{"id":"https://openalex.org/W111669285","doi":null,"title":"Use of antibiotics to prevent hepatitis and typhlitis in male scid mice spontaneously infected with Helicobacter hepaticus.","display_name":"Use of antibiotics to prevent hepatitis and typhlitis in male scid mice spontaneously infected with Helicobacter hepaticus.","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W111669285","mag":"111669285","pmid":"https://pubmed.ncbi.nlm.nih.gov/7474875"},"language":"en","primary_location":{"id":"pmid:7474875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7474875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory animal science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077319515","display_name":"R J Russell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Russell","raw_affiliation_strings":["Animal Production, Harlan Sprague Dawley, Inc., Indianapolis, IN 46229-0176, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Production, Harlan Sprague Dawley, Inc., Indianapolis, IN 46229-0176, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052291553","display_name":"Diana C. Haines","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D C Haines","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026882105","display_name":"Miriam R. Anver","orcid":"https://orcid.org/0000-0003-2665-8794","observed_orcids":["https://orcid.org/0000-0003-2665-8794"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M R Anver","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019267073","display_name":"J K Battles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J K Battles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027564558","display_name":"Peter L. Gorelick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P L Gorelick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016221558","display_name":"L L Blumenauer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L L Blumenauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105416455","display_name":"Matthew A. Gonda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Gonda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103509373","display_name":"J.M. Ward","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Ward","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7852,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.89825908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"45","issue":"4","first_page":"373","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.5976999998092651,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.5976999998092651,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":0.15549999475479126,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.13379999995231628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-hepaticus","display_name":"Helicobacter hepaticus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/scid-mice","display_name":"SCID mice","score":0.7559999823570251},{"id":"https://openalex.org/keywords/amoxicillin","display_name":"amoxicillin","score":0.7440000176429749},{"id":"https://openalex.org/keywords/antibiotic-prophylaxis","display_name":"antibiotic prophylaxis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/chronic-hepatitis","display_name":"chronic hepatitis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/typhlitis","display_name":"typhlitis","score":0.8999999761581421},{"id":"https://openalex.org/keywords/neomycin","display_name":"neomycin","score":0.7289999723434448},{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":0.8489999771118164},{"id":"https://openalex.org/keywords/bismuth","display_name":"bismuth","score":0.781000018119812},{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.9670000076293945},{"id":"https://openalex.org/keywords/oral-antibiotic-administration","display_name":"oral antibiotic administration","score":0.4880000054836273},{"id":"https://openalex.org/keywords/bacterial-killing","display_name":"bacterial killing","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C2779708577","wikidata":"https://www.wikidata.org/wiki/Q201928","display_name":"Amoxicillin","level":3,"score":0.8396874666213989},{"id":"https://openalex.org/C2777396551","wikidata":"https://www.wikidata.org/wiki/Q169569","display_name":"Metronidazole","level":3,"score":0.7474898099899292},{"id":"https://openalex.org/C2777507495","wikidata":"https://www.wikidata.org/wiki/Q185317","display_name":"Cecum","level":2,"score":0.6953848600387573},{"id":"https://openalex.org/C2779841869","wikidata":"https://www.wikidata.org/wiki/Q423098","display_name":"Neomycin","level":3,"score":0.6840453743934631},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6375395655632019},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5180349946022034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4965727925300598},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.384556382894516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3784521520137787},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33608630299568176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31992238759994507}],"mesh":[{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000658","descriptor_name":"Amoxicillin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001729","descriptor_name":"Bismuth","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001729","descriptor_name":"Bismuth","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002429","descriptor_name":"Cecal Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002429","descriptor_name":"Cecal Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002429","descriptor_name":"Cecal Diseases","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D002432","descriptor_name":"Cecum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006520","descriptor_name":"Hepatitis, Animal","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006520","descriptor_name":"Hepatitis, Animal","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009355","descriptor_name":"Neomycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009355","descriptor_name":"Neomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012376","descriptor_name":"Rodent Diseases","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012376","descriptor_name":"Rodent Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016998","descriptor_name":"Helicobacter","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:7474875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7474875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory animal science","raw_type":"Journal Article"},{"id":"mag:111669285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7474875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G271163783","display_name":"ANIMAL PRODUCTION AT THE NCI FREDERICK FACILITY","funder_award_id":"n01cm023911-066","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2410163290","https://openalex.org/W7095608525","https://openalex.org/W7097531230","https://openalex.org/W2108977511","https://openalex.org/W2434189855","https://openalex.org/W1989070393","https://openalex.org/W7064979586","https://openalex.org/W3028797729","https://openalex.org/W7214122936","https://openalex.org/W2775224052"],"abstract_inverted_index":{"The":[0,26,212],"use":[1,85],"of":[2,51,76,81,86,113,125,132,154,172,186,206,215],"antibiotic":[3,78,92,136,174],"combinations":[4,28],"to":[5,217],"prevent":[6],"acute":[7],"and":[8,12,36,71,84,100,123,128,143,159,162,184,208,227],"progressive":[9,97],"chronic":[10,98],"hepatitis":[11,99,226],"proliferative":[13],"typhlitis":[14,228],"associated":[15],"with":[16,135,146,197],"Helicobacter":[17],"hepaticus":[18,156,203],"infection":[19],"in":[20,108,120,129],"male":[21],"scid/NCr":[22],"mice":[23,54,63,127,133,142,178,195,220],"was":[24],"evaluated.":[25],"drug":[27],"used":[29],"were":[30,40,64,104,118,148,179,188,199],"amoxicillin-metronidazole-bismuth,":[31],"tetracycline-metronidazole-bismuth,":[32],"amoxicillin-neomycin,":[33],"neomycin":[34],"alone,":[35],"amoxicillin":[37,95,147,198,216],"alone.":[38],"Treatments":[39],"administered":[41],"per":[42],"os":[43],"for":[44,152,201],"14":[45],"days":[46,73,161,169],"beginning":[47],"at":[48,67,157,167],"4":[49],"weeks":[50],"age.":[52],"All":[53,176,194],"remained":[55],"clinically":[56],"normal":[57],"throughout":[58],"the":[59,77,91,109,121,130,173,222],"study.":[60],"Specimens":[61],"from":[62],"evaluated":[65,149],"histologically":[66,107],"21,":[68],"60,":[69],"90,":[70],"120":[72],"after":[74,170],"initiation":[75,171],"treatments.":[79],"Results":[80],"histologic":[82],"examination":[83],"special":[87],"stains":[88],"indicated":[89],"that":[90],"regimens":[93,137],"containing":[94,139],"prevented":[96],"typhlitis.":[101],"Helical":[102,116],"bacteria":[103,117],"not":[105,138],"observed":[106,119],"liver":[110,122],"or":[111],"cecum":[112,124,131],"amoxicillin-treated":[114],"mice.":[115],"untreated":[126,177],"treated":[134,145,196],"amoxicillin.":[140],"Untreated":[141],"those":[144],"by":[150,163,181,190,204,230],"culture":[151,207],"presence":[153],"H.":[155,202,231],"60":[158],"90":[160,168],"polymerase":[164,191,209],"chain":[165,192,210],"reaction":[166],"treatment.":[175],"test-positive":[180],"fecal/cecal":[182],"culture,":[183],"three":[185],"five":[187],"positive":[189],"reaction.":[193,211],"negative":[200],"results":[205],"oral":[213],"administration":[214],"young":[218],"scid":[219],"via":[221],"drinking":[223],"water":[224],"prevents":[225],"caused":[229],"hepaticus.":[232]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
