{"id":"https://openalex.org/W112085316","doi":null,"title":"The Use of Human Dendritic Cell Subsets in Cancer Vaccines","display_name":"The Use of Human Dendritic Cell Subsets in Cancer Vaccines","publication_year":2011,"publication_date":"2011-10-18","ids":{"openalex":"https://openalex.org/W112085316","mag":"112085316"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/212446","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/212446","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dspace.library.uu.nl:8080/handle/1874/212446","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072753077","display_name":"Johanna M. Sweere","orcid":"https://orcid.org/0000-0002-9602-8117","observed_orcids":["https://orcid.org/0000-0002-9602-8117"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Johanna M. Sweere","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9602-8117","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5072753077"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cancer-vaccines","display_name":"cancer vaccines","score":0.9549999833106995},{"id":"https://openalex.org/keywords/myeloid-dendritic-cells","display_name":"myeloid dendritic cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":1.0},{"id":"https://openalex.org/keywords/monocyte-derived-dendritic-cells","display_name":"monocyte-derived dendritic cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/ex-vivo-dendritic-cell-generation","display_name":"ex vivo dendritic cell generation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/vaccine-adjuvants","display_name":"vaccine adjuvants","score":0.8360000252723694},{"id":"https://openalex.org/keywords/in-vivo-targeting","display_name":"in vivo targeting","score":0.7289999723434448},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6439999938011169},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5117756724357605},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5116363167762756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48275989294052124},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35897892713546753},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3411022424697876},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3296131491661072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2981013059616089},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.15498027205467224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12891077995300293}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/212446","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/212446","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},{"id":"mag:112085316","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/handle/1874/212446/Master%20Thesis%20Jolien%20Sweere%203145298.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/212446","doi":null,"is_oa":true,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/212446","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":230,"referenced_works":["https://openalex.org/W62529038","https://openalex.org/W125231219","https://openalex.org/W193748226","https://openalex.org/W1484561730","https://openalex.org/W1485212944","https://openalex.org/W1487365740","https://openalex.org/W1499169356","https://openalex.org/W1501459393","https://openalex.org/W1511825494","https://openalex.org/W1517310071","https://openalex.org/W1525207872","https://openalex.org/W1527849714","https://openalex.org/W1535284466","https://openalex.org/W1544965678","https://openalex.org/W1549303438","https://openalex.org/W1550301398","https://openalex.org/W1559523991","https://openalex.org/W1585754595","https://openalex.org/W1855946711","https://openalex.org/W1908804993","https://openalex.org/W1941498105","https://openalex.org/W1946037828","https://openalex.org/W1964493928","https://openalex.org/W1965293768","https://openalex.org/W1966553244","https://openalex.org/W1968321644","https://openalex.org/W1968848897","https://openalex.org/W1970573066","https://openalex.org/W1970763846","https://openalex.org/W1971069331","https://openalex.org/W1971522146","https://openalex.org/W1971595657","https://openalex.org/W1973393382","https://openalex.org/W1974778244","https://openalex.org/W1975191869","https://openalex.org/W1975829923","https://openalex.org/W1975983909","https://openalex.org/W1977190145","https://openalex.org/W1978063849","https://openalex.org/W1978494950","https://openalex.org/W1978741561","https://openalex.org/W1979255880","https://openalex.org/W1981989535","https://openalex.org/W1982682466","https://openalex.org/W1984390981","https://openalex.org/W1985033543","https://openalex.org/W1986910957","https://openalex.org/W1987009989","https://openalex.org/W1988428698","https://openalex.org/W1988651416","https://openalex.org/W1989552966","https://openalex.org/W1990459651","https://openalex.org/W1991331687","https://openalex.org/W1991636753","https://openalex.org/W1991807956","https://openalex.org/W1995825455","https://openalex.org/W1995970041","https://openalex.org/W1996290893","https://openalex.org/W1996398553","https://openalex.org/W1996521528","https://openalex.org/W1997951134","https://openalex.org/W1999511070","https://openalex.org/W2000504443","https://openalex.org/W2002122771","https://openalex.org/W2002251604","https://openalex.org/W2002406225","https://openalex.org/W2002662941","https://openalex.org/W2006060684","https://openalex.org/W2006772331","https://openalex.org/W2009421256","https://openalex.org/W2009571791","https://openalex.org/W2009730968","https://openalex.org/W2010011171","https://openalex.org/W2010105350","https://openalex.org/W2011007492","https://openalex.org/W2012136117","https://openalex.org/W2012574191","https://openalex.org/W2013781770","https://openalex.org/W2013947028","https://openalex.org/W2015812428","https://openalex.org/W2016605730","https://openalex.org/W2017213329","https://openalex.org/W2017583377","https://openalex.org/W2018280156","https://openalex.org/W2020046379","https://openalex.org/W2021626880","https://openalex.org/W2021875752","https://openalex.org/W2022258692","https://openalex.org/W2025482003","https://openalex.org/W2026798920","https://openalex.org/W2028648297","https://openalex.org/W2028713402","https://openalex.org/W2031462618","https://openalex.org/W2031745114","https://openalex.org/W2031751347","https://openalex.org/W2033877575","https://openalex.org/W2035298740","https://openalex.org/W2035376519","https://openalex.org/W2038300953","https://openalex.org/W2039027083","https://openalex.org/W2039248453","https://openalex.org/W2041433337","https://openalex.org/W2042194530","https://openalex.org/W2042433863","https://openalex.org/W2045877830","https://openalex.org/W2047488334","https://openalex.org/W2047900555","https://openalex.org/W2048021979","https://openalex.org/W2048991194","https://openalex.org/W2049332097","https://openalex.org/W2050313920","https://openalex.org/W2050628678","https://openalex.org/W2051121992","https://openalex.org/W2051361937","https://openalex.org/W2051731494","https://openalex.org/W2051940924","https://openalex.org/W2052065441","https://openalex.org/W2053706526","https://openalex.org/W2057666417","https://openalex.org/W2058522478","https://openalex.org/W2061720114","https://openalex.org/W2065110815","https://openalex.org/W2066761700","https://openalex.org/W2067015198","https://openalex.org/W2067654508","https://openalex.org/W2068323100","https://openalex.org/W2069486064","https://openalex.org/W2070220308","https://openalex.org/W2070377914","https://openalex.org/W2070770310","https://openalex.org/W2074740959","https://openalex.org/W2076599494","https://openalex.org/W2078009629","https://openalex.org/W2079093197","https://openalex.org/W2082982244","https://openalex.org/W2082992807","https://openalex.org/W2084697718","https://openalex.org/W2086082311","https://openalex.org/W2087097732","https://openalex.org/W2087166273","https://openalex.org/W2088141188","https://openalex.org/W2088639793","https://openalex.org/W2091514639","https://openalex.org/W2091548845","https://openalex.org/W2092277031","https://openalex.org/W2093058513","https://openalex.org/W2093432644","https://openalex.org/W2093852189","https://openalex.org/W2093993256","https://openalex.org/W2094158049","https://openalex.org/W2096296951","https://openalex.org/W2097984354","https://openalex.org/W2099697271","https://openalex.org/W2102143045","https://openalex.org/W2102469275","https://openalex.org/W2103786481","https://openalex.org/W2104525960","https://openalex.org/W2106566281","https://openalex.org/W2109044040","https://openalex.org/W2111253388","https://openalex.org/W2111945592","https://openalex.org/W2112598631","https://openalex.org/W2112724852","https://openalex.org/W2113048515","https://openalex.org/W2113429621","https://openalex.org/W2113896298","https://openalex.org/W2115855421","https://openalex.org/W2116673455","https://openalex.org/W2116716017","https://openalex.org/W2116891319","https://openalex.org/W2118537722","https://openalex.org/W2118923225","https://openalex.org/W2119817247","https://openalex.org/W2120002004","https://openalex.org/W2120315525","https://openalex.org/W2122664628","https://openalex.org/W2123190790","https://openalex.org/W2124060773","https://openalex.org/W2124095515","https://openalex.org/W2124145182","https://openalex.org/W2124376809","https://openalex.org/W2126278133","https://openalex.org/W2128142540","https://openalex.org/W2128940859","https://openalex.org/W2129374849","https://openalex.org/W2130272079","https://openalex.org/W2131301484","https://openalex.org/W2131495414","https://openalex.org/W2132929600","https://openalex.org/W2133052709","https://openalex.org/W2134653497","https://openalex.org/W2135811373","https://openalex.org/W2136964874","https://openalex.org/W2137594178","https://openalex.org/W2137814185","https://openalex.org/W2140734388","https://openalex.org/W2141120240","https://openalex.org/W2141288099","https://openalex.org/W2141354546","https://openalex.org/W2143565660","https://openalex.org/W2144887013","https://openalex.org/W2147784618","https://openalex.org/W2148115090","https://openalex.org/W2148343285","https://openalex.org/W2148510816","https://openalex.org/W2148531142","https://openalex.org/W2151777859","https://openalex.org/W2151809081","https://openalex.org/W2152865079","https://openalex.org/W2153008625","https://openalex.org/W2157014808","https://openalex.org/W2158311244","https://openalex.org/W2160236174","https://openalex.org/W2160686798","https://openalex.org/W2161092473","https://openalex.org/W2163574914","https://openalex.org/W2165114410","https://openalex.org/W2165123753","https://openalex.org/W2165330900","https://openalex.org/W2168401979","https://openalex.org/W2170600649","https://openalex.org/W2171236933","https://openalex.org/W2186895617","https://openalex.org/W2261691410","https://openalex.org/W2264976931","https://openalex.org/W2406075375","https://openalex.org/W2415042629","https://openalex.org/W2418088160","https://openalex.org/W2467120680","https://openalex.org/W3038830718"],"related_works":["https://openalex.org/W2902030323","https://openalex.org/W4318754666","https://openalex.org/W3005718174","https://openalex.org/W4362595232","https://openalex.org/W1491388102","https://openalex.org/W2268562005","https://openalex.org/W1987477455","https://openalex.org/W2008991149","https://openalex.org/W2944539242","https://openalex.org/W2168722379"],"abstract_inverted_index":{"Dendritic":[0],"cells":[1],"(DC)":[2],"have":[3,28],"been":[4],"used":[5],"as":[6,37,57],"therapeutic":[7,70],"tools":[8],"in":[9,23,94,150,161,167],"cancer":[10],"vaccines":[11,53],"for":[12,130],"more":[13],"than":[14],"a":[15,114],"decade.":[16],"The":[17],"majority":[18],"of":[19,26,51,65,80,106,128,173],"clinical":[20,49],"trials":[21],"conducted":[22],"this":[24],"field":[25],"immunotherapy":[27],"employed":[29],"DC":[30,39,83,87,91,139],"generated":[31],"ex":[32],"vivo":[33,168],"from":[34],"monocytes":[35],"(moDC),":[36],"these":[38,102],"can":[40,190],"be":[41,191],"easily":[42],"propagated":[43],"into":[44],"large":[45],"numbers.":[46],"However,":[47,166],"the":[48,58,76,95,118,195],"efficacy":[50],"moDC-based":[52],"has":[54,113],"remained":[55],"unsatisfactory,":[56],"laborious":[59],"culturing":[60,145],"protocols":[61],"lead":[62],"to":[63,73,133,158,193],"exhaustion":[64],"their":[66,131],"immunostimulatory":[67],"capacity.":[68],"Novel":[69],"strategies":[71],"seek":[72],"capitalize":[74],"on":[75,117],"distinct":[77],"biological":[78],"functions":[79],"naturally":[81],"occurring":[82],"subsets,":[84],"i.e.":[85],"myeloid":[86],"(mDC)":[88],"and":[89,98,121,125,152,164,171,199],"plasmacytoid":[90],"(pDC).":[92],"Present":[93],"skin,":[96],"blood":[97],"secondary":[99],"lymphoid":[100],"organs,":[101],"subsets":[103,140],"are":[104,127,148,156,181],"capable":[105],"eliciting":[107],"potent":[108,178],"anti-tumour":[109,202],"responses.":[110],"Each":[111],"subset":[112],"specified":[115],"effect":[116],"immune":[119,197],"system,":[120],"especially":[122],"skin":[123],"mDC":[124],"pDC":[126],"interest":[129],"capacity":[132],"induce":[134],"tumour":[135],"regression.":[136],"Although":[137],"natural":[138],"do":[141],"not":[142],"require":[143],"extensive":[144],"periods,":[146],"they":[147],"low":[149],"frequency":[151],"complicated":[153],"isolation":[154],"techniques":[155,170],"required":[157],"obtain":[159],"them":[160],"sufficient":[162],"number":[163],"purity.":[165],"targeting":[169],"identification":[172],"vaccine":[174],"adjuvants":[175],"that":[176],"provide":[177],"activation":[179],"stimuli":[180],"promising":[182],"developments.":[183],"Combination":[184],"therapies":[185],"with":[186],"conventional":[187],"anti-cancer":[188],"drugs":[189],"considered":[192],"overcome":[194],"tolerogenic":[196],"environment":[198],"stimulate":[200],"efficient":[201],"immunity.":[203]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}