{"id":"https://openalex.org/W1136845723","doi":null,"title":"Molecular and cellular mechanisms of heart regeneration in zebrafish","display_name":"Molecular and cellular mechanisms of heart regeneration in zebrafish","publication_year":2010,"publication_date":"2010-06-30","ids":{"openalex":"https://openalex.org/W1136845723","mag":"1136845723"},"language":"en","primary_location":{"id":"pmh:oai:dnet:tdr_________::51b1b67daa2ffe2eed97323b14ab7a4d","doi":null,"is_oa":false,"landing_page_url":"http://www.tdx.cat/TDX-0124111-085910","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10803/7216","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051777155","display_name":"Eduard Sleep Ronquillo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eduard Sleep Ronquillo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5051777155"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.9070000052452087},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cardiomyocyte-proliferation","display_name":"cardiomyocyte proliferation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cardiomyocyte-dedifferentiation","display_name":"cardiomyocyte dedifferentiation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/plk1","display_name":"PLK1","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cardiac-progenitor-cells","display_name":"cardiac progenitor cells","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cardiac-stem-cells","display_name":"cardiac stem cells","score":0.5690000057220459},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cardiac-injury","display_name":"cardiac injury","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.7728135585784912},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4050287902355194},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.39862361550331116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2735177278518677}],"mesh":[],"locations_count":6,"locations":[{"id":"pmh:oai:dnet:tdr_________::51b1b67daa2ffe2eed97323b14ab7a4d","doi":null,"is_oa":false,"landing_page_url":"http://www.tdx.cat/TDX-0124111-085910","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:hispana.mcu.es:6597511","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/7216","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null},{"id":"pmh:oai:repositori-api.upf.edu:10230/12240","doi":null,"is_oa":false,"landing_page_url":"http://www.tdx.cat/TDX-0124111-085910","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:repositori.upf.edu:10803/7216","doi":null,"is_oa":true,"landing_page_url":"http://www.tdx.cat/TDX-0124111-085910","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/7216","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/7216","pdf_url":"http://hdl.handle.net/10803/7216","source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1136845723","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Eduard_Sleep/publication/49582659_Molecular_and_cellular_mechanisms_of_heart_regeneration_in_zebrafish/links/53f229a90cf2bc0c40e71b98.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:hispana.mcu.es:6597511","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/7216","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1136845723.pdf","grobid_xml":"https://content.openalex.org/works/W1136845723.grobid-xml"},"referenced_works_count":163,"referenced_works":["https://openalex.org/W34912133","https://openalex.org/W50949581","https://openalex.org/W1231869524","https://openalex.org/W1514820219","https://openalex.org/W1530415409","https://openalex.org/W1559457086","https://openalex.org/W1572805438","https://openalex.org/W1595724760","https://openalex.org/W1598385484","https://openalex.org/W1857560941","https://openalex.org/W1932232911","https://openalex.org/W1965128951","https://openalex.org/W1966202908","https://openalex.org/W1967080927","https://openalex.org/W1969670626","https://openalex.org/W1970029778","https://openalex.org/W1970097521","https://openalex.org/W1972304405","https://openalex.org/W1974093611","https://openalex.org/W1975493013","https://openalex.org/W1976995280","https://openalex.org/W1978717530","https://openalex.org/W1981522023","https://openalex.org/W1981692093","https://openalex.org/W1982334864","https://openalex.org/W1982719958","https://openalex.org/W1983779136","https://openalex.org/W1984219920","https://openalex.org/W1984439372","https://openalex.org/W1985207433","https://openalex.org/W1985538729","https://openalex.org/W1987821849","https://openalex.org/W1988257487","https://openalex.org/W1990582376","https://openalex.org/W1992697273","https://openalex.org/W1993219445","https://openalex.org/W1993624225","https://openalex.org/W1994279105","https://openalex.org/W1995473546","https://openalex.org/W1998095389","https://openalex.org/W1998271270","https://openalex.org/W1998756807","https://openalex.org/W1998970920","https://openalex.org/W1999604714","https://openalex.org/W2003742149","https://openalex.org/W2004606489","https://openalex.org/W2007164914","https://openalex.org/W2009530575","https://openalex.org/W2011393212","https://openalex.org/W2017100119","https://openalex.org/W2017307944","https://openalex.org/W2017567461","https://openalex.org/W2019331028","https://openalex.org/W2019751519","https://openalex.org/W2019950538","https://openalex.org/W2022087854","https://openalex.org/W2022367603","https://openalex.org/W2023327619","https://openalex.org/W2024119600","https://openalex.org/W2025621779","https://openalex.org/W2025909669","https://openalex.org/W2026545247","https://openalex.org/W2028036560","https://openalex.org/W2029309165","https://openalex.org/W2030445959","https://openalex.org/W2030618223","https://openalex.org/W2031609492","https://openalex.org/W2032382800","https://openalex.org/W2033650586","https://openalex.org/W2036182754","https://openalex.org/W2036211290","https://openalex.org/W2036820557","https://openalex.org/W2039435553","https://openalex.org/W2040825881","https://openalex.org/W2041082150","https://openalex.org/W2041739600","https://openalex.org/W2042686954","https://openalex.org/W2043474702","https://openalex.org/W2054024812","https://openalex.org/W2054536322","https://openalex.org/W2055935926","https://openalex.org/W2057830548","https://openalex.org/W2058267372","https://openalex.org/W2058704011","https://openalex.org/W2059485167","https://openalex.org/W2063434280","https://openalex.org/W2064922804","https://openalex.org/W2065171831","https://openalex.org/W2067185634","https://openalex.org/W2067646863","https://openalex.org/W2068289479","https://openalex.org/W2068456839","https://openalex.org/W2069463594","https://openalex.org/W2072505153","https://openalex.org/W2074442006","https://openalex.org/W2074843296","https://openalex.org/W2076112920","https://openalex.org/W2078699298","https://openalex.org/W2079632995","https://openalex.org/W2079793168","https://openalex.org/W2080067533","https://openalex.org/W2080419619","https://openalex.org/W2081399277","https://openalex.org/W2083892587","https://openalex.org/W2090873791","https://openalex.org/W2092620729","https://openalex.org/W2093279832","https://openalex.org/W2095059099","https://openalex.org/W2097685453","https://openalex.org/W2100920433","https://openalex.org/W2101816987","https://openalex.org/W2101986300","https://openalex.org/W2104206289","https://openalex.org/W2104214146","https://openalex.org/W2104946303","https://openalex.org/W2105824459","https://openalex.org/W2106058491","https://openalex.org/W2110168421","https://openalex.org/W2111763078","https://openalex.org/W2114765756","https://openalex.org/W2117283769","https://openalex.org/W2120231073","https://openalex.org/W2122616632","https://openalex.org/W2126747203","https://openalex.org/W2128493164","https://openalex.org/W2128707394","https://openalex.org/W2130275438","https://openalex.org/W2130586251","https://openalex.org/W2131953775","https://openalex.org/W2132531056","https://openalex.org/W2136350868","https://openalex.org/W2136815240","https://openalex.org/W2137755780","https://openalex.org/W2139689863","https://openalex.org/W2141279088","https://openalex.org/W2141744996","https://openalex.org/W2145009672","https://openalex.org/W2147930121","https://openalex.org/W2149186578","https://openalex.org/W2150614509","https://openalex.org/W2150761291","https://openalex.org/W2152224682","https://openalex.org/W2155300776","https://openalex.org/W2158797557","https://openalex.org/W2159247182","https://openalex.org/W2160950853","https://openalex.org/W2161533644","https://openalex.org/W2163525929","https://openalex.org/W2166137664","https://openalex.org/W2166291320","https://openalex.org/W2166496450","https://openalex.org/W2166550261","https://openalex.org/W2167808312","https://openalex.org/W2169604969","https://openalex.org/W2171022526","https://openalex.org/W2171200951","https://openalex.org/W2172240299","https://openalex.org/W2185090025","https://openalex.org/W2272656670","https://openalex.org/W2324990885","https://openalex.org/W2399950152","https://openalex.org/W2409254519","https://openalex.org/W3114222320"],"related_works":["https://openalex.org/W1998457769","https://openalex.org/W2126747203","https://openalex.org/W7009852031","https://openalex.org/W2999957248","https://openalex.org/W3007365203","https://openalex.org/W2357906572","https://openalex.org/W6940103861","https://openalex.org/W2030166554","https://openalex.org/W4407888744","https://openalex.org/W2104082179"],"abstract_inverted_index":{"In":[0],"contrast":[1],"to":[2,9,28,154],"mammals,":[3],"zebrafish":[4,112,140,159],"do":[5,22],"have":[6,129],"the":[7,50,107,111],"ability":[8],"regenerate":[10],"their":[11],"heart":[12,54,113,141,156],"after":[13],"injury.":[14],"A":[15],"better":[16],"understanding":[17,155],"of":[18,52,64,92,97,110,134],"how":[19],"regenerationcompetent":[20],"species":[21],"so":[23],"should":[24,161],"help":[25],"developing":[26],"strategies":[27],"enhance":[29],"human":[30],"cardiac":[31,166],"regeneration.":[32,127],"Here,":[33],"by":[34,85,115],"genetic":[35],"lineage-tracing":[36],"using":[37],"an":[38],"inducible":[39],"Cre/lox":[40,216],"system,":[41],"we":[42,120],"show":[43,121],"that":[44,80,122,143],"newly":[45],"formed":[46],"cardiomyocytes":[47],"arise":[48],"from":[49],"proliferation":[51,82],"differentiated":[53],"muscle":[55],"cells.":[56],"These":[57],"results":[58],"argue":[59],"against":[60],"a":[61,132,200,204,269,274,295,315],"significant":[62],"contribution":[63],"stem":[65],"or":[66],"progenitor":[67],"cells":[68],"in":[69,106,158,168],"this":[70],"process.":[71],"Our":[72],"microarray":[73,256],"and":[74,89,160],"electron":[75],"microscopy":[76],"data":[77,148],"provide":[78,162],"evidence":[79],"cardiomyocyte":[81,87],"is":[83,104,124],"accomplished":[84],"limited":[86],"dedifferentiation":[88],"increased":[90],"expression":[91],"cell":[93],"cycle":[94],"regulators.":[95],"One":[96],"these":[98],"genes,":[99],"polo-like":[100,289],"kinase":[101,290],"1":[102,291],"(plk1),":[103,292],"upregulated":[105],"regenerating":[108],"area":[109],"and,":[114],"specifically":[116],"inhibiting":[117],"plk1":[118],"activity,":[119],"it":[123],"essential":[125],"for":[126,165],"We":[128],"also":[130],"identified":[131],"series":[133],"additional":[135],"transcripts":[136],"differentially":[137],"expressed":[138],"during":[139],"regeneration":[142,157],"warrant":[144],"further":[145],"research.":[146],"The":[147],"presented":[149],"here":[150],"offer":[151],"new":[152],"insights":[153],"useful":[163],"information":[164],"repair":[167],"humans.De":[169],"manera":[170,329],"oposada":[171],"als":[172],"mam\u00edfers,":[173],"els":[174],"peixos":[175],"zebra":[176,302,338,359],"s\u00ed":[177],"tenen":[178],"la":[179,206,224,231,263,307,316,332,350,353,365],"capicitat":[180],"de":[181,196,208,217,220,226,230,233,244,255,258,265,277,279,300,324,328,352],"regenerar":[182,197],"el":[183,283,288,336,357],"cor":[184,299],"despr\u00e9s":[185],"d'una":[186],"lesi\u00f3.":[187],"Entenent":[188],"millor":[189],"com":[190],"s'ho":[191],"fan":[192],"les":[193],"esp\u00e8cies":[194],"capaces":[195],"hauria":[198],"d'ajudar-nos":[199],"desenvolupar":[201],"estrat\u00e8gies":[202],"per":[203,314,364],"augmentar":[205],"capacitat":[207],"regeneraci\u00f3":[209,333,354],"en":[210,249,335,349,356,368],"humans.":[211,369],"Aqu\u00ed,":[212],"mitjan\u00e7ant":[213],"un":[214,275,304],"sistema":[215],"tra\u00e7at":[218],"gen\u00e8tic":[219],"llinatge,":[221],"mostrem":[222,310],"que":[223,262,281,311,326,340],"creaci\u00f3":[225],"nous":[227],"cardiomi\u00f2cits":[228,266],"prov\u00e9":[229],"proliferaci\u00f3":[232,264],"c\u00e8l\u00b7lules":[234,245],"card\u00edaques":[235],"diferenciades.":[236],"Aquests":[237],"resultats":[238,345],"discrepen":[239],"amb":[240],"una":[241,270,321],"contribuci\u00f3":[242],"significativa":[243],"mare":[246],"o":[247],"progenitores":[248],"aquest":[250],"proc\u00e9s.":[251],"Les":[252],"dades":[253],"obtingudes":[254],"i":[257,273,339,360],"microsc\u00f2pia":[259],"electr\u00f2nica":[260],"evidencien":[261],"\u00e9s":[267,312],"deguda":[268],"dediferenciaci\u00f3":[271],"parcial":[272],"increment":[276],"l'expressi\u00f3":[278],"gens":[280],"promouen":[282],"cicle":[284],"cel\u00b7lular.":[285],"Un":[286],"d'aquests,":[287],"augmenta":[293],"d'expressi\u00f3":[294],"l'\u00e0rea":[296],"regenerant":[297],"del":[298],"peix":[301,337,358],"i,":[303],"cop":[305],"inhibida":[306],"seva":[308],"activitat,":[309],"essencial":[313],"regeneraci\u00f3.":[317],"Tamb\u00e9":[318],"hem":[319],"identificat":[320],"s\u00e8rie":[322],"adicional":[323],"tr\u00e0nscrits":[325],"s'expressen":[327],"diferencial":[330],"durant":[331],"card\u00edaca":[334,355,367],"mereixen":[341],"m\u00e9s":[342],"investigaci\u00f3.":[343],"Els":[344],"aqu\u00ed":[346],"presents":[347],"profunditzen":[348],"comprensi\u00f3":[351],"ofereixen":[361],"informaci\u00f3":[362],"rellevant":[363],"ter\u00e0pia":[366]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}