{"id":"https://openalex.org/W113807572","doi":"https://doi.org/10.1096/fasebj.21.5.a260-b","title":"REGULATION OF APOPTOSIS IN BREAST CANCER CELLS INDUCED BY CIS\u2010PLATIN AND L\u2010PPMP","display_name":"REGULATION OF APOPTOSIS IN BREAST CANCER CELLS INDUCED BY CIS\u2010PLATIN AND L\u2010PPMP","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W113807572","doi":"https://doi.org/10.1096/fasebj.21.5.a260-b","mag":"113807572"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a260-b","doi":"https://doi.org/10.1096/fasebj.21.5.a260-b","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a260-b","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100710177","display_name":"Rui Ma","orcid":"https://orcid.org/0000-0001-8226-6571","observed_orcids":["https://orcid.org/0000-0001-8226-6571"]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Ma","raw_affiliation_strings":["Chemistry and Biochemistry University of Notre Dame 444 Stepan Hall Notre Dame IN 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry University of Notre Dame 444 Stepan Hall Notre Dame IN 46556","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064901786","display_name":"Yoonie Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yoonie Cho","raw_affiliation_strings":["Chemistry and Biochemistry University of Notre Dame 444 Stepan Hall Notre Dame IN 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry University of Notre Dame 444 Stepan Hall Notre Dame IN 46556","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003531562","display_name":"Gabriel Crowford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Crowford","raw_affiliation_strings":["Chemistry and Biochemistry University of Notre Dame 444 Stepan Hall Notre Dame IN 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry University of Notre Dame 444 Stepan Hall Notre Dame IN 46556","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062183859","display_name":"Denise Pineda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise Pineda","raw_affiliation_strings":["Chemistry and Biochemistry University of Notre Dame 444 Stepan Hall Notre Dame IN 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry University of Notre Dame 444 Stepan Hall Notre Dame IN 46556","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christopher Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Thomas","raw_affiliation_strings":["Chemistry and Biochemistry University of Notre Dame 444 Stepan Hall Notre Dame IN 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry University of Notre Dame 444 Stepan Hall Notre Dame IN 46556","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102331613","display_name":"Sipra Banerjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sipra Banerjee","raw_affiliation_strings":["Cleveland Clinic Foundation, Department of Cancer Biology Cleveland OH 44129"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic Foundation, Department of Cancer Biology Cleveland OH 44129","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111643124","display_name":"Subhash C. Basu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subhash Basu","raw_affiliation_strings":["Chemistry and Biochemistry University of Notre Dame 444 Stepan Hall Notre Dame IN 46556"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry and Biochemistry University of Notre Dame 444 Stepan Hall Notre Dame IN 46556","institution_ids":["https://openalex.org/I107639228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01300106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8299999833106995},{"id":"https://openalex.org/keywords/glycosyltransferases","display_name":"glycosyltransferases","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.492000013589859},{"id":"https://openalex.org/keywords/gd3-ganglioside","display_name":"GD3 ganglioside","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mitochondrial-trafficking","display_name":"mitochondrial trafficking","score":0.6890000104904175},{"id":"https://openalex.org/keywords/golgi-membranes","display_name":"Golgi membranes","score":0.8610000014305115},{"id":"https://openalex.org/keywords/sulfatide","display_name":"sulfatide","score":0.6439999938011169},{"id":"https://openalex.org/keywords/skbr3","display_name":"SKBR3","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/mda-mb-468-cells","display_name":"MDA-MB-468","score":0.9739999771118164},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6729999780654907},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.5419999957084656},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.699999988079071},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.8989999890327454},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7252925038337708},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5822004079818726},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.5817672610282898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45287737250328064},{"id":"https://openalex.org/C2777183694","wikidata":"https://www.wikidata.org/wiki/Q413364","display_name":"Gliotoxin","level":3,"score":0.44674667716026306},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44608771800994873},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4331057667732239},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.42478153109550476},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4091903567314148},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40206673741340637},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3368988037109375},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3336832523345947},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2807827591896057},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21539944410324097},{"id":"https://openalex.org/C2779787849","wikidata":"https://www.wikidata.org/wiki/Q134359","display_name":"Aspergillus fumigatus","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a260-b","doi":"https://doi.org/10.1096/fasebj.21.5.a260-b","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a260-b","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2168458938","https://openalex.org/W1568333508","https://openalex.org/W4253307354","https://openalex.org/W2287515401","https://openalex.org/W2910506949","https://openalex.org/W2010731942","https://openalex.org/W151695286","https://openalex.org/W80744218","https://openalex.org/W2040860790","https://openalex.org/W200412855"],"abstract_inverted_index":{"The":[0,126,139],"overall":[1],"objective":[2],"of":[3,11,38,52,64,101,113,135,158,160,184,190],"our":[4],"study":[5],"is":[6,96,129],"to":[7,44,118,124,132],"elucidate":[8],"the":[9,16,99,111,133,188],"regulation":[10,100],"glycolipid":[12],"glycosyltransferases":[13],"(GSL\u2010GLTs)":[14],"and":[15,26,54,92,144,154,166],"related":[17],"signal":[18,79],"transduction":[19,80],"during":[20,103,168],"apoptosis":[21,169],"(induced":[22],"by":[23],"cis":[24,121,191],"\u2010platin":[25,192],"L\u2010PPMP)":[27],"in":[28,85,180,187,215],"human":[29],"breast":[30],"carcinoma":[31],"cells":[32],"(SKBR\u20103,":[33],"MCF\u20107,":[34],"MDA\u2010468).":[35],"Abnormal":[36],"expression":[37,207],"any":[39,136],"particular":[40],"GSL\u2010GLT":[41,108,147,162],"may":[42],"lead":[43],"a":[45,61,68],"distorted":[46],"sequence.":[47],"A":[48],"recently":[49],"characterized":[50],"trafficking":[51],"ceramide":[53],"GD3":[55],"ganglioside":[56],"into":[57],"mitochondria":[58],"has":[59],"revealed":[60],"novel":[62],"function":[63],"this":[65],"GSL":[66],"as":[67,88],"death":[69],"effector":[70],"(":[71,196],"Glycoconj":[72,197],"J":[73,198],".":[74,199],"2004;":[75],"20":[76],"(5):\u201330).":[77],"Different":[78],"pathways":[81],"could":[82],"be":[83],"involved":[84],"apoptosis,":[86],"such":[87],"MAPKs,":[89],"Akt,":[90],"NF\u2010kB":[91],"caspases":[93],"cascades.":[94],"Little":[95],"known":[97],"about":[98],"GSL\u2010GLTs":[102],"apoptosis.":[104],"We":[105],"tested":[106,145],"different":[107],"activities":[109,148,163],"with":[110],"treatment":[112],"anti\u2010cancer":[114],"reagent":[115],"L\u2010PPMP":[116],"(1":[117],"16\u03bcM)":[119],"or":[120,178],"\u2010Platin":[122],"(10":[123],"200\u03bcM).":[125],"enzyme":[127],"inhibition":[128],"not":[130],"due":[131],"presence":[134,189],"free":[137],"inducers.":[138],"Golgi":[140],"membranes":[141],"were":[142],"isolated":[143],"for":[146],"(GalT\u20104,":[149,164],"GalT\u20105,":[150],"SAT\u20101,":[151],"SAT\u20102,":[152],"SAT\u20103":[153],"SAT\u20104).":[155],"Sharp":[156],"decrease":[157],"some":[159],"these":[161,173],"GalT\u20105":[165],"SAT\u20104)":[167],"suggests":[170],"that":[171],"perhaps":[172],"enzymes":[174],"are":[175,214],"either":[176],"inactivated":[177],"down\u2010regulated":[179],"their":[181],"expression.":[182],"Deregulation":[183],"replication":[185],"complexes":[186],"was":[193],"also":[194],"observed":[195],"2006;":[200],"23":[201],"(3\u20134):\u201387).":[202],"Further":[203],"studies":[204],"on":[205],"gene":[206,210],"using":[208],"GLT":[209],"chip":[211],"\u2010":[212],"arrays":[213],"progress.":[216]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
