{"id":"https://openalex.org/W11285335","doi":null,"title":"\u0414\u0435\u0442\u0435\u043a\u0446\u0438\u044f \u0443\u0440\u043e\u0432\u043d\u044f \u0433\u0435\u0442\u0435\u0440\u043e\u043f\u043b\u0430\u0437\u043c\u0438\u0438 \u043c\u0443\u0442\u0430\u0446\u0438\u0438 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0433\u0435\u043d\u043e\u043c\u0430 g14459a \u0432 \u0433\u043e\u043c\u043e\u0433\u0435\u043d\u0430\u0442\u0430\u0445 \u0438\u043c\u0442\u0438\u043c\u044b \u0430\u043e\u0440\u0442\u044b \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430","display_name":"\u0414\u0435\u0442\u0435\u043a\u0446\u0438\u044f \u0443\u0440\u043e\u0432\u043d\u044f \u0433\u0435\u0442\u0435\u0440\u043e\u043f\u043b\u0430\u0437\u043c\u0438\u0438 \u043c\u0443\u0442\u0430\u0446\u0438\u0438 \u043c\u0438\u0442\u043e\u0445\u043e\u043d\u0434\u0440\u0438\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0433\u0435\u043d\u043e\u043c\u0430 g14459a \u0432 \u0433\u043e\u043c\u043e\u0433\u0435\u043d\u0430\u0442\u0430\u0445 \u0438\u043c\u0442\u0438\u043c\u044b \u0430\u043e\u0440\u0442\u044b \u0447\u0435\u043b\u043e\u0432\u0435\u043a\u0430","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W11285335","mag":"11285335"},"language":"ru","primary_location":{"id":"mag:11285335","doi":null,"is_oa":true,"landing_page_url":"https://cyberleninka.ru/article/n/detektsiya-urovnya-geteroplazmii-mutatsii-mitohondrialnogo-genoma-g14459a-v-gomogenatah-imtimy-aorty-cheloveka","pdf_url":null,"source":{"id":"https://openalex.org/S4404664070","display_name":"\u0410\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437 \u0438 \u0434\u0438\u0441\u043b\u0438\u043f\u0438\u0434\u0435\u043c\u0438\u0438","issn_l":"2219-8202","issn":["2219-8202","2409-2355"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u0410\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437 \u0438 \u0434\u0438\u0441\u043b\u0438\u043f\u0438\u0434\u0435\u043c\u0438\u0438","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://cyberleninka.ru/article/n/detektsiya-urovnya-geteroplazmii-mutatsii-mitohondrialnogo-genoma-g14459a-v-gomogenatah-imtimy-aorty-cheloveka","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002529013","display_name":"Margarita A. Sazonova","orcid":"https://orcid.org/0000-0002-8610-4593","observed_orcids":["https://orcid.org/0000-0002-8610-4593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margarita A. Sazonova","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8610-4593","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034407182","display_name":"Valeria A. Barinova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0412. \u0410. \u0411\u0430\u0440\u0438\u043d\u043e\u0432\u0430","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045973265","display_name":"\u0412. \u0412. \u0421\u0438\u043d\u0451\u0432","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u0412. \u0412. \u0421\u0438\u043d\u0451\u0432","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102888343","display_name":"Maria M. Chicheva","orcid":"https://orcid.org/0000-0002-8014-8798","observed_orcids":["https://orcid.org/0000-0002-8014-8798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u041c. \u041c. \u0427\u0438\u0447\u0451\u0432\u0430","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110011140","display_name":"Konstantin Y. Mitrofanov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u041a. \u042e. \u041c\u0438\u0442\u0440\u043e\u0444\u0430\u043d\u043e\u0432","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011701279","display_name":"Andrey V. Zhelankin","orcid":"https://orcid.org/0000-0002-3014-2005","observed_orcids":["https://orcid.org/0000-0002-3014-2005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrey V. Zhelankin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3014-2005","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013576761","display_name":"Zukhra B. Khasanova","orcid":"https://orcid.org/0000-0002-4689-7955","observed_orcids":["https://orcid.org/0000-0002-4689-7955"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zukhra B. Khasanova","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4689-7955","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108259895","display_name":"Larisa A. Egorova","orcid":"https://orcid.org/0000-0001-9777-3832","observed_orcids":["https://orcid.org/0000-0001-9777-3832"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u041b \u0410 \u0415\u0433\u043e\u0440\u043e\u0432\u0430","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077715103","display_name":"Igor Alexandrovich Sobenin","orcid":"https://orcid.org/0000-0003-0978-6444","observed_orcids":["https://orcid.org/0000-0003-0978-6444"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor A. Sobenin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0978-6444","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028012180","display_name":"Anton Y. Postnov","orcid":"https://orcid.org/0000-0002-2501-7269","observed_orcids":["https://orcid.org/0000-0002-2501-7269"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anton Y. Postnov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2501-7269","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00064271,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-heteroplasmy","display_name":"mitochondrial heteroplasmy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/mitochondrial-genome","display_name":"mitochondrial genome","score":0.8220000267028809},{"id":"https://openalex.org/keywords/aortic-intima","display_name":"aortic intima","score":0.8489999771118164},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7210000157356262},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.44999998807907104},{"id":"https://openalex.org/keywords/human-aorta","display_name":"human aorta","score":0.41600000858306885}],"concepts":[{"id":"https://openalex.org/C181561989","wikidata":"https://www.wikidata.org/wiki/Q2581905","display_name":"Heteroplasmy","level":4,"score":0.9154764413833618},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.6522479057312012},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5245806574821472},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48019444942474365},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.46840542554855347},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.46555477380752563},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45107904076576233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43395358324050903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33518487215042114},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3335146903991699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2602055072784424}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:11285335","doi":null,"is_oa":true,"landing_page_url":"https://cyberleninka.ru/article/n/detektsiya-urovnya-geteroplazmii-mutatsii-mitohondrialnogo-genoma-g14459a-v-gomogenatah-imtimy-aorty-cheloveka","pdf_url":null,"source":{"id":"https://openalex.org/S4404664070","display_name":"\u0410\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437 \u0438 \u0434\u0438\u0441\u043b\u0438\u043f\u0438\u0434\u0435\u043c\u0438\u0438","issn_l":"2219-8202","issn":["2219-8202","2409-2355"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u0410\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437 \u0438 \u0434\u0438\u0441\u043b\u0438\u043f\u0438\u0434\u0435\u043c\u0438\u0438","raw_type":null}],"best_oa_location":{"id":"mag:11285335","doi":null,"is_oa":true,"landing_page_url":"https://cyberleninka.ru/article/n/detektsiya-urovnya-geteroplazmii-mutatsii-mitohondrialnogo-genoma-g14459a-v-gomogenatah-imtimy-aorty-cheloveka","pdf_url":null,"source":{"id":"https://openalex.org/S4404664070","display_name":"\u0410\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437 \u0438 \u0434\u0438\u0441\u043b\u0438\u043f\u0438\u0434\u0435\u043c\u0438\u0438","issn_l":"2219-8202","issn":["2219-8202","2409-2355"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u0410\u0442\u0435\u0440\u043e\u0441\u043a\u043b\u0435\u0440\u043e\u0437 \u0438 \u0434\u0438\u0441\u043b\u0438\u043f\u0438\u0434\u0435\u043c\u0438\u0438","raw_type":null},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1205348863","https://openalex.org/W1995588572","https://openalex.org/W1995746334","https://openalex.org/W2006818082","https://openalex.org/W2111694919","https://openalex.org/W2141315581"],"related_works":["https://openalex.org/W561538716","https://openalex.org/W7218312421","https://openalex.org/W7099515431","https://openalex.org/W1995588572","https://openalex.org/W7100928061","https://openalex.org/W1892238288","https://openalex.org/W1987936501","https://openalex.org/W2035461748","https://openalex.org/W2258131890","https://openalex.org/W2210151141"],"abstract_inverted_index":{"Objective:":[0],"The":[1,24,70],"aim":[2],"of":[3,10,17,32,40,58,94,98,106,124,135,143,161],"this":[4,127],"study":[5],"was":[6,68,119],"the":[7,11,50,56,75,84,95,107,116,122,149,152],"pilot":[8],"analysis":[9],"heteroplasmy":[12,125],"level":[13,123],"for":[14,126],"mutation":[15,71,128,155],"G14459A":[16,67,154],"human":[18,162],"mitochondrial":[19,79,99],"genome.":[20],"Materials":[21],"and":[22,34,61,110],"Methods:":[23],"DNA":[25],"samples":[26],"were":[27,52],"isolated":[28],"from":[29],"total":[30,133],"homogenates":[31,134,142],"normal":[33,144],"affected":[35,136],"by":[36,42,137],"atherosclerosis":[37,138],"aortic":[38,163],"intima":[39,139],"individuals":[41],"a":[43,92],"method":[44],"ofthe":[45,78],"phenol-chloroform":[46],"extraction.":[47],"After":[48],"PCR":[49],"amplificates":[51],"pyrosequenced":[53],"to":[54,104,112,141,148],"identify":[55],"percent":[57],"heteroplasmy.":[59],"Results":[60],"discussion:":[62],"A":[63],"single":[64],"nucleotide":[65],"substitution":[66],"analyzed.":[69],"is":[72,129,156],"localized":[73],"in":[74,81,83,115,132],"coding":[76],"region":[77],"genome,":[80],"particular,":[82],"gene":[85],"NADH":[86,108],"dehydrogenase":[87,109],"subunit":[88,97],"6.":[89],"It":[90,118],"causes":[91],"defect":[93],"protein":[96],"respiratory":[100],"chain":[101],"enzyme,":[102],"leading":[103],"dysfunction":[105],"possibly":[111],"oxidative":[113],"stress":[114],"body.":[117],"found":[120],"that":[121],"significantly":[130],"higher":[131],"compared":[140],"intima.":[145,164],"Conclusion:":[146],"According":[147],"data":[150],"resultingfrom":[151],"study,":[153],"associated":[157],"with":[158],"atherosclerotic":[159],"lesions":[160]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}