{"id":"https://openalex.org/W112418132","doi":null,"title":"Impaired metabolism in X-linked muscular dystrophy: experimental evaluation of potential therapies to improve calcium regulation, bioenergetics and muscle architecture","display_name":"Impaired metabolism in X-linked muscular dystrophy: experimental evaluation of potential therapies to improve calcium regulation, bioenergetics and muscle architecture","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W112418132","mag":"112418132"},"language":"en","primary_location":{"id":"pmh:oai:eprints.vu.edu.au:1448","doi":null,"is_oa":true,"landing_page_url":"https://vuir.vu.edu.au/1448/","pdf_url":"https://vuir.vu.edu.au/1448/1/rybalka.pdf","source":{"id":"https://openalex.org/S4306400215","display_name":"Victoria University Research Repository (Victoria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I41156924","host_organization_name":"Victoria University of Wellington","host_organization_lineage":["https://openalex.org/I41156924"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://vuir.vu.edu.au/1448/1/rybalka.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012060954","display_name":"Emma Rybalka","orcid":"https://orcid.org/0000-0002-4854-0036","observed_orcids":["https://orcid.org/0000-0002-4854-0036"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Emma Rybalka","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4854-0036","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012060954"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duchenne-muscular-dystrophy","display_name":"Duchenne muscular dystrophy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mdx-mice","display_name":"mdx mice","score":0.8820000290870667},{"id":"https://openalex.org/keywords/x-linked-muscular-dystrophy","display_name":"X-linked muscular dystrophy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/mitochondrial-atp-synthesis","display_name":"mitochondrial ATP production","score":0.8539999723434448},{"id":"https://openalex.org/keywords/bioenergetics","display_name":"bioenergetics","score":0.7940000295639038},{"id":"https://openalex.org/keywords/creatine-supplementation","display_name":"creatine supplementation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/whey-protein","display_name":"whey protein","score":0.9480000138282776},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.828000009059906},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.39899998903274536},{"id":"https://openalex.org/keywords/muscle-architecture","display_name":"muscle architecture","score":0.4560000002384186},{"id":"https://openalex.org/keywords/diaphragm","display_name":"diaphragm","score":0.7310000061988831},{"id":"https://openalex.org/keywords/tibialis-anterior","display_name":"tibialis anterior","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.625}],"concepts":[{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.824811577796936},{"id":"https://openalex.org/C2779030066","wikidata":"https://www.wikidata.org/wiki/Q1137767","display_name":"Muscular dystrophy","level":2,"score":0.7361007928848267},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5758121013641357},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5125841498374939},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.44344013929367065},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.44190162420272827},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3593582212924957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32142817974090576},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32118818163871765},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3206573724746704},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30886977910995483},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18429794907569885},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.11893150210380554}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.vu.edu.au:1448","doi":null,"is_oa":true,"landing_page_url":"https://vuir.vu.edu.au/1448/","pdf_url":"https://vuir.vu.edu.au/1448/1/rybalka.pdf","source":{"id":"https://openalex.org/S4306400215","display_name":"Victoria University Research Repository (Victoria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I41156924","host_organization_name":"Victoria University of Wellington","host_organization_lineage":["https://openalex.org/I41156924"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:112418132","doi":null,"is_oa":false,"landing_page_url":"http://eprints.vu.edu.au/1448/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:eprints.vu.edu.au:1448","doi":null,"is_oa":true,"landing_page_url":"https://vuir.vu.edu.au/1448/","pdf_url":"https://vuir.vu.edu.au/1448/1/rybalka.pdf","source":{"id":"https://openalex.org/S4306400215","display_name":"Victoria University Research Repository (Victoria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I41156924","host_organization_name":"Victoria University of Wellington","host_organization_lineage":["https://openalex.org/I41156924"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W112418132.pdf","grobid_xml":"https://content.openalex.org/works/W112418132.grobid-xml"},"referenced_works_count":694,"referenced_works":["https://openalex.org/W10680619","https://openalex.org/W23509255","https://openalex.org/W24005137","https://openalex.org/W37286935","https://openalex.org/W40508611","https://openalex.org/W42451266","https://openalex.org/W42574947","https://openalex.org/W45194730","https://openalex.org/W48500119","https://openalex.org/W72225115","https://openalex.org/W75957001","https://openalex.org/W93517807","https://openalex.org/W93858874","https://openalex.org/W96750190","https://openalex.org/W116341769","https://openalex.org/W120704073","https://openalex.org/W133994192","https://openalex.org/W139026977","https://openalex.org/W148403024","https://openalex.org/W151533114","https://openalex.org/W174097160","https://openalex.org/W188536477","https://openalex.org/W195031074","https://openalex.org/W200521644","https://openalex.org/W211405958","https://openalex.org/W243733511","https://openalex.org/W588570051","https://openalex.org/W843235078","https://openalex.org/W989840353","https://openalex.org/W1208244564","https://openalex.org/W1260453475","https://openalex.org/W1444118799","https://openalex.org/W1480415840","https://openalex.org/W1482629448","https://openalex.org/W1483833346","https://openalex.org/W1485537415","https://openalex.org/W1495930413","https://openalex.org/W1496871717","https://openalex.org/W1500047101","https://openalex.org/W1505685265","https://openalex.org/W1506154298","https://openalex.org/W1514743713","https://openalex.org/W1515343735","https://openalex.org/W1516828999","https://openalex.org/W1518262295","https://openalex.org/W1534652943","https://openalex.org/W1536343685","https://openalex.org/W1549895552","https://openalex.org/W1552023984","https://openalex.org/W1555531912","https://openalex.org/W1556485756","https://openalex.org/W1559018234","https://openalex.org/W1559546823","https://openalex.org/W1559795048","https://openalex.org/W1560838288","https://openalex.org/W1563422013","https://openalex.org/W1573193689","https://openalex.org/W1575714747","https://openalex.org/W1577734122","https://openalex.org/W1591572497","https://openalex.org/W1592698849","https://openalex.org/W1596427554","https://openalex.org/W1608141030","https://openalex.org/W1620546484","https://openalex.org/W1628785169","https://openalex.org/W1688774372","https://openalex.org/W1705241395","https://openalex.org/W1747748421","https://openalex.org/W1748754899","https://openalex.org/W1752377265","https://openalex.org/W1803792965","https://openalex.org/W1804213683","https://openalex.org/W1821085646","https://openalex.org/W1832331880","https://openalex.org/W1849159432","https://openalex.org/W1850312794","https://openalex.org/W1861332892","https://openalex.org/W1889871926","https://openalex.org/W1895697393","https://openalex.org/W1906240697","https://openalex.org/W1906846423","https://openalex.org/W1914136894","https://openalex.org/W1930882462","https://openalex.org/W1936284749","https://openalex.org/W1938282147","https://openalex.org/W1938320888","https://openalex.org/W1941910566","https://openalex.org/W1949811505","https://openalex.org/W1952579501","https://openalex.org/W1952906612","https://openalex.org/W1964142515","https://openalex.org/W1964393311","https://openalex.org/W1964531354","https://openalex.org/W1964709412","https://openalex.org/W1964881119","https://openalex.org/W1965029487","https://openalex.org/W1966050731","https://openalex.org/W1967138034","https://openalex.org/W1967330198","https://openalex.org/W1967344358","https://openalex.org/W1967523918","https://openalex.org/W1968306591","https://openalex.org/W1968869845","https://openalex.org/W1968951897","https://openalex.org/W1969262971","https://openalex.org/W1969471587","https://openalex.org/W1969683520","https://openalex.org/W1969983508","https://openalex.org/W1970269001","https://openalex.org/W1970506684","https://openalex.org/W1970734629","https://openalex.org/W1970848490","https://openalex.org/W1971340527","https://openalex.org/W1971617455","https://openalex.org/W1972268752","https://openalex.org/W1972440897","https://openalex.org/W1972652247","https://openalex.org/W1972671890","https://openalex.org/W1973487567","https://openalex.org/W1973583835","https://openalex.org/W1973980541","https://openalex.org/W1974082432","https://openalex.org/W1974086574","https://openalex.org/W1974256573","https://openalex.org/W1974296878","https://openalex.org/W1974508591","https://openalex.org/W1974543599","https://openalex.org/W1974582208","https://openalex.org/W1974692929","https://openalex.org/W1975247334","https://openalex.org/W1975884987","https://openalex.org/W1976362673","https://openalex.org/W1976710138","https://openalex.org/W1977085472","https://openalex.org/W1977182349","https://openalex.org/W1977203311","https://openalex.org/W1977362203","https://openalex.org/W1977645957","https://openalex.org/W1978059480","https://openalex.org/W1978275124","https://openalex.org/W1979046360","https://openalex.org/W1979069474","https://openalex.org/W1980229570","https://openalex.org/W1980448760","https://openalex.org/W1982594839","https://openalex.org/W1983103640","https://openalex.org/W1983324471","https://openalex.org/W1983507539","https://openalex.org/W1983536345","https://openalex.org/W1983606052","https://openalex.org/W1983783341","https://openalex.org/W1984281363","https://openalex.org/W1984322384","https://openalex.org/W1984419476","https://openalex.org/W1984433501","https://openalex.org/W1984802456","https://openalex.org/W1984910052","https://openalex.org/W1984995581","https://openalex.org/W1985086376","https://openalex.org/W1985377308","https://openalex.org/W1985396526","https://openalex.org/W1985522818","https://openalex.org/W1986001697","https://openalex.org/W1986124091","https://openalex.org/W1986168271","https://openalex.org/W1986522707","https://openalex.org/W1986672870","https://openalex.org/W1986720672","https://openalex.org/W1986744707","https://openalex.org/W1987501962","https://openalex.org/W1987711577","https://openalex.org/W1988060154","https://openalex.org/W1988070091","https://openalex.org/W1988209321","https://openalex.org/W1989046922","https://openalex.org/W1989284694","https://openalex.org/W1989631411","https://openalex.org/W1990149391","https://openalex.org/W1990585109","https://openalex.org/W1990705483","https://openalex.org/W1990940337","https://openalex.org/W1991248271","https://openalex.org/W1991466322","https://openalex.org/W1991518335","https://openalex.org/W1991753089","https://openalex.org/W1991988594","https://openalex.org/W1992084466","https://openalex.org/W1992102975","https://openalex.org/W1992325911","https://openalex.org/W1992591328","https://openalex.org/W1992606048","https://openalex.org/W1992813176","https://openalex.org/W1993401199","https://openalex.org/W1993492839","https://openalex.org/W1994513923","https://openalex.org/W1994693592","https://openalex.org/W1994782981","https://openalex.org/W1994831592","https://openalex.org/W1996049663","https://openalex.org/W1996692422","https://openalex.org/W1996977570","https://openalex.org/W1998152747","https://openalex.org/W1998738935","https://openalex.org/W1998850785","https://openalex.org/W1999096805","https://openalex.org/W1999113624","https://openalex.org/W1999251579","https://openalex.org/W2000507307","https://openalex.org/W2000855370","https://openalex.org/W2001415246","https://openalex.org/W2001548627","https://openalex.org/W2001887958","https://openalex.org/W2002092352","https://openalex.org/W2002469842","https://openalex.org/W2003597344","https://openalex.org/W2003730995","https://openalex.org/W2004245295","https://openalex.org/W2004291111","https://openalex.org/W2005402291","https://openalex.org/W2007152754","https://openalex.org/W2007664904","https://openalex.org/W2007709380","https://openalex.org/W2008239768","https://openalex.org/W2008362561","https://openalex.org/W2008491098","https://openalex.org/W2008757109","https://openalex.org/W2008980136","https://openalex.org/W2009232421","https://openalex.org/W2010094123","https://openalex.org/W2010435893","https://openalex.org/W2010520196","https://openalex.org/W2010572143","https://openalex.org/W2010761592","https://openalex.org/W2010762668","https://openalex.org/W2011245066","https://openalex.org/W2011345909","https://openalex.org/W2012135330","https://openalex.org/W2012412435","https://openalex.org/W2012956823","https://openalex.org/W2013578935","https://openalex.org/W2013621644","https://openalex.org/W2015000540","https://openalex.org/W2015364457","https://openalex.org/W2015631186","https://openalex.org/W2015638013","https://openalex.org/W2015798899","https://openalex.org/W2015868607","https://openalex.org/W2016265023","https://openalex.org/W2016465574","https://openalex.org/W2016711181","https://openalex.org/W2017200318","https://openalex.org/W2017347652","https://openalex.org/W2018050588","https://openalex.org/W2018483078","https://openalex.org/W2018600945","https://openalex.org/W2018793031","https://openalex.org/W2019229921","https://openalex.org/W2019544139","https://openalex.org/W2019625498","https://openalex.org/W2019895139","https://openalex.org/W2020002251","https://openalex.org/W2020160382","https://openalex.org/W2020178087","https://openalex.org/W2020372983","https://openalex.org/W2020769270","https://openalex.org/W2020800885","https://openalex.org/W2020888843","https://openalex.org/W2021434619","https://openalex.org/W2021472936","https://openalex.org/W2021715589","https://openalex.org/W2021749053","https://openalex.org/W2021902228","https://openalex.org/W2022223340","https://openalex.org/W2022764512","https://openalex.org/W2023191886","https://openalex.org/W2023421441","https://openalex.org/W2024393219","https://openalex.org/W2024906556","https://openalex.org/W2024929666","https://openalex.org/W2025548626","https://openalex.org/W2026914540","https://openalex.org/W2027570515","https://openalex.org/W2028178258","https://openalex.org/W2028288286","https://openalex.org/W2028436089","https://openalex.org/W2028477639","https://openalex.org/W2028527392","https://openalex.org/W2028689205","https://openalex.org/W2029593819","https://openalex.org/W2029914169","https://openalex.org/W2030438343","https://openalex.org/W2031223556","https://openalex.org/W2031277966","https://openalex.org/W2031482129","https://openalex.org/W2031789342","https://openalex.org/W2032191440","https://openalex.org/W2032611621","https://openalex.org/W2033047769","https://openalex.org/W2033214690","https://openalex.org/W2033573230","https://openalex.org/W2034507898","https://openalex.org/W2034790803","https://openalex.org/W2034791458","https://openalex.org/W2034800263","https://openalex.org/W2034862605","https://openalex.org/W2035079270","https://openalex.org/W2035456940","https://openalex.org/W2036885504","https://openalex.org/W2036970859","https://openalex.org/W2037388152","https://openalex.org/W2037460774","https://openalex.org/W2037493727","https://openalex.org/W2037578230","https://openalex.org/W2038491737","https://openalex.org/W2039027050","https://openalex.org/W2039105236","https://openalex.org/W2039147968","https://openalex.org/W2039306818","https://openalex.org/W2039547987","https://openalex.org/W2039576057","https://openalex.org/W2039974483","https://openalex.org/W2040168630","https://openalex.org/W2040607662","https://openalex.org/W2040984978","https://openalex.org/W2041550965","https://openalex.org/W2042991371","https://openalex.org/W2043173428","https://openalex.org/W2044279551","https://openalex.org/W2044338026","https://openalex.org/W2044699197","https://openalex.org/W2044859197","https://openalex.org/W2044957691","https://openalex.org/W2045008468","https://openalex.org/W2045357418","https://openalex.org/W2045642677","https://openalex.org/W2045659422","https://openalex.org/W2046562971","https://openalex.org/W2047035294","https://openalex.org/W2047117385","https://openalex.org/W2047136624","https://openalex.org/W2047947118","https://openalex.org/W2048210319","https://openalex.org/W2048864017","https://openalex.org/W2048927326","https://openalex.org/W2049920183","https://openalex.org/W2050289652","https://openalex.org/W2050330888","https://openalex.org/W2050659771","https://openalex.org/W2050861180","https://openalex.org/W2051018818","https://openalex.org/W2051640749","https://openalex.org/W2051686468","https://openalex.org/W2052145893","https://openalex.org/W2052427726","https://openalex.org/W2052445665","https://openalex.org/W2052651806","https://openalex.org/W2053068327","https://openalex.org/W2053079324","https://openalex.org/W2053302665","https://openalex.org/W2053586641","https://openalex.org/W2053610826","https://openalex.org/W2054314636","https://openalex.org/W2054460914","https://openalex.org/W2054835208","https://openalex.org/W2055254549","https://openalex.org/W2056077806","https://openalex.org/W2056214185","https://openalex.org/W2056389106","https://openalex.org/W2057289143","https://openalex.org/W2057591716","https://openalex.org/W2058140775","https://openalex.org/W2058807250","https://openalex.org/W2059622376","https://openalex.org/W2060055554","https://openalex.org/W2060293784","https://openalex.org/W2060499329","https://openalex.org/W2060501387","https://openalex.org/W2060502177","https://openalex.org/W2060765516","https://openalex.org/W2060890640","https://openalex.org/W2061012426","https://openalex.org/W2061287688","https://openalex.org/W2061548709","https://openalex.org/W2061842924","https://openalex.org/W2061936950","https://openalex.org/W2061985194","https://openalex.org/W2062125039","https://openalex.org/W2062578421","https://openalex.org/W2062739715","https://openalex.org/W2062746471","https://openalex.org/W2063267590","https://openalex.org/W2063631572","https://openalex.org/W2063827988","https://openalex.org/W2063893684","https://openalex.org/W2064415844","https://openalex.org/W2064670731","https://openalex.org/W2064879307","https://openalex.org/W2064902846","https://openalex.org/W2065255554","https://openalex.org/W2065358818","https://openalex.org/W2065383397","https://openalex.org/W2065509440","https://openalex.org/W2066713136","https://openalex.org/W2067178684","https://openalex.org/W2067221444","https://openalex.org/W2067254948","https://openalex.org/W2067312442","https://openalex.org/W2067682110","https://openalex.org/W2067783268","https://openalex.org/W2068048197","https://openalex.org/W2068053899","https://openalex.org/W2068661278","https://openalex.org/W2069289373","https://openalex.org/W2069417547","https://openalex.org/W2070021449","https://openalex.org/W2070037836","https://openalex.org/W2070523542","https://openalex.org/W2070530153","https://openalex.org/W2070547903","https://openalex.org/W2070764343","https://openalex.org/W2070848002","https://openalex.org/W2070936696","https://openalex.org/W2071226544","https://openalex.org/W2071234680","https://openalex.org/W2071675514","https://openalex.org/W2072088562","https://openalex.org/W2073003303","https://openalex.org/W2073218761","https://openalex.org/W2073548665","https://openalex.org/W2073704146","https://openalex.org/W2074423796","https://openalex.org/W2075021173","https://openalex.org/W2075151495","https://openalex.org/W2075468751","https://openalex.org/W2075900474","https://openalex.org/W2076307303","https://openalex.org/W2076738615","https://openalex.org/W2076918486","https://openalex.org/W2076969546","https://openalex.org/W2077281360","https://openalex.org/W2078718449","https://openalex.org/W2078723347","https://openalex.org/W2078789189","https://openalex.org/W2078918521","https://openalex.org/W2079264235","https://openalex.org/W2079720722","https://openalex.org/W2079920800","https://openalex.org/W2080370878","https://openalex.org/W2080669215","https://openalex.org/W2081203811","https://openalex.org/W2081447952","https://openalex.org/W2081517058","https://openalex.org/W2081834777","https://openalex.org/W2081902497","https://openalex.org/W2081999200","https://openalex.org/W2082133354","https://openalex.org/W2082478076","https://openalex.org/W2082609015","https://openalex.org/W2083298529","https://openalex.org/W2083308741","https://openalex.org/W2083812366","https://openalex.org/W2083826827","https://openalex.org/W2084451402","https://openalex.org/W2084765835","https://openalex.org/W2086390603","https://openalex.org/W2086486507","https://openalex.org/W2086675887","https://openalex.org/W2087337895","https://openalex.org/W2087412907","https://openalex.org/W2087726424","https://openalex.org/W2087803244","https://openalex.org/W2088265860","https://openalex.org/W2089256281","https://openalex.org/W2089275949","https://openalex.org/W2089583559","https://openalex.org/W2090029662","https://openalex.org/W2090240729","https://openalex.org/W2090288989","https://openalex.org/W2090699719","https://openalex.org/W2090801772","https://openalex.org/W2091154394","https://openalex.org/W2091163726","https://openalex.org/W2091302400","https://openalex.org/W2091582164","https://openalex.org/W2092077225","https://openalex.org/W2092429991","https://openalex.org/W2092990269","https://openalex.org/W2093469696","https://openalex.org/W2093560632","https://openalex.org/W2093571786","https://openalex.org/W2093703326","https://openalex.org/W2093907840","https://openalex.org/W2094069034","https://openalex.org/W2094087897","https://openalex.org/W2095036479","https://openalex.org/W2095183708","https://openalex.org/W2095245008","https://openalex.org/W2096008312","https://openalex.org/W2096643396","https://openalex.org/W2096856910","https://openalex.org/W2097179544","https://openalex.org/W2097831093","https://openalex.org/W2097974950","https://openalex.org/W2098016509","https://openalex.org/W2099203431","https://openalex.org/W2099336033","https://openalex.org/W2100381069","https://openalex.org/W2100753430","https://openalex.org/W2101185281","https://openalex.org/W2101657904","https://openalex.org/W2102492718","https://openalex.org/W2104729808","https://openalex.org/W2106025379","https://openalex.org/W2106081526","https://openalex.org/W2106490838","https://openalex.org/W2106889940","https://openalex.org/W2108283346","https://openalex.org/W2108409970","https://openalex.org/W2108764665","https://openalex.org/W2110228756","https://openalex.org/W2110795636","https://openalex.org/W2112510700","https://openalex.org/W2113561239","https://openalex.org/W2113999599","https://openalex.org/W2114610666","https://openalex.org/W2114625725","https://openalex.org/W2114701571","https://openalex.org/W2115090363","https://openalex.org/W2117012616","https://openalex.org/W2117059432","https://openalex.org/W2117494436","https://openalex.org/W2118162388","https://openalex.org/W2119448420","https://openalex.org/W2119552671","https://openalex.org/W2119812021","https://openalex.org/W2119841148","https://openalex.org/W2119966340","https://openalex.org/W2119980642","https://openalex.org/W2120613427","https://openalex.org/W2121793070","https://openalex.org/W2122059149","https://openalex.org/W2122274477","https://openalex.org/W2122535995","https://openalex.org/W2122864516","https://openalex.org/W2123038957","https://openalex.org/W2123231624","https://openalex.org/W2125387035","https://openalex.org/W2125942201","https://openalex.org/W2128303661","https://openalex.org/W2128635872","https://openalex.org/W2128650326","https://openalex.org/W2129861564","https://openalex.org/W2129946289","https://openalex.org/W2129961360","https://openalex.org/W2130122556","https://openalex.org/W2130513320","https://openalex.org/W2130547944","https://openalex.org/W2130935744","https://openalex.org/W2131277634","https://openalex.org/W2131310568","https://openalex.org/W2131355261","https://openalex.org/W2131902596","https://openalex.org/W2132205005","https://openalex.org/W2134811841","https://openalex.org/W2135393487","https://openalex.org/W2135900186","https://openalex.org/W2135914921","https://openalex.org/W2136293998","https://openalex.org/W2136828475","https://openalex.org/W2137723543","https://openalex.org/W2138368478","https://openalex.org/W2139865704","https://openalex.org/W2140352289","https://openalex.org/W2141260882","https://openalex.org/W2141725752","https://openalex.org/W2141810738","https://openalex.org/W2142488497","https://openalex.org/W2142800802","https://openalex.org/W2144031727","https://openalex.org/W2144072685","https://openalex.org/W2144116778","https://openalex.org/W2144236229","https://openalex.org/W2144306475","https://openalex.org/W2145206598","https://openalex.org/W2145303230","https://openalex.org/W2145639407","https://openalex.org/W2145751901","https://openalex.org/W2146610807","https://openalex.org/W2147284446","https://openalex.org/W2147724465","https://openalex.org/W2148078855","https://openalex.org/W2149115643","https://openalex.org/W2149479293","https://openalex.org/W2149543855","https://openalex.org/W2149742956","https://openalex.org/W2151220183","https://openalex.org/W2152456372","https://openalex.org/W2152891500","https://openalex.org/W2154041187","https://openalex.org/W2154214377","https://openalex.org/W2154449937","https://openalex.org/W2154540873","https://openalex.org/W2154589167","https://openalex.org/W2154621114","https://openalex.org/W2155676752","https://openalex.org/W2155918643","https://openalex.org/W2156976744","https://openalex.org/W2157429518","https://openalex.org/W2158347147","https://openalex.org/W2159164732","https://openalex.org/W2159716095","https://openalex.org/W2159850782","https://openalex.org/W2160002590","https://openalex.org/W2160400422","https://openalex.org/W2161498359","https://openalex.org/W2161923795","https://openalex.org/W2162305258","https://openalex.org/W2162938937","https://openalex.org/W2163742256","https://openalex.org/W2163958066","https://openalex.org/W2164158641","https://openalex.org/W2164530460","https://openalex.org/W2165868509","https://openalex.org/W2166059867","https://openalex.org/W2166060488","https://openalex.org/W2166877291","https://openalex.org/W2169158684","https://openalex.org/W2169436026","https://openalex.org/W2169788367","https://openalex.org/W2170828331","https://openalex.org/W2171981785","https://openalex.org/W2172174202","https://openalex.org/W2172530119","https://openalex.org/W2177034728","https://openalex.org/W2177495592","https://openalex.org/W2178286819","https://openalex.org/W2178313645","https://openalex.org/W2182637946","https://openalex.org/W2187384985","https://openalex.org/W2187677346","https://openalex.org/W2208484551","https://openalex.org/W2209248032","https://openalex.org/W2210986612","https://openalex.org/W2278674792","https://openalex.org/W2284208499","https://openalex.org/W2285480884","https://openalex.org/W2285680126","https://openalex.org/W2290495595","https://openalex.org/W2297198811","https://openalex.org/W2309998720","https://openalex.org/W2327656791","https://openalex.org/W2330772164","https://openalex.org/W2336695849","https://openalex.org/W2338211589","https://openalex.org/W2338890813","https://openalex.org/W2341421474","https://openalex.org/W2341709337","https://openalex.org/W2342262766","https://openalex.org/W2343963166","https://openalex.org/W2394951169","https://openalex.org/W2396712276","https://openalex.org/W2397742643","https://openalex.org/W2398960951","https://openalex.org/W2399793110","https://openalex.org/W2409323230","https://openalex.org/W2410005511","https://openalex.org/W2410525949","https://openalex.org/W2410731842","https://openalex.org/W2411390742","https://openalex.org/W2411815690","https://openalex.org/W2411991595","https://openalex.org/W2412647751","https://openalex.org/W2412883775","https://openalex.org/W2413694458","https://openalex.org/W2413720149","https://openalex.org/W2413994889","https://openalex.org/W2414303319","https://openalex.org/W2415704966","https://openalex.org/W2415721714","https://openalex.org/W2416618290","https://openalex.org/W2417930207","https://openalex.org/W2426012546","https://openalex.org/W2430392320","https://openalex.org/W2433347163","https://openalex.org/W2460568658","https://openalex.org/W2465673478","https://openalex.org/W2471988094","https://openalex.org/W2472704204","https://openalex.org/W2799503982","https://openalex.org/W2982815105","https://openalex.org/W3026670008","https://openalex.org/W4248786683","https://openalex.org/W4317926856","https://openalex.org/W4323282388"],"related_works":["https://openalex.org/W2064216954","https://openalex.org/W7099584210","https://openalex.org/W1204928164","https://openalex.org/W7037689766","https://openalex.org/W1974086574","https://openalex.org/W1965202745","https://openalex.org/W2914149792","https://openalex.org/W1976108471","https://openalex.org/W2082941327","https://openalex.org/W42574947"],"abstract_inverted_index":{"Duchenne":[0],"Muscular":[1],"Dystrophy":[2],"(DMD)":[3],"is":[4,119,260,337,487,723,796,825,925],"a":[5,19,84,105,177,305,397,422,440,548,759,814,818,831,872,905,1008],"severe":[6],"and":[7,17,30,33,57,82,97,100,124,132,183,253,278,346,353,402,407,439,464,492,559,566,598,605,641,663,737,758,822,836,845,865,884,886,932,979,1007,1011,1024,1031,1062,1070],"progressive":[8,918],"skeletal":[9,264,356,416,666,811,919,966],"muscle":[10,265,309,342,427,457,490,667,812,829,863,875,901,920,967,977],"wasting":[11,458,921],"disease":[12,936],"characterised":[13],"by":[14,396,431,482,531,547,562,633,680,720,830,946,1003],"[Ca2+]-induced":[15],"hyper-catabolism,":[16],"subsequently,":[18],"higher":[20],"demand":[21],"for":[22,326,520,622,676,696,1046],"energy":[23,96,344,837,930],"production":[24,164],"to":[25,43,58,83,127,176,221,237,251,257,270,275,317,319,324,413,445,451,461,466,470,489,497,587,596,628,637,705,733,744,780,817,895,928,959,963,987,1014,1018,1036,1042,1067],"modulate":[26,781,1037],"intracellular":[27,93,288,471,479,630,677,786,802,1038],"Ca2+":[28,63,94,480,526,540,570,595,611,631,678,708,773,953,1021,1027],"homeostasis,":[29],"protein":[31,89,98,181,229,292,787,793,803,1039],"degradation":[32],"synthesis":[34,1040],"pathways.":[35,195],"The":[36,991],"broad":[37],"aim":[38],"of":[39,49,55,62,76,107,116,167,191,197,234,280,307,331,369,392,426,443,494,500,505,524,594,602,625,644,739,754,771,784,800,808,833,861,889,972,976,983,993,1054,1060],"this":[40,70,617,824,913],"thesis":[41,71,914],"was":[42,204,211,219,227,245,294,419,535,573,580,840,957],"elucidate":[44],"potential":[45],"defects":[46],"in":[47,64,91,144,184,207,214,223,248,254,312,340,350,379,400,503,512,660,724,827,874,899,923,1056],"metabolism":[48,293],"the":[50,60,74,77,108,113,137,142,150,189,198,232,241,298,308,332,483,498,521,538,588,592,600,614,623,634,642,656,681,717,740,745,752,806,858,887,910,917,934,947,1015,1044,1057],"C57BL/10":[51],"mdx":[52,146,168,249,263,355,415,665,810,965],"mouse":[53],"model":[54],"DMD,":[56,1061],"determine":[59],"role":[61,873],"any":[65],"such":[66,376,508,704,1017,1041],"defects.":[67],"In":[68],"particular,":[69],"has":[72,129,158,266,388,652,690,749],"examined":[73],"efficacy":[75],"nutritional":[78],"supplements":[79,777,1051],"creatine":[80,370,550],"(Cr)":[81],"lesser":[85,178,441],"extent,":[86],"isolated":[87],"whey":[88],"(WP),":[90],"improving":[92],"regulation,":[95],"balance":[99],"tissue":[101,852,864,978,985],"architecture,":[102,968],"thus":[103,285,374,870,903],"alleviating":[104],"degree":[106,442],"dystrophic":[109,117,208,235,354,664,809,964],"pathology.":[110],"1.":[111],"Whether":[112],"ATP-producing":[114],"capacity":[115,675,1045],"mitochondria":[118,143,242,325],"defective":[120],"remains":[121],"largely":[122],"contentious,":[123],"no":[125,692,768],"study":[126,618,748],"date":[128],"directly":[130],"quantified":[131],"contrasted":[133],"ATP-production":[134],"rate":[135,165,349,572],"under":[136,180,576],"major":[138],"macronutrient":[139,172,193,272,300],"pathways":[140,302],"feeding":[141],"either":[145],"hind":[147],"limb":[148],"or":[149,701,711],"more":[151],"human":[152,351,661],"DMD":[153,313,352,662,924,948],"phenotype-like":[154],"diaphragm.":[155],"Chapter":[156,386,514,688,994],"Three":[157],"demonstrated":[159,389,536,582,691],"severely":[160],"depressed":[161,213],"mitochondrial":[162,228,236],"ATP":[163,327,468,545,558,560],"(MAPR)":[166],"diaphragm":[169,255],"across":[170,188],"all":[171,192],"substrate":[173,194,276,301],"pathways,":[174],"but":[175,210,714],"extent":[179],"metabolism,":[182],"tibialis":[185],"anterior":[186],"(TA)":[187],"sum":[190],"Function":[196],"electron":[199],"transport":[200],"chain":[201],"complex":[202],"II":[203],"not":[205,790],"impaired":[206],"diaphragm,":[209],"notably":[212],"TA.":[215,258],"Citrate":[216],"synthase":[217],"activity":[218],"comparable":[220],"controls":[222],"both":[224,555],"muscles,":[225],"as":[226,429,509,567,878,1066],"content.":[230],"However,":[231],"susceptibility":[233],"mechanical":[238],"damage":[239,428,444],"during":[240,647],"isolation":[243],"process":[244],"significantly":[246],"greater":[247],"compared":[250,256,412,894],"controls,":[252],"It":[259,534,579,651,795,839],"postulated":[261],"that":[262,304,448,456,473,510,537,583,599,655,716,798,823,843,916,933,950,997],"an":[267,287,517,673,941],"intrinsic":[268,942],"inability":[269],"utilise":[271],"substrates":[273],"leading":[274],"\u201cback-up\u201d":[277],"inhibition/down-regulation":[279],"key":[281],"Krebs\u2019":[282],"cycle":[283],"enzymes,":[284,565],"creating":[286],"\u201cstarvation\u201d":[289],"scenario.":[290],"That":[291],"less":[295],"affected":[296],"than":[297],"other":[299],"suggests":[303],"portion":[306],"hyper-catabolism":[310],"observed":[311,659],"may":[314],"occur":[315],"due":[316],"autophagy":[318],"increase":[320,1043],"amino":[321,834],"acid":[322,835],"funnelling":[323],"production.":[328],"2.":[329],"Supplementation":[330],"high-energy":[333],"storage":[334],"nutrient":[335],"Cr":[336,404,626,669,697,721,764,844,855,955,998,1030],"demonstrably":[338],"beneficial":[339,657],"maintaining":[341,380,725,1004],"function,":[343],"status":[345],"cell":[347,475,501],"survival":[348,502],"muscle.":[357,417],"Long-term":[358],"chronic":[359,398],"dose":[360,399],"supplementation":[361,405,627,670,698,722,755,847,856,956,999,1033],"regimes,":[362],"however,":[363],"have":[364],"been":[365,653],"associated":[366,420],"with":[367,421,756,763],"down-regulation":[368,395],"transporter":[371],"(CreaT)":[372],"expression":[373,783],"making":[375],"regimes":[377],"futile":[378],"consistently":[381],"high":[382,584,1009],"intramuscular":[383,989],"PCr":[384,604,639],"stores.":[385],"Four":[387],"successful":[390],"prevention":[391],"CreaT":[393],"mRNA":[394],"utero":[401],"life-long":[403],"protocol,":[406],"subsequently":[408,729,951],"persistently":[409],"elevated":[410],"[PCr]":[411,1006],"unsupplemented":[414,828],"This":[418,453,747],"drastically":[423,608],"reduced":[424,970,980],"amount":[425],"depicted":[430],"Evan\u2019s":[432],"blue":[433],"dye":[434],"(EBD)":[435],"uptake":[436,571,727,1022],"into":[437],"myofibres,":[438],"those":[446],"fibres":[447,893,898],"were":[449,778],"permeant":[450],"EBD.":[452],"unequivocally":[454],"demonstrates":[455],"occurs":[459],"secondary":[460,732,986],"metabolic":[462,648,943],"compromise":[463],"failure":[465],"maintain":[467,1019],"supply":[469],"mechanisms":[472],"promote":[474],"survival.":[476,1048],"3.":[477],"Effective":[478],"regulation":[481],"sarcoplasmic":[484],"reticulum":[485],"(SR)":[486],"integral":[488],"function":[491,703],"becomes":[493],"paramount":[495],"importance":[496],"maintenance":[499,975],"conditions":[504],"increasing":[506,638],"[Ca2+]i":[507],"evident":[511,922],"DMD.":[513],"Five":[515,995],"details":[516],"optimised":[518],"method":[519],"fluorometric":[522],"quantitation":[523],"SR":[525,539,569,589,635,682,707,772],"flux":[527,774],"kinetics":[528],"currently":[529],"utilised":[530],"our":[532],"laboratory.":[533],"ATPase":[541],"(SERCA)":[542],"preferentially":[543],"utilises":[544],"produced":[546,561],"linked":[549],"kinase":[551],"(CK)":[552],"system":[553],"over":[554],"exogenously":[556],"administered":[557],"SR-linked":[563],"glycolytic":[564],"such,":[568],"considerably":[574],"faster":[575],"these":[577,1050],"conditions.":[578],"also":[581,750,841,1034],"[ADP]":[585,607,646,736],"proximal":[586,743,1013],"vesicles":[590],"impairs":[591],"binding":[593],"Fura-2":[597],"presence":[601],"25mM":[603],"low":[606],"reduces":[609],"passive":[610,1026],"leak":[612,710],"from":[613,672,813],"SR.":[615,746],"Thus,":[616,1049],"provides":[619],"sound":[620],"rationale":[621],"use":[624],"improve":[629],"handling":[632,679],"subsequent":[636],"stores":[640],"buffering":[643,734],"rising":[645,735],"compromise.":[649],"4.":[650],"suggested":[654],"effects":[658,753,850],"following":[668],"result":[671],"improved":[674],"and,":[683],"therefore,":[684,939],"delayed":[685],"degenerative":[686,973],"progression.":[687],"Six":[689],"direct":[693,769],"modulatory":[694],"effect":[695,1002],"on":[699,851],"SERCA":[700],"RyR":[702],"increase/decrease":[706],"uptake,":[709],"release":[712],"rates,":[713],"postulates":[715],"benefit":[718,1055],"imparted":[719],"maximum":[726,1020],"(and":[728],"release)":[730],"velocity":[731,1023],"collapse":[738],"ATP:ADP":[741,1010],"ratio":[742],"investigated":[751],"WP":[757,766,846,1032],"Cr+WP":[760,879],"combination.":[761],"As":[762],"supplementation,":[765],"induced":[767],"modulation":[770],"kinetics.":[775],"Both":[776,1029],"shown":[779,958],"differential":[782],"specific":[785],"pools,":[788],"although":[789],"necessarily":[791],"net":[792],"accretion.":[794],"speculated":[797],"modification":[799],"expressed":[801],"pools":[804],"permits":[805],"\u201cswitching\u201d":[807],"\u201cfunctional\u201d":[815],"phenotype":[816],"\u201ccell":[819],"survival\u201d":[820],"phenotype,":[821],"inhibited":[826],"lack":[832],"resources.":[838],"apparent":[842],"exerted":[848],"different":[849],"architecture":[853],"maintenance.":[854],"increased":[857,881,988],"proportional":[859,981],"area":[860,982],"functional":[862,900],"decreased":[866],"non-muscle":[867,984],"\u201cgap\u201d":[868],"areas":[869],"suggesting":[871],"hypertrophy,":[876],"where":[877],"combined":[880],"active/recent":[882],"degeneration":[883],"regeneration":[885],"proportion":[888],"centrally-nucleated":[890],"previously":[891],"damaged":[892],"peripherally-nucleated":[896],"undamaged":[897],"tissue,":[902],"indicating":[904],"potentially":[906],"damaging":[907],"effect.":[908],"Collectively,":[909],"studies":[911],"comprising":[912],"indicate":[915],"closely":[926],"related":[927],"dissipating":[929],"stores,":[931],"primary":[935],"pathology":[937],"may,":[938],"be":[940,1053],"defect":[944],"caused":[945],"genotype":[949],"induces":[952],"dys-regulation.":[954],"provide":[960],"several":[961],"benefits":[962],"including":[969],"severity":[971],"cycles,":[974],"[PCr].":[990],"findings":[992],"suggest":[996],"modulates":[1000],"its":[1001],"normal":[1005],"PCr:Cr":[1012],"SR,":[1016],"reduce":[1025],"leak.":[1028],"seem":[1035],"myofibre":[1047],"could":[1052],"adjunct":[1058],"treatment":[1059],"warrant":[1063],"further":[1064],"investigation":[1065],"their":[1068],"long-term":[1069],"mechanistic":[1071],"efficacy.":[1072]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
