{"id":"https://openalex.org/W111676423","doi":"https://doi.org/10.1007/978-1-4614-6549-2_5","title":"The Biology of K-Ras Signaling Pathways in Pancreatic Cancer","display_name":"The Biology of K-Ras Signaling Pathways in Pancreatic Cancer","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W111676423","doi":"https://doi.org/10.1007/978-1-4614-6549-2_5","mag":"111676423"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4614-6549-2_5","doi":"https://doi.org/10.1007/978-1-4614-6549-2_5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4614-6549-2_5","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Genetics of Pancreatic Cancer","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2477261067","display_name":"Molecular Genetics of Pancreatic Cancer"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003355400","display_name":"Helen Court","orcid":"https://orcid.org/0000-0002-4873-0008","observed_orcids":["https://orcid.org/0000-0002-4873-0008"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen Court","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, 550 First Avenue, New York, NY, USA","Department of Cell Biology, NYU School of Medicine, 550 First Avenue, New York, NY, USA","Department of Medicine, NYU School of Medicine, 550 First Avenue, New York, NY, USA","The Cancer Institute, NYU School of Medicine, 550 First Avenue, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, 550 First Avenue, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Cell Biology, NYU School of Medicine, 550 First Avenue, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Medicine, NYU School of Medicine, 550 First Avenue, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"The Cancer Institute, NYU School of Medicine, 550 First Avenue, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067102350","display_name":"Mark R. Philips","orcid":"https://orcid.org/0000-0002-1179-8156","observed_orcids":["https://orcid.org/0000-0002-1179-8156"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Philips","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, 550 First Avenue, New York, NY, USA","Department of Cell Biology, NYU School of Medicine, 550 First Avenue, New York, NY, USA","Department of Medicine, NYU School of Medicine, 550 First Avenue, New York, NY, USA","The Cancer Institute, NYU School of Medicine, 550 First Avenue, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, 550 First Avenue, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Cell Biology, NYU School of Medicine, 550 First Avenue, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]},{"raw_affiliation_string":"Department of Medicine, NYU School of Medicine, 550 First Avenue, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"The Cancer Institute, NYU School of Medicine, 550 First Avenue, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056698491","display_name":"Dafna Bar\u2010Sagi","orcid":"https://orcid.org/0000-0003-2597-8948","observed_orcids":["https://orcid.org/0000-0003-2597-8948"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dafna Bar-Sagi","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, 550 First Avenue, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, 550 First Avenue, New York, NY, USA","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056698491"],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0803622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"83","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.14329999685287476,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.878000020980835},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9629999995231628},{"id":"https://openalex.org/keywords/oncogenic-ras-signaling","display_name":"oncogenic Ras signaling","score":0.6019999980926514},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.5450000166893005},{"id":"https://openalex.org/keywords/cancer-cell-growth","display_name":"cancer cell growth","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7712112665176392},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.742555558681488},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6578606963157654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5554453730583191},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5238614082336426},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4874908924102783},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45586422085762024},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.41348063945770264},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24927446246147156},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2284446358680725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21564030647277832},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.21178975701332092}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4614-6549-2_5","doi":"https://doi.org/10.1007/978-1-4614-6549-2_5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4614-6549-2_5","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Genetics of Pancreatic Cancer","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":248,"referenced_works":["https://openalex.org/W198944900","https://openalex.org/W207418012","https://openalex.org/W250613533","https://openalex.org/W1524333424","https://openalex.org/W1526836724","https://openalex.org/W1554441898","https://openalex.org/W1555536872","https://openalex.org/W1557621377","https://openalex.org/W1585517331","https://openalex.org/W1606506184","https://openalex.org/W1611984863","https://openalex.org/W1752845679","https://openalex.org/W1756625003","https://openalex.org/W1786647014","https://openalex.org/W1788753937","https://openalex.org/W1824220821","https://openalex.org/W1842332833","https://openalex.org/W1898589533","https://openalex.org/W1964489808","https://openalex.org/W1964717481","https://openalex.org/W1964930474","https://openalex.org/W1965045013","https://openalex.org/W1965887568","https://openalex.org/W1966973445","https://openalex.org/W1967661601","https://openalex.org/W1968050307","https://openalex.org/W1969201526","https://openalex.org/W1969560454","https://openalex.org/W1970370172","https://openalex.org/W1970615437","https://openalex.org/W1970766774","https://openalex.org/W1980249052","https://openalex.org/W1980447806","https://openalex.org/W1980952363","https://openalex.org/W1981102848","https://openalex.org/W1982263288","https://openalex.org/W1982967858","https://openalex.org/W1984863053","https://openalex.org/W1985057592","https://openalex.org/W1986773595","https://openalex.org/W1987220381","https://openalex.org/W1988911160","https://openalex.org/W1989773675","https://openalex.org/W1991028764","https://openalex.org/W1992409084","https://openalex.org/W1992864103","https://openalex.org/W1992995822","https://openalex.org/W1993875664","https://openalex.org/W1994331967","https://openalex.org/W1995216176","https://openalex.org/W1995304819","https://openalex.org/W1996593753","https://openalex.org/W1996729627","https://openalex.org/W1997093183","https://openalex.org/W1999275756","https://openalex.org/W2001779124","https://openalex.org/W2002355858","https://openalex.org/W2003267467","https://openalex.org/W2004150448","https://openalex.org/W2004755394","https://openalex.org/W2004769917","https://openalex.org/W2010955929","https://openalex.org/W2011282245","https://openalex.org/W2011377286","https://openalex.org/W2011946800","https://openalex.org/W2012405690","https://openalex.org/W2013646631","https://openalex.org/W2013973825","https://openalex.org/W2014356084","https://openalex.org/W2015010022","https://openalex.org/W2018159884","https://openalex.org/W2020189113","https://openalex.org/W2021012077","https://openalex.org/W2021766591","https://openalex.org/W2022066131","https://openalex.org/W2023560058","https://openalex.org/W2023830997","https://openalex.org/W2024710490","https://openalex.org/W2028170357","https://openalex.org/W2028519621","https://openalex.org/W2029167057","https://openalex.org/W2031960993","https://openalex.org/W2033204562","https://openalex.org/W2033589713","https://openalex.org/W2035394593","https://openalex.org/W2036277985","https://openalex.org/W2037524894","https://openalex.org/W2039117920","https://openalex.org/W2041234310","https://openalex.org/W2041834434","https://openalex.org/W2043497705","https://openalex.org/W2044865509","https://openalex.org/W2045696239","https://openalex.org/W2046427109","https://openalex.org/W2047743989","https://openalex.org/W2049617964","https://openalex.org/W2050253364","https://openalex.org/W2051626784","https://openalex.org/W2051841073","https://openalex.org/W2053407374","https://openalex.org/W2055386493","https://openalex.org/W2055975580","https://openalex.org/W2056646351","https://openalex.org/W2056765060","https://openalex.org/W2057159445","https://openalex.org/W2058511768","https://openalex.org/W2058778918","https://openalex.org/W2061019978","https://openalex.org/W2061340775","https://openalex.org/W2062706311","https://openalex.org/W2062983115","https://openalex.org/W2063188304","https://openalex.org/W2063382154","https://openalex.org/W2065951262","https://openalex.org/W2066135299","https://openalex.org/W2066696278","https://openalex.org/W2067900929","https://openalex.org/W2068032848","https://openalex.org/W2068345721","https://openalex.org/W2068862752","https://openalex.org/W2069269337","https://openalex.org/W2070023258","https://openalex.org/W2070841378","https://openalex.org/W2070968699","https://openalex.org/W2073683003","https://openalex.org/W2075612889","https://openalex.org/W2077137690","https://openalex.org/W2077325021","https://openalex.org/W2078626338","https://openalex.org/W2078931367","https://openalex.org/W2079067257","https://openalex.org/W2079389107","https://openalex.org/W2080099116","https://openalex.org/W2080719056","https://openalex.org/W2081681778","https://openalex.org/W2082690401","https://openalex.org/W2082777785","https://openalex.org/W2083690533","https://openalex.org/W2084239507","https://openalex.org/W2085330118","https://openalex.org/W2085483616","https://openalex.org/W2086102829","https://openalex.org/W2088293068","https://openalex.org/W2088693506","https://openalex.org/W2089784089","https://openalex.org/W2090702802","https://openalex.org/W2090748725","https://openalex.org/W2091155804","https://openalex.org/W2091444805","https://openalex.org/W2091999960","https://openalex.org/W2093226717","https://openalex.org/W2095381863","https://openalex.org/W2095630332","https://openalex.org/W2096010941","https://openalex.org/W2097259163","https://openalex.org/W2097709883","https://openalex.org/W2097755642","https://openalex.org/W2098517576","https://openalex.org/W2099536948","https://openalex.org/W2100519108","https://openalex.org/W2100794900","https://openalex.org/W2101228747","https://openalex.org/W2102690338","https://openalex.org/W2104662829","https://openalex.org/W2106439231","https://openalex.org/W2106755467","https://openalex.org/W2106912046","https://openalex.org/W2108247214","https://openalex.org/W2108462977","https://openalex.org/W2109099165","https://openalex.org/W2113280225","https://openalex.org/W2114247191","https://openalex.org/W2114414968","https://openalex.org/W2116332105","https://openalex.org/W2116602759","https://openalex.org/W2117667508","https://openalex.org/W2119444855","https://openalex.org/W2119651686","https://openalex.org/W2122028042","https://openalex.org/W2122441872","https://openalex.org/W2123879591","https://openalex.org/W2124018740","https://openalex.org/W2125247841","https://openalex.org/W2126663928","https://openalex.org/W2127076236","https://openalex.org/W2128519797","https://openalex.org/W2128899239","https://openalex.org/W2129140055","https://openalex.org/W2129176863","https://openalex.org/W2130112621","https://openalex.org/W2130887139","https://openalex.org/W2131070390","https://openalex.org/W2132387165","https://openalex.org/W2133362776","https://openalex.org/W2133508418","https://openalex.org/W2133591242","https://openalex.org/W2135184154","https://openalex.org/W2135242575","https://openalex.org/W2136076059","https://openalex.org/W2136940817","https://openalex.org/W2136990999","https://openalex.org/W2138155367","https://openalex.org/W2139172177","https://openalex.org/W2140118120","https://openalex.org/W2140228520","https://openalex.org/W2140343175","https://openalex.org/W2140736039","https://openalex.org/W2140946995","https://openalex.org/W2141179865","https://openalex.org/W2142454421","https://openalex.org/W2143291443","https://openalex.org/W2143859186","https://openalex.org/W2144175203","https://openalex.org/W2145206598","https://openalex.org/W2148054025","https://openalex.org/W2148094237","https://openalex.org/W2149077527","https://openalex.org/W2152181022","https://openalex.org/W2153078918","https://openalex.org/W2154164444","https://openalex.org/W2154229063","https://openalex.org/W2154296805","https://openalex.org/W2157733612","https://openalex.org/W2158134441","https://openalex.org/W2158407439","https://openalex.org/W2158819616","https://openalex.org/W2159594827","https://openalex.org/W2160823559","https://openalex.org/W2161810908","https://openalex.org/W2162508596","https://openalex.org/W2163188200","https://openalex.org/W2164034599","https://openalex.org/W2165110092","https://openalex.org/W2165928290","https://openalex.org/W2166994863","https://openalex.org/W2168412354","https://openalex.org/W2169705599","https://openalex.org/W2312830897","https://openalex.org/W2314235576","https://openalex.org/W2441231988","https://openalex.org/W2609456246","https://openalex.org/W2783761121","https://openalex.org/W3213070366","https://openalex.org/W4232777855","https://openalex.org/W4238567307","https://openalex.org/W4252139475","https://openalex.org/W4299676702","https://openalex.org/W7075739058"],"related_works":["https://openalex.org/W2570368090","https://openalex.org/W2343240173","https://openalex.org/W1963997955","https://openalex.org/W2518515584","https://openalex.org/W206288319","https://openalex.org/W2290534626","https://openalex.org/W2080716654","https://openalex.org/W2119370602","https://openalex.org/W4379932035","https://openalex.org/W2250059052"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}