https://orcid.org/0000-0003-0825-3806","observed_orcids":["https://orcid.org/0000-0003-0825-3806"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Femke M.S. de Vrij","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0825-3806","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004639920"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.05270000174641609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9070000052452087},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.8309999704360962},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9020000100135803},{"id":"https://openalex.org/keywords/protein-quality-control","display_name":"protein quality control","score":0.8809999823570251},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7689999938011169},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/proteasome-activity","display_name":"proteasome activity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/ad-pathogenesis","display_name":"AD pathogenesis","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.8673504590988159},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.7464966773986816},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6380687355995178},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5958811640739441},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4773388206958771},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46265655755996704},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.45834729075431824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.446856290102005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38283950090408325},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3342512845993042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2400428056716919},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22008320689201355},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21038615703582764},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15525025129318237}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dare.uva.nl:openaire/f66c6bc0-02c0-4cac-93cf-8edf36e942d5","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/mutant-ubiquitin-and-the-proteasome-in-alzheimers-disease(f66c6bc0-02c0-4cac-93cf-8edf36e942d5).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"de Vrij, F M S 2005, 'Mutant ubiquitin and the proteasome in Alzheimer's disease', Doctor of Philosophy, Universiteit van Amsterdam.","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:uvapub:oai:dare.uva.nl:publications/f66c6bc0-02c0-4cac-93cf-8edf36e942d5","doi":null,"is_oa":true,"landing_page_url":"https://dare.uva.nl/personal/pure/en/publications/mutant-ubiquitin-and-the-proteasome-in-alzheimers-disease(f66c6bc0-02c0-4cac-93cf-8edf36e942d5).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:114401722","doi":null,"is_oa":false,"landing_page_url":"https://pure.uva.nl/ws/files/4082973/49923_Thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dare.uva.nl:openaire/f66c6bc0-02c0-4cac-93cf-8edf36e942d5","doi":null,"is_oa":true,"landing_page_url":"https://handle.uba.uva.nl/personal/pure/en/publications/mutant-ubiquitin-and-the-proteasome-in-alzheimers-disease(f66c6bc0-02c0-4cac-93cf-8edf36e942d5).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400088","display_name":"UvA-DARE (University of Amsterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887064364","host_organization_name":"University of Amsterdam","host_organization_lineage":["https://openalex.org/I887064364"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"de Vrij, F M S 2005, 'Mutant ubiquitin and the proteasome in Alzheimer's disease', Doctor of Philosophy, Universiteit van Amsterdam.","raw_type":"info:eu-repo/semantics/other"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325060","display_name":"Hersenstichting","ror":"https://ror.org/04y8met08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":310,"referenced_works":["https://openalex.org/W5479169","https://openalex.org/W37387537","https://openalex.org/W39614084","https://openalex.org/W58149416","https://openalex.org/W131054948","https://openalex.org/W135235169","https://openalex.org/W149130878","https://openalex.org/W172906062","https://openalex.org/W1261866575","https://openalex.org/W1480786153","https://openalex.org/W1481321944","https://openalex.org/W1481615478","https://openalex.org/W1497941038","https://openalex.org/W1511827873","https://openalex.org/W1515490675","https://openalex.org/W1519470329","https://openalex.org/W1528908480","https://openalex.org/W1529474377","https://openalex.org/W1530130622","https://openalex.org/W1532188427","https://openalex.org/W1533591905","https://openalex.org/W1538925586","https://openalex.org/W1539232350","https://openalex.org/W1544371346","https://openalex.org/W1552448470","https://openalex.org/W1568953429","https://openalex.org/W1570610869","https://openalex.org/W1574133290","https://openalex.org/W1584825376","https://openalex.org/W1584834830","https://openalex.org/W1586863418","https://openalex.org/W1588279803","https://openalex.org/W1598585009","https://openalex.org/W1600934558","https://openalex.org/W1607874074","https://openalex.org/W1608434453","https://openalex.org/W1617816798","https://openalex.org/W1618846043","https://openalex.org/W1708445842","https://openalex.org/W1734372511","https://openalex.org/W1765198312","https://openalex.org/W1848907877","https://openalex.org/W1877873625","https://openalex.org/W1940638574","https://openalex.org/W1947552193","https://openalex.org/W1948557773","https://openalex.org/W1964819733","https://openalex.org/W1965295123","https://openalex.org/W1965788922","https://openalex.org/W1967464880","https://openalex.org/W1967826288","https://openalex.org/W1967887646","https://openalex.org/W1968330653","https://openalex.org/W1969334823","https://openalex.org/W1970320169","https://openalex.org/W1973231428","https://openalex.org/W1973637060","https://openalex.org/W1973963032","https://openalex.org/W1974359257","https://openalex.org/W1976915707","https://openalex.org/W1977277944","https://openalex.org/W1977813572","https://openalex.org/W1978668412","https://openalex.org/W1979047408","https://openalex.org/W1979369962","https://openalex.org/W1979408355","https://openalex.org/W1979773315","https://openalex.org/W1979970115","https://openalex.org/W1981449360","https://openalex.org/W1981916517","https://openalex.org/W1983345237","https://openalex.org/W1983532821","https://openalex.org/W1983882750","https://openalex.org/W1984826365","https://openalex.org/W1986188355","https://openalex.org/W1986413832","https://openalex.org/W1986552075","https://openalex.org/W1986698717","https://openalex.org/W1986900475","https://openalex.org/W1987208997","https://openalex.org/W1987444426","https://openalex.org/W1987467454","https://openalex.org/W1987927755","https://openalex.org/W1988457275","https://openalex.org/W1989141893","https://openalex.org/W1990124621","https://openalex.org/W1990752558","https://openalex.org/W1991211989","https://openalex.org/W1991241547","https://openalex.org/W1991927407","https://openalex.org/W1992577657","https://openalex.org/W1993705148","https://openalex.org/W1993878844","https://openalex.org/W1994939674","https://openalex.org/W1995344309","https://openalex.org/W1995805772","https://openalex.org/W1996001841","https://openalex.org/W1997369314","https://openalex.org/W1999073817","https://openalex.org/W1999442278","https://openalex.org/W1999631936","https://openalex.org/W2000409052","https://openalex.org/W2000548634","https://openalex.org/W2000937091","https://openalex.org/W2002918617","https://openalex.org/W2003696769","https://openalex.org/W2004034281","https://openalex.org/W2004251585","https://openalex.org/W2005175785","https://openalex.org/W2005722151","https://openalex.org/W2006363660","https://openalex.org/W2006388911","https://openalex.org/W2007422965","https://openalex.org/W2007922488","https://openalex.org/W2009761723","https://openalex.org/W2009763210","https://openalex.org/W2010416572","https://openalex.org/W2010515885","https://openalex.org/W2011339216","https://openalex.org/W2011531910","https://openalex.org/W2012781495","https://openalex.org/W2013339424","https://openalex.org/W2014141366","https://openalex.org/W2015432131","https://openalex.org/W2015945333","https://openalex.org/W2017105675","https://openalex.org/W2017605422","https://openalex.org/W2017770853","https://openalex.org/W2017938846","https://openalex.org/W2018046986","https://openalex.org/W2018105817","https://openalex.org/W2018851870","https://openalex.org/W2019761433","https://openalex.org/W2024550359","https://openalex.org/W2024786692","https://openalex.org/W2025331058","https://openalex.org/W2026263038","https://openalex.org/W2026449022","https://openalex.org/W2026632566","https://openalex.org/W2026749024","https://openalex.org/W2027955308","https://openalex.org/W2028007176","https://openalex.org/W2029270045","https://openalex.org/W2029682800","https://openalex.org/W2030182984","https://openalex.org/W2032258076","https://openalex.org/W2032374711","https://openalex.org/W2032687897","https://openalex.org/W2033262835","https://openalex.org/W2033398667","https://openalex.org/W2033778029","https://openalex.org/W2034692278","https://openalex.org/W2034999180","https://openalex.org/W2035282018","https://openalex.org/W2035589234","https://openalex.org/W2036362108","https://openalex.org/W2036758460","https://openalex.org/W2036933501","https://openalex.org/W2036950925","https://openalex.org/W2037322147","https://openalex.org/W2037801678","https://openalex.org/W2037873496","https://openalex.org/W2038684439","https://openalex.org/W2039820498","https://openalex.org/W2040863926","https://openalex.org/W2042652033","https://openalex.org/W2043011920","https://openalex.org/W2044460749","https://openalex.org/W2046031602","https://openalex.org/W2046720254","https://openalex.org/W2046860176","https://openalex.org/W2047649942","https://openalex.org/W2047989388","https://openalex.org/W2048450765","https://openalex.org/W2048640332","https://openalex.org/W2048737347","https://openalex.org/W2048975745","https://openalex.org/W2049748848","https://openalex.org/W2050070432","https://openalex.org/W2050181337","https://openalex.org/W2051022720","https://openalex.org/W2052216540","https://openalex.org/W2052742260","https://openalex.org/W2053116497","https://openalex.org/W2054726866","https://openalex.org/W2055361873","https://openalex.org/W2056956751","https://openalex.org/W2057491765","https://openalex.org/W2057832589","https://openalex.org/W2058168682","https://openalex.org/W2058855163","https://openalex.org/W2059453878","https://openalex.org/W2061050157","https://openalex.org/W2061883196","https://openalex.org/W2063505049","https://openalex.org/W2064394604","https://openalex.org/W2065331357","https://openalex.org/W2066486174","https://openalex.org/W2066792703","https://openalex.org/W2067563932","https://openalex.org/W2069749705","https://openalex.org/W2069807839","https://openalex.org/W2071191421","https://openalex.org/W2071358321","https://openalex.org/W2071972588","https://openalex.org/W2072337406","https://openalex.org/W2072368664","https://openalex.org/W2072718213","https://openalex.org/W2072847935","https://openalex.org/W2074701223","https://openalex.org/W2075428562","https://openalex.org/W2076344205","https://openalex.org/W2078721873","https://openalex.org/W2079438371","https://openalex.org/W2079943469","https://openalex.org/W2080274663","https://openalex.org/W2080553628","https://openalex.org/W2080807703","https://openalex.org/W2081206164","https://openalex.org/W2081768153","https://openalex.org/W2081892455","https://openalex.org/W2082195309","https://openalex.org/W2084681571","https://openalex.org/W2084957666","https://openalex.org/W2084979786","https://openalex.org/W2085533241","https://openalex.org/W2085760247","https://openalex.org/W2086245307","https://openalex.org/W2087171956","https://openalex.org/W2087551351","https://openalex.org/W2088073674","https://openalex.org/W2088269376","https://openalex.org/W2088913270","https://openalex.org/W2088997949","https://openalex.org/W2089865526","https://openalex.org/W2090650498","https://openalex.org/W2090829119","https://openalex.org/W2091022458","https://openalex.org/W2093761069","https://openalex.org/W2094478098","https://openalex.org/W2095404216","https://openalex.org/W2095745901","https://openalex.org/W2096313573","https://openalex.org/W2096386031","https://openalex.org/W2097336990","https://openalex.org/W2097355576","https://openalex.org/W2101251583","https://openalex.org/W2101362932","https://openalex.org/W2101667070","https://openalex.org/W2104270305","https://openalex.org/W2105378817","https://openalex.org/W2105704879","https://openalex.org/W2105729193","https://openalex.org/W2105796226","https://openalex.org/W2106142655","https://openalex.org/W2106814023","https://openalex.org/W2106906885","https://openalex.org/W2107275666","https://openalex.org/W2107900038","https://openalex.org/W2108102646","https://openalex.org/W2109040303","https://openalex.org/W2109363402","https://openalex.org/W2111524632","https://openalex.org/W2112216133","https://openalex.org/W2114219396","https://openalex.org/W2115885986","https://openalex.org/W2115978010","https://openalex.org/W2118267556","https://openalex.org/W2118518385","https://openalex.org/W2119782201","https://openalex.org/W2121448546","https://openalex.org/W2121963977","https://openalex.org/W2122922661","https://openalex.org/W2127639747","https://openalex.org/W2128195111","https://openalex.org/W2130764195","https://openalex.org/W2131423447","https://openalex.org/W2131575598","https://openalex.org/W2131954858","https://openalex.org/W2132104987","https://openalex.org/W2134786936","https://openalex.org/W2137826660","https://openalex.org/W2138007390","https://openalex.org/W2138496162","https://openalex.org/W2139946382","https://openalex.org/W2142885321","https://openalex.org/W2142943752","https://openalex.org/W2144398929","https://openalex.org/W2145033741","https://openalex.org/W2145138002","https://openalex.org/W2147368157","https://openalex.org/W2148034814","https://openalex.org/W2149931901","https://openalex.org/W2150123812","https://openalex.org/W2151538478","https://openalex.org/W2156998090","https://openalex.org/W2157359173","https://openalex.org/W2157618233","https://openalex.org/W2159093573","https://openalex.org/W2161093330","https://openalex.org/W2165417923","https://openalex.org/W2166486694","https://openalex.org/W2166987747","https://openalex.org/W2168079270","https://openalex.org/W2169152986","https://openalex.org/W2202598304","https://openalex.org/W2287657100","https://openalex.org/W2379179491","https://openalex.org/W2412153316","https://openalex.org/W2791163698"],"related_works":["https://openalex.org/W2106142655","https://openalex.org/W2333535617","https://openalex.org/W2321596887","https://openalex.org/W2172238326","https://openalex.org/W2147719913","https://openalex.org/W3010885030","https://openalex.org/W4416935947","https://openalex.org/W1998832782","https://openalex.org/W7098419949","https://openalex.org/W3088340380"],"abstract_inverted_index":{"The":[0,34],"ubiquitin":[1],"proteasome":[2,58],"system":[3,11],"(UPS)":[4],"is":[5,104,116],"the":[6,43,46,75,89,92,102,114],"major":[7],"protein":[8],"quality":[9],"control":[10],"in":[12,48,57,62,66,74,94],"eukaryotic":[13],"cells.":[14],"Many":[15],"neurodegenerative":[16,49],"diseases":[17],"are":[18],"characterized":[19],"by":[20],"aggregates":[21],"and":[22,110],"inclusions":[23],"of":[24,45,78,91,101],"aberrant":[25],"proteins,":[26],"implying":[27],"a":[28,98],"sub-optimal":[29],"functioning":[30],"or":[31],"defective":[32],"UPS.":[33],"last":[35],"few":[36],"years":[37],"have":[38],"seen":[39],"increasing":[40],"evidence":[41],"for":[42],"involvement":[44,90],"UPS":[47,83,93,103,115],"disorders,":[50],"including":[51],"Alzheimer's":[52],"disease":[53],"(AD).":[54],"Notably,":[55],"decreases":[56],"activity":[59],"were":[60,80],"detected":[61],"several":[63],"cortical":[64],"areas":[65],"AD":[67,79,95,108],"patients.":[68],"In":[69],"addition,":[70],"proteins":[71],"that":[72],"accumulate":[73],"classical":[76],"hallmarks":[77],"linked":[81],"to":[82,113],"function.":[84],"This":[85],"review":[86],"specifically":[87],"discusses":[88],"pathogenesis.":[96],"First,":[97],"detailed":[99],"overview":[100],"presented,":[105],"after":[106],"which":[107],"pathology":[109],"its":[111],"relation":[112],"discussed.":[117],"11":[118],"GENERAL":[119],"INTRODUcTION":[120]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}