{"id":"https://openalex.org/W112739107","doi":"https://doi.org/10.1016/s0065-3160(08)00005-1","title":"Structural and biological impact of radical addition reactions with DNA nucleobases","display_name":"Structural and biological impact of radical addition reactions with DNA nucleobases","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W112739107","doi":"https://doi.org/10.1016/s0065-3160(08)00005-1","mag":"112739107"},"language":"en","primary_location":{"id":"doi:10.1016/s0065-3160(08)00005-1","doi":"https://doi.org/10.1016/s0065-3160(08)00005-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0065-3160(08)00005-1","pdf_url":null,"source":{"id":"https://openalex.org/S43417565","display_name":"Advances in physical organic chemistry","issn_l":"0065-3160","issn":["0065-3160","2162-5921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Physical Organic Chemistry","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4248651409","display_name":null},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038862912","display_name":"Richard A. Manderville","orcid":"https://orcid.org/0000-0003-4035-8093","observed_orcids":["https://orcid.org/0000-0003-4035-8093"]},"institutions":[{"id":"https://openalex.org/I79817857","display_name":"University of Guelph","ror":"https://ror.org/01r7awg59","country_code":"CA","type":"education","lineage":["https://openalex.org/I79817857"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Richard A. Manderville","raw_affiliation_strings":["Departments of Chemistry and Toxicology, University of Guelph, Guelph, ON N1G 2W1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Toxicology, University of Guelph, Guelph, ON N1G 2W1, Canada","institution_ids":["https://openalex.org/I79817857"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038862912"],"corresponding_institution_ids":["https://openalex.org/I79817857"],"apc_list":null,"apc_paid":null,"fwci":1.582,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.81320616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"177","last_page":"218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.1543000042438507,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.0203000009059906,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.722000002861023},{"id":"https://openalex.org/keywords/radical-addition","display_name":"radical addition","score":0.656000018119812},{"id":"https://openalex.org/keywords/dna-nucleobases","display_name":"DNA nucleobases","score":0.9240000247955322},{"id":"https://openalex.org/keywords/2-deoxyguanosine","display_name":"2'-deoxyguanosine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.8690000176429749},{"id":"https://openalex.org/keywords/covalent-dna-modification","display_name":"covalent DNA modification","score":0.6259999871253967},{"id":"https://openalex.org/keywords/chemical-carcinogenesis","display_name":"chemical carcinogenesis","score":0.9120000004768372},{"id":"https://openalex.org/keywords/electrophilic-addition","display_name":"electrophilic addition","score":0.6299999952316284},{"id":"https://openalex.org/keywords/oligonucleotide-synthesis","display_name":"oligonucleotide synthesis","score":0.718999981880188},{"id":"https://openalex.org/keywords/phosphoramidite","display_name":"phosphoramidite","score":0.8130000233650208},{"id":"https://openalex.org/keywords/ochratoxin-a","display_name":"ochratoxin A","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C61234307","wikidata":"https://www.wikidata.org/wiki/Q422960","display_name":"Nucleobase","level":3,"score":0.9316442012786865},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5595464706420898},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4745110869407654},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3288730978965759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22871693968772888},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18224680423736572}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0065-3160(08)00005-1","doi":"https://doi.org/10.1016/s0065-3160(08)00005-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0065-3160(08)00005-1","pdf_url":null,"source":{"id":"https://openalex.org/S43417565","display_name":"Advances in physical organic chemistry","issn_l":"0065-3160","issn":["0065-3160","2162-5921"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Physical Organic Chemistry","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":214,"referenced_works":["https://openalex.org/W181520079","https://openalex.org/W1487243507","https://openalex.org/W1520153121","https://openalex.org/W1520315220","https://openalex.org/W1535023526","https://openalex.org/W1547817405","https://openalex.org/W1562777547","https://openalex.org/W1584878126","https://openalex.org/W1964422567","https://openalex.org/W1965790988","https://openalex.org/W1966206863","https://openalex.org/W1966814641","https://openalex.org/W1967775878","https://openalex.org/W1967839472","https://openalex.org/W1968381499","https://openalex.org/W1968969258","https://openalex.org/W1969445814","https://openalex.org/W1969615892","https://openalex.org/W1970783889","https://openalex.org/W1972489128","https://openalex.org/W1974756029","https://openalex.org/W1979907816","https://openalex.org/W1981120794","https://openalex.org/W1981153084","https://openalex.org/W1981329009","https://openalex.org/W1981622411","https://openalex.org/W1982045707","https://openalex.org/W1982243106","https://openalex.org/W1983574014","https://openalex.org/W1984367999","https://openalex.org/W1984736034","https://openalex.org/W1985579253","https://openalex.org/W1985687573","https://openalex.org/W1987557669","https://openalex.org/W1987952194","https://openalex.org/W1988004447","https://openalex.org/W1989596109","https://openalex.org/W1990915519","https://openalex.org/W1991506593","https://openalex.org/W1993498225","https://openalex.org/W1993720865","https://openalex.org/W1994730001","https://openalex.org/W1996124476","https://openalex.org/W1996132242","https://openalex.org/W1996197564","https://openalex.org/W1996750161","https://openalex.org/W1997193111","https://openalex.org/W1998127752","https://openalex.org/W1998808749","https://openalex.org/W1999977358","https://openalex.org/W2000774559","https://openalex.org/W2001257943","https://openalex.org/W2002091803","https://openalex.org/W2004461656","https://openalex.org/W2006070503","https://openalex.org/W2006246700","https://openalex.org/W2006418071","https://openalex.org/W2007248665","https://openalex.org/W2007544926","https://openalex.org/W2008592200","https://openalex.org/W2010133509","https://openalex.org/W2010844179","https://openalex.org/W2012171557","https://openalex.org/W2012997912","https://openalex.org/W2013615285","https://openalex.org/W2014168546","https://openalex.org/W2014386281","https://openalex.org/W2014652970","https://openalex.org/W2016013190","https://openalex.org/W2016526856","https://openalex.org/W2016729820","https://openalex.org/W2017909097","https://openalex.org/W2019153563","https://openalex.org/W2019369653","https://openalex.org/W2019580536","https://openalex.org/W2019641156","https://openalex.org/W2021475582","https://openalex.org/W2022420408","https://openalex.org/W2022449668","https://openalex.org/W2022785992","https://openalex.org/W2026838497","https://openalex.org/W2027604638","https://openalex.org/W2027784487","https://openalex.org/W2028463335","https://openalex.org/W2028964417","https://openalex.org/W2029229226","https://openalex.org/W2029257212","https://openalex.org/W2029345766","https://openalex.org/W2031109095","https://openalex.org/W2031853663","https://openalex.org/W2031973327","https://openalex.org/W2033435931","https://openalex.org/W2036472213","https://openalex.org/W2036542803","https://openalex.org/W2037426867","https://openalex.org/W2037935725","https://openalex.org/W2038389845","https://openalex.org/W2039015617","https://openalex.org/W2039103433","https://openalex.org/W2039241150","https://openalex.org/W2039732651","https://openalex.org/W2039814680","https://openalex.org/W2039941241","https://openalex.org/W2040820853","https://openalex.org/W2040843368","https://openalex.org/W2040868214","https://openalex.org/W2044202228","https://openalex.org/W2044710231","https://openalex.org/W2045267091","https://openalex.org/W2045402010","https://openalex.org/W2045489285","https://openalex.org/W2046900004","https://openalex.org/W2047001643","https://openalex.org/W2048043985","https://openalex.org/W2049055429","https://openalex.org/W2049383029","https://openalex.org/W2049526125","https://openalex.org/W2050581983","https://openalex.org/W2051020728","https://openalex.org/W2052211560","https://openalex.org/W2052863020","https://openalex.org/W2052991677","https://openalex.org/W2053041957","https://openalex.org/W2054226158","https://openalex.org/W2055092548","https://openalex.org/W2055648569","https://openalex.org/W2056124202","https://openalex.org/W2056304204","https://openalex.org/W2057561114","https://openalex.org/W2058044047","https://openalex.org/W2058833562","https://openalex.org/W2060245901","https://openalex.org/W2060266492","https://openalex.org/W2060912121","https://openalex.org/W2060937481","https://openalex.org/W2061508611","https://openalex.org/W2063894827","https://openalex.org/W2064275805","https://openalex.org/W2064576961","https://openalex.org/W2065091408","https://openalex.org/W2065512114","https://openalex.org/W2065677017","https://openalex.org/W2066314749","https://openalex.org/W2067115769","https://openalex.org/W2068062711","https://openalex.org/W2071561301","https://openalex.org/W2071774595","https://openalex.org/W2072901432","https://openalex.org/W2073356400","https://openalex.org/W2073891390","https://openalex.org/W2075082629","https://openalex.org/W2075293051","https://openalex.org/W2075417276","https://openalex.org/W2076642496","https://openalex.org/W2077368756","https://openalex.org/W2078334852","https://openalex.org/W2078458676","https://openalex.org/W2078677832","https://openalex.org/W2078734222","https://openalex.org/W2079880043","https://openalex.org/W2080345568","https://openalex.org/W2082338217","https://openalex.org/W2082414100","https://openalex.org/W2085134918","https://openalex.org/W2085434957","https://openalex.org/W2086365723","https://openalex.org/W2086994340","https://openalex.org/W2087276593","https://openalex.org/W2088111404","https://openalex.org/W2088876058","https://openalex.org/W2088943427","https://openalex.org/W2090262385","https://openalex.org/W2090521521","https://openalex.org/W2091337681","https://openalex.org/W2092515517","https://openalex.org/W2093196009","https://openalex.org/W2095301528","https://openalex.org/W2105499761","https://openalex.org/W2106191623","https://openalex.org/W2109893157","https://openalex.org/W2112157184","https://openalex.org/W2113007696","https://openalex.org/W2113912029","https://openalex.org/W2118720215","https://openalex.org/W2121656629","https://openalex.org/W2128822546","https://openalex.org/W2135455427","https://openalex.org/W2135851251","https://openalex.org/W2139885239","https://openalex.org/W2140740752","https://openalex.org/W2149308625","https://openalex.org/W2149346504","https://openalex.org/W2152174303","https://openalex.org/W2152804372","https://openalex.org/W2160790360","https://openalex.org/W2161772510","https://openalex.org/W2167463754","https://openalex.org/W2167767129","https://openalex.org/W2168044784","https://openalex.org/W2168136834","https://openalex.org/W2173888602","https://openalex.org/W2181778443","https://openalex.org/W2191897958","https://openalex.org/W2204293707","https://openalex.org/W2207086206","https://openalex.org/W2327534068","https://openalex.org/W2412937450","https://openalex.org/W2416542799","https://openalex.org/W2798790684","https://openalex.org/W2949224388","https://openalex.org/W2949781110","https://openalex.org/W2951192132","https://openalex.org/W2952294913","https://openalex.org/W4240843885"],"related_works":["https://openalex.org/W4234370766","https://openalex.org/W2411314728","https://openalex.org/W2058000339","https://openalex.org/W3139728681","https://openalex.org/W2076642496","https://openalex.org/W2141892996","https://openalex.org/W2897467201","https://openalex.org/W2036456525","https://openalex.org/W2030373576","https://openalex.org/W2793142080"],"abstract_inverted_index":null,"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}