{"id":"https://openalex.org/W1131946572","doi":null,"title":"Retinoic acid aliphatic amide inhibits the AMPK-HIF-1\u03b1 pathway in human ovarian cancer.","display_name":"Retinoic acid aliphatic amide inhibits the AMPK-HIF-1\u03b1 pathway in human ovarian cancer.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W1131946572","mag":"1131946572","pmid":"https://pubmed.ncbi.nlm.nih.gov/26261517","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525851"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3508569","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525851","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525851","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022676887","display_name":"Xiaolan Yu","orcid":"https://orcid.org/0000-0003-1588-9693","observed_orcids":["https://orcid.org/0000-0003-1588-9693"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-Lan Yu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Affiliated TCM Hospital of Sichuan Medical University Sichuan, 646000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Affiliated TCM Hospital of Sichuan Medical University Sichuan, 646000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110203743","display_name":"Jiyi Xia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji-Yi Xia","raw_affiliation_strings":["Researh Center for Drug and Functional Food of Sichuan Medical University Sichuan, 646000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Researh Center for Drug and Functional Food of Sichuan Medical University Sichuan, 646000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061728628","display_name":"Haiqiong Ye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai-Qiong Ye","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Affiliated Hospital of Sichuan Medical University Sichuan, 646000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Affiliated Hospital of Sichuan Medical University Sichuan, 646000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100445604","display_name":"Xia Li","orcid":"https://orcid.org/0000-0003-0849-4140","observed_orcids":["https://orcid.org/0000-0003-0849-4140"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xia Li","raw_affiliation_strings":["Department of Obstetrics and Gynecology, The Hosipital of Traditional Chinese Medicine of Leshan Sichuan, 614000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, The Hosipital of Traditional Chinese Medicine of Leshan Sichuan, 614000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100778986","display_name":"Yujiao Zhang","orcid":"https://orcid.org/0000-0002-8820-1602","observed_orcids":["https://orcid.org/0000-0002-8820-1602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-Jiao Zhang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Affiliated Hospital of Sichuan Medical University Sichuan, 646000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Affiliated Hospital of Sichuan Medical University Sichuan, 646000, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008583186","display_name":"Xiguang Mao","orcid":"https://orcid.org/0000-0003-3965-7272","observed_orcids":["https://orcid.org/0000-0003-3965-7272"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xi-Guang Mao","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Affiliated Hospital of Sichuan Medical University Sichuan, 646000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Affiliated Hospital of Sichuan Medical University Sichuan, 646000, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2072,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.49876667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"8","issue":"6","first_page":"6416","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.06319999694824219,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.875},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.7400000095367432},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8460000157356262},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.6759999990463257},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.7450000047683716},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.921999990940094},{"id":"https://openalex.org/keywords/sdhb","display_name":"SDHB","score":0.8510000109672546},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.625}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7298610210418701},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6526996493339539},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.6321521997451782},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5711086988449097},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5655961036682129},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5478987693786621},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.519492506980896},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.49419382214546204},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.48766958713531494},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4643137454986572},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.34945210814476013},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3301737606525421},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3273971676826477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3093147873878479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28871244192123413},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28196755051612854},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.2395205795764923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22129103541374207},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.19428136944770813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09210148453712463},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05876284837722778}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3508569","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525851","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:26261517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26261517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical and experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4525851","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4525851/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Clin Exp Pathol","raw_type":"Text"},{"id":"mag:1131946572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26261517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3508569","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4525851","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W172276776","https://openalex.org/W187466943","https://openalex.org/W271188307","https://openalex.org/W1605223584","https://openalex.org/W1632989995","https://openalex.org/W1966932597","https://openalex.org/W1967863783","https://openalex.org/W1971234510","https://openalex.org/W1975463322","https://openalex.org/W1983833034","https://openalex.org/W1989037081","https://openalex.org/W1994682335","https://openalex.org/W1998258610","https://openalex.org/W2006036234","https://openalex.org/W2007051270","https://openalex.org/W2009183764","https://openalex.org/W2012583627","https://openalex.org/W2019683289","https://openalex.org/W2025199554","https://openalex.org/W2044874695","https://openalex.org/W2045962235","https://openalex.org/W2051089827","https://openalex.org/W2064193977","https://openalex.org/W2077626320","https://openalex.org/W2085551560","https://openalex.org/W2091068407","https://openalex.org/W2110426041","https://openalex.org/W2113053818","https://openalex.org/W2129420347","https://openalex.org/W2129917446","https://openalex.org/W2135424721","https://openalex.org/W2137990944","https://openalex.org/W2139439558","https://openalex.org/W2142859055","https://openalex.org/W2156073283","https://openalex.org/W2157183541","https://openalex.org/W2158610635","https://openalex.org/W2163386261","https://openalex.org/W2164857934","https://openalex.org/W2254093732","https://openalex.org/W2325083761","https://openalex.org/W2333245858","https://openalex.org/W2402530137","https://openalex.org/W2420856930"],"related_works":["https://openalex.org/W994799610","https://openalex.org/W2406121966","https://openalex.org/W2332892439","https://openalex.org/W1967643634","https://openalex.org/W7016581349","https://openalex.org/W298607638","https://openalex.org/W2312566670","https://openalex.org/W2372814069","https://openalex.org/W4297225374","https://openalex.org/W1966998283"],"abstract_inverted_index":{"Ovarian":[0],"carcinoma":[1,153],"the":[2,13,41,120],"commonly":[3],"observed":[4],"gynecological":[5],"cancers":[6],"has":[7],"a":[8,140],"high":[9],"mortality":[10],"rate.":[11],"In":[12],"present":[14],"study":[15],"effect":[16],"of":[17,83,94,99,105,114,122,125,150],"retinoic":[18],"acid":[19],"aliphatic":[20],"amide":[21],"(RACA)":[22],"in":[23,62,116,128,133,135,143],"ovarian":[24,117,152],"cancer":[25,130],"cells":[26,118,131],"was":[27,37,56],"investigated":[28],"using":[29],"proliferation,":[30,76,145],"migration":[31,79,147],"and":[32,51,65,78,86,96,102,148],"invasion":[33,77],"assays.":[34],"Western":[35],"blot":[36],"used":[38,57],"to":[39,58],"examine":[40],"Bcl-2,":[42],"cleaved":[43,106],"caspase":[44,107],"3,":[45],"p-ERK,":[46],"MMP-2,":[47,97],"p-FAK,":[48,103],"P-P38,":[49],"p-AMPK\u03b1":[50],"HIF-1\u03b1":[52,60,115,126],"protein":[53],"expression.":[54],"CoCl2":[55],"induce":[59],"expression":[61,127],"SKOV3ip.":[63,84],"1":[64,85],"HEY-A8":[66,87],"cells.":[67,88],"The":[68],"results":[69],"revealed":[70],"that":[71],"RACA":[72,89,109,138],"treatment":[73,90,110],"prompted":[74],"cell":[75,144],"but":[80],"inhibited":[81],"apoptosis":[82,149],"also":[91,111],"induced":[92],"upregulation":[93],"Bcl-2":[95],"activation":[98,121],"p-P38,":[100],"p-ERK":[101],"inhibition":[104],"3.":[108],"caused":[112],"upregulatation":[113],"with":[119],"p-AMPK\u03b1.":[123],"Upregulation":[124],"CoCl2-treated":[129],"resulted":[132],"decrease":[134],"SDHB.":[136],"Thus":[137],"plays":[139],"key":[141],"role":[142],"invasion,":[146],"human":[151],"through":[154],"AMPK-HIF-1\u03b1":[155],"pathway.":[156]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}