{"id":"https://openalex.org/W11269616","doi":null,"title":"Adipokines: novel players in rheumatic diseases.","display_name":"Adipokines: novel players in rheumatic diseases.","publication_year":2013,"publication_date":"2013-02-01","ids":{"openalex":"https://openalex.org/W11269616","mag":"11269616","pmid":"https://pubmed.ncbi.nlm.nih.gov/23449109"},"language":"en","primary_location":{"id":"pmid:23449109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23449109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/20.500.11940/1964","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011112502","display_name":"Javier Conde","orcid":"https://orcid.org/0000-0002-2187-479X","observed_orcids":["https://orcid.org/0000-0002-2187-479X"]},"institutions":[{"id":"https://openalex.org/I4210158352","display_name":"Servicio Gallego de Salud","ror":"https://ror.org/0591s4t67","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158352"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Conde","raw_affiliation_strings":["Laboratory of NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases, SERGAS, Santiago University Clinical Hospital Institute of Medical Research, Santiago de Compostela, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of NeuroEndocrine Interaction in Rheumatology and Inflammatory Diseases, SERGAS, Santiago University Clinical Hospital Institute of Medical Research, Santiago de Compostela, Spain","institution_ids":["https://openalex.org/I4210158352"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059950077","display_name":"Morena Scotece","orcid":"https://orcid.org/0000-0002-1150-2933","observed_orcids":["https://orcid.org/0000-0002-1150-2933"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morena Scotece","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103236640","display_name":"Ver\u00f3nica Alexandra Melo L\u00f3pez","orcid":"https://orcid.org/0000-0001-8410-2343","observed_orcids":["https://orcid.org/0000-0001-8410-2343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ver\u00f3nica L\u00f3pez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014810154","display_name":"Rodolfo G\u00f3mez","orcid":"https://orcid.org/0000-0002-1309-1023","observed_orcids":["https://orcid.org/0000-0002-1309-1023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodolfo G\u00f3mez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024322272","display_name":"Francisca Lago","orcid":"https://orcid.org/0000-0002-4593-8399","observed_orcids":["https://orcid.org/0000-0002-4593-8399"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisca Lago","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015960269","display_name":"Jes\u00fas Pino","orcid":"https://orcid.org/0000-0002-1847-1199","observed_orcids":["https://orcid.org/0000-0002-1847-1199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jes\u00fas Pino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071926023","display_name":"Juan Jes\u00fas G\u00f3mez-Reino","orcid":"https://orcid.org/0000-0001-5229-6294","observed_orcids":["https://orcid.org/0000-0001-5229-6294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Jes\u00fas G\u00f3mez-Reino","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041596182","display_name":"Oreste Gualillo","orcid":"https://orcid.org/0000-0002-7154-1328","observed_orcids":["https://orcid.org/0000-0002-7154-1328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oreste Gualillo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.296,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.96231105,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"81","first_page":"73","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":1.0},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/rheumatic-diseases","display_name":"rheumatic diseases","score":0.9380000233650208},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.9950000047683716},{"id":"https://openalex.org/keywords/adipokine-signaling","display_name":"adipokine signaling","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.8956074118614197},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8389042615890503},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7844278812408447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7064986228942871},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5333312153816223},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.49698904156684875},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.44295769929885864},{"id":"https://openalex.org/C2993075670","wikidata":"https://www.wikidata.org/wiki/Q2313934","display_name":"Load bearing","level":2,"score":0.41955018043518066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3856213688850403},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3527339696884155},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3479743003845215},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17970597743988037},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08727717399597168},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0747670829296112},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0713348388671875},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.06496575474739075},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012216","descriptor_name":"Rheumatic Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054392","descriptor_name":"Adipokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:23449109","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23449109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},{"id":"pmh:oai:dnet:runa________::04ce504532fd1769fcb782785db55ae8","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11940/1964","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:runa.sergas.gal:20.500.11940/1964","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11940/1964","pdf_url":null,"source":{"id":"https://openalex.org/S4306402506","display_name":"RUNA. Repositorio Institucional del Sergas (Servicio Gallego de Salud (SERGAS))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210158352","host_organization_name":"Servicio Gallego de Salud","host_organization_lineage":["https://openalex.org/I4210158352"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:11269616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23449109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:dnet:runa________::04ce504532fd1769fcb782785db55ae8","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11940/1964","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2131268090","https://openalex.org/W7099037667","https://openalex.org/W2007299168","https://openalex.org/W2924908529","https://openalex.org/W2811010140","https://openalex.org/W2040540846","https://openalex.org/W2051316518","https://openalex.org/W161454154","https://openalex.org/W2161069764","https://openalex.org/W7098825488"],"abstract_inverted_index":{"A":[0],"large":[1],"body":[2],"of":[3,34,40,66,81,102],"evidence":[4],"from":[5],"clinical":[6],"and":[7,19,79,88,113],"experimental":[8],"studies":[9,54],"is":[10,25,60],"aiding":[11],"to":[12,31,62],"understand":[13],"the":[14,32,41,77,96,100,106],"close":[15],"relationships":[16],"between":[17],"obesity":[18,29],"rheumatic":[20,83,110],"diseases.":[21],"For":[22],"instance,":[23],"it":[24],"generally":[26],"accepted":[27],"that":[28,56],"contributes":[30],"development":[33,78],"osteoarthritis":[35,87,112],"by":[36],"increasing":[37],"mechanical":[38,51],"load":[39],"joints,":[42],"at":[43],"least":[44],"in":[45,76],"weight":[46],"bearing":[47],"joints.":[48],"However,":[49],"besides":[50],"effects,":[52],"recent":[53,97],"demonstrated":[55],"white":[57],"adipose":[58],"tissue":[59],"able":[61],"secrete":[63],"a":[64,73],"plethora":[65],"soluble":[67],"factors,":[68],"called":[69],"adipokines,":[70],"which":[71],"have":[72],"critical":[74],"role":[75],"progression":[80],"some":[82],"diseases":[84],"such":[85],"as":[86],"rheumatoid":[89,114],"arthritis.":[90,115],"In":[91],"this":[92],"article,":[93],"we":[94],"summarize":[95],"findings":[98],"on":[99],"interaction":[101],"certain":[103],"adipokines":[104],"with":[105],"two":[107],"most":[108],"common":[109],"diseases:":[111]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}