{"id":"https://openalex.org/W111785960","doi":"https://doi.org/10.2340/0001555566337339","title":"The regulation of subcutaneous blood flow in patient with Dercum\u00b4s disease","display_name":"The regulation of subcutaneous blood flow in patient with Dercum\u00b4s disease","publication_year":1986,"publication_date":"1986-07-01","ids":{"openalex":"https://openalex.org/W111785960","doi":"https://doi.org/10.2340/0001555566337339","mag":"111785960","pmid":"https://pubmed.ncbi.nlm.nih.gov/2430406"},"language":"en","primary_location":{"id":"doi:10.2340/0001555566337339","doi":"https://doi.org/10.2340/0001555566337339","is_oa":true,"landing_page_url":"https://doi.org/10.2340/0001555566337339","pdf_url":"https://medicaljournalssweden.se/actadv/article/download/6759/10108","source":{"id":"https://openalex.org/S4210210846","display_name":"Acta Dermato Venereologica","issn_l":"0001-5555","issn":["0001-5555","1651-2057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317100","host_organization_name":"Soc for Publication of\u00a0Acta Dermato-Venereologica","host_organization_lineage":["https://openalex.org/P4310317100"],"host_organization_lineage_names":["Soc for Publication of\u00a0Acta Dermato-Venereologica"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Dermato-Venereologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://medicaljournalssweden.se/actadv/article/download/6759/10108","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053906255","display_name":"Knud Skagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"K Skagen","raw_affiliation_strings":["Department of Internat Medicine and Endocrinology, Herlev University Hospital, DK-2730 Herlev, Denmark","Deparrment of Interna/ Medicine and Endocrinology, Her/eu Uniuersity Hospital, Herleu, and","Department of Pathology, Finsen lnstitute, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internat Medicine and Endocrinology, Herlev University Hospital, DK-2730 Herlev, Denmark","institution_ids":["https://openalex.org/I2801827564"]},{"raw_affiliation_string":"Deparrment of Interna/ Medicine and Endocrinology, Her/eu Uniuersity Hospital, Herleu, and","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, Finsen lnstitute, Copenhagen, Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"P Petersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"P Petersen","raw_affiliation_strings":["Deparrment of Interna/ Medicine and Endocrinology, Her/eu Uniuersity Hospital, Herleu, and","Department of Internat Medicine and Endocrinology, Herlev University Hospital, DK-2730 Herlev, Denmark","Department of Pathology, Finsen lnstitute, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparrment of Interna/ Medicine and Endocrinology, Her/eu Uniuersity Hospital, Herleu, and","institution_ids":[]},{"raw_affiliation_string":"Department of Internat Medicine and Endocrinology, Herlev University Hospital, DK-2730 Herlev, Denmark","institution_ids":["https://openalex.org/I2801827564"]},{"raw_affiliation_string":"Department of Pathology, Finsen lnstitute, Copenhagen, Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077250723","display_name":"Jens Kastrup","orcid":"https://orcid.org/0000-0002-3668-5393","observed_orcids":["https://orcid.org/0000-0002-3668-5393"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"J Kastrup","raw_affiliation_strings":["Deparrment of Interna/ Medicine and Endocrinology, Her/eu Uniuersity Hospital, Herleu, and","Department of Internat Medicine and Endocrinology, Herlev University Hospital, DK-2730 Herlev, Denmark","Department of Pathology, Finsen lnstitute, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparrment of Interna/ Medicine and Endocrinology, Her/eu Uniuersity Hospital, Herleu, and","institution_ids":[]},{"raw_affiliation_string":"Department of Internat Medicine and Endocrinology, Herlev University Hospital, DK-2730 Herlev, Denmark","institution_ids":["https://openalex.org/I2801827564"]},{"raw_affiliation_string":"Department of Pathology, Finsen lnstitute, Copenhagen, Denmark","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026027700","display_name":"TOVE N\u00d8RGAARD","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"T. N\u00f8rgaard","raw_affiliation_strings":["Deparrment of Interna/ Medicine and Endocrinology, Her/eu Uniuersity Hospital, Herleu, and","Department of Internat Medicine and Endocrinology, Herlev University Hospital, DK-2730 Herlev, Denmark","Department of Pathology, Finsen lnstitute, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Deparrment of Interna/ Medicine and Endocrinology, Her/eu Uniuersity Hospital, Herleu, and","institution_ids":[]},{"raw_affiliation_string":"Department of Internat Medicine and Endocrinology, Herlev University Hospital, DK-2730 Herlev, Denmark","institution_ids":["https://openalex.org/I2801827564"]},{"raw_affiliation_string":"Department of Pathology, Finsen lnstitute, Copenhagen, Denmark","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801827564"],"apc_list":{"value":1600,"currency":"EUR","value_usd":1725},"apc_paid":{"value":1600,"currency":"EUR","value_usd":1725},"fwci":1.1415,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.75848441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"66","issue":"4","first_page":"337","last_page":"339"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.1429000049829483,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.1429000049829483,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.10050000250339508,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13363","display_name":"Soft tissue tumors and treatment","score":0.09839999675750732,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dercum-s-disease","display_name":"Dercum's disease","score":0.9470000267028809},{"id":"https://openalex.org/keywords/adiposis-dolorosa","display_name":"adiposis dolorosa","score":0.9990000128746033},{"id":"https://openalex.org/keywords/subcutaneous-blood-flow","display_name":"subcutaneous blood flow","score":0.9340000152587891},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.7509999871253967},{"id":"https://openalex.org/keywords/lidocaine","display_name":"lidocaine","score":0.7960000038146973},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.75},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2780149897","wikidata":"https://www.wikidata.org/wiki/Q216935","display_name":"Lidocaine","level":2,"score":0.8999437093734741},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7946361303329468},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6498750448226929},{"id":"https://openalex.org/C2777300098","wikidata":"https://www.wikidata.org/wiki/Q1164665","display_name":"Subcutaneous tissue","level":2,"score":0.5548789501190186},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5247107744216919},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5099664926528931},{"id":"https://openalex.org/C2908519926","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstrictor Agents","level":3,"score":0.4954477548599243},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.49100783467292786},{"id":"https://openalex.org/C111774379","wikidata":"https://www.wikidata.org/wiki/Q1364253","display_name":"Autoregulation","level":3,"score":0.45372676849365234},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30028432607650757},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.26509904861450195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2432379424571991},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.20424798130989075}],"mesh":[{"descriptor_ui":"D000274","descriptor_name":"Adiposis Dolorosa","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000274","descriptor_name":"Adiposis Dolorosa","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001132","descriptor_name":"Arm","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008012","descriptor_name":"Lidocaine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011865","descriptor_name":"Radioisotope Dilution Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014980","descriptor_name":"Xenon Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2340/0001555566337339","doi":"https://doi.org/10.2340/0001555566337339","is_oa":true,"landing_page_url":"https://doi.org/10.2340/0001555566337339","pdf_url":"https://medicaljournalssweden.se/actadv/article/download/6759/10108","source":{"id":"https://openalex.org/S4210210846","display_name":"Acta Dermato Venereologica","issn_l":"0001-5555","issn":["0001-5555","1651-2057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317100","host_organization_name":"Soc for Publication of\u00a0Acta Dermato-Venereologica","host_organization_lineage":["https://openalex.org/P4310317100"],"host_organization_lineage_names":["Soc for Publication of\u00a0Acta Dermato-Venereologica"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Dermato-Venereologica","raw_type":"journal-article"},{"id":"pmid:2430406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2430406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta dermato-venereologica","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.2340/0001555566337339","doi":"https://doi.org/10.2340/0001555566337339","is_oa":true,"landing_page_url":"https://doi.org/10.2340/0001555566337339","pdf_url":"https://medicaljournalssweden.se/actadv/article/download/6759/10108","source":{"id":"https://openalex.org/S4210210846","display_name":"Acta Dermato Venereologica","issn_l":"0001-5555","issn":["0001-5555","1651-2057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317100","host_organization_name":"Soc for Publication of\u00a0Acta Dermato-Venereologica","host_organization_lineage":["https://openalex.org/P4310317100"],"host_organization_lineage_names":["Soc for Publication of\u00a0Acta Dermato-Venereologica"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Dermato-Venereologica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W111785960.pdf","grobid_xml":"https://content.openalex.org/works/W111785960.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W1984730520","https://openalex.org/W2076153201","https://openalex.org/W2315334369"],"related_works":["https://openalex.org/W137432027","https://openalex.org/W2063343826","https://openalex.org/W2082687947","https://openalex.org/W4229878186","https://openalex.org/W2010310956","https://openalex.org/W2412847637","https://openalex.org/W2038143451","https://openalex.org/W1984730520","https://openalex.org/W1997343568","https://openalex.org/W2315334369"],"abstract_inverted_index":{"Dercum's":[0],"disease":[1],"or":[2],"adiposis":[3],"dolorosa":[4],"is":[5,24,132],"a":[6,28,101],"poorly":[7],"understood":[8],"disorder":[9],"with":[10,57],"painful":[11],"fatty":[12],"deposits":[13],"in":[14,38,66,73,85,105,108,119],"the":[15,19,30,44,109,113],"skin":[16],"localized":[17],"to":[18,64,117],"lower":[20],"extremities.":[21],"The":[22,49,60,123],"etiology":[23],"unknown.":[25],"In":[26],"such":[27],"patient":[29,50],"mechanisms":[31,140],"of":[32,35,82,125],"local":[33,45,61],"regulation":[34],"blood":[36,83],"flow":[37,84],"subcutaneous":[39,86],"tissue":[40,87],"was":[41,51,70,88],"investigated":[42],"by":[43],"133Xenon":[46],"washout":[47],"technique.":[48],"reinvestigated":[52],"one":[53],"week":[54],"after":[55,78,94,128],"treatment":[56],"intravenous":[58,129],"lidocaine.":[59],"vasoconstrictor":[62,110,115],"response":[63,116],"increase":[65,104,118],"venous":[67,120],"transmural":[68,121],"pressure":[69],"not":[71],"present":[72,89],"this":[74],"patient,":[75],"but":[76,134],"reappeared":[77],"lidocaine":[79,95,130],"treatment.":[80,96],"Autoregulation":[81],"before":[90],"as":[91,93,136,138],"well":[92,137],"It":[97],"seems":[98],"likely":[99],"that":[100],"pain":[102,126],"elicited":[103],"sympathetic":[106],"activity":[107],"fibres":[111],"abolished":[112],"normal":[114],"pressure.":[122],"mechanism":[124],"relief":[127],"infusion":[131],"uncertain,":[133],"central":[135],"peripheral":[139],"may":[141],"be":[142],"considered.":[143]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}