{"id":"https://openalex.org/W112866697","doi":null,"title":"Utilisation de la pharmacocinetique de population dans le d\u00e9veloppement pr\u00e9clinique d'un nouvel antidiab\u00e8tique : le tungstate de sodium","display_name":"Utilisation de la pharmacocinetique de population dans le d\u00e9veloppement pr\u00e9clinique d'un nouvel antidiab\u00e8tique : le tungstate de sodium","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W112866697","mag":"112866697"},"language":"fr","primary_location":{"id":"pmh:hdl:10068/729037","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/729037","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034101316","display_name":"Sophie Le Lamer-D\u00e9champs","orcid":"https://orcid.org/0000-0003-3074-4898","observed_orcids":["https://orcid.org/0000-0003-3074-4898"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sophie Le Lamer-Deschamps","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5034101316"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.2870999872684479,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.2870999872684479,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.21130000054836273,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.10050000250339508,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-tungstate","display_name":"sodium tungstate","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antidiabetic-drugs","display_name":"antidiabetic drugs","score":0.8790000081062317},{"id":"https://openalex.org/keywords/population-pharmacokinetics","display_name":"population pharmacokinetics","score":0.781000018119812},{"id":"https://openalex.org/keywords/pharmacokinetic-pharmacodynamic-modeling","display_name":"pharmacokinetic-pharmacodynamic modeling","score":0.75},{"id":"https://openalex.org/keywords/plasma-torch","display_name":"plasma torch","score":0.5049999952316284},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.3449999988079071},{"id":"https://openalex.org/keywords/food-effect","display_name":"food effect","score":0.42800000309944153},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5329999923706055},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.640999972820282},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/two-compartment-model","display_name":"two-compartment model","score":0.6710000038146973},{"id":"https://openalex.org/keywords/linear-pharmacokinetics","display_name":"linear pharmacokinetics","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.6307968497276306},{"id":"https://openalex.org/C2780927105","wikidata":"https://www.wikidata.org/wiki/Q418410","display_name":"Sodium tungstate","level":3,"score":0.48513373732566833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3783092498779297},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32231223583221436},{"id":"https://openalex.org/C542268612","wikidata":"https://www.wikidata.org/wiki/Q743","display_name":"Tungsten","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:hdl:10068/729037","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10068/729037","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"mag:112866697","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/2002MON13503","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7062654746","https://openalex.org/W2261236201","https://openalex.org/W7120703688","https://openalex.org/W1980415425","https://openalex.org/W2267795250","https://openalex.org/W2988678457","https://openalex.org/W111030550","https://openalex.org/W2980199520","https://openalex.org/W4254652191","https://openalex.org/W2938268390"],"abstract_inverted_index":{"La":[0,45,79,160],"premi\u00e8re":[1],"partie":[2,47,81,162],"de":[3,13,35,37,56,58,65,67,74,86,93,100,116,144,148,176,215,233,237,244,260,306],"notre":[4],"travail":[5],"pr\u00e9sente":[6],"les":[7,32,157,164,251,267,279],"donn\u00e9es":[8,280],"bibliographiques":[9],"sur":[10,156,250],"le":[11,24,63,72,88,96,171,296,309],"tungstate":[12,92],"sodium,":[14],"ses":[15],"propri\u00e9t\u00e9s":[16],"chimiques,":[17],"physiologiques":[18],"et":[19,27,40,53,69,106,112,128,133,140,153,167,185,189,197,209,213,224,229,247,289,308],"pharmacologiques.":[20],"Son":[21],"utilisation":[22],"dans":[23,31,62],"diab\u00e8te":[25,36,249],"sucr\u00e9":[26],"son":[28],"activit\u00e9":[29],"antidiab\u00e9tique":[30],"mod\u00e8le":[33,285],"exp\u00e9rimentaux":[34],"types":[38],"I":[39],"II,":[41],"sont":[42,281],"ensuite":[43],"d\u00e9velopp\u00e9s.":[44],"deuxi\u00e8me":[46],"concerne":[48,163],"la":[49,54,75,145,149,234,238,245,275,298,304],"mise":[50],"au":[51],"point":[52],"validation":[55],"m\u00e9thodes":[57],"dosage":[59],"du":[60,91,151,154,240,242,248],"tungst\u00e8ne":[61],"plasma":[64],"chien,":[66],"rat":[68,172],"d'homme":[70],"par":[71,103,126,138,179,198,218,303],"technique":[73],"torche":[76],"\u00e0":[77,195,207,286],"plasma.":[78],"troisi\u00e8me":[80],"a":[82,254,262],"pour":[83,265],"objectif":[84],"i)":[85,175],"d\u00e9terminer":[87],"profil":[89],"pharmacocin\u00e9tique":[90,276],"sodium":[94],"chez":[95,170,192,203],"chien":[97],"apr\u00e8s":[98,113,173],"administrations":[99,114,174],"dose":[101,146,177,235],"unique":[102,178],"voies":[104,180],"intraveineuse":[105,181],"orale":[107,186,200,220],"(":[108,182,187,227],"25,":[109],"50":[110],"mg/kg),":[111],"orales":[115],"doses":[117,216],"r\u00e9p\u00e9t\u00e9es":[118,217],"pendant":[119,221],"11":[120],"(7,":[121],"14":[122],"mg/kg":[123,135],"trois":[124,136],"fois":[125,137],"jour)":[127,139],"80":[129],"jours":[130,226],"(5,":[131],"10":[132],"20":[134,230],"ii)":[141,214],"d'\u00e9tudier":[142],"l'influence":[143],"administr\u00e9e,":[147,236],"dur\u00e9e":[150,239],"traitement":[152],"sexe":[155],"param\u00e8tres":[158,252],"pharmacocin\u00e9tiques.":[159],"derni\u00e8re":[161],"\u00e9tudes":[165],"pharmacocin\u00e9tiques":[166,253],"toxiococin\u00e9tiques":[168],"r\u00e9alis\u00e9es":[169],"9":[183],"mg/kg)":[184,191,202],"35.9":[188],"107.7":[190],"des":[193,204,210],"animaux":[194,205,211],"jeun,":[196],"voie":[199,219],"(35.9":[201],"non":[206],"jeun":[208],"diab\u00e9tiques,":[212],"7,":[222],"8":[223],"28":[225],"50,100":[228],"mg/kg/jour).":[231],"L'influence":[232],"traitement,":[241],"sexe,":[243],"nourriture":[246,307],"\u00e9t\u00e9":[255,263],"successivement":[256],"\u00e9tudi\u00e9e.":[257],"Une":[258],"approche":[259],"population":[261],"utilis\u00e9e":[264],"mod\u00e9liser":[266],"courbes":[268],"concentration-temps.":[269],"Quelle":[270],"que":[271],"soit":[272],"l'esp\u00e8ce":[273],"consid\u00e9r\u00e9e,":[274],"est":[277,300],"lin\u00e9aire,":[278],"compatibles":[282],"avec":[283],"un":[284],"2":[287],"compartiments":[288],"une":[290],"vitesse":[291],"d'absorption":[292],"d'ordre":[293],"1.":[294],"Chez":[295],"rat,":[297],"biodisponibilit\u00e9":[299],"significativement":[301],"modifi\u00e9e":[302],"prise":[305],"sexe.":[310]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
