{"id":"https://openalex.org/W11153108","doi":null,"title":"Generation of plasmin during acute attacks of hereditary angioedema.","display_name":"Generation of plasmin during acute attacks of hereditary angioedema.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W11153108","mag":"11153108","pmid":"https://pubmed.ncbi.nlm.nih.gov/8426080"},"language":"en","primary_location":{"id":"pmid:8426080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8426080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050004441","display_name":"Massimo Cugno","orcid":"https://orcid.org/0000-0002-9918-0763","observed_orcids":["https://orcid.org/0000-0002-9918-0763"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Cugno","raw_affiliation_strings":["Istituto di Medicina Interna, Ospedale Policlinico, Universit\u00e0 di Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna, Ospedale Policlinico, Universit\u00e0 di Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080558143","display_name":"C. Erik Hack","orcid":"https://orcid.org/0009-0000-7281-8002","observed_orcids":["https://orcid.org/0009-0000-7281-8002"]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C E Hack","raw_affiliation_strings":["Sanquin Blood Supply Foundation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanquin Blood Supply Foundation;","institution_ids":["https://openalex.org/I3020210244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073464444","display_name":"Jan Paul de Boer","orcid":"https://orcid.org/0000-0001-6218-6128","observed_orcids":["https://orcid.org/0000-0001-6218-6128"]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J P de Boer","raw_affiliation_strings":["Sanquin Blood Supply Foundation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanquin Blood Supply Foundation;","institution_ids":["https://openalex.org/I3020210244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113768269","display_name":"Anke J. M. Eerenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A J Eerenberg","raw_affiliation_strings":["Sanquin Blood Supply Foundation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanquin Blood Supply Foundation;","institution_ids":["https://openalex.org/I3020210244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022485785","display_name":"Angelo Agostoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A Agostoni","raw_affiliation_strings":["Sanquin Blood Supply Foundation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanquin Blood Supply Foundation;","institution_ids":["https://openalex.org/I3020210244"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073049397","display_name":"Marco Cicardi","orcid":"https://orcid.org/0000-0003-1251-225X","observed_orcids":["https://orcid.org/0000-0003-1251-225X"]},"institutions":[{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M Cicardi","raw_affiliation_strings":["Sanquin Blood Supply Foundation;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanquin Blood Supply Foundation;","institution_ids":["https://openalex.org/I3020210244"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6299,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.89163259,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"121","issue":"1","first_page":"38","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hereditary-angioedema","display_name":"hereditary angioedema","score":1.0},{"id":"https://openalex.org/keywords/plasmin","display_name":"plasmin","score":0.8180000185966492},{"id":"https://openalex.org/keywords/c1-inhibitor-deficiency","display_name":"C1 inhibitor deficiency","score":0.878000020980835},{"id":"https://openalex.org/keywords/kallikrein","display_name":"kallikrein","score":0.7649999856948853},{"id":"https://openalex.org/keywords/factor-xiia","display_name":"factor XIIa","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9449999928474426},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/contact-system-activation","display_name":"contact activation","score":0.7080000042915344},{"id":"https://openalex.org/keywords/vasoactive-mediators","display_name":"vasoactive mediators","score":0.8920000195503235},{"id":"https://openalex.org/keywords/acute-attacks","display_name":"acute attacks","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2781317560","wikidata":"https://www.wikidata.org/wiki/Q24721273","display_name":"High-molecular-weight kininogen","level":5,"score":0.9230800867080688},{"id":"https://openalex.org/C2781071845","wikidata":"https://www.wikidata.org/wiki/Q21173374","display_name":"Plasmin","level":3,"score":0.8549866080284119},{"id":"https://openalex.org/C2777788586","wikidata":"https://www.wikidata.org/wiki/Q2096745","display_name":"Hereditary angioedema","level":2,"score":0.8263025283813477},{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.8177143931388855},{"id":"https://openalex.org/C2777902427","wikidata":"https://www.wikidata.org/wiki/Q6413860","display_name":"Kininogen","level":4,"score":0.8031507134437561},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.6321198344230652},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6169833540916443},{"id":"https://openalex.org/C2779931649","wikidata":"https://www.wikidata.org/wiki/Q416510","display_name":"C1-inhibitor","level":3,"score":0.6165052652359009},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.5629146099090576},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.5582703351974487},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.5191006660461426},{"id":"https://openalex.org/C2777167447","wikidata":"https://www.wikidata.org/wiki/Q339499","display_name":"Factor XII","level":3,"score":0.5110286474227905},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.4766726791858673},{"id":"https://openalex.org/C152328610","wikidata":"https://www.wikidata.org/wiki/Q7240014","display_name":"Prekallikrein","level":4,"score":0.4615936279296875},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4310021996498108},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40490633249282837},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.37658822536468506},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.3636912703514099},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33634042739868164},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2948891520500183},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2652439773082733},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.23218309879302979},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1971593201160431},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17590025067329407},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08919548988342285}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005342","descriptor_name":"Fibrinolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8426080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8426080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of laboratory and clinical medicine","raw_type":"Journal Article"},{"id":"mag:11153108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8426080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1973740388","https://openalex.org/W1897147442","https://openalex.org/W2994680393","https://openalex.org/W2340244022","https://openalex.org/W2092039357","https://openalex.org/W2070438071","https://openalex.org/W7095163974","https://openalex.org/W2018030670","https://openalex.org/W2105280280","https://openalex.org/W2970392282"],"abstract_inverted_index":{"Hereditary":[0],"angioedema":[1],"is":[2,204],"caused":[3],"by":[4,69,101,111],"a":[5,10,35],"genetic":[6],"deficiency":[7],"of":[8,17,25,34,41,73,95,117,142,149,197,209],"C1-inhibitor,":[9],"serine":[11],"protease":[12],"inhibitor":[13,119,144],"that":[14,191,195],"regulates":[15],"activation":[16,40,54,208],"complement,":[18,50],"contact,":[19,51],"and":[20,27,52,64,81,88,109,156,170],"fibrinolytic":[21,53,211],"systems.":[22,44],"Symptoms":[23],"(bouts":[24],"subcutaneous":[26],"mucous":[28],"swelling)":[29],"depend":[30],"on":[31],"the":[32,47,127,132,186,193,207,210],"release":[33,196],"vasoactive":[36,198],"mediator,":[37],"probably":[38],"through":[39],"these":[42],"three":[43],"We":[45],"studied":[46],"interrelationship":[48],"among":[49],"in":[55,188,200],"23":[56],"patients":[57],"with":[58,206],"hereditary":[59,201],"angiodema,":[60],"18":[61],"during":[62,66],"remission":[63],"five":[65],"an":[67],"attack,":[68],"measuring":[70],"plasma":[71,115,140],"levels":[72,116,141],"C1-C1":[74,118,143],"inhibitor,":[75,78,80],"factor":[76],"XIIa-C1":[77],"kallikrein-C1":[79],"plasmin-alpha":[82,150,167],"2-antiplasmin":[83,151,168],"complexes,":[84],"tissue":[85],"plasminogen":[86,90],"activator,":[87],"urokinase":[89],"activator.":[91],"In":[92],"addition,":[93],"cleavage":[94],"high-molecular":[96,158,172],"weight":[97,159,173],"kininogen":[98,160,174],"was":[99,175],"detected":[100],"sodium":[102],"dodecyl":[103],"sulfate":[104],"polyacrylamide":[105],"gel":[106],"electrophoresis":[107],"analysis":[108],"quantified":[110],"densitometry.":[112],"During":[113,135],"remission,":[114],"complexes":[120,145,152,169],"were":[121,130,161],"elevated":[122],"(p":[123],"=":[124,154,178],"0.0002),":[125],"whereas":[126],"other":[128],"parameters":[129],"within":[131],"normal":[133],"range.":[134],"acute":[136],"attacks,":[137],"not":[138],"only":[139],"but":[146],"also":[147],"those":[148],"(P":[153],"0.0009)":[155],"cleaved":[157,171],"elevated.":[162],"A":[163],"positive":[164],"correlation":[165],"between":[166],"observed":[176],"(r":[177],"0.75,":[179],"p":[180],"<":[181],"0.001).":[182],"This":[183],"article":[184],"presents":[185],"first":[187],"vivo":[189],"evidence":[190],"supports":[192],"concept":[194],"mediators":[199],"angiodema":[202],"attacks":[203],"associated":[205],"system.":[212]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}