{"id":"https://openalex.org/W113706255","doi":null,"title":"[Clinical reevaluation of continuous intravenous infusion of 5-fluorouracil--plasma concentrations and clinical dose by continuous intravenous and 60-min infusions].","display_name":"[Clinical reevaluation of continuous intravenous infusion of 5-fluorouracil--plasma concentrations and clinical dose by continuous intravenous and 60-min infusions].","publication_year":1990,"publication_date":"1990-02-01","ids":{"openalex":"https://openalex.org/W113706255","mag":"113706255","pmid":"https://pubmed.ncbi.nlm.nih.gov/2301952"},"language":"ja","primary_location":{"id":"pmid:2301952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2301952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074688612","display_name":"T Nakatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118675","display_name":"Kawasaki Municipal Hospital","ror":"https://ror.org/025bm0k33","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210118675"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T Nakatsu","raw_affiliation_strings":["Dept. of Surgery Kawasaki Municipal Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Surgery Kawasaki Municipal Hospital","institution_ids":["https://openalex.org/I4210118675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111406089","display_name":"I Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Yokoyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108472406","display_name":"K Tsuyuki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Tsuyuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Y Soh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Soh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032982366","display_name":"G Hanai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Hanai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030715946","display_name":"H. Matsumoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Matsumoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Kubo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Kubo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033764996","display_name":"Kazuhiko Matsumoto","orcid":"https://orcid.org/0000-0002-7391-5469","observed_orcids":["https://orcid.org/0000-0002-7391-5469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Matsumoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111439579","display_name":"Katsuhiko Nohga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Nohga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110738437","display_name":"H Koyanagi","orcid":"https://orcid.org/0009-0007-5980-5849","observed_orcids":["https://orcid.org/0009-0007-5980-5849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Koyanagi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"17","issue":"2","first_page":"253","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14189","display_name":"Intravenous Infusion Technology and Safety","score":0.044599998742341995,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/continuous-intravenous-infusion","display_name":"continuous intravenous infusion","score":0.9919999837875366},{"id":"https://openalex.org/keywords/infusion-pumps","display_name":"infusion pumps","score":0.5889999866485596},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.6949999928474426},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9700000286102295},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.8679999709129333},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.9850000143051147},{"id":"https://openalex.org/keywords/advanced-cancer","display_name":"advanced cancer","score":0.878000020980835},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/dose-scheduling","display_name":"dose scheduling","score":0.527999997138977},{"id":"https://openalex.org/keywords/outpatient-chemotherapy","display_name":"outpatient chemotherapy","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C2911027401","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Intravenous Infusions","level":2,"score":0.7687104940414429},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7519280910491943},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6892271637916565},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6364239454269409},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.6084100008010864},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5485655665397644},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.5251172184944153},{"id":"https://openalex.org/C3018112808","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Continuous infusion","level":2,"score":0.5145379900932312},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.47483450174331665},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4698951244354248},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.41097697615623474},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.39557167887687683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23980125784873962},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007260","descriptor_name":"Infusion Pumps","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012186","descriptor_name":"Retroperitoneal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012186","descriptor_name":"Retroperitoneal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2301952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2301952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gan to kagaku ryoho. Cancer & chemotherapy","raw_type":"English Abstract"},{"id":"mag:113706255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2301952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2077234029","https://openalex.org/W2965595766","https://openalex.org/W2069183803","https://openalex.org/W1499195169","https://openalex.org/W2110617366","https://openalex.org/W2138865276","https://openalex.org/W1993801226","https://openalex.org/W2056101890","https://openalex.org/W7099215410","https://openalex.org/W1572753496"],"abstract_inverted_index":{"Daily":[0],"and":[1,14,31,207,246],"intermittent":[2,15],"continuous":[3],"intravenous":[4,17],"infusions":[5],"[by":[6],"gravity":[7],"drip,":[8],"(IVG)":[9],"or":[10,82,162],"infusion":[11,19],"pump,":[12],"(IVP)]":[13],"short-time":[16,157],"drip":[18],"of":[20,42,93,104,120],"5-FU":[21,43,63,198],"were":[22,34,58,71,137,202,211,220],"carried":[23],"out":[24],"on":[25],"advanced":[26],"cancer":[27],"patients.":[28],"The":[29],"MTD":[30],"dose-limiting":[32,134],"toxicity":[33],"investigated":[35],"in":[36,48,123,140,143,149,194,214],"relation":[37],"to":[38,74],"the":[39,94,124,150,154,195,205,218,230],"plasma":[40,151,215],"concentrations":[41,70],"determined":[44],"by":[45,242,252],"HPLC.":[46],"Responses":[47],"eleven":[49],"patients":[50,79,97,106,167,183,196],"receiving":[51,80,107,156],"IVG":[52,81,144,159,206,253],"administration":[53,84,109,160],"daily":[54],"at":[55,86,111,171],"8-21":[56],"mg/kg/day":[57],"NC,":[59],"but":[60,127,217],"those":[61],"given":[62,168,184,197],"alone":[64],"showed":[65,98,117,177],"no":[66],"adverse":[67,179],"reactions.":[68,180],"Plasma":[69],"too":[72],"low":[73],"be":[75,236],"determined.":[76],"In":[77,181],"9":[78],"IVP":[83,108,141,208,243],"weekly":[85,110,169],"60":[87,175,200,238,250],"mg/kg":[88,113,173,239,248],"for":[89,114,174,199,240,244,249,254],"24":[90],"hr,":[91],"1":[92],"5":[95],"evaluable":[96],"reduced":[99],"hepatic":[100],"metastatic":[101,121],"lesions.":[102],"One":[103],"4":[105],"120":[112],"48":[115],"hr":[116],"a":[118,164],"disappearance":[119],"lesions":[122],"skeletal":[125],"muscle,":[126],"bone":[128,187],"marrow":[129,188],"suppression":[130,189],"was":[131,190,224],"observed":[132],"as":[133],"toxicity.":[135],"Pharmacokinetics":[136],"more":[138],"stable":[139],"than":[142],"with":[145],"less":[146],"individual":[147,212],"difference":[148],"concentrations.":[152],"Among":[153],"outpatients":[155],"iv,":[158],"once":[161],"twice":[163],"week,":[165],"2":[166],"administrations":[170],"20":[172,247],"min":[176,201],"slight":[178],"6":[182],"high-dose":[185],"administrations,":[186],"observed.":[191],"When":[192],"pharmacokinetics":[193],"compared":[203],"between":[204],"groups,":[209],"there":[210],"differences":[213,219],"concentrations,":[216],"not":[221],"significant.":[222],"It":[223],"concluded":[225],"from":[226],"above":[227],"results":[228],"that":[229],"following":[231],"practical":[232],"dose":[233],"schedules":[234],"would":[235],"recommendable:":[237],"24hr/week":[241],"inpatients":[245],"min/week":[251],"outpatients.":[255]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
