{"id":"https://openalex.org/W112441600","doi":null,"title":"Role of notch signaling in breast cancer metastasis","display_name":"Role of notch signaling in breast cancer metastasis","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W112441600","mag":"112441600"},"language":"en","primary_location":{"id":"pmh:oai:opensiuc.lib.siu.edu:dissertations-1514","doi":null,"is_oa":false,"landing_page_url":"https://opensiuc.lib.siu.edu/cgi/viewcontent.cgi?article=1514&context=dissertations","pdf_url":null,"source":{"id":"https://openalex.org/S4377196411","display_name":"OpenSIUC (Southern Illinois University Carbondale)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I110378019","host_organization_name":"Southern Illinois University Carbondale","host_organization_lineage":["https://openalex.org/I110378019"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029680030","display_name":"Fei Xing","orcid":"https://orcid.org/0000-0001-6350-0764","observed_orcids":["https://orcid.org/0000-0001-6350-0764"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fei Xing","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6350-0764","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5029680030"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00730597,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.14339999854564667,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9509999752044678},{"id":"https://openalex.org/keywords/breast-cancer-metastasis","display_name":"breast cancer metastasis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/jagged2","display_name":"Jagged2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/notch-ligands","display_name":"Notch ligands","score":0.7870000004768372},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9369999766349792},{"id":"https://openalex.org/keywords/bone-marrow-stroma","display_name":"bone marrow stroma","score":0.781000018119812},{"id":"https://openalex.org/keywords/cancer-stem-like-cells","display_name":"cancer stem-like cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.8999999761581421},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.7919999957084656},{"id":"https://openalex.org/keywords/reactive-astrocytes","display_name":"reactive astrocytes","score":0.9290000200271606},{"id":"https://openalex.org/keywords/jag1","display_name":"JAG1","score":0.9070000052452087},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.9649999737739563},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.6650000214576721},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8399999737739563},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6620214581489563},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.6540477871894836},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5474598407745361},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46161967515945435},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3939930498600006},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34109431505203247},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3085688054561615},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0799604058265686}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:opensiuc.lib.siu.edu:dissertations-1514","doi":null,"is_oa":false,"landing_page_url":"https://opensiuc.lib.siu.edu/cgi/viewcontent.cgi?article=1514&context=dissertations","pdf_url":null,"source":{"id":"https://openalex.org/S4377196411","display_name":"OpenSIUC (Southern Illinois University Carbondale)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I110378019","host_organization_name":"Southern Illinois University Carbondale","host_organization_lineage":["https://openalex.org/I110378019"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations","raw_type":"text"},{"id":"mag:112441600","doi":null,"is_oa":false,"landing_page_url":"https://opensiuc.lib.siu.edu/cgi/viewcontent.cgi?article=1514&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2018338136","https://openalex.org/W2171427413","https://openalex.org/W7095598831","https://openalex.org/W2104366087","https://openalex.org/W2027497744","https://openalex.org/W7100358841","https://openalex.org/W2089283565","https://openalex.org/W2134976066","https://openalex.org/W2912991335","https://openalex.org/W2151155898"],"abstract_inverted_index":{"Notch":[0,19,43,76,130,203,259,371,388,409],"signaling":[1,20,131,260,372,389],"is":[2,24,97,229,283,330],"often":[3],"and":[4,52,60,86,104,129,150,165,174,192,214,225,227,237,280,301,310,458],"aberrantly":[5],"activated":[6,370,387],"by":[7,46,143,169,200,395],"hypoxia":[8,47,144,168,191],"during":[9],"tumor":[10,22,51,66,146,211,223,293,343],"progression;":[11],"however,":[12],"the":[13,30,40,57,71,89,102,136,194,250,256,271,274,281,286,295,299,311,324,346,359,364,386,405,416,431,462],"exact":[14],"pathological":[15,325],"role":[16,221,257],"of":[17,33,42,74,91,107,113,141,172,196,253,258,273,285,308,327,361,374,398,433],"hypoxia-induced":[18,206],"in":[21,48,56,65,78,83,120,145,155,186,209,222,261,276,294,345,363,368,390,420,444],"metastasis":[23,263,329,418],"as":[25,240,304,306,331],"yet":[26,332],"poorly":[27,333],"understood.":[28,334],"In":[29,249,335],"first":[31],"part":[32,252],"this":[34,254,336],"study,":[35,255],"we":[36,338,401],"aimed":[37],"to":[38,61,183,231,454],"define":[39],"mechanism":[41,326],"ligand":[44],"activation":[45,208,356],"both":[49,127,210],"primary":[50],"bone":[53,187,216],"stromal":[54],"cells":[55,147,199,344,377],"metastatic":[58,246,289,292,341,435,464],"niche":[59,440],"clarify":[62],"their":[63,202,439,442],"roles":[64],"progression.":[67],"We":[68,382],"have":[69,402],"analyzed":[70],"expression":[72,90,171,360],"profiles":[73],"various":[75],"liagnds":[77],"779":[79],"breast":[80,108,247,277,342,436],"cancer":[81,109,197,278,375],"patients":[82,279,318],"GEO":[84],"database":[85],"found":[87,182,339,384],"that":[88,126,340,385,404],"Jagged2":[92,119,128,142,179,207,228],"among":[93,316],"all":[94],"five":[95],"ligands":[96],"most":[98,287],"significantly":[99,161,357,414],"correlated":[100],"with":[101],"overall-":[103],"metastasis-free":[105],"survival":[106,154,166,314],"patients.":[110],"The":[111,291],"results":[112,425],"our":[114,421],"immunohistochemical":[115],"(IHC)":[116],"analysis":[117],"for":[118,245,270,430,441,461],"61":[121],"clinical":[122],"samples":[123],"also":[124,151,181,383],"revealed":[125],"were":[132],"strongly":[133],"up-regulated":[134,185,392],"at":[135],"hypoxic":[137],"invasive":[138,212],"front.":[139],"Activation":[140],"induced":[148],"EMT":[149],"promoted":[152,193],"cell":[153],"vitro.":[156],"Notably,":[157],"a":[158,219,233,241,427,445,451,456],"\u00e3-secretase":[159],"inhibitor":[160],"blocked":[162],"Notch-mediated":[163],"invasion":[164],"under":[167,190],"promoting":[170,396],"E-cadherin":[173],"inhibiting":[175],"Akt":[176],"phosphorylation.":[177],"Importantly,":[178],"was":[180,264],"be":[184,232],"marrow":[188],"stroma":[189,217],"growth":[195,419],"stem-like":[198,376],"activating":[201],"signaling.":[204],"Therefore,":[205],"front":[213],"normal":[215],"plays":[218],"critical":[220],"progression":[224],"metastasis,":[226],"considered":[230],"valuable":[234],"prognostic":[235],"marker":[236],"may":[238],"serve":[239],"novel":[242,428,457],"therapeutic":[243],"target":[244,460],"cancer.":[248],"second":[251],"brain":[262,282,296,328,347,417,463],"investigated.":[265],"Metastatic":[266],"diseases":[267],"are":[268],"responsible":[269],"majority":[272],"deaths":[275],"one":[284,312],"common":[288],"sites.":[290],"profoundly":[297],"affects":[298],"cognitive":[300],"sensory":[302],"functions":[303],"well":[305],"morbidity":[307],"patients,":[309],"year":[313],"rate":[315],"these":[317],"remains":[319],"less":[320],"than":[321],"20%.":[322],"However,":[323],"report,":[337],"highly":[348],"expressed":[349],"IL-1\u00e2":[350],"which":[351,367,449],"can":[352,413],"\"activate\"":[353],"astrocytes.":[354],"This":[355],"augmented":[358],"JAG1":[362],"reactive":[365],"astrocytes,":[366],"turn":[369],"pathway":[373],"(CSCs)":[378],"upon":[379],"direct":[380],"interaction.":[381],"CSCs":[391,437],"Sox2":[393],"followed":[394],"self-renewal":[397,443],"CSCs.":[399],"Furthermore,":[400],"shown":[403],"blood-brain":[406],"barrier":[407],"permeable":[408],"inhibitor,":[410],"Compound":[411],"E,":[412],"suppress":[415],"animal":[422],"model.":[423],"These":[424],"represent":[426],"paradigm":[429],"understanding":[432],"how":[434],"re-establish":[438],"totally":[446],"different":[447],"microenvironment,":[448],"opens":[450],"new":[452],"avenue":[453],"identify":[455],"specific":[459],"disease":[465]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
