{"id":"https://openalex.org/W112282734","doi":null,"title":"THE EFFECT OF BMP4 AND MECHANICAL STIMULATION ON MUSCLE- DERIVED STEM CELLS: IMPLICATIONS FOR BONE AND ARTICULAR CARTILAGE REGENERATION","display_name":"THE EFFECT OF BMP4 AND MECHANICAL STIMULATION ON MUSCLE- DERIVED STEM CELLS: IMPLICATIONS FOR BONE AND ARTICULAR CARTILAGE REGENERATION","publication_year":2007,"publication_date":"2007-06-12","ids":{"openalex":"https://openalex.org/W112282734","mag":"112282734"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:6607","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/6607/1/CorsiKA_etdPitt2007.pdf","pdf_url":"http://d-scholarship.pitt.edu/6607/1/CorsiKA_etdPitt2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/6607/1/CorsiKA_etdPitt2007.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108519880","display_name":"Karin A. Corsi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karin A. Corsi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108519880"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01389488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.8910999894142151,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.8910999894142151,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-derived-stem-cells","display_name":"muscle-derived stem cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/bmp4","display_name":"BMP4","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mechanical-stimulation","display_name":"mechanical stimulation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":1.0},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.847000002861023},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.6620000004768372},{"id":"https://openalex.org/keywords/articular-cartilage-regeneration","display_name":"articular cartilage regeneration","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.7350000143051147},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.7490000128746033},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8830000162124634},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9610000252723694},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.5490000247955322},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.47200000286102295},{"id":"https://openalex.org/keywords/cell-orientation","display_name":"cell orientation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.6899999976158142},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.628000020980835},{"id":"https://openalex.org/keywords/heterotopic-bone-formation","display_name":"ectopic bone formation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.7662148475646973},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6117127537727356},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.4896388649940491},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4854620099067688},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44095373153686523},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.4352942705154419},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.415300577878952},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4142778515815735},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3376077711582184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33104732632637024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19918426871299744},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.19891688227653503},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07017773389816284},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:6607","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/6607/1/CorsiKA_etdPitt2007.pdf","pdf_url":"http://d-scholarship.pitt.edu/6607/1/CorsiKA_etdPitt2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:112282734","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/6607/1/CorsiKA_etdPitt2007.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:6607","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/6607/1/CorsiKA_etdPitt2007.pdf","pdf_url":"http://d-scholarship.pitt.edu/6607/1/CorsiKA_etdPitt2007.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W112282734.pdf","grobid_xml":"https://content.openalex.org/works/W112282734.grobid-xml"},"referenced_works_count":217,"referenced_works":["https://openalex.org/W117544831","https://openalex.org/W126539919","https://openalex.org/W189077365","https://openalex.org/W570795997","https://openalex.org/W1480928262","https://openalex.org/W1508777555","https://openalex.org/W1544751778","https://openalex.org/W1553444759","https://openalex.org/W1589859980","https://openalex.org/W1606976518","https://openalex.org/W1609684706","https://openalex.org/W1632446354","https://openalex.org/W1663371441","https://openalex.org/W1875828395","https://openalex.org/W1891660453","https://openalex.org/W1922697055","https://openalex.org/W1964541581","https://openalex.org/W1964572245","https://openalex.org/W1965155044","https://openalex.org/W1967025304","https://openalex.org/W1968590981","https://openalex.org/W1968822620","https://openalex.org/W1968936958","https://openalex.org/W1969976832","https://openalex.org/W1970031582","https://openalex.org/W1970086540","https://openalex.org/W1973006978","https://openalex.org/W1974897852","https://openalex.org/W1976446375","https://openalex.org/W1977950302","https://openalex.org/W1978405687","https://openalex.org/W1979787711","https://openalex.org/W1980688897","https://openalex.org/W1984706102","https://openalex.org/W1985682361","https://openalex.org/W1985760249","https://openalex.org/W1986912067","https://openalex.org/W1988592246","https://openalex.org/W1988873510","https://openalex.org/W1990854759","https://openalex.org/W1991415492","https://openalex.org/W1994481920","https://openalex.org/W1994586809","https://openalex.org/W1994596418","https://openalex.org/W1994678155","https://openalex.org/W1996028216","https://openalex.org/W1997588556","https://openalex.org/W1997812904","https://openalex.org/W1998870649","https://openalex.org/W1999013968","https://openalex.org/W1999014699","https://openalex.org/W2000706451","https://openalex.org/W2002559995","https://openalex.org/W2003329152","https://openalex.org/W2003367516","https://openalex.org/W2004356764","https://openalex.org/W2004613847","https://openalex.org/W2006174806","https://openalex.org/W2006797212","https://openalex.org/W2007564570","https://openalex.org/W2008063990","https://openalex.org/W2010095588","https://openalex.org/W2010635910","https://openalex.org/W2011318200","https://openalex.org/W2013035509","https://openalex.org/W2013164206","https://openalex.org/W2013911798","https://openalex.org/W2013970253","https://openalex.org/W2014691108","https://openalex.org/W2016401372","https://openalex.org/W2016482190","https://openalex.org/W2017129570","https://openalex.org/W2017786515","https://openalex.org/W2019101681","https://openalex.org/W2019983212","https://openalex.org/W2020811802","https://openalex.org/W2021753367","https://openalex.org/W2024115441","https://openalex.org/W2025046506","https://openalex.org/W2025831725","https://openalex.org/W2026344537","https://openalex.org/W2027736364","https://openalex.org/W2028644833","https://openalex.org/W2029378381","https://openalex.org/W2030588530","https://openalex.org/W2031244033","https://openalex.org/W2031304372","https://openalex.org/W2036519060","https://openalex.org/W2036920124","https://openalex.org/W2036925553","https://openalex.org/W2037360849","https://openalex.org/W2039962739","https://openalex.org/W2040560891","https://openalex.org/W2040796174","https://openalex.org/W2041865157","https://openalex.org/W2041926615","https://openalex.org/W2043585992","https://openalex.org/W2043805424","https://openalex.org/W2044864383","https://openalex.org/W2045530641","https://openalex.org/W2046080398","https://openalex.org/W2046126395","https://openalex.org/W2046873552","https://openalex.org/W2050351042","https://openalex.org/W2051325743","https://openalex.org/W2052673490","https://openalex.org/W2053648508","https://openalex.org/W2054854833","https://openalex.org/W2055846324","https://openalex.org/W2058645214","https://openalex.org/W2058930168","https://openalex.org/W2059532057","https://openalex.org/W2060529951","https://openalex.org/W2064770982","https://openalex.org/W2065063645","https://openalex.org/W2065547075","https://openalex.org/W2065584680","https://openalex.org/W2065694620","https://openalex.org/W2065836836","https://openalex.org/W2065885294","https://openalex.org/W2066687881","https://openalex.org/W2067716147","https://openalex.org/W2069745732","https://openalex.org/W2070170734","https://openalex.org/W2070470162","https://openalex.org/W2073346348","https://openalex.org/W2073814154","https://openalex.org/W2074331658","https://openalex.org/W2075079425","https://openalex.org/W2075377709","https://openalex.org/W2077969224","https://openalex.org/W2078957191","https://openalex.org/W2080333427","https://openalex.org/W2080367498","https://openalex.org/W2081928132","https://openalex.org/W2083168487","https://openalex.org/W2084909069","https://openalex.org/W2085008098","https://openalex.org/W2085179516","https://openalex.org/W2085993701","https://openalex.org/W2086013207","https://openalex.org/W2086059908","https://openalex.org/W2086794837","https://openalex.org/W2086977202","https://openalex.org/W2087803244","https://openalex.org/W2088142207","https://openalex.org/W2088670027","https://openalex.org/W2089194398","https://openalex.org/W2090883656","https://openalex.org/W2092206949","https://openalex.org/W2092233035","https://openalex.org/W2092658506","https://openalex.org/W2092839502","https://openalex.org/W2093271566","https://openalex.org/W2093413490","https://openalex.org/W2094579915","https://openalex.org/W2095335313","https://openalex.org/W2095503159","https://openalex.org/W2097505420","https://openalex.org/W2097850892","https://openalex.org/W2099045086","https://openalex.org/W2100198835","https://openalex.org/W2100250587","https://openalex.org/W2101103995","https://openalex.org/W2102209250","https://openalex.org/W2102300005","https://openalex.org/W2103031848","https://openalex.org/W2103663737","https://openalex.org/W2104161119","https://openalex.org/W2107503723","https://openalex.org/W2113580698","https://openalex.org/W2116425152","https://openalex.org/W2118798131","https://openalex.org/W2120032969","https://openalex.org/W2120188930","https://openalex.org/W2122059149","https://openalex.org/W2122367477","https://openalex.org/W2122538288","https://openalex.org/W2125272276","https://openalex.org/W2130448342","https://openalex.org/W2132028114","https://openalex.org/W2132131875","https://openalex.org/W2133585105","https://openalex.org/W2135903352","https://openalex.org/W2137563421","https://openalex.org/W2139689863","https://openalex.org/W2142250806","https://openalex.org/W2143978350","https://openalex.org/W2144611337","https://openalex.org/W2146235933","https://openalex.org/W2148399690","https://openalex.org/W2149790590","https://openalex.org/W2150134228","https://openalex.org/W2150600914","https://openalex.org/W2151165961","https://openalex.org/W2151964857","https://openalex.org/W2154771084","https://openalex.org/W2155419259","https://openalex.org/W2156001590","https://openalex.org/W2157023674","https://openalex.org/W2159999899","https://openalex.org/W2162184056","https://openalex.org/W2163299797","https://openalex.org/W2165438231","https://openalex.org/W2166661372","https://openalex.org/W2166862801","https://openalex.org/W2169334227","https://openalex.org/W2172069215","https://openalex.org/W2173497140","https://openalex.org/W2176502069","https://openalex.org/W2178438681","https://openalex.org/W2236789517","https://openalex.org/W2278906020","https://openalex.org/W2408650536","https://openalex.org/W2413866391","https://openalex.org/W4300038485","https://openalex.org/W6987196020"],"related_works":["https://openalex.org/W2915008344","https://openalex.org/W2076327216","https://openalex.org/W2147963648","https://openalex.org/W2562968555","https://openalex.org/W2031451353","https://openalex.org/W1894976709","https://openalex.org/W1999013968","https://openalex.org/W4248121430","https://openalex.org/W2140374290","https://openalex.org/W2014971566"],"abstract_inverted_index":{"The":[0,159,326],"prevalence":[1],"of":[2,63,113,137,186,195,210,221,243,256,265,291,301,322,335],"bone":[3,56,120,343],"and":[4,45,50,94,107,163,212,223,262,273,298,312,315,344],"articular":[5,345],"cartilage":[6,346],"injuries":[7],"is":[8],"expected":[9],"to":[10,67,124,152],"increase":[11],"with":[12,55,89,235],"the":[13,110,133,140,143,155,175,192,205,208,218,251,254,260,286,295,320,332],"aging":[14],"population.":[15],"As":[16],"a":[17,116,168,183,338],"possible":[18],"therapeutic":[19],"option,":[20],"stem":[21,34],"cell-based":[22],"therapies":[23],"are":[24],"being":[25],"investigated.":[26,228],"It":[27],"has":[28],"previously":[29],"been":[30],"reported":[31],"that":[32,84,129,191],"muscle-derived":[33],"cells":[35],"(MDSCs)":[36],"isolated":[37],"from":[38,328],"mouse":[39],"skeletal":[40],"muscle":[41],"can":[42,303,316],"undergo":[43],"osteogenic":[44,79,92,134,156,193,263,289,297],"chondrogenic":[46,219,233,248,299],"differentiation":[47,74,135,157,194,220,264,290,300],"in":[48,51,77,171,225],"vitro":[49,78,226],"vivo":[52],"when":[53,122],"stimulated":[54,88],"morphogenetic":[57],"protein":[58],"4":[59],"(BMP4).":[60],"One":[61],"goal":[62],"this":[64,73,329],"project":[65,330],"was":[66,82,180,227,267],"determine":[68],"whether":[69],"cell":[70,130,279,310,323,340],"sex":[71,131,311],"influences":[72,132],"potential.":[75],"Using":[76],"assays,":[80],"it":[81],"determined":[83],"male":[85],"MDSCs":[86,100,196,230,266,302,336],"(M-MDSCs)":[87],"BMP4":[90,106,148,211],"expressed":[91],"markers":[93],"displayed":[95],"more":[96,117],"mineralization":[97],"than":[98],"female":[99],"(F-MDSCs).":[101],"In":[102,139,204,250,293],"vivo,":[103],"M-MDSCs":[104,224],"expressing":[105],"implanted":[108],"into":[109],"hind":[111],"limb":[112],"mice":[114],"induced":[115],"robust":[118],"ectopic":[119],"formation":[121],"compared":[123],"F-MDSCs.":[125],"These":[126,188],"results":[127,189,327],"suggest":[128,190],"potential":[136,339],"MDSCs.":[138,292],"second":[141],"study,":[142,207,253],"signaling":[144,324],"pathways":[145,166],"involved":[146],"during":[147],"stimulation":[149,258,277],"were":[150],"investigated":[151,268],"further":[153],"characterize":[154],"process.":[158],"phosphatidyl":[160],"inositol":[161],"3-kinase":[162],"p38":[164],"MAPK":[165],"played":[167],"positive":[169],"role":[170],"MDSC":[172],"osteogenesis,":[173],"while":[174],"extracellular":[176],"signal-regulated":[177],"kinase":[178],"pathway":[179],"identified":[181],"as":[182,337],"negative":[184],"regulator":[185],"osteogenesis.":[187],"could":[197],"be":[198,304,317],"manipulated":[199],"by":[200,269,306],"regulating":[201],"these":[202],"pathways.":[203,325],"third":[206],"effect":[209,255],"transforming":[213],"growth":[214,313],"factor-b1":[215],"(TGF-b1)":[216],"on":[217,259],"F-":[222],"All":[229],"tested":[231],"underwent":[232],"differentiation,":[234],"no":[236],"significant":[237],"sex-related":[238],"differences":[239],"observed.":[240],"However,":[241],"addition":[242],"TGF-b1":[244],"synergistically":[245],"enhanced":[246],"BMP4-induced":[247,296],"differentiation.":[249],"final":[252],"mechanical":[257],"proliferation":[261,287],"using":[270],"both":[271],"biaxial":[272],"uniaxial":[274],"strain.":[275],"Mechanical":[276],"affected":[278],"orientation,":[280],"but":[281],"did":[282],"not":[283],"significantly":[284],"affect":[285],"or":[288],"conclusion,":[294],"influenced":[305],"several":[307],"factors":[308,314],"including":[309],"guided":[318],"through":[319],"manipulation":[321],"support":[331],"continued":[333],"investigation":[334],"source":[341],"for":[342],"tissue":[347],"engineering.":[348]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
