{"id":"https://openalex.org/W1123543704","doi":"https://doi.org/10.1371/journal.pone.0135738","title":"Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin \u03b1IIb\u03b23 and Lyn Kinase","display_name":"Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin \u03b1IIb\u03b23 and Lyn Kinase","publication_year":2015,"publication_date":"2015-08-20","ids":{"openalex":"https://openalex.org/W1123543704","doi":"https://doi.org/10.1371/journal.pone.0135738","mag":"1123543704","pmid":"https://pubmed.ncbi.nlm.nih.gov/26291522","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4546160"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0135738","doi":"https://doi.org/10.1371/journal.pone.0135738","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0135738","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0135738&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0135738&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029068008","display_name":"Huiying Zhi","orcid":"https://orcid.org/0000-0002-0041-3740","observed_orcids":["https://orcid.org/0000-0002-0041-3740"]},"institutions":[{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huiying Zhi","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I4210117001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034570457","display_name":"Jing Dai","orcid":"https://orcid.org/0000-0002-1889-6621","observed_orcids":["https://orcid.org/0000-0002-1889-6621","https://orcid.org/0009-0006-8359-5098"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Dai","raw_affiliation_strings":["Ruijing Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruijing Hospital Affiliated Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2801556517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100701947","display_name":"Junling Liu","orcid":"https://orcid.org/0000-0002-2510-790X","observed_orcids":["https://orcid.org/0000-0002-2510-790X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junling Liu","raw_affiliation_strings":["Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai JiaoTong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai JiaoTong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087562716","display_name":"Jieqing Zhu","orcid":"https://orcid.org/0000-0003-4508-4263","observed_orcids":["https://orcid.org/0000-0003-4508-4263"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jieqing Zhu","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America","Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I4210117001"]},{"raw_affiliation_string":"Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041058094","display_name":"Debra K. Newman","orcid":"https://orcid.org/0000-0001-9674-0801","observed_orcids":["https://orcid.org/0000-0001-9674-0801"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra K. Newman","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America; Department of Microbiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America","Department of Microbiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America; Department of Microbiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I4210117001"]},{"raw_affiliation_string":"Department of Microbiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031121462","display_name":"Cunji Gao","orcid":"https://orcid.org/0000-0002-9375-7891","observed_orcids":["https://orcid.org/0000-0002-9375-7891"]},"institutions":[{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Cunji Gao","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America; Chronic Disease Research Institute, Department of Nutrition and Food Hygiene, Zhejiang University School of Public Health, Hangzhou, China","Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America","Chronic Disease Research Institute, Department of Nutrition and Food Hygiene, Zhejiang University School of Public Health, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America; Chronic Disease Research Institute, Department of Nutrition and Food Hygiene, Zhejiang University School of Public Health, Hangzhou, China","institution_ids":["https://openalex.org/I4210117001","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I4210117001"]},{"raw_affiliation_string":"Chronic Disease Research Institute, Department of Nutrition and Food Hygiene, Zhejiang University School of Public Health, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043749891","display_name":"Peter J. Newman","orcid":"https://orcid.org/0000-0001-8853-7707","observed_orcids":["https://orcid.org/0000-0001-8853-7707"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter J. Newman","raw_affiliation_strings":["Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America; Department of Cell biology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America","Department of Cell biology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America; Department of Cell biology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I4210117001"]},{"raw_affiliation_string":"Department of Cell biology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5043749891"],"corresponding_institution_ids":["https://openalex.org/I204308271","https://openalex.org/I4210117001"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.4044,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.92238542,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"8","first_page":"e0135738","last_page":"e0135738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/thrombus-formation","display_name":"thrombus formation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/igg-immune-complexes","display_name":"IgG immune complexes","score":0.9929999709129333},{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lyn-kinase","display_name":"Lyn kinase","score":0.9390000104904175},{"id":"https://openalex.org/keywords/fcgammariia","display_name":"Fc\u03b3RIIa","score":0.9309999942779541},{"id":"https://openalex.org/keywords/syk","display_name":"Syk","score":0.8109999895095825},{"id":"https://openalex.org/keywords/platelet-adhesion","display_name":"platelet adhesion","score":0.8109999895095825},{"id":"https://openalex.org/keywords/platelet-spreading","display_name":"platelet spreading","score":0.8709999918937683},{"id":"https://openalex.org/keywords/fibrinogen-receptor-antagonists","display_name":"fibrinogen receptor antagonists","score":0.8659999966621399},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.5130000114440918},{"id":"https://openalex.org/keywords/platelet-adhesion-receptors","display_name":"platelet adhesion receptors","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C175818844","wikidata":"https://www.wikidata.org/wiki/Q2463389","display_name":"LYN","level":4,"score":0.8699898719787598},{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.6858105063438416},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6415949463844299},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6314780116081238},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.6156740188598633},{"id":"https://openalex.org/C2779931124","wikidata":"https://www.wikidata.org/wiki/Q417823","display_name":"Fc receptor","level":3,"score":0.574237585067749},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5659264326095581},{"id":"https://openalex.org/C2778474638","wikidata":"https://www.wikidata.org/wiki/Q575241","display_name":"Immune complex","level":3,"score":0.5439808368682861},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.46340250968933105},{"id":"https://openalex.org/C119524353","wikidata":"https://www.wikidata.org/wiki/Q5145908","display_name":"Collagen receptor","level":4,"score":0.41246312856674194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39290791749954224},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3301035165786743},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.3252164125442505},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31399714946746826},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.30536243319511414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28122881054878235},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27939704060554504},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.102215975522995},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.08426713943481445}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010973","descriptor_name":"Platelet Adhesiveness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019038","descriptor_name":"Platelet Glycoprotein GPIb-IX Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019039","descriptor_name":"Platelet Glycoprotein GPIIb-IIIa Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0135738","doi":"https://doi.org/10.1371/journal.pone.0135738","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0135738","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0135738&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3521080","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4546160","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4546160","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4546160","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:26291522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26291522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3d2d7c3aed69436e949d5c0b6101daa2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3d2d7c3aed69436e949d5c0b6101daa2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 10, Iss 8, p e0135738 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1515538","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Platelet_Activation_and_Thrombus_Formation_over_IgG_Immune_Complexes_Requires_Integrin_945_IIb_946_3_and_Lyn_Kinase_/1515538","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0135738","doi":"https://doi.org/10.1371/journal.pone.0135738","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0135738","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0135738&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1731509664","display_name":"Molecular & Cellular Mechanisms in Transfusion Medicine","funder_award_id":"P01HL044612","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G255394560","display_name":"\u8c03\u8282\u8840\u6813\u5f62\u6210\u7684\u65b0\u9014\u5f84\uff1a\u6574\u5408\u7d20\u5931\u6d3b\u53ca\u8840\u5c0f\u677f\u805a\u96c6\u4f53\u89e3\u79bb\u673a\u5236\u7684\u7814\u7a76","funder_award_id":"81270586","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G314277607","display_name":"Conformational regulation in integrin bidirectional transmembrane signaling","funder_award_id":"R56HL122985","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G570512489","display_name":null,"funder_award_id":"HL-44612","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000175688","display_name":null,"funder_award_id":"HL-44612","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306571","display_name":"American Society of Hematology","ror":"https://ror.org/02nw48b86"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322927","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1123543704.pdf","grobid_xml":"https://content.openalex.org/works/W1123543704.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W49181605","https://openalex.org/W85127246","https://openalex.org/W180669350","https://openalex.org/W185288001","https://openalex.org/W1483690774","https://openalex.org/W1530177683","https://openalex.org/W1540012817","https://openalex.org/W1540271729","https://openalex.org/W1549544590","https://openalex.org/W1564372652","https://openalex.org/W1565477787","https://openalex.org/W1602732476","https://openalex.org/W1643983504","https://openalex.org/W1813739341","https://openalex.org/W1965875493","https://openalex.org/W1968497165","https://openalex.org/W1968821921","https://openalex.org/W1969202046","https://openalex.org/W1972408385","https://openalex.org/W1973611836","https://openalex.org/W1975495359","https://openalex.org/W1975810807","https://openalex.org/W1982536372","https://openalex.org/W1983007339","https://openalex.org/W1989853813","https://openalex.org/W1994420770","https://openalex.org/W1997036712","https://openalex.org/W2002389505","https://openalex.org/W2003698382","https://openalex.org/W2011809282","https://openalex.org/W2016810960","https://openalex.org/W2019845729","https://openalex.org/W2020898985","https://openalex.org/W2027266132","https://openalex.org/W2033093970","https://openalex.org/W2034626872","https://openalex.org/W2046737719","https://openalex.org/W2056668880","https://openalex.org/W2074960178","https://openalex.org/W2075363343","https://openalex.org/W2076891149","https://openalex.org/W2084333005","https://openalex.org/W2124758818","https://openalex.org/W2134916100","https://openalex.org/W2171187567","https://openalex.org/W2321193344","https://openalex.org/W2323604728","https://openalex.org/W2406965583","https://openalex.org/W2414595006","https://openalex.org/W4313344679"],"related_works":["https://openalex.org/W7098369161","https://openalex.org/W2980558983","https://openalex.org/W1549415843","https://openalex.org/W2415908609","https://openalex.org/W2339428266","https://openalex.org/W2030495929","https://openalex.org/W2139493420","https://openalex.org/W2536584806","https://openalex.org/W3182544687","https://openalex.org/W1864087818"],"abstract_inverted_index":{"IgG":[0,78,157],"immune":[1,29,79,105,158,220,235],"complexes":[2,80,159],"contribute":[3],"to":[4,34,37,90,116,124,138,160,196,229],"the":[5,42,45,56,59,96,145],"etiology":[6],"and":[7,20,23,70,73,111,120,132,135,140,147,167,174,186,192,217],"pathogenesis":[8],"of":[9,44,58,76,86,95,99,149,156],"numerous":[10],"autoimmune":[11],"disorders,":[12],"including":[13],"heparin-induced":[14],"thrombocytopenia,":[15],"systemic":[16],"lupus":[17],"erythematosus,":[18],"rheumatoid-":[19],"collagen-induced":[21],"arthritis,":[22],"chronic":[24],"glomerulonephritis.":[25],"Patients":[26],"suffering":[27,233],"from":[28,234,240],"complex-related":[30],"disorders":[31,237],"are":[32],"known":[33],"be":[35,227],"susceptible":[36],"platelet-mediated":[38],"thrombotic":[39,107],"events.":[40,204],"Though":[41],"role":[43,57],"Fc":[46],"receptor,":[47,63],"Fc\u03b3RIIa,":[48,215],"in":[49,66,104,144,200,219],"initiating":[50],"platelet":[51,61,68,165,172,202,222],"activation":[52,69,203],"is":[53,81],"well":[54],"understood,":[55],"major":[60],"adhesion":[62,72,166],"integrin":[64],"\u03b1IIb\u03b23,":[65,121],"amplifying":[67],"mediating":[71],"aggregation":[74],"downstream":[75],"encountering":[77],"poorly":[82],"understood.":[83],"The":[84],"goal":[85],"this":[87],"investigation":[88],"was":[89,162],"gain":[91],"a":[92,210],"better":[93],"understanding":[94],"relative":[97],"roles":[98,199],"these":[100],"two":[101],"receptor":[102,152],"systems":[103],"complex-mediated":[106],"complications.":[108],"Human":[109],"platelets,":[110],"mouse":[112],"platelets":[113],"genetically":[114],"engineered":[115],"differentially":[117],"express":[118],"Fc\u03b3RIIa":[119,161],"were":[122,194],"allowed":[123],"interact":[125],"with":[126,242],"IgG-coated":[127,178],"surfaces":[128,179],"under":[129],"both":[130],"static":[131],"flow":[133],"conditions,":[134],"their":[136],"ability":[137],"spread":[139],"form":[141],"thrombi":[142],"evaluated":[143],"presence":[146],"absence":[148],"clinically-used":[150],"fibrinogen":[151],"antagonists.":[153],"Although":[154],"binding":[155],"sufficient":[163],"for":[164,184],"initial":[168],"signal":[169],"transduction":[170],"events,":[171],"spreading":[173],"thrombus":[175],"formation":[176],"over":[177],"showed":[180],"an":[181],"absolute":[182],"requirement":[183],"\u03b1IIb\u03b23":[185,218],"its":[187],"ligands.":[188],"Tyrosine":[189],"kinases":[190],"Lyn":[191],"Syk":[193],"found":[195],"play":[197],"key":[198],"IgG-induced":[201],"Taken":[205],"together,":[206],"our":[207],"data":[208],"suggest":[209],"complex":[211,236],"functional":[212],"interplay":[213],"between":[214],"Lyn,":[216],"complex-induced":[221],"activation.":[223],"Future":[224],"studies":[225],"may":[226],"warranted":[228],"determine":[230],"whether":[231],"patients":[232],"might":[238],"benefit":[239],"treatment":[241],"anti-\u03b1IIb\u03b23-directed":[243],"therapeutics.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}