{"id":"https://openalex.org/W114355099","doi":null,"title":"Recent advances in the systemic therapy of breast cancer.","display_name":"Recent advances in the systemic therapy of breast cancer.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W114355099","mag":"114355099","pmid":"https://pubmed.ncbi.nlm.nih.gov/21765658","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3117550"},"language":"en","primary_location":{"id":"pmid:21765658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21765658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ochsner journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3117550/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103495455","display_name":"JOHN TOTTERDALE COLE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799767083","display_name":"Ochsner Medical Center","ror":"https://ror.org/0290qyp66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336053918","https://openalex.org/I2799767083"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J T Cole","raw_affiliation_strings":["Section on Hematology and Oncology, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Hematology and Oncology, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, LA","institution_ids":["https://openalex.org/I2799767083"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103495455"],"corresponding_institution_ids":["https://openalex.org/I2799767083"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.00925186,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"2","issue":"1","first_page":"24","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.10080000013113022,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9909999966621399},{"id":"https://openalex.org/keywords/systemic-treatment","display_name":"systemic therapy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":0.9739999771118164},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":1.0},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":1.0},{"id":"https://openalex.org/keywords/high-dose-chemotherapy","display_name":"high-dose chemotherapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/stem-cell-rescue","display_name":"stem cell rescue","score":0.8989999890327454},{"id":"https://openalex.org/keywords/oral-chemotherapy","display_name":"oral chemotherapy","score":0.7239999771118164},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.8330000042915344},{"id":"https://openalex.org/keywords/breast-cancer-prevention","display_name":"breast cancer prevention","score":0.7450000047683716},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.972000002861023},{"id":"https://openalex.org/keywords/palliative-care","display_name":"palliative care","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8130351305007935},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7763384580612183},{"id":"https://openalex.org/C185926286","wikidata":"https://www.wikidata.org/wiki/Q1929812","display_name":"Systemic therapy","level":4,"score":0.6861521601676941},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.6290876865386963},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.6094140410423279},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5733639597892761},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5540277361869812},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.535706639289856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4520164132118225},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.44705572724342346}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:21765658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21765658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ochsner journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3117550","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3117550/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ochsner J","raw_type":"Text"},{"id":"mag:114355099","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21765658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3117550","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3117550/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ochsner J","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1785581158","https://openalex.org/W1812067939","https://openalex.org/W1843618725","https://openalex.org/W1846747462","https://openalex.org/W1848336847","https://openalex.org/W1852147417","https://openalex.org/W1854164300","https://openalex.org/W1899541887","https://openalex.org/W1900945709","https://openalex.org/W1906721103","https://openalex.org/W1909697168","https://openalex.org/W1918151945","https://openalex.org/W1920828316","https://openalex.org/W1924346446","https://openalex.org/W1927722732","https://openalex.org/W1933350662","https://openalex.org/W1934173384","https://openalex.org/W1939003096","https://openalex.org/W1940165440","https://openalex.org/W1946819517","https://openalex.org/W1954585625","https://openalex.org/W1960713055","https://openalex.org/W1968965382","https://openalex.org/W1985460342","https://openalex.org/W1990582579","https://openalex.org/W2006174096","https://openalex.org/W2019220522","https://openalex.org/W2043711125","https://openalex.org/W2066547081","https://openalex.org/W2066550282","https://openalex.org/W2095156669","https://openalex.org/W2097514725","https://openalex.org/W2128848742","https://openalex.org/W2141056749","https://openalex.org/W2141647078","https://openalex.org/W2143989581","https://openalex.org/W2148078311","https://openalex.org/W2159459001","https://openalex.org/W2165664908","https://openalex.org/W2172185687","https://openalex.org/W2222638000","https://openalex.org/W2227235589","https://openalex.org/W2228671601","https://openalex.org/W2259615536","https://openalex.org/W2271753451","https://openalex.org/W2274246668","https://openalex.org/W2276085691","https://openalex.org/W2298694094","https://openalex.org/W2313308602","https://openalex.org/W2322012902","https://openalex.org/W2344444710"],"related_works":["https://openalex.org/W632452041","https://openalex.org/W4237986567","https://openalex.org/W2112721704","https://openalex.org/W7099273758","https://openalex.org/W2372677470","https://openalex.org/W2017427076","https://openalex.org/W2470040617","https://openalex.org/W2155946383","https://openalex.org/W2464966065","https://openalex.org/W2942054879"],"abstract_inverted_index":{"A":[0],"number":[1],"of":[2,15,22,43,46,57,76,84,108,114],"advances":[3],"have":[4],"been":[5],"made":[6],"over":[7],"the":[8,12,20,23,29,44,55,65,73,82,106,120],"last":[9],"decade":[10],"in":[11],"systemic":[13],"therapy":[14,68,79],"breast":[16,37,70,85,121],"cancer,":[17],"including":[18],"1)":[19],"introduction":[21],"taxanes,":[24],"paclitaxel":[25],"and":[26,35,60,87,100,110],"docetaxel,":[27],"into":[28],"treatment":[30],"regimes":[31],"for":[32,69,116],"both":[33,105],"early":[34],"advanced":[36],"cancer;":[38,71,86],"2)":[39],"a":[40,111],"greater":[41],"understanding":[42],"use":[45],"high-dose":[47],"chemotherapy,":[48],"supplemented":[49],"with":[50,119],"stem":[51],"cell":[52],"rescue;":[53],"3)":[54],"development":[56,83],"newer":[58],"parenteral":[59],"oral":[61],"chemotherapeutic":[62],"drugs;":[63],"4)":[64],"first":[66,74],"biologic":[67],"5)":[72],"demonstration":[75],"effective":[77,89],"drug":[78],"to":[80,91],"prevent":[81,94],"6)":[88],"agents":[90],"palliate":[92],"and/or":[93],"complications":[95],"from":[96],"bone":[97],"metastasis.":[98],"These":[99],"other":[101],"developments":[102],"are":[103],"allowing":[104],"extension":[107],"life":[109,115],"better":[112],"quality":[113],"those":[117],"stricken":[118],"cancer.":[122]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}