{"id":"https://openalex.org/W113686829","doi":null,"title":"mRNA-based gene transfer as a tool for gene and cell therapy.","display_name":"mRNA-based gene transfer as a tool for gene and cell therapy.","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W113686829","mag":"113686829","pmid":"https://pubmed.ncbi.nlm.nih.gov/17932806"},"language":"en","primary_location":{"id":"pmid:17932806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17932806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in molecular therapeutics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037454723","display_name":"Viggo F. Van Tendeloo","orcid":"https://orcid.org/0000-0003-3217-9917","observed_orcids":["https://orcid.org/0000-0003-3217-9917"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]},{"id":"https://openalex.org/I4210102047","display_name":"Antwerp University Hospital","ror":"https://ror.org/01hwamj44","country_code":"BE","type":"funder","lineage":["https://openalex.org/I4210102047"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Viggo F I Van Tendeloo","raw_affiliation_strings":["Antwerp University, Vaccine & Infectious Disease Institute, Center for Cellular Therapy and Regenerative Medicine, Faculty of Medicine, Antwerp University Hospital (UZA), B-2650 Edegem, Belgium. viggo.van.tendeloo@uza.be"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Antwerp University, Vaccine & Infectious Disease Institute, Center for Cellular Therapy and Regenerative Medicine, Faculty of Medicine, Antwerp University Hospital (UZA), B-2650 Edegem, Belgium. viggo.van.tendeloo@uza.be","institution_ids":["https://openalex.org/I149213910","https://openalex.org/I4210102047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049558588","display_name":"Peter Ponsaerts","orcid":"https://orcid.org/0000-0002-1892-6499","observed_orcids":["https://orcid.org/0000-0002-1892-6499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Ponsaerts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015223856","display_name":"Zwi Nisan Berneman","orcid":"https://orcid.org/0000-0002-9133-4588","observed_orcids":["https://orcid.org/0000-0002-9133-4588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zwi N Berneman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8386,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.91627489,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"9","issue":"5","first_page":"423","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-viral-gene-therapy","display_name":"non-viral gene therapy","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.734000027179718},{"id":"https://openalex.org/keywords/electroporation","display_name":"electroporation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/rna-transfection","display_name":"RNA transfection","score":0.7039999961853027},{"id":"https://openalex.org/keywords/transient-expression","display_name":"transient expression","score":0.6389999985694885},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.8393980264663696},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.6998697519302368},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6650023460388184},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5955134630203247},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5899770855903625},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5767570734024048},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5537030100822449},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.5444610118865967},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.5350573658943176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5241315960884094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5039436221122742},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44782108068466187},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43828973174095154},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.42126885056495667},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40859198570251465},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4015626609325409},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17637783288955688},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14422756433486938},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07365459203720093}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017690","descriptor_name":"Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:17932806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17932806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in molecular therapeutics","raw_type":"Journal Article"},{"id":"mag:113686829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17932806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2046959285","https://openalex.org/W2053359824","https://openalex.org/W2469115847","https://openalex.org/W3136337465","https://openalex.org/W2019962265","https://openalex.org/W2031454462","https://openalex.org/W2404131008","https://openalex.org/W2221797292","https://openalex.org/W81585652","https://openalex.org/W47932177"],"abstract_inverted_index":{"In":[0,144],"the":[1,15,29,33,86,124,161],"field":[2],"of":[3,20,56,113,127,147,163],"nonviral":[4],"gene":[5,8,149,169],"therapy,":[6],"mRNA-based":[7],"transfer":[9,150],"has":[10],"generated":[11],"much":[12],"interest":[13],"over":[14,67],"last":[16],"decade.":[17],"The":[18,54],"combination":[19],"RNA":[21,102,128,148,164],"as":[22,32,97,166],"a":[23,77,98,167],"versatile":[24,168],"protein":[25],"delivery":[26],"molecule":[27],"and":[28,45,71,81,129,159],"dendritic":[30],"cell":[31,37],"most":[34],"potent":[35],"antigen-presenting":[36],"is":[38],"an":[39,109],"attractive":[40],"approach":[41],"to":[42,76,83,100,132],"induce":[43],"cellular":[44,142],"potentially":[46],"therapeutic":[47],"immune":[48],"responses":[49],"in":[50,114,141],"patients":[51],"with":[52,108],"cancer.":[53],"success":[55],"mRNA":[57,136],"transfection":[58,165],"stems":[59],"from":[60],"its":[61,139],"superior":[62],"cytoplasmic":[63],"expression":[64,80],"efficiency,":[65],"simplicity":[66],"viral":[68],"transduction":[69],"protocols,":[70],"clinical":[72],"safety":[73],"profile":[74],"(due":[75],"strictly":[78],"transient":[79],"inability":[82],"integrate":[84],"into":[85,103,123,151],"host":[87],"genome).":[88],"Most":[89],"researchers":[90],"have":[91,137],"exploited":[92],"low-voltage":[93],"electrical":[94],"pulses":[95],"(electroporation)":[96],"means":[99],"introduce":[101],"cells,":[104],"but":[105],"other":[106,153],"methods":[107],"even":[110],"higher":[111],"degree":[112],"vivo":[115],"applicability":[116],"are":[117,156],"under":[118],"development.":[119],"Recently,":[120],"more":[121],"insights":[122],"immunological":[125],"properties":[126],"optimized":[130],"strategies":[131],"produce":[133],"highly":[134],"translatable":[135],"increased":[138],"efficacy":[140],"vaccination.":[143],"addition,":[145],"application":[146],"areas":[152],"than":[154],"immunotherapy":[155],"slowly":[157],"emerging":[158],"underscore":[160],"potential":[162],"therapy":[170],"tool.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
