{"id":"https://openalex.org/W11222018","doi":null,"title":"Review Article Stem Cells, Phenotypic Inversion, and Differentiation","display_name":"Review Article Stem Cells, Phenotypic Inversion, and Differentiation","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W11222018","mag":"11222018"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.573.6903","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.573.6903","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ijcem.com/files/IJCEM712001.pdf","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025821325","display_name":"Robert W. Siggins","orcid":"https://orcid.org/0000-0003-3380-9458","observed_orcids":["https://orcid.org/0000-0003-3380-9458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert W. Siggins Ii","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055151897","display_name":"Ping \u5e73 Zhang \u5f20","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027200834","display_name":"David A. Welsh","orcid":"https://orcid.org/0000-0002-0008-6161","observed_orcids":["https://orcid.org/0000-0002-0008-6161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Welsh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088661822","display_name":"Nicole J. LeCapitaine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole J. Lecapitaine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029247654","display_name":"Steve Nelson","orcid":"https://orcid.org/0000-0003-0303-0160","observed_orcids":["https://orcid.org/0000-0003-0303-0160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Nelson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00114009,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.49950000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.49950000643730164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.4108999967575073,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stem-cells","display_name":"stem cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/quiescent-stem-cells","display_name":"quiescent stem cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/ex-vivo-expansion","display_name":"ex vivo expansion","score":0.7490000128746033},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/microtubule-cytoskeleton","display_name":"microtubule cytoskeleton","score":0.9660000205039978},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.824377179145813},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7221207022666931},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6761119961738586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6445815563201904},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.6037620902061462},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.48123693466186523},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.463830828666687},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.45343485474586487},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.43631216883659363},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4186989963054657},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.3336571455001831},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16162961721420288},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.573.6903","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.573.6903","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ijcem.com/files/IJCEM712001.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":172,"referenced_works":["https://openalex.org/W130474040","https://openalex.org/W186620247","https://openalex.org/W1223322285","https://openalex.org/W1479673257","https://openalex.org/W1495710350","https://openalex.org/W1540305565","https://openalex.org/W1541800741","https://openalex.org/W1542079437","https://openalex.org/W1555386903","https://openalex.org/W1588840730","https://openalex.org/W1600103888","https://openalex.org/W1708950638","https://openalex.org/W1809185041","https://openalex.org/W1861988602","https://openalex.org/W1880227053","https://openalex.org/W1888328500","https://openalex.org/W1950443613","https://openalex.org/W1963516163","https://openalex.org/W1963729602","https://openalex.org/W1964004789","https://openalex.org/W1964307098","https://openalex.org/W1966177375","https://openalex.org/W1975025595","https://openalex.org/W1975087758","https://openalex.org/W1975864442","https://openalex.org/W1976998737","https://openalex.org/W1982359478","https://openalex.org/W1983497110","https://openalex.org/W1984206717","https://openalex.org/W1984347108","https://openalex.org/W1984979304","https://openalex.org/W1988383731","https://openalex.org/W1988393390","https://openalex.org/W1989873586","https://openalex.org/W1990765139","https://openalex.org/W1991962444","https://openalex.org/W1992016845","https://openalex.org/W1993423043","https://openalex.org/W1993861298","https://openalex.org/W1994695846","https://openalex.org/W1995539279","https://openalex.org/W1995639685","https://openalex.org/W1995947461","https://openalex.org/W1996236153","https://openalex.org/W1999736053","https://openalex.org/W2006717309","https://openalex.org/W2008294451","https://openalex.org/W2008804214","https://openalex.org/W2009265893","https://openalex.org/W2009594776","https://openalex.org/W2010031978","https://openalex.org/W2010442791","https://openalex.org/W2014631569","https://openalex.org/W2015933167","https://openalex.org/W2017418598","https://openalex.org/W2018171716","https://openalex.org/W2018716983","https://openalex.org/W2019630592","https://openalex.org/W2020366708","https://openalex.org/W2021312689","https://openalex.org/W2023668418","https://openalex.org/W2025607087","https://openalex.org/W2027936687","https://openalex.org/W2028036560","https://openalex.org/W2028428776","https://openalex.org/W2028680679","https://openalex.org/W2030113770","https://openalex.org/W2030136187","https://openalex.org/W2030811514","https://openalex.org/W2032618534","https://openalex.org/W2033926629","https://openalex.org/W2035894845","https://openalex.org/W2036834412","https://openalex.org/W2038347351","https://openalex.org/W2039763508","https://openalex.org/W2041106449","https://openalex.org/W2042357573","https://openalex.org/W2043436613","https://openalex.org/W2045709849","https://openalex.org/W2048771411","https://openalex.org/W2049320863","https://openalex.org/W2049736461","https://openalex.org/W2051070943","https://openalex.org/W2052319461","https://openalex.org/W2054449258","https://openalex.org/W2057159461","https://openalex.org/W2057181207","https://openalex.org/W2058781233","https://openalex.org/W2059911212","https://openalex.org/W2064331238","https://openalex.org/W2067019666","https://openalex.org/W2069301068","https://openalex.org/W2070453770","https://openalex.org/W2070793750","https://openalex.org/W2071631797","https://openalex.org/W2072425808","https://openalex.org/W2073032682","https://openalex.org/W2075365946","https://openalex.org/W2077415858","https://openalex.org/W2080373548","https://openalex.org/W2082262367","https://openalex.org/W2083632015","https://openalex.org/W2083720592","https://openalex.org/W2084459463","https://openalex.org/W2086118286","https://openalex.org/W2086810512","https://openalex.org/W2086943348","https://openalex.org/W2087919222","https://openalex.org/W2088048329","https://openalex.org/W2088263789","https://openalex.org/W2090712568","https://openalex.org/W2091253171","https://openalex.org/W2091706208","https://openalex.org/W2092890208","https://openalex.org/W2092910438","https://openalex.org/W2094574469","https://openalex.org/W2097689792","https://openalex.org/W2097922149","https://openalex.org/W2097960755","https://openalex.org/W2098741056","https://openalex.org/W2100302916","https://openalex.org/W2101763504","https://openalex.org/W2102366997","https://openalex.org/W2102445577","https://openalex.org/W2102799140","https://openalex.org/W2103546044","https://openalex.org/W2105418252","https://openalex.org/W2105495977","https://openalex.org/W2105889909","https://openalex.org/W2106289833","https://openalex.org/W2107883924","https://openalex.org/W2109130014","https://openalex.org/W2109879006","https://openalex.org/W2114978842","https://openalex.org/W2116872683","https://openalex.org/W2119739306","https://openalex.org/W2123744383","https://openalex.org/W2125987139","https://openalex.org/W2128011380","https://openalex.org/W2129438003","https://openalex.org/W2129827413","https://openalex.org/W2130350889","https://openalex.org/W2131999768","https://openalex.org/W2132287808","https://openalex.org/W2134237864","https://openalex.org/W2135185370","https://openalex.org/W2137715553","https://openalex.org/W2137956216","https://openalex.org/W2137956382","https://openalex.org/W2138977668","https://openalex.org/W2139147346","https://openalex.org/W2141310245","https://openalex.org/W2142046859","https://openalex.org/W2147403100","https://openalex.org/W2147649093","https://openalex.org/W2148459495","https://openalex.org/W2152237832","https://openalex.org/W2154104720","https://openalex.org/W2157216615","https://openalex.org/W2158088166","https://openalex.org/W2158449289","https://openalex.org/W2159999899","https://openalex.org/W2160525733","https://openalex.org/W2161753466","https://openalex.org/W2162645376","https://openalex.org/W2165867905","https://openalex.org/W2227902555","https://openalex.org/W2260062438","https://openalex.org/W2397491552","https://openalex.org/W2411064223","https://openalex.org/W4230605418","https://openalex.org/W6931824552"],"related_works":["https://openalex.org/W117841190","https://openalex.org/W2589784958","https://openalex.org/W2051980282","https://openalex.org/W1928644833","https://openalex.org/W2082259335","https://openalex.org/W3021599154","https://openalex.org/W2209174161","https://openalex.org/W2479350587","https://openalex.org/W3037792577","https://openalex.org/W2016458781","https://openalex.org/W175758705","https://openalex.org/W2116094926","https://openalex.org/W2036537461","https://openalex.org/W3144432602","https://openalex.org/W2061283831","https://openalex.org/W2015196706","https://openalex.org/W2000653782","https://openalex.org/W2314751617","https://openalex.org/W71100875","https://openalex.org/W2118291464"],"abstract_inverted_index":{"Abstract:":[0],"Stem":[1,109],"cells":[2,29,51,78,86,100,110],"possess":[3,114],"the":[4,20,26,138],"potential":[5],"to":[6,16,36,41,43,98,113,156],"cure":[7],"a":[8,66,103,130],"myriad":[9],"of":[10,23,49,61,73,96,140,151],"ailments":[11],"ranging":[12],"from":[13],"congenital":[14],"diseases":[15],"illnesses":[17],"acquired":[18],"through":[19,149],"physiological":[21],"process":[22],"aging.":[24],"In":[25],"adult,":[27],"these":[28,50],"are":[30,79,111],"extremely":[31],"rare":[32],"and":[33,87,117,144],"often":[34],"difficult":[35],"isolate":[37],"in":[38,137],"numbers":[39,72],"sufficient":[40,71],"apply":[42],"medical":[44],"treatment.":[45],"Ex":[46],"vivo":[47],"expansion":[48],"will":[52],"be":[53,89],"required":[54,121],"for":[55,69,106,122,133],"most":[56],"meaningful":[57],"interventions.":[58],"The":[59,126],"discovery":[60],"stem/progenitor":[62],"cell":[63,124,142],"inversion":[64,95],"offers":[65],"new":[67],"avenue":[68],"obtaining":[70],"stem":[74,85,99,123,157],"cells.":[75],"Adult":[76],"progenitor":[77],"much":[80],"more":[81],"common":[82],"than":[83],"quiescent":[84],"can":[88],"isolated":[90],"with":[91],"minimal":[92],"interventions;":[93],"therefore,":[94],"progenitors":[97],"may":[101,154],"become":[102],"feasible":[104],"approach":[105],"therapeutic":[107],"purposes.":[108],"known":[112],"few":[115],"mitochondria,":[116],"mitochondrial":[118,134,152],"biogenesis":[119],"is":[120,129],"differentiation.":[125],"microtubule":[127],"cytoskeleton":[128],"major":[131],"regulator":[132],"biogenesis.":[135],"Investigations":[136],"area":[139],"controlling":[141],"differentiation":[143],"inducing":[145],"phenotypic":[146],"inversion,":[147],"possibly":[148],"manipulation":[150],"biogenesis,":[153],"contribute":[155],"cell-based":[158],"therapies.":[159]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-27T00:00:00"}
