{"id":"https://openalex.org/W1129610","doi":null,"title":"Improvement of vestibular compensation by Levo-sulpiride in acute unilateral labyrinthine dysfunction.","display_name":"Improvement of vestibular compensation by Levo-sulpiride in acute unilateral labyrinthine dysfunction.","publication_year":2004,"publication_date":"2004-04-01","ids":{"openalex":"https://openalex.org/W1129610","mag":"1129610","pmid":"https://pubmed.ncbi.nlm.nih.gov/15468991"},"language":"en","primary_location":{"id":"pmid:15468991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15468991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065368016","display_name":"Diego Zanetti","orcid":"https://orcid.org/0000-0002-8116-4108","observed_orcids":["https://orcid.org/0000-0002-8116-4108"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"D Zanetti","raw_affiliation_strings":["Otorhinolaryngology Department, University of Brescia, Italy. diego_zanetti@iol.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Otorhinolaryngology Department, University of Brescia, Italy. diego_zanetti@iol.it","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063972067","display_name":"N. CIVIERO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Civiero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000536367","display_name":"Cristiano Balzanelli","orcid":"https://orcid.org/0000-0001-5114-2728","observed_orcids":["https://orcid.org/0000-0001-5114-2728"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Balzanelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072943433","display_name":"Marcello Tonini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tonini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070567916","display_name":"Alessandro Antonelli","orcid":"https://orcid.org/0000-0002-7455-8803","observed_orcids":["https://orcid.org/0000-0002-7455-8803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A R Antonelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"24","issue":"2","first_page":"49","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11950","display_name":"Cardiovascular Syncope and Autonomic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vestibular-compensation","display_name":"vestibular compensation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/acute-vertigo","display_name":"acute vertigo","score":0.7889999747276306},{"id":"https://openalex.org/keywords/peripheral-vestibular-dysfunction","display_name":"peripheral vestibular dysfunction","score":0.7990000247955322},{"id":"https://openalex.org/keywords/unilateral-vestibular-lesion","display_name":"unilateral vestibular lesion","score":0.6790000200271606},{"id":"https://openalex.org/keywords/dopamine-d2-receptor-antagonism","display_name":"dopamine D2 receptor antagonism","score":0.7020000219345093},{"id":"https://openalex.org/keywords/vestibular-suppressants","display_name":"vestibular suppressants","score":0.7129999995231628},{"id":"https://openalex.org/keywords/electronystagmography","display_name":"electronystagmography","score":0.9010000228881836},{"id":"https://openalex.org/keywords/recurrent-vertigo","display_name":"recurrent vertigo","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9143558144569397},{"id":"https://openalex.org/C2780806966","wikidata":"https://www.wikidata.org/wiki/Q422418","display_name":"Sulpiride","level":4,"score":0.8708600401878357},{"id":"https://openalex.org/C190041318","wikidata":"https://www.wikidata.org/wiki/Q596832","display_name":"Vestibular system","level":2,"score":0.6251087188720703},{"id":"https://openalex.org/C2779135839","wikidata":"https://www.wikidata.org/wiki/Q2531983","display_name":"Vertigo","level":2,"score":0.5649469494819641},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5555974841117859},{"id":"https://openalex.org/C2778372437","wikidata":"https://www.wikidata.org/wiki/Q368995","display_name":"Betahistine","level":3,"score":0.47855979204177856},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.4034516513347626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27539893984794617},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.21712768077850342},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1961289644241333},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.1898503601551056}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001301","descriptor_name":"Audiometry, Pure-Tone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004584","descriptor_name":"Electronystagmography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008575","descriptor_name":"Meniere Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008575","descriptor_name":"Meniere Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013469","descriptor_name":"Sulpiride","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013469","descriptor_name":"Sulpiride","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013469","descriptor_name":"Sulpiride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013469","descriptor_name":"Sulpiride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014717","descriptor_name":"Vertigo","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D014717","descriptor_name":"Vertigo","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014722","descriptor_name":"Vestibule, Labyrinth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15468991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15468991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","raw_type":"Clinical Trial"},{"id":"mag:1129610","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15468991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W35032327","https://openalex.org/W1179988290","https://openalex.org/W1714144352","https://openalex.org/W1820305336","https://openalex.org/W1896846313","https://openalex.org/W1969704831","https://openalex.org/W1987813437","https://openalex.org/W1988300555","https://openalex.org/W2018281640","https://openalex.org/W2020028005","https://openalex.org/W2025096269","https://openalex.org/W2026971644","https://openalex.org/W2061244298","https://openalex.org/W2070473169","https://openalex.org/W2077912746","https://openalex.org/W2090951137","https://openalex.org/W2098516360","https://openalex.org/W2108611459","https://openalex.org/W2334067492","https://openalex.org/W2402899867","https://openalex.org/W2416118163"],"related_works":["https://openalex.org/W1896846313","https://openalex.org/W12863977","https://openalex.org/W2472400224","https://openalex.org/W2055847326","https://openalex.org/W2074597368","https://openalex.org/W2507327409","https://openalex.org/W2130497136","https://openalex.org/W2507255385","https://openalex.org/W6630317","https://openalex.org/W2724289488"],"abstract_inverted_index":{"L-sulpiride":[0,178],"is":[1],"the":[2,10,33,60,73,76,105,112,121,165,198,218,227,233],"levorotatory":[3],"enantiomer":[4],"of":[5,9,12,36,59,62,75,81,86,134,141,195,200,206,213,224,226],"sulpiride,":[6],"a":[7,17,66,79,92,127,182],"neuroleptic":[8],"family":[11],"benzamide":[13],"derivatives;":[14],"it":[15],"has":[16,40],"characteristic":[18],"antagonist":[19],"effect":[20],"on":[21],"central":[22],"DA2":[23],"dopaminergic":[24],"receptors":[25],"and":[26,49,124,137,148,211,229],"dopamine":[27],"DA1":[28],"\"autoreceptors\".":[29],"Its":[30],"efficacy":[31],"in":[32,78,91,167,187,204],"symptomatic":[34,171],"control":[35,93],"acute":[37],"vertigo":[38,85,215],"spells":[39],"been":[41],"recognized,":[42],"apart":[43],"from":[44],"its":[45,63,230],"well-known":[46],"antiemetic,":[47],"antidyspeptic":[48],"anti-depressant":[50],"properties,":[51],"at":[52,146],"high":[53],"dosages.":[54],"To":[55],"establish":[56],"objective":[57],"parameters":[58],"results":[61],"clinical":[64,132],"application,":[65],"randomized":[67],"prospective":[68],"study":[69],"was":[70,102,160,197],"started":[71],"comparing":[72],"effects":[74],"drug":[77,101,228],"group":[80,94],"87":[82],"patients":[83,166],"with":[84,89,96,120,232],"peripheral":[87],"origin,":[88],"those":[90],"treated":[95],"other":[97],"vestibular":[98,135,189,202,234],"suppressants.":[99],"The":[100,222],"administered":[103],"via":[104],"intravenous":[106],"route,":[107],"25":[108],"mg":[109],"t.i.d.,":[110],"for":[111,126],"first":[113],"3":[114],"days,":[115],"then":[116,150],"by":[117],"oral":[118],"administration,":[119],"same":[122],"schedule":[123],"dosage,":[125],"further":[128],"7":[129],"days.":[130],"After":[131],"evaluation":[133],"signs":[136],"symptoms,":[138],"electronystagmographic":[139],"recordings":[140],"rotatory":[142],"tests":[143],"were":[144,149],"obtained,":[145],"admission":[147],"controlled":[151],"after":[152],"6":[153,219],"months.":[154],"A":[155],"subjective":[156],"Visual":[157],"Analogue":[158],"Scale":[159],"also":[161],"delivered":[162],"daily":[163],"to":[164,169,175,180],"order":[168],"monitor":[170],"improvements.":[172],"When":[173],"compared":[174],"conventional":[176],"treatments,":[177],"appeared":[179],"induce":[181],"statistically":[183],"significant":[184],"faster":[185],"recovery":[186],"unilateral":[188],"lesions.":[190],"An":[191],"unexpected":[192],"favourable":[193],"outcome":[194],"treatment":[196],"facilitation":[199],"spontaneous":[201],"compensation,":[203],"terms":[205],"lesser":[207],"residual":[208],"labyrinthine":[209],"dysfunction":[210],"reduction":[212],"recurrent":[214],"attacks":[216],"during":[217],"months":[220],"follow-up.":[221],"mechanisms":[223],"action":[225],"interaction":[231],"system":[235],"are":[236],"discussed.":[237]},"counts_by_year":[{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}