{"id":"https://openalex.org/W112371194","doi":null,"title":"NTP technical report on the toxicity studies of Butanal oxime (CAS No. 110-69-0) administered in drinking water and by gavage to F344/N rats and B6C3F1 mice.","display_name":"NTP technical report on the toxicity studies of Butanal oxime (CAS No. 110-69-0) administered in drinking water and by gavage to F344/N rats and B6C3F1 mice.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W112371194","mag":"112371194","pmid":"https://pubmed.ncbi.nlm.nih.gov/15017436"},"language":"en","primary_location":{"id":"pmid:15017436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15017436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicity report series","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025757475","display_name":"Leo T. Burka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Leo T Burka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5025757475"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1381,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.4908546,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"69","first_page":"1","last_page":"F10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11493","display_name":"Water Treatment and Disinfection","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldoximes","display_name":"aldoximes","score":0.9359999895095825},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.5080000162124634},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.6850000023841858},{"id":"https://openalex.org/keywords/reproductive-toxicity","display_name":"reproductive toxicity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.8059999942779541},{"id":"https://openalex.org/keywords/carcinogenicity","display_name":"carcinogenicity","score":0.49900001287460327},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.5559999942779541},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.47699999809265137},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.6679999828338623},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/skin-irritation","display_name":"skin irritation","score":0.35199999809265137},{"id":"https://openalex.org/keywords/eye-irritation","display_name":"eye irritation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/skin-sensitization","display_name":"skin sensitization","score":0.5189999938011169},{"id":"https://openalex.org/keywords/inhalation-toxicity","display_name":"inhalation toxicity","score":0.5170000195503235},{"id":"https://openalex.org/keywords/occupational-exposure","display_name":"occupational exposure","score":0.460999995470047},{"id":"https://openalex.org/keywords/f344-n-rats","display_name":"F344/N rats","score":0.8320000171661377},{"id":"https://openalex.org/keywords/b6c3f1-mice","display_name":"B6C3F1 mice","score":1.0}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6128055453300476},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.5389254093170166},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.5123587846755981},{"id":"https://openalex.org/C2777495288","wikidata":"https://www.wikidata.org/wiki/Q1755926","display_name":"No-observed-adverse-effect level","level":3,"score":0.49348270893096924},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.49197742342948914},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.47598448395729065},{"id":"https://openalex.org/C2779648554","wikidata":"https://www.wikidata.org/wiki/Q182738","display_name":"Oxime","level":2,"score":0.4120074510574341},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3896118700504303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3799111843109131},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.37196213006973267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36820048093795776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36464497447013855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34166228771209717},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1550154983997345},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1412402093410492}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006403","descriptor_name":"Hematologic Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060766","descriptor_name":"Drinking Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15017436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15017436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicity report series","raw_type":"Journal Article"},{"id":"mag:112371194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15017436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.8100000023841858}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4298167214","https://openalex.org/W4301971537","https://openalex.org/W4298114160","https://openalex.org/W7100910935","https://openalex.org/W4229739127","https://openalex.org/W125643414","https://openalex.org/W1996007023","https://openalex.org/W2071806421","https://openalex.org/W4230806123","https://openalex.org/W1976846233"],"abstract_inverted_index":{"Butanal":[0,15,633,686],"oxime":[1,16,39,112,324,481,538,634,687,728],"is":[2],"used":[3],"as":[4,22,518,563,565,607,609],"a":[5,23,483,486],"volatile":[6],"antiskinning":[7],"agent":[8],"in":[9,43,52,75,113,117,270,290,361,419,444,449,468,489,555,566,584,590,616,620,641,646,663,676,691,703,712,714],"paints,":[10],"inks,":[11],"and":[12,30,34,68,83,96,100,134,147,163,170,198,214,217,219,223,239,255,272,276,292,316,320,369,391,400,433,447,463,485,491,497,509,511,528,558,587,592,604,623,627,670,698,719],"similar":[13],"products.":[14],"was":[17,262,278,542,553,639,661,674],"chosen":[18],"for":[19,46,56,62,192,342,729],"toxicology":[20,71],"testing":[21],"representative":[24],"of":[25,93,121,165,204,210,231,283,313,329,358,383,389,412,417,425,435,441,458,465,473,495,523,548,573,599,630,649,706,717],"the":[26,89,181,202,205,232,249,267,279,309,355,359,362,381,384,413,436,442,466,469,474,520,543,549,571,574,621,647,704],"aldoxime":[27],"class.":[28],"Male":[29,234],"female":[31,98,135,156,171,215,224,295,318,401,502,526,593,720],"F344/N":[32],"rats":[33,99,172,197,216,254,275,319,348,422,490,503,527,557,586],"B6C3F1":[35],"mice":[36,101,199,225,235,256,277,321,402,515,559,721],"received":[37,102,322],"butanal":[38,111,128,323,480,537,727],"(99":[40],"percent":[41,54,651,654,667],"pure)":[42],"drinking":[44,114],"water":[45,166],"15":[47],"days":[48,339],"or":[49,108,125,141,152,175,243,260,335,350,376,406,507,652,679,682],"by":[50,253,266,325,732],"gavage":[51,326,476],"0.5":[53],"methylcellulose":[55],"14":[57,343,730],"weeks.":[58,344],"Animals":[59],"were":[60,73,178,189,226,287,300,305,351,373,377,408,516,519,580,613,628,710],"evaluated":[61],"clinical":[63,281,453],"pathology,":[64],"reproductive":[65],"system":[66],"effects,":[67],"histopathology.":[69],"Genetic":[70],"studies":[72,477],"conducted":[74],"Salmonella":[76],"typhimurium,":[77],"cultured":[78,692],"Chinese":[79,693],"hamster":[80,683,694],"ovary":[81,695],"cells,":[82,696],"mouse":[84,365],"peripheral":[85,715],"blood":[86,716],"erythrocytes.":[87],"In":[88,308,530],"15-day":[90],"studies,":[91,311],"groups":[92,312],"five":[94,97],"male":[95,133,145,169,213,222,315,394,398,500,514,585,591,718],"0,":[103,330],"312,":[104],"625,":[105],"1,250,":[106],"2,500,":[107],"5,000":[109,176,220,237,244,273,293],"ppm":[110,177,212,221,238,245,259,274,294],"water,":[115],"resulting":[116],"average":[118,186],"daily":[119,187],"doses":[120,188,328],"approximately":[122],"40,":[123],"70,":[124],"100":[126,390,496],"mg":[127],"oxime/kg":[129],"body":[130,160,208,387],"weight":[131,161,247],"to":[132,144,155,159,536,570,636,724],"rats;":[136],"45,":[137,148],"90,":[138],"130,":[139,151],"200,":[140,334],"300":[142],"mg/kg":[143,154,347,364,393,397,405,421,451,499,506,513,525,625,726],"mice;":[146],"85,":[149],"100,":[150,333],"170":[153],"mice.":[157,296,492,529,594],"Due":[158],"loss":[162,424,457],"lack":[164],"consumption,":[167],"all":[168],"receiving":[173,236,241,257],"2,500":[174,218,242,271,291],"removed":[179],"from":[180],"study":[182],"on":[183],"day":[184],"9;":[185],"not":[190,306],"calculated":[191],"these":[193],"groups.":[194],"All":[195,345],"other":[196],"survived":[200,569],"until":[201],"end":[203,382,572],"studies.":[206,575],"Mean":[207,386],"weights":[209,286,388,494,522],"1,250":[211,258],"significantly":[227,288],"less":[228,263,409],"than":[229,264,410],"those":[230,411],"controls.":[233,268,414],"females":[240,371],"lost":[246],"during":[248,354],"study.":[250,385],"Water":[251],"consumption":[252],"greater":[261,407],"that":[265,479,532,560,568],"Thinness":[269],"only":[280],"finding":[282],"toxicity.":[284],"Spleen":[285,493],"decreased":[289],"No":[297],"chemical-related":[298,577],"lesions":[299],"observed":[301,554,615,711],"grossly;":[302],"histologic":[303],"examinations":[304],"performed.":[307],"14-week":[310,475],"10":[314,317,653],"at":[327],"25,":[331],"50,":[332],"600":[336,346,363,396,420,450,512,624,725],"mg/kg,":[337],"5":[338,650],"per":[340],"week":[341,357],"died":[349,533,561],"killed":[352,374,378],"moribund":[353],"first":[356],"study;":[360],"groups,":[366,618,626],"seven":[367],"males":[368],"nine":[370],"died,":[372],"moribund,":[375],"accidentally":[379],"before":[380],"200":[392,498,510,524,622],"rats,":[395,501],"mice,":[399,452],"administered":[403,504,722],"50":[404,505],"Clinical":[415],"findings":[416,454,579],"toxicity":[418],"included":[423,455],"coordination,":[426],"wobbly":[427],"gait,":[428],"shaking,":[429],"blinking,":[430],"constant":[431],"grooming":[432],"scratching":[434],"face,":[437],"head":[438],"weaving,":[439],"burying":[440,464],"face":[443,467],"bedding,":[445],"lethargy,":[446],"prostration;":[448],"ataxia,":[456],"balance":[459],"after":[460],"rearing,":[461],"squinting,":[462],"bedding.":[470],"Hematology":[471],"results":[472],"indicate":[478],"induces":[482],"methemoglobinemia":[484],"responsive":[487],"anemia":[488],"greater,":[508],"increased,":[517],"liver":[521,656,684],"animals":[531,567],"early":[534,562],"due":[535],"administration,":[539],"hepatocellular":[540],"necrosis":[541],"primary":[544],"pathologic":[545],"finding.":[546],"Degeneration":[547],"nasal":[550,578],"olfactory":[551],"epithelium":[552],"dosed":[556,617],"well":[564,608],"Additional":[576],"respiratory":[581],"epithelial":[582],"changes":[583],"suppurative":[588],"exudate":[589],"Increased":[595],"incidences":[596],"and/or":[597],"severities":[598],"splenic":[600],"hematopoietic":[601],"cell":[602],"proliferation":[603],"pigmentation":[605],"(hemosiderin)":[606],"bone":[610],"marrow":[611],"hyperplasia":[612],"also":[614],"particularly":[619],"indicative":[629],"erythrocyte":[631],"damage.":[632],"(3":[635],"10,000":[637],"ug/plate)":[638],"mutagenic":[640,672],"S.":[642],"typhimurium":[643],"strain":[644],"TA1535":[645],"presence":[648],"rat":[655,668,681],"S9;":[657],"an":[658],"equivocal":[659],"response":[660],"seen":[662,675],"TA100":[664],"with":[665,678,697],"30":[666],"S9,":[669],"no":[671],"activity":[673],"TA98,":[677],"without":[680,699],"S9.":[685,700],"induced":[688],"chromosomal":[689],"aberrations":[690],"Significant":[701],"increases":[702],"frequencies":[705],"micronucleated":[707],"normochromatic":[708],"erythrocytes":[709],"vivo":[713],"25":[723],"weeks":[731],"gavage.":[733],"Synonyms:":[734],"Butanaloxime;":[735],"butylaldoxime;":[736],"butyraldehyde":[737],"oxime;":[738,740],"n-butyraldehyde":[739],"butyraldoxime;":[741],"n-butyraldoxime":[742],"Trade":[743],"names:":[744],"Exkin":[745,747],"1,":[746],"No.":[748],"1":[749],"Anti-Skinning":[750],"Agent,":[751],"Skino":[752],"#1,":[753],"Troykyd":[754],"Anti-Skin":[755],"BTO":[756]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
