{"id":"https://openalex.org/W11291880","doi":null,"title":"Perioperative bleeding and thromboembolic risk during non-cardiac surgery in patients with mechanical prosthetic heart valves: an institutional review.","display_name":"Perioperative bleeding and thromboembolic risk during non-cardiac surgery in patients with mechanical prosthetic heart valves: an institutional review.","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W11291880","mag":"11291880","pmid":"https://pubmed.ncbi.nlm.nih.gov/10461238"},"language":"en","primary_location":{"id":"pmid:10461238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10461238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart valve disease","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014714790","display_name":"Thierry Pierre Carrel","orcid":"https://orcid.org/0000-0002-7881-6822","observed_orcids":["https://orcid.org/0000-0002-7881-6822"]},"institutions":[{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"T P Carrel","raw_affiliation_strings":["Clinic for Cardio-Vascular Surgery, University Hospital, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinic for Cardio-Vascular Surgery, University Hospital, Bern, Switzerland","institution_ids":["https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070691398","display_name":"W Klingenmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Klingenmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090190845","display_name":"Paul Moha\u00e7si","orcid":"https://orcid.org/0000-0002-4542-9287","observed_orcids":["https://orcid.org/0000-0002-4542-9287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P J Mohacsi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031067849","display_name":"PA Berdat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Berdat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058463755","display_name":"Ulrich Althaus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Althaus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1823,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.87612574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"8","issue":"4","first_page":"392","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.861299991607666,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.059700001031160355,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11930","display_name":"Cardiac, Anesthesia and Surgical Outcomes","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanical-heart-valves","display_name":"mechanical heart valves","score":0.859000027179718},{"id":"https://openalex.org/keywords/noncardiac-surgery","display_name":"non-cardiac surgery","score":0.9760000109672546},{"id":"https://openalex.org/keywords/perioperative-bleeding","display_name":"perioperative bleeding","score":0.8479999899864197},{"id":"https://openalex.org/keywords/thromboembolism","display_name":"thromboembolism","score":0.8830000162124634},{"id":"https://openalex.org/keywords/oral-anticoagulation","display_name":"oral anticoagulation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/intravenous-heparin","display_name":"intravenous heparin","score":0.9580000042915344},{"id":"https://openalex.org/keywords/anticoagulation-discontinuation","display_name":"anticoagulation discontinuation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/cerebral-embolism","display_name":"cerebral embolism","score":0.800000011920929},{"id":"https://openalex.org/keywords/postoperative-bleeding","display_name":"postoperative bleeding","score":0.6600000262260437},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/prosthetic-mitral-valve","display_name":"mitral valve prosthesis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/aortic-valve-replacement","display_name":"aortic valve replacement","score":0.9670000076293945},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9841634035110474},{"id":"https://openalex.org/C31174226","wikidata":"https://www.wikidata.org/wiki/Q64855140","display_name":"Perioperative","level":2,"score":0.6433660387992859},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.6227750182151794},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.5548612475395203},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.4475496709346771},{"id":"https://openalex.org/C2777185221","wikidata":"https://www.wikidata.org/wiki/Q275466","display_name":"Embolism","level":2,"score":0.43327975273132324},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.397293359041214},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.23431971669197083}],"mesh":[{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006350","descriptor_name":"Heart Valve Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013514","descriptor_name":"Surgical Procedures, Operative","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D016063","descriptor_name":"Blood Loss, Surgical","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D016063","descriptor_name":"Blood Loss, Surgical","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D017052","descriptor_name":"Hospital Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10461238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10461238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of heart valve disease","raw_type":"Journal Article"},{"id":"mag:11291880","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10461238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2041655445","https://openalex.org/W2418795322","https://openalex.org/W2275944659","https://openalex.org/W1563948667","https://openalex.org/W2500899290","https://openalex.org/W80533265","https://openalex.org/W2105973477","https://openalex.org/W7112350602","https://openalex.org/W4384154069","https://openalex.org/W4248427527"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS":[2],"OF":[3],"THE":[4],"STUDY:":[5],"The":[6],"study":[7],"aim":[8],"was":[9,95,103,146,215],"to":[10],"determine":[11],"the":[12,40,212],"risk":[13,214],"of":[14,33,42,51,107,121,131,240,287],"thromboembolic":[15,278],"and":[16,45,74,81,83,92,110,117,164,186,209,230,244,270,277],"bleeding":[17,189,276],"complications":[18,179,199,226,281],"in":[19,195,203,216,231],"patients":[20,53,204,217,232],"with":[21,60,135,153,193,205,218,233],"mechanical":[22,64],"heart":[23,65,89],"valve":[24,90,208,223],"prostheses":[25],"who":[26],"underwent":[27,67],"non-cardiac":[28,69,93,144,263],"surgery":[29,43,70,94,145,234,264],"under":[30],"different":[31],"regimens":[32],"perioperative":[34,272],"anticoagulation.":[35,133,260],"Data":[36],"were":[37,137],"analyzed":[38],"on":[39],"basis":[41],"type":[44],"underlying":[46],"disease.":[47],"METHODS:":[48],"A":[49],"series":[50],"235":[52],"(mean":[54],"age":[55],"63":[56],"+/-":[57,97],"4.5":[58],"years)":[59],"one":[61,285],"or":[62,114,127],"two":[63],"valves":[66],"subsequent":[68],"comprising":[71],"abdominal,":[72],"vascular":[73],"thoracic,":[75],"orthopedic,":[76],"urologic,":[77],"neurosurgery,":[78],"ENT,":[79],"plastic":[80],"reconstructive,":[82],"gynecologic":[84],"operations.":[85],"Mean":[86],"interval":[87],"between":[88],"replacement":[91],"3.9":[96],"3.3":[98],"years.":[99],"Perioperative":[100],"oral":[101,108,122,132,242,268,291],"anticoagulation":[102,109,123,269],"managed":[104],"by":[105,115,128],"discontinuation":[106,116],"intravenous":[111,125,273],"heparin":[112,274],"administration;":[113],"early":[118],"postoperative":[119,188],"re-institution":[120],"without":[124,258],"heparin;":[126],"no":[129],"withdrawal":[130],"Patients":[134],"bioprostheses":[136],"excluded.":[138],"RESULTS:":[139],"Overall":[140],"hospital":[141],"mortality":[142],"during":[143],"2.9%.":[147],"Thromboembolic":[148,198,280],"events":[149],"included":[150,180],"cerebral":[151],"embolism":[152,174],"transient":[154],"deficit":[155],"(n":[156,161,167,175,183,190],"=":[157,162,168,176,184,191],"3),":[158],"residual":[159],"defect":[160,166],"1)":[163],"irreversible":[165],"1),":[169],"as":[170,172],"well":[171],"peripheral":[173],"11).":[177],"Hemorrhagic":[178],"wound":[181],"hematoma":[182],"10)":[185],"increased":[187],"8)":[192],"re-exploration":[194],"five":[196],"patients.":[197],"occurred":[200,227],"most":[201],"often":[202],"prosthetic":[206],"mitral":[207],"atrial":[210],"fibrillation;":[211],"lowest":[213],"sinus":[219],"rhythm":[220],"after":[221,228],"aortic":[222],"replacement.":[224],"Most":[225],"discharge":[229],"for":[235],"malignancy,":[236],"within":[237,284],"10":[238],"days":[239],"instituting":[241],"anticoagulation,":[243,292],"despite":[245,289],"a":[246],"therapeutic":[247],"INR":[248],"value.":[249],"CONCLUSIONS:":[250],"Minor":[251],"surgical":[252],"procedures":[253],"can":[254],"be":[255],"performed":[256],"safely":[257],"discontinuing":[259,267],"When":[261],"major":[262],"is":[265,296],"planned,":[266],"starting":[271],"minimizes":[275],"risks.":[279],"may":[282],"occur":[283],"month":[286],"surgery,":[288],"adequate":[290],"though":[293],"permanent":[294],"morbidity":[295],"low.":[297]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
