{"id":"https://openalex.org/W112124670","doi":null,"title":"Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma.","display_name":"Randomized trial of chlorpromazine, caffeine, and methyl-CCNU in disseminated melanoma.","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W112124670","mag":"112124670","pmid":"https://pubmed.ncbi.nlm.nih.gov/6991102"},"language":"en","primary_location":{"id":"pmid:6991102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6991102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reports","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072681003","display_name":"Cohen Mh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M H Cohen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044481779","display_name":"David Schoenfeld","orcid":"https://orcid.org/0000-0003-1948-3711","observed_orcids":["https://orcid.org/0000-0003-1948-3711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Schoenfeld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108988406","display_name":"J Wolter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Wolter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3791,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.6123528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"64","issue":"1","first_page":"151","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.05959999933838844,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disseminated-melanoma","display_name":"disseminated melanoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.871999979019165},{"id":"https://openalex.org/keywords/semustine","display_name":"methyl-CCNU","score":0.8259999752044678},{"id":"https://openalex.org/keywords/chlorpromazine","display_name":"chlorpromazine","score":0.9330000281333923},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.5540000200271606},{"id":"https://openalex.org/keywords/l1210-cells","display_name":"L1210 leukemia","score":0.7369999885559082},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.37599998712539673},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8216102123260498},{"id":"https://openalex.org/C2778775820","wikidata":"https://www.wikidata.org/wiki/Q407972","display_name":"Chlorpromazine","level":2,"score":0.798697829246521},{"id":"https://openalex.org/C2779434656","wikidata":"https://www.wikidata.org/wiki/Q415378","display_name":"Lomustine","level":5,"score":0.6310375928878784},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.5348784923553467},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4932989180088043},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.44604694843292236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38674241304397583},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36256909370422363},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3214600086212158},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.31574133038520813},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.07098302245140076},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.05197858810424805}],"mesh":[{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002746","descriptor_name":"Chlorpromazine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009607","descriptor_name":"Nitrosourea Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012673","descriptor_name":"Semustine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012673","descriptor_name":"Semustine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:6991102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6991102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer treatment reports","raw_type":"Clinical Trial"},{"id":"mag:112124670","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6991102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2412140549","https://openalex.org/W1964592706","https://openalex.org/W2077696396","https://openalex.org/W18599219","https://openalex.org/W2079741711","https://openalex.org/W2473433800","https://openalex.org/W2412855854","https://openalex.org/W2402834374","https://openalex.org/W2343128466","https://openalex.org/W2418608019"],"abstract_inverted_index":{"One":[0],"hundred":[1],"and":[2,36,58,62,70,80,94],"fifty-seven":[3],"evaluable":[4],"patients":[5],"with":[6],"advanced":[7],"metastatic":[8],"malignant":[9,102],"melanoma":[10],"were":[11],"randomly":[12],"assigned":[13],"to":[14],"receive":[15],"either":[16],"methyl-CCNU":[17],"(MeCCNU)":[18],"(200":[19],"mg/m2":[20,34,39],"orally":[21],"every":[22],"6":[23],"weeks)":[24],"(82":[25],"patients)":[26],"or":[27],"a":[28],"combination":[29,54,112],"of":[30],"MeCCNU,":[31],"chlorpromazine":[32,95],"(50":[33],"im),":[35],"caffeine":[37,93],"(600":[38],"sc)":[40],"in":[41,101,113,116],"the":[42,53,82,90,105],"periumbilical":[43],"area":[44],"(75":[45],"patients).":[46],"The":[47,74,87],"response":[48],"rate":[49],"was":[50,77,81],"12%":[51],"for":[52,64,84,109],"(three":[55],"complete":[56,68],"responses":[57,69],"six":[59],"partial":[60,72],"responses)":[61],"11%":[63],"MeCCNU":[65,99],"alone":[66],"(two":[67],"seven":[71],"responses).":[73],"median":[75],"survival":[76],"20":[78],"weeks":[79],"same":[83],"both":[85],"treatments.":[86],"data":[88],"support":[89],"hypothesis":[91],"that":[92],"do":[96],"not":[97],"enhance":[98],"activity":[100],"melanoma,":[103],"unlike":[104],"marked":[106],"enhancement":[107],"seen":[108],"this":[110],"drug":[111],"L1210":[114],"leukemia":[115],"mice.":[117]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}