{"id":"https://openalex.org/W11138111","doi":"https://doi.org/10.1016/s0022-5347(17)39970-6","title":"Elevated Transferrin Receptor Content in Human Prostate Cancer Cell Lines Assessed in Vitro and in Vivo","display_name":"Elevated Transferrin Receptor Content in Human Prostate Cancer Cell Lines Assessed in Vitro and in Vivo","publication_year":1990,"publication_date":"1990-02-01","ids":{"openalex":"https://openalex.org/W11138111","doi":"https://doi.org/10.1016/s0022-5347(17)39970-6","mag":"11138111","pmid":"https://pubmed.ncbi.nlm.nih.gov/1688956"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5347(17)39970-6","doi":"https://doi.org/10.1016/s0022-5347(17)39970-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)39970-6","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036678244","display_name":"Harold N Keer","orcid":"https://orcid.org/0000-0003-0753-4921","observed_orcids":["https://orcid.org/0000-0003-0753-4921"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harold N. Keer","raw_affiliation_strings":["From the Department of Urology, Northwestern University Medical School, Chicago, Illinois","Upjohn Company, Molecular Biology Research, Kalamazoo, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Northwestern University Medical School, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Upjohn Company, Molecular Biology Research, Kalamazoo, Michigan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109079740","display_name":"James M. Kozlowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Kozlowski","raw_affiliation_strings":["From the Department of Urology, Northwestern University Medical School, Chicago, Illinois","Upjohn Company, Molecular Biology Research, Kalamazoo, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Northwestern University Medical School, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Upjohn Company, Molecular Biology Research, Kalamazoo, Michigan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054491434","display_name":"Yvonne Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yvonne C. Tsai","raw_affiliation_strings":["From the Department of Urology, Northwestern University Medical School, Chicago, Illinois","Upjohn Company, Molecular Biology Research, Kalamazoo, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Northwestern University Medical School, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Upjohn Company, Molecular Biology Research, Kalamazoo, Michigan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030411648","display_name":"Chung Lee","orcid":"https://orcid.org/0000-0003-0855-4553","observed_orcids":["https://orcid.org/0000-0003-0855-4553"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung Lee","raw_affiliation_strings":["From the Department of Urology, Northwestern University Medical School, Chicago, Illinois","Upjohn Company, Molecular Biology Research, Kalamazoo, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Northwestern University Medical School, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Upjohn Company, Molecular Biology Research, Kalamazoo, Michigan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033658477","display_name":"Robert N. McEwan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert N. McEwan","raw_affiliation_strings":["From the Department of Urology, Northwestern University Medical School, Chicago, Illinois","Upjohn Company, Molecular Biology Research, Kalamazoo, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Northwestern University Medical School, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Upjohn Company, Molecular Biology Research, Kalamazoo, Michigan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077385643","display_name":"John T. Grayhack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Grayhack","raw_affiliation_strings":["From the Department of Urology, Northwestern University Medical School, Chicago, Illinois","Upjohn Company, Molecular Biology Research, Kalamazoo, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Urology, Northwestern University Medical School, Chicago, Illinois","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Upjohn Company, Molecular Biology Research, Kalamazoo, Michigan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.9956,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.73597076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"143","issue":"2","first_page":"381","last_page":"385"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.4375,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.4375,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.4309000074863434,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/du145-cells","display_name":"DU145 cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.5099999904632568},{"id":"https://openalex.org/keywords/epithelial-cells","display_name":"epithelial cells","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.7139999866485596},{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7815824151039124},{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.781049907207489},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.7040423154830933},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.7006019949913025},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6896063685417175},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.6721053719520569},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6377169489860535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6143406629562378},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5530246496200562},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5132489204406738},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5080423355102539},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4968874752521515},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.429158091545105},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3857806622982025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32695814967155457},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3267097473144531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21630626916885376},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0701688826084137},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011470","descriptor_name":"Prostatic Hyperplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5347(17)39970-6","doi":"https://doi.org/10.1016/s0022-5347(17)39970-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-5347(17)39970-6","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:1688956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1688956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4364532161","display_name":null,"funder_award_id":"DK39250","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4414482720","display_name":"CELLULAR AND CHEMICAL ASPECTS OF BENIGN PROSTATIC GROWTH","funder_award_id":"5p50dk039250-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1419228847","https://openalex.org/W1488274351","https://openalex.org/W1498549327","https://openalex.org/W1570650398","https://openalex.org/W1969898317","https://openalex.org/W1970626129","https://openalex.org/W1976384834","https://openalex.org/W1983015819","https://openalex.org/W1983649348","https://openalex.org/W1985727076","https://openalex.org/W1987072043","https://openalex.org/W2015113703","https://openalex.org/W2019465667","https://openalex.org/W2026457056","https://openalex.org/W2047670736","https://openalex.org/W2066053565","https://openalex.org/W2066912376","https://openalex.org/W2073325679","https://openalex.org/W2080580789","https://openalex.org/W2128635872","https://openalex.org/W2137330819","https://openalex.org/W2144680000","https://openalex.org/W2152183134","https://openalex.org/W2154261604","https://openalex.org/W2166800133","https://openalex.org/W2233306577","https://openalex.org/W2394818590","https://openalex.org/W2410905836","https://openalex.org/W2418814546","https://openalex.org/W2442956053","https://openalex.org/W2528897116","https://openalex.org/W2624933186"],"related_works":["https://openalex.org/W4241716451","https://openalex.org/W2734072387","https://openalex.org/W2955433629","https://openalex.org/W1974454659","https://openalex.org/W2026484589","https://openalex.org/W1986568013","https://openalex.org/W1600851462","https://openalex.org/W2007473681","https://openalex.org/W2011946110","https://openalex.org/W603593325"],"abstract_inverted_index":{"Transferrin":[0],"receptors":[1],"(TfR)":[2],"were":[3,40,105,115,145],"measured":[4],"in":[5,52,60,79,118,139,149],"benign":[6,68,126],"and":[7,27,37,98,107,110,125,142],"malignant":[8,124],"prostatic":[9,69,82],"cells":[10,93,132],"by":[11],"performing":[12],"Scatchard":[13,73],"analysis":[14,74],"following":[15],"the":[16,87,119,150,166],"administration":[17],"of":[18,46,90,122,165],"125I-transferrin.":[19],"Established":[20],"human":[21,67,170],"prostate":[22,171],"cancer":[23],"cell":[24,63],"lines":[25],"(PC-3":[26,35],"DU-145)":[28],"as":[29,31,161],"well":[30],"biologically":[32],"aggressive":[33],"variants":[34],"ASC":[36,92,130],"PC-3":[38,91,129],"DES)":[39],"shown":[41],"to":[42,137],"possess":[43],"significant":[44],"levels":[45,135,144],"high":[47],"affinity":[48],"TfR":[49,56,114,134],"when":[50],"assessed":[51],"vitro.":[53],"In":[54],"contrast,":[55],"content":[57],"was":[58,75],"negligible":[59],"cultured":[61],"stromal":[62,109],"fractions":[64],"derived":[65,81],"from":[66,86],"hyperplasia":[70],"(BPH)":[71],"specimens.":[72,102],"also":[76],"performed":[77],"on":[78],"vivo":[80],"tissues:":[83],"tumors":[84],"resulting":[85],"subcutaneous":[88],"xenografting":[89],"into":[94],"athymic,":[95],"nude":[96],"mice":[97],"fresh":[99],"BPH":[100,151],"surgical":[101],"These":[103,153],"tissues":[104],"dissociated":[106],"their":[108,138],"epithelial":[111,120,127],"components":[112],"separated.":[113],"only":[116],"detected":[117],"component":[121],"both":[123],"cells.":[128,152],"tumor":[131,172],"exhibited":[133],"comparable":[136],"vitro":[140],"expression":[141],"these":[143],"10-fold":[146],"greater":[147],"than":[148],"findings":[154],"suggest":[155],"that":[156],"elevated":[157],"TfRs":[158],"may":[159],"serve":[160],"another":[162],"useful":[163],"marker":[164],"transformed":[167],"phenotype":[168],"within":[169],"systems.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}