{"id":"https://openalex.org/W113698564","doi":"https://doi.org/10.1152/jappl.1985.58.5.1729","title":"Electrical properties of monolayers cultured from cells of human tracheal mucosa","display_name":"Electrical properties of monolayers cultured from cells of human tracheal mucosa","publication_year":1985,"publication_date":"1985-05-01","ids":{"openalex":"https://openalex.org/W113698564","doi":"https://doi.org/10.1152/jappl.1985.58.5.1729","mag":"113698564","pmid":"https://pubmed.ncbi.nlm.nih.gov/2581929"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1985.58.5.1729","doi":"https://doi.org/10.1152/jappl.1985.58.5.1729","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1985.58.5.1729","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026572261","display_name":"Jonathan H. Widdicombe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. H. Widdicombe","raw_affiliation_strings":["","University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005447367","display_name":"DAVID L. COLEMAN","orcid":"https://orcid.org/0000-0002-1773-6597","observed_orcids":["https://orcid.org/0000-0002-1773-6597"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. L. Coleman","raw_affiliation_strings":["","University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045698000","display_name":"Walter E. Finkbeiner","orcid":"https://orcid.org/0000-0002-4387-3659","observed_orcids":["https://orcid.org/0000-0002-4387-3659"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. E. Finkbeiner","raw_affiliation_strings":["","University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029011117","display_name":"I. K. Tuet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. K. Tuet","raw_affiliation_strings":["","University of California at San Francisco,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"University of California at San Francisco,","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":2.2699,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.88498443,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"58","issue":"5","first_page":"1729","last_page":"1735"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epithelial-monolayers","display_name":"epithelial monolayers","score":0.8209999799728394},{"id":"https://openalex.org/keywords/short-circuit-current","display_name":"short-circuit current","score":0.7730000019073486},{"id":"https://openalex.org/keywords/transepithelial-potential-difference","display_name":"transepithelial potential difference","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.7639999985694885},{"id":"https://openalex.org/keywords/epithelial-permeability","display_name":"epithelial permeability","score":0.6539999842643738},{"id":"https://openalex.org/keywords/amiloride","display_name":"amiloride","score":0.5789999961853027},{"id":"https://openalex.org/keywords/ouabain","display_name":"ouabain","score":0.9660000205039978},{"id":"https://openalex.org/keywords/bumetanide","display_name":"bumetanide","score":0.9070000052452087},{"id":"https://openalex.org/keywords/furosemide","display_name":"furosemide","score":0.949999988079071},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.9229999780654907},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.968999981880188},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apical-membrane","display_name":"apical membrane","score":0.4300000071525574},{"id":"https://openalex.org/keywords/basolateral-membrane","display_name":"basolateral membrane","score":0.7549999952316284},{"id":"https://openalex.org/keywords/polarized-epithelium","display_name":"polarized epithelium","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.761269211769104},{"id":"https://openalex.org/C2778212192","wikidata":"https://www.wikidata.org/wiki/Q275926","display_name":"Bumetanide","level":4,"score":0.7595030069351196},{"id":"https://openalex.org/C2779133857","wikidata":"https://www.wikidata.org/wiki/Q285911","display_name":"Ouabain","level":3,"score":0.7356435060501099},{"id":"https://openalex.org/C7070889","wikidata":"https://www.wikidata.org/wiki/Q902488","display_name":"Monolayer","level":2,"score":0.6353834867477417},{"id":"https://openalex.org/C3018436504","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Apical membrane","level":3,"score":0.5596097111701965},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.5289162397384644},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5279544591903687},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5064200162887573},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.4318752586841583},{"id":"https://openalex.org/C39587587","wikidata":"https://www.wikidata.org/wiki/Q5383698","display_name":"Epithelial polarity","level":3,"score":0.4300985038280487},{"id":"https://openalex.org/C2780098789","wikidata":"https://www.wikidata.org/wiki/Q898356","display_name":"Glycocalyx","level":2,"score":0.422904908657074},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.41301190853118896},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39383935928344727},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.35512644052505493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34966957569122314},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33026444911956787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3012177050113678},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.2734804153442383},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2516782283782959},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23822087049484253},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.1661093533039093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11779233813285828},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000584","descriptor_name":"Amiloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004232","descriptor_name":"Diuretics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004553","descriptor_name":"Electric Conductivity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010042","descriptor_name":"Ouabain","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011458","descriptor_name":"Prostaglandins E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011460","descriptor_name":"Prostaglandins F","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jappl.1985.58.5.1729","doi":"https://doi.org/10.1152/jappl.1985.58.5.1729","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1985.58.5.1729","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:2581929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2581929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2692838629","display_name":null,"funder_award_id":"HL 24136","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2396750528","https://openalex.org/W2417996784","https://openalex.org/W2087765037","https://openalex.org/W2066276416","https://openalex.org/W2337280044","https://openalex.org/W2412898273","https://openalex.org/W2034428571","https://openalex.org/W2114509412","https://openalex.org/W2322985522","https://openalex.org/W2073862596"],"abstract_inverted_index":{"Dispersed":[0],"isolated":[1],"cells":[2,18,40],"were":[3,19],"obtained":[4,20],"from":[5,67,126],"human":[6],"tracheal":[7],"mucosa":[8],"by":[9,31,73,100],"digestion":[10],"with":[11],"collagenase.":[12],"Up":[13],"to":[14,26,117,158],"1.5":[15],"X":[16],"10(8)":[17],"per":[21],"trachea":[22],"and":[23,61,88,104,107,135],"showed":[24,82],"up":[25],"95%":[27],"viability,":[28],"as":[29],"judged":[30],"trypan":[32],"blue":[33],"exclusion.":[34],"When":[35],"grown":[36,78],"in":[37],"culture,":[38],"the":[39,50,118,127,132],"formed":[41],"monolayers":[42,51],"after":[43,160],"approximately":[44,161],"4":[45],"days.":[46],"Electron":[47],"microscopy":[48],"of":[49,84,92,131],"revealed":[52],"a":[53,62,68],"polarized":[54],"structure.":[55],"An":[56],"apical":[57,128],"membrane,":[58],"containing":[59],"microvilli":[60],"pronounced":[63],"glycocalyx,":[64],"was":[65,98],"separated":[66],"relatively":[69],"unspecialized":[70],"basolateral":[71,119],"membrane":[72],"typical":[74],"tight":[75],"junctions.":[76],"Monolayers":[77],"on":[79,152],"nucleopore":[80],"filters":[81],"resistances":[83],"44-1,800":[85],"omega.":[86],"cm2":[87],"transepithelial":[89],"potential":[90],"differences":[91],"0.1-7.6":[93],"mV.":[94],"Short-circuit":[95],"current":[96],"(Isc)":[97],"increased":[99],"isoproterenol,":[101],"prostaglandins":[102],"E2":[103],"F2":[105],"alpha,":[106],"bradykinin.":[108],"The":[109],"loop":[110],"diuretic,":[111],"bumetanide,":[112],"reduced":[113],"Isc":[114,157],"when":[115],"added":[116],"(serosal)":[120],"side":[121,130],"but":[122],"had":[123,149],"no":[124,150],"effect":[125,151],"(mucosal)":[129],"monolayers.":[133],"Furosemide":[134],"MK-196":[136],"also":[137],"inhibited":[138,142],"Isc.":[139,143,153],"Mucosal":[140],"amiloride":[141,145],"Serosal":[144,154],"or":[146],"mucosal":[147],"ouabain":[148,155],"brought":[156],"zero":[159],"15":[162],"min.":[163]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
