{"id":"https://openalex.org/W112434256","doi":"https://doi.org/10.1042/bj0950344","title":"EFFECT OF PYRIDOXINE DEFICIENCY ON NUCLEIC ACID METABOLISM IN THE RAT","display_name":"EFFECT OF PYRIDOXINE DEFICIENCY ON NUCLEIC ACID METABOLISM IN THE RAT","publication_year":1965,"publication_date":"1965-05-01","ids":{"openalex":"https://openalex.org/W112434256","doi":"https://doi.org/10.1042/bj0950344","mag":"112434256","pmid":"https://pubmed.ncbi.nlm.nih.gov/14340082","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1214328"},"language":"en","primary_location":{"id":"doi:10.1042/bj0950344","doi":"https://doi.org/10.1042/bj0950344","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj0950344","pdf_url":"https://portlandpress.com/biochemj/article-pdf/95/2/344/704065/bj0950344.pdf","source":{"id":"https://openalex.org/S4210221754","display_name":"Biochemical Journal","issn_l":"0006-2936","issn":["0006-2936"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/95/2/344/704065/bj0950344.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074152201","display_name":"A C Trakatellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AC TRAKATELLIS","raw_affiliation_strings":["Biochemistry Department, University of Pittsburgh School of Medicine, Pittsburgh, Pa., U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, University of Pittsburgh School of Medicine, Pittsburgh, Pa., U.S.A","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025321269","display_name":"Axelrod Ae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AE AXELROD","raw_affiliation_strings":["Biochemistry Department, University of Pittsburgh School of Medicine, Pittsburgh, Pa., U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Department, University of Pittsburgh School of Medicine, Pittsburgh, Pa., U.S.A","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":2.925,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.88095238,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"95","issue":"2","first_page":"344","last_page":"349"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-b6-deficiency","display_name":"vitamin B6 deficiency","score":1.0},{"id":"https://openalex.org/keywords/nucleic-acid-metabolism","display_name":"nucleic acid metabolism","score":0.902999997138977},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.6859999895095825},{"id":"https://openalex.org/keywords/rna-synthesis","display_name":"RNA synthesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pyridoxal-5-phosphate","display_name":"pyridoxal phosphate","score":0.847000002861023},{"id":"https://openalex.org/keywords/formate-incorporation","display_name":"formate incorporation","score":0.5830000042915344},{"id":"https://openalex.org/keywords/serine-incorporation","display_name":"serine incorporation","score":0.6909999847412109},{"id":"https://openalex.org/keywords/adenine-incorporation","display_name":"adenine incorporation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/thymidine-incorporation","display_name":"thymidine incorporation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/deoxyuridine-incorporation","display_name":"deoxyuridine incorporation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/methionine","display_name":"methionine","score":0.7829999923706055},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.7770000100135803},{"id":"https://openalex.org/keywords/spleen","display_name":"spleen","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/vitamin-b6","display_name":"vitamin B6","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C2776514930","wikidata":"https://www.wikidata.org/wiki/Q423746","display_name":"Pyridoxine","level":2,"score":0.8711837530136108},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.7342326641082764},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.6741787195205688},{"id":"https://openalex.org/C2909176517","wikidata":"https://www.wikidata.org/wiki/Q205130","display_name":"Pyridoxine Deficiency","level":3,"score":0.630804181098938},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5560805797576904},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5160162448883057},{"id":"https://openalex.org/C2776834122","wikidata":"https://www.wikidata.org/wiki/Q418957","display_name":"Pyridoxal phosphate","level":4,"score":0.4975030720233917},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4944591522216797},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4854736626148224},{"id":"https://openalex.org/C2780859938","wikidata":"https://www.wikidata.org/wiki/Q3065731","display_name":"Pyridoxal","level":3,"score":0.4691884517669678},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.46900200843811035},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4618062376976013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3450600206851959},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16338416934013367},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.13740581274032593},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005561","descriptor_name":"Formates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011732","descriptor_name":"Pyridoxal Phosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014166","descriptor_name":"Transferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D026681","descriptor_name":"Vitamin B 6 Deficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj0950344","doi":"https://doi.org/10.1042/bj0950344","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj0950344","pdf_url":"https://portlandpress.com/biochemj/article-pdf/95/2/344/704065/bj0950344.pdf","source":{"id":"https://openalex.org/S4210221754","display_name":"Biochemical Journal","issn_l":"0006-2936","issn":["0006-2936"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:14340082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14340082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1214328","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1214328/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1042/bj0950344","doi":"https://doi.org/10.1042/bj0950344","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj0950344","pdf_url":"https://portlandpress.com/biochemj/article-pdf/95/2/344/704065/bj0950344.pdf","source":{"id":"https://openalex.org/S4210221754","display_name":"Biochemical Journal","issn_l":"0006-2936","issn":["0006-2936"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W112434256.pdf","grobid_xml":"https://content.openalex.org/works/W112434256.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1539815393","https://openalex.org/W1775749144","https://openalex.org/W1826317107","https://openalex.org/W1882383213","https://openalex.org/W1906197854","https://openalex.org/W1917997814","https://openalex.org/W1977105131","https://openalex.org/W1981090781","https://openalex.org/W4211188725","https://openalex.org/W4313375974"],"related_works":["https://openalex.org/W1944059154","https://openalex.org/W2330727942","https://openalex.org/W1826317107","https://openalex.org/W2411283394","https://openalex.org/W2035007435","https://openalex.org/W1992108784","https://openalex.org/W2023903669","https://openalex.org/W2427060090","https://openalex.org/W2041818859","https://openalex.org/W2264944324"],"abstract_inverted_index":{"1.":[0],"The":[1,45,64,110,186],"nucleic":[2,196],"acid":[3],"metabolism":[4],"in":[5,88,122,177,203,211],"the":[6,15,35,62,81,86,98,123,129,142,145,148,170,175,193,206,212,218],"pyridoxine-deficient":[7],"rat":[8],"has":[9],"been":[10],"investigated":[11],"through":[12],"studies":[13],"on":[14,50,128,147,192],"incorporation":[16,36,51,65,89,99,111,130,149,178],"of":[17,37,47,77,90,100,112,125,131,144,150,166,179,189,195,208,214],"radioactivity":[18,38,91,101,113,132,151,180],"from":[19,39,92,102,114,133,152,181],"various":[20],"isotopically":[21],"labelled":[22],"compounds":[23],"into":[24,52,66,135,154,162],"liver":[25,53],"and":[26,29,55,57,106,137,183,198],"spleen":[27,58,67,155,163],"DNA":[28,56,68,136,156],"RNA.":[30,164],"2.":[31],"In":[32,95],"pyridoxine":[33,78,96,126,167,190],"deficiency,":[34,97],"sodium":[40],"[(14)C]formate":[41],"was":[42,60,69,108,116,157],"apparently":[43],"increased.":[44],"magnitude":[46],"this":[48],"effect":[49,124,143],"RNA":[54,59,138],"approximately":[61],"same.":[63],"enhanced":[70],"to":[71,205],"a":[72],"much":[73],"greater":[74,159],"degree.":[75],"Administration":[76,165],"24hr.":[79,168],"before":[80,169],"rats":[82,171],"were":[83,139,172],"killed":[84,173],"reversed":[85,174],"changes":[87,176],"[(14)C]formate.":[93],"3.":[94],"dl-[3-(14)C]serine,":[103],"[8-(14)C]adenine,":[104],"[Me-(3)H]thymidine":[105],"[2-(14)C]deoxyuridine":[107],"decreased.":[109],"l-[Me-(14)C]methionine":[115],"not":[117],"affected.":[118],"No":[119],"noteworthy":[120],"differences":[121],"deficiency":[127,146,191],"dl-[3-(14)C]serine":[134],"observed,":[140],"whereas":[141],"[8-(14)C]adenine":[153],"somewhat":[158],"than":[160],"that":[161],"[3-(14)C]serine":[182],"[8-(14)C]adenine.":[184],"4.":[185],"adverse":[187],"effects":[188],"biosynthesis":[194],"acids":[197],"cell":[199],"multiplication":[200],"are":[201],"discussed":[202],"relation":[204],"role":[207],"pyridoxal":[209],"phosphate":[210],"production":[213],"C(1)":[215],"units":[216],"via":[217],"serine-hydroxymethylase":[219],"reaction.":[220]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}