{"id":"https://openalex.org/W113456161","doi":"https://doi.org/10.2460/ajvr.1983.44.02.247","title":"Association of increased estradiol and progesterone blood values with altered bovine polymorphonuclear leukocyte function","display_name":"Association of increased estradiol and progesterone blood values with altered bovine polymorphonuclear leukocyte function","publication_year":1983,"publication_date":"1983-02-01","ids":{"openalex":"https://openalex.org/W113456161","doi":"https://doi.org/10.2460/ajvr.1983.44.02.247","mag":"113456161","pmid":"https://pubmed.ncbi.nlm.nih.gov/6681945"},"language":"en","primary_location":{"id":"doi:10.2460/ajvr.1983.44.02.247","doi":"https://doi.org/10.2460/ajvr.1983.44.02.247","is_oa":false,"landing_page_url":"https://doi.org/10.2460/ajvr.1983.44.02.247","pdf_url":null,"source":{"id":"https://openalex.org/S196975874","display_name":"American Journal of Veterinary Research","issn_l":"0002-9645","issn":["0002-9645","1943-5681"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Veterinary Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043298435","display_name":"James A. Roth","orcid":"https://orcid.org/0000-0003-3562-668X","observed_orcids":["https://orcid.org/0000-0003-3562-668X"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Roth","raw_affiliation_strings":["From the Departments of Veterinary Microbiology and Preventive Medicine (Roth, Kaeberle) and Veterinary Clinical Sciences (Appell), Iowa State Universty, Ames, IA 50011, and the Animal Health Diagnostic Laboratory (Nachreiner), College of Veterinary Medicine, Michigan State University, East Lansing, MI 40909"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Veterinary Microbiology and Preventive Medicine (Roth, Kaeberle) and Veterinary Clinical Sciences (Appell), Iowa State Universty, Ames, IA 50011, and the Animal Health Diagnostic Laboratory (Nachreiner), College of Veterinary Medicine, Michigan State University, East Lansing, MI 40909","institution_ids":["https://openalex.org/I173911158","https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marlin L. Kaeberle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marlin L. Kaeberle","raw_affiliation_strings":["From the Departments of Veterinary Microbiology and Preventive Medicine (Roth, Kaeberle) and Veterinary Clinical Sciences (Appell), Iowa State Universty, Ames, IA 50011, and the Animal Health Diagnostic Laboratory (Nachreiner), College of Veterinary Medicine, Michigan State University, East Lansing, MI 40909"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Veterinary Microbiology and Preventive Medicine (Roth, Kaeberle) and Veterinary Clinical Sciences (Appell), Iowa State Universty, Ames, IA 50011, and the Animal Health Diagnostic Laboratory (Nachreiner), College of Veterinary Medicine, Michigan State University, East Lansing, MI 40909","institution_ids":["https://openalex.org/I173911158","https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086108725","display_name":"Loren H. Appell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loren H. Appell","raw_affiliation_strings":["From the Departments of Veterinary Microbiology and Preventive Medicine (Roth, Kaeberle) and Veterinary Clinical Sciences (Appell), Iowa State Universty, Ames, IA 50011, and the Animal Health Diagnostic Laboratory (Nachreiner), College of Veterinary Medicine, Michigan State University, East Lansing, MI 40909"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Veterinary Microbiology and Preventive Medicine (Roth, Kaeberle) and Veterinary Clinical Sciences (Appell), Iowa State Universty, Ames, IA 50011, and the Animal Health Diagnostic Laboratory (Nachreiner), College of Veterinary Medicine, Michigan State University, East Lansing, MI 40909","institution_ids":["https://openalex.org/I173911158","https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111118011","display_name":"R. F. Nachreiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ray F. Nachreiner","raw_affiliation_strings":["From the Departments of Veterinary Microbiology and Preventive Medicine (Roth, Kaeberle) and Veterinary Clinical Sciences (Appell), Iowa State Universty, Ames, IA 50011, and the Animal Health Diagnostic Laboratory (Nachreiner), College of Veterinary Medicine, Michigan State University, East Lansing, MI 40909"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Veterinary Microbiology and Preventive Medicine (Roth, Kaeberle) and Veterinary Clinical Sciences (Appell), Iowa State Universty, Ames, IA 50011, and the Animal Health Diagnostic Laboratory (Nachreiner), College of Veterinary Medicine, Michigan State University, East Lansing, MI 40909","institution_ids":["https://openalex.org/I173911158","https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.266,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.944334,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"44","issue":"2","first_page":"247","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9580000042915344},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":1.0},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9769999980926514},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.902999997138977},{"id":"https://openalex.org/keywords/neutrophil-function","display_name":"neutrophil function","score":0.8690000176429749},{"id":"https://openalex.org/keywords/estrous-cycle","display_name":"estrous cycle","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cattle","display_name":"cattle","score":0.5799999833106995},{"id":"https://openalex.org/keywords/random-migration","display_name":"random migration","score":0.6639999747276306},{"id":"https://openalex.org/keywords/nitroblue-tetrazolium-reduction","display_name":"nitroblue tetrazolium reduction","score":0.9269999861717224},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.871999979019165},{"id":"https://openalex.org/keywords/steroid-hormones","display_name":"steroid hormones","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5397473573684692},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45292580127716064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43505656719207764},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4092823565006256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38105514645576477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3562489151954651},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3230277895927429},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13379546999931335}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000920","descriptor_name":"Antibody-Dependent Cell Cytotoxicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004971","descriptor_name":"Estrus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009580","descriptor_name":"Nitroblue Tetrazolium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012974","descriptor_name":"Sodium Iodide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2460/ajvr.1983.44.02.247","doi":"https://doi.org/10.2460/ajvr.1983.44.02.247","is_oa":false,"landing_page_url":"https://doi.org/10.2460/ajvr.1983.44.02.247","pdf_url":null,"source":{"id":"https://openalex.org/S196975874","display_name":"American Journal of Veterinary Research","issn_l":"0002-9645","issn":["0002-9645","1943-5681"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-2","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Veterinary Research","raw_type":"journal-article"},{"id":"pmid:6681945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6681945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of veterinary research","raw_type":"Journal Article"},{"id":"mag:113456161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6681945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2124800734","https://openalex.org/W2000789236","https://openalex.org/W2059628866","https://openalex.org/W2017418748","https://openalex.org/W2169056724","https://openalex.org/W2142851427","https://openalex.org/W7098690202","https://openalex.org/W2049794381","https://openalex.org/W2404455222","https://openalex.org/W4391167154"],"abstract_inverted_index":{"Polymorphonuclear":[0],"leukocyte":[1],"(PMN)":[2],"function":[3],"and":[4,10,50,104,113],"serum":[5,56,83,90,93],"concentrations":[6,58],"of":[7,39,76,101,132],"estradiol,":[8],"progesterone,":[9],"cortisol":[11],"(hydrocortisone)":[12],"were":[13,26,59,96],"monitored":[14],"concurrently":[15],"in":[16,123,139],"clinically":[17],"normal":[18,129],"cows":[19],"during":[20,127],"the":[21,128,133],"estrous":[22,130],"cycle.":[23],"Five":[24],"parameters":[25],"used":[27],"to":[28],"evaluate":[29],"PMN":[30,140],"function:":[31],"(i)":[32],"random":[33,63,111],"migration":[34,112],"under":[35],"agarose,":[36],"(ii)":[37],"ingestion":[38,75],"125I-labeled":[40],"Staphylococcus":[41],"aureus,":[42],"(iii)":[43],"nitroblue":[44],"tetrazolium":[45],"(NBT)":[46],"reduction,":[47,72],"(iv)":[48],"iodination,":[49,73],"(v)":[51],"antibody-dependent":[52,114],"cell-mediated":[53,115],"cytotoxicity.":[54,116],"Increased":[55,82,92],"estradiol":[57,84],"associated":[60,87,97,136],"with":[61,88,98,109,137],"enhanced":[62,110],"migration,":[64],"but":[65,108],"had":[66],"no":[67],"apparent":[68],"effect":[69],"on":[70],"NBT":[71,102],"or":[74],"S":[77],"aureus":[78],"by":[79,106],"bovine":[80],"PMN.":[81],"was":[85],"also":[86],"increased":[89],"cortisol.":[91],"progesterone":[94],"values":[95,126],"a":[99],"depression":[100],"reduction":[103],"iodination":[105],"PMN,":[107],"These":[117],"results":[118],"indicate":[119],"that":[120],"physiologic":[121],"changes":[122],"steroid":[124],"hormone":[125],"cycle":[131],"cow":[134],"are":[135],"alterations":[138],"function.":[141]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}