{"id":"https://openalex.org/W112305994","doi":null,"title":"Le r\u00f4le du APC (Anaphase-Promoting Complex) au cours de la phase G2/M apr\u00e8s dommage de l\u2019ADN","display_name":"Le r\u00f4le du APC (Anaphase-Promoting Complex) au cours de la phase G2/M apr\u00e8s dommage de l\u2019ADN","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W112305994","mag":"112305994"},"language":"fr","primary_location":{"id":"mag:112305994","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00247413","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HAL (Le Centre pour la Communication Scientifique Directe)","raw_type":null},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://theses.hal.science/tel-00247413","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101517474","display_name":"Lee J","orcid":"https://orcid.org/0000-0003-0672-6892","observed_orcids":["https://orcid.org/0000-0003-0672-6892"]},"institutions":[{"id":"https://openalex.org/I4210152516","display_name":"Institut de Biologie Structurale","ror":"https://ror.org/04szabx38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210091409","https://openalex.org/I4210096427","https://openalex.org/I4210113668","https://openalex.org/I4210152516","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Lee J","raw_affiliation_strings":["Institut de biologie structurale"],"raw_orcid":"https://orcid.org/0000-0003-0672-6892","affiliations":[{"raw_affiliation_string":"Institut de biologie structurale","institution_ids":["https://openalex.org/I4210152516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101517474"],"corresponding_institution_ids":["https://openalex.org/I4210152516"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8213000297546387,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0689999982714653,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.052400000393390656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anaphase-promoting-complex","display_name":"anaphase-promoting complex","score":0.9959999918937683},{"id":"https://openalex.org/keywords/g2-m-checkpoint","display_name":"G2/M checkpoint","score":0.8880000114440918},{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.8119999766349792},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.7120000123977661},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mitotic-exit","display_name":"mitotic exit","score":0.6449999809265137},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.6499999761581421},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.578000009059906},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.8207482695579529},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.7904254198074341},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.7138615250587463},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.6500766277313232},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5952414274215698},{"id":"https://openalex.org/C53420372","wikidata":"https://www.wikidata.org/wiki/Q22299157","display_name":"Anaphase","level":4,"score":0.5922306776046753},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.5444558262825012},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5312820672988892},{"id":"https://openalex.org/C107888121","wikidata":"https://www.wikidata.org/wiki/Q418432","display_name":"Anaphase-promoting complex","level":5,"score":0.5169117450714111},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5115135908126831},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4716060757637024},{"id":"https://openalex.org/C175732170","wikidata":"https://www.wikidata.org/wiki/Q9064829","display_name":"Spindle checkpoint","level":5,"score":0.4439036250114441},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4086807072162628},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34736526012420654},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25147873163223267},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24290421605110168},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.2343335747718811},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.1324087381362915}],"mesh":[],"locations_count":4,"locations":[{"id":"mag:112305994","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00247413","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HAL (Le Centre pour la Communication Scientifique Directe)","raw_type":null},{"id":"pmh:hdl:10068/828401","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10068/828401","pdf_url":null,"source":{"id":"https://openalex.org/S4377196900","display_name":"OpenGrey (Institut de l'Information Scientifique et Technique)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1295345811","host_organization_name":"Institut de l'Information Scientifique et Technique","host_organization_lineage":["https://openalex.org/I1295345811"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"U - Thesis"},{"id":"pmh:oai:HAL:tel-00247413v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/tel-00247413v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular Biology. Universit\u00e9 Joseph-Fourier - Grenoble I, 2007. English. ⟨NNT : ⟩","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:150184624","doi":null,"is_oa":false,"landing_page_url":"http://www.theses.fr/2007GRE10173","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"mag:112305994","doi":null,"is_oa":true,"landing_page_url":"https://theses.hal.science/tel-00247413","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HAL (Le Centre pour la Communication Scientifique Directe)","raw_type":null},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1509901905","https://openalex.org/W1552030014","https://openalex.org/W1634739671","https://openalex.org/W1847864430","https://openalex.org/W1964517213","https://openalex.org/W1969385456","https://openalex.org/W1973570584","https://openalex.org/W1976544913","https://openalex.org/W1982060264","https://openalex.org/W1982071939","https://openalex.org/W2003906429","https://openalex.org/W2005717642","https://openalex.org/W2008117987","https://openalex.org/W2008751957","https://openalex.org/W2015519364","https://openalex.org/W2015851881","https://openalex.org/W2016492849","https://openalex.org/W2020494268","https://openalex.org/W2029304297","https://openalex.org/W2031014816","https://openalex.org/W2038197766","https://openalex.org/W2039412073","https://openalex.org/W2044057392","https://openalex.org/W2049838249","https://openalex.org/W2058377017","https://openalex.org/W2060328544","https://openalex.org/W2072472133","https://openalex.org/W2080125477","https://openalex.org/W2084810833","https://openalex.org/W2102230270","https://openalex.org/W2102566010","https://openalex.org/W2106869142","https://openalex.org/W2109845164","https://openalex.org/W2118668591","https://openalex.org/W2132817913","https://openalex.org/W2136306650","https://openalex.org/W2141627232","https://openalex.org/W2147242002","https://openalex.org/W2150451425","https://openalex.org/W2151784069","https://openalex.org/W2153057184","https://openalex.org/W2153574313","https://openalex.org/W2157374362","https://openalex.org/W2171961817","https://openalex.org/W2326093492","https://openalex.org/W7027339250"],"related_works":["https://openalex.org/W150184624","https://openalex.org/W7098207637","https://openalex.org/W427500488","https://openalex.org/W2288440862","https://openalex.org/W7143428843","https://openalex.org/W1555720545","https://openalex.org/W3160657817","https://openalex.org/W2404897095","https://openalex.org/W87281657","https://openalex.org/W6992733686"],"abstract_inverted_index":{"DNA":[0,17,29,37,48,68,96,144,199,206,218,230,250,255,276],"damaging":[1,18],"agents":[2,19,62],"are":[3,71],"the":[4,26,34,80,102,111,188],"most":[5,117],"widely":[6],"used":[7],"treatment":[8,55],"in":[9,42,45,52,75,201,204,210,213,227],"fight":[10],"against":[11],"cancer.":[12],"The":[13,146,262],"effective":[14],"use":[15],"of":[16,28,72,79,86,104,172,187,232,239,265],"for":[20,119,161],"killing":[21],"tumors":[22],"depends":[23],"on":[24],"understanding":[25],"mechanism":[27,103],"damage":[30,38,69,97,200,207,256],"checkpoint":[31,81,141,247],"arrest":[32,51,94,106,274],"at":[33],"molecular":[35],"level.":[36],"checkpoints":[39,70],"impose":[40],"delays":[41],"cell":[43,112,189,272],"cycle":[44,113,273],"response":[46],"to":[47,83,259],"damage.":[49,145,251,277],"Cells":[50],"G2/M":[53],"after":[54,95,143,249,275],"with":[56,124,153,228],"DNA-damaging":[57],"agents,":[58],"such":[59],"as":[60],"chemotherapeutic":[61],"and":[63,139,166,224],"x-rays.":[64],"In":[65],"human":[66],"cells":[67,202,212,220],"critical":[73],"importance":[74],"carcinogenesis":[76],"since":[77],"inactivation":[78],"leads":[82,258],"increased":[84],"rates":[85],"mutation,":[87],"chromosomal":[88],"loss":[89],"or":[90],"aneuploidy.":[91],"While":[92],"G-1":[93,185],"has":[98],"been":[99],"extensively":[100],"studied,":[101],"G2":[105,115,140,222,246],"is":[107,116,148,158,178,196],"less":[108],"clear.":[109],"Among":[110],"checkpoints,":[114],"crucial":[118],"preventing":[120],"entry":[121],"into":[122],"mitosis":[123,165,182],"damaged":[125],"DNA.":[126],"We":[127,191],"have":[128],"found":[129],"a":[130,149,229,266],"previously":[131],"unrecognized":[132],"link":[133],"between":[134],"anaphase":[135],"promoting":[136],"complex":[137,152],"(APC)":[138],"control":[142,248],"APC":[147,157,176,195,240,260,269],"large":[150],"multi-protein":[151],"E3-ubiquitin":[154],"ligase":[155],"activity.":[156],"best":[159],"known":[160],"regulating":[162],"progression":[163],"through":[164],"mitotic":[167,174],"exit":[168],"activity":[169,177,241],"by":[170,242,268],"degradation":[171],"various":[173],"substrates.":[175],"high":[179],"from":[180],"late":[181,184,214],"until":[183],"phase":[186],"cycle.":[190],"surprisingly":[192],"find":[193],"that":[194,237,257],"activated":[197],"following":[198],"arrested":[203,226],"G2.":[205],"was":[208],"induced":[209],"synchronized":[211],"S":[215],"phase.":[216],"Following":[217],"damage,":[219],"show":[221,236],"delay":[223],"remain":[225],"content":[231],"4N.":[233],"Importantly,":[234],"we":[235],"down-regulation":[238],"siRNA":[243],"technique":[244],"abolishes":[245],"We've":[252],"analyzed":[253],"how":[254],"activation.":[261],"specific":[263],"destruction":[264],"regulator":[267],"may":[270],"govern":[271]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}