{"id":"https://openalex.org/W111475874","doi":null,"title":"[Acute-phase reaction].","display_name":"[Acute-phase reaction].","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W111475874","mag":"111475874","pmid":"https://pubmed.ncbi.nlm.nih.gov/12722605"},"language":"fr","primary_location":{"id":"pmid:12722605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12722605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Revue du praticien","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004326349","display_name":"Bernard Bonnotte","orcid":"https://orcid.org/0000-0001-7229-3808","observed_orcids":["https://orcid.org/0000-0001-7229-3808","https://orcid.org/0000-0002-1098-4598"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bernard Bonnotte","raw_affiliation_strings":["INSERM U. 517 facult\u00e9 de m\u00e9decine de Dijon, service de m\u00e9decine interne, immunologie clinique. Bernard.Bonnotte@u-bourgogne.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U. 517 facult\u00e9 de m\u00e9decine de Dijon, service de m\u00e9decine interne, immunologie clinique. Bernard.Bonnotte@u-bourgogne.fr","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111655161","display_name":"Nils\u2010Olivier Olsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nils-Olivier Olsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021429172","display_name":"B. Lorcerie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard Lorcerie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3114,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.52864436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"53","issue":"5","first_page":"489","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-phase-response","display_name":"acute phase response","score":0.949999988079071},{"id":"https://openalex.org/keywords/acute-phase-proteins","display_name":"acute phase proteins","score":0.9810000061988831},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hepatocyte-protein-synthesis","display_name":"hepatocyte protein synthesis","score":0.7429999709129333},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.8849999904632568},{"id":"https://openalex.org/keywords/neoplasms","display_name":"neoplasms","score":0.9430000185966492},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/allergic-diseases","display_name":"allergic diseases","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C57194454","wikidata":"https://www.wikidata.org/wiki/Q424211","display_name":"Acute-phase protein","level":3,"score":0.9415296316146851},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.6015665531158447},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5995341539382935},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5927066802978516},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.553534746170044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5126804113388062},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.5080521106719971},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.4693273901939392},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.4569447934627533},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2236746847629547},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1510220468044281},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000209","descriptor_name":"Acute-Phase Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000210","descriptor_name":"Acute-Phase Reaction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000210","descriptor_name":"Acute-Phase Reaction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000210","descriptor_name":"Acute-Phase Reaction","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12722605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12722605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Revue du praticien","raw_type":"Journal Article"},{"id":"mag:111475874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12722605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4243705086","https://openalex.org/W2167937185","https://openalex.org/W4243545296","https://openalex.org/W7100941589","https://openalex.org/W7097306957","https://openalex.org/W7165121679","https://openalex.org/W2317184793","https://openalex.org/W167520106","https://openalex.org/W4308626200","https://openalex.org/W2039933947"],"abstract_inverted_index":{"The":[0,13,55,75],"systemic":[1],"changes":[2,14,25],"induced":[3,31],"by":[4,29,32],"inflammation":[5],"have":[6],"been":[7],"referred":[8],"as":[9],"the":[10,16,46,52,67,82],"acute-phase":[11,19,53,62,79],"response.":[12],"in":[15,26],"concentrations":[17],"of":[18,36,77,84],"proteins":[20],"are":[21],"due":[22],"largely":[23],"to":[24,58,65],"their":[27],"production":[28],"hepatocytes":[30],"pro-inflammatory":[33],"cytokines.":[34],"Because":[35],"its":[37,85],"specificity,":[38],"sensibility":[39],"and":[40,72],"short":[41],"half-life,":[42],"C-reactive":[43],"protein":[44],"is":[45,64,81],"most":[47],"useful":[48],"indicator":[49],"among":[50],"all":[51],"proteins.":[54],"clinical":[56],"strategy":[57],"deal":[59],"with":[60],"an":[61,78],"response":[63,80],"search":[66],"aetiology:":[68],"infections,":[69],"neoplasms,":[70],"auto-immune":[71],"allergic":[73],"diseases.":[74],"treatment":[76,83],"aetiology.":[86]},"counts_by_year":[{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
