{"id":"https://openalex.org/W111378461","doi":"https://doi.org/10.1054/bjoc.1999.1098","title":"Alterations in cathepsin H activity and protein patterns in human colorectal carcinomas","display_name":"Alterations in cathepsin H activity and protein patterns in human colorectal carcinomas","publication_year":2000,"publication_date":"2000-04-01","ids":{"openalex":"https://openalex.org/W111378461","doi":"https://doi.org/10.1054/bjoc.1999.1098","mag":"111378461","pmid":"https://pubmed.ncbi.nlm.nih.gov/10755408","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2374483"},"language":"en","primary_location":{"id":"doi:10.1054/bjoc.1999.1098","doi":"https://doi.org/10.1054/bjoc.1999.1098","is_oa":true,"landing_page_url":"https://doi.org/10.1054/bjoc.1999.1098","pdf_url":"https://www.nature.com/articles/6691098.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/6691098.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036781427","display_name":"Elisabetta C. del Re","orcid":"https://orcid.org/0000-0002-9645-4845","observed_orcids":["https://orcid.org/0000-0002-9645-4845"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E C del Re","raw_affiliation_strings":["Department of Pathology, Boston University School of Medicine, MA 02118, USA","Department of Pathology, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Boston University School of Medicine, MA 02118, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Pathology, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112039425","display_name":"Sania Shuja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Shuja","raw_affiliation_strings":["Department of Mallory Institute of Pathology, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA","Department of Pathology, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mallory Institute of Pathology, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Pathology, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057406444","display_name":"Jinguo Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Cai","raw_affiliation_strings":["Department of Pathology, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024824522","display_name":"Mary Jo Murnane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Murnane","raw_affiliation_strings":["Department of Biochemistry, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA","Department of Mallory Institute of Pathology, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA","Department of Pathology, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Mallory Institute of Pathology, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Pathology, Boston University School of Medicine, L804, 715 Albany Street, Boston, 02118, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":0.8154,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.69602345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"82","issue":"7","first_page":"1317","last_page":"1326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cathepsin-h","display_name":"cathepsin H","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.5440000295639038},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.5910000205039978},{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cathepsin-l","display_name":"cathepsin L","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-processing","display_name":"protein processing","score":0.4959999918937683},{"id":"https://openalex.org/keywords/tumor-location","display_name":"tumor location","score":0.3779999911785126},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C173633252","wikidata":"https://www.wikidata.org/wiki/Q3663475","display_name":"Cathepsin D","level":3,"score":0.7693043947219849},{"id":"https://openalex.org/C28021979","wikidata":"https://www.wikidata.org/wiki/Q14911946","display_name":"Cathepsin B","level":3,"score":0.6947827339172363},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6299436092376709},{"id":"https://openalex.org/C2780034444","wikidata":"https://www.wikidata.org/wiki/Q5052485","display_name":"Cathepsin L","level":4,"score":0.5591645240783691},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.5590189695358276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5025603771209717},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4493386149406433},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43155914545059204},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40563565492630005},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34704896807670593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2930959463119507},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.256507933139801},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08951002359390259}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056655","descriptor_name":"Cathepsin H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1054/bjoc.1999.1098","doi":"https://doi.org/10.1054/bjoc.1999.1098","is_oa":true,"landing_page_url":"https://doi.org/10.1054/bjoc.1999.1098","pdf_url":"https://www.nature.com/articles/6691098.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1507443","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2374483","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2374483","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2374483","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:10755408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10755408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.274.9416","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.274.9416","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/63/e8/Br_J_Cancer_2000_Apr_6_82(7)_1317-1326.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1054/bjoc.1999.1098","doi":"https://doi.org/10.1054/bjoc.1999.1098","is_oa":true,"landing_page_url":"https://doi.org/10.1054/bjoc.1999.1098","pdf_url":"https://www.nature.com/articles/6691098.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3049809687","display_name":null,"funder_award_id":"CA51865","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7863288800","display_name":"CYSTEINE CATHEPSIN &HUMAN COLORECTAL TUMOR PROGRESSION","funder_award_id":"5r01ca051865-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W111378461.pdf","grobid_xml":"https://content.openalex.org/works/W111378461.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W151066863","https://openalex.org/W973899072","https://openalex.org/W1552511798","https://openalex.org/W1563376649","https://openalex.org/W1619991575","https://openalex.org/W1775749144","https://openalex.org/W1812339273","https://openalex.org/W1888659246","https://openalex.org/W1964189685","https://openalex.org/W1965480710","https://openalex.org/W1967719446","https://openalex.org/W1973879804","https://openalex.org/W1979933355","https://openalex.org/W1984429323","https://openalex.org/W1988956187","https://openalex.org/W1990273557","https://openalex.org/W1996078782","https://openalex.org/W1997622394","https://openalex.org/W1999476324","https://openalex.org/W2017491563","https://openalex.org/W2018289835","https://openalex.org/W2035524762","https://openalex.org/W2041680207","https://openalex.org/W2045002629","https://openalex.org/W2046431326","https://openalex.org/W2046755079","https://openalex.org/W2052593722","https://openalex.org/W2058049327","https://openalex.org/W2062215694","https://openalex.org/W2068897967","https://openalex.org/W2074374822","https://openalex.org/W2077461674","https://openalex.org/W2080450814","https://openalex.org/W2084862719","https://openalex.org/W2090751795","https://openalex.org/W2101108802","https://openalex.org/W2102618304","https://openalex.org/W2104691673","https://openalex.org/W2111066407","https://openalex.org/W2121127215","https://openalex.org/W2145108148","https://openalex.org/W2161654709","https://openalex.org/W2169944161","https://openalex.org/W2275576700","https://openalex.org/W2313374748","https://openalex.org/W2325453239","https://openalex.org/W2331848977","https://openalex.org/W2339671919","https://openalex.org/W2410154757","https://openalex.org/W2428262620","https://openalex.org/W2496835007"],"related_works":["https://openalex.org/W2062215694","https://openalex.org/W7017830992","https://openalex.org/W2097924381","https://openalex.org/W2400877311","https://openalex.org/W2041712788","https://openalex.org/W1993984564","https://openalex.org/W2083023407","https://openalex.org/W1996815806","https://openalex.org/W1563376649","https://openalex.org/W2404364307"],"abstract_inverted_index":{"Our":[0],"analyses":[1],"of":[2,118,151,162,202,208,214,219,227,236,270,278],"cathepsin":[3,83,112,125,175,229,241,272,291,299,309],"H":[4,113,126,176,230,242,273,292,300,310],"activity":[5,36,61,142,244,263],"levels":[6],"and":[7,32,56,67,76,85,108,143,191,221],"protein":[8,177,187,206,217,256,293],"forms":[9,178,294],"in":[10,40,64,73,89,102,132,174,179,295,298,312],"human":[11],"colorectal":[12,41,121],"cancers":[13,42,71,135,150,195],"compared":[14,43,155],"to":[15,44,78,97,156,285],"matched":[16],"control":[17,45],"mucosa":[18,46,182],"support":[19],"the":[20,90,152,203,215,222,251,279],"concept":[21],"that":[22,111],"altered":[23],"proteinase":[24],"expression":[25,119,198,213,269,301],"patterns":[26],"may":[27],"reflect":[28],"both":[29,140],"cancer":[30,122],"stage":[31,69,104],"site.":[33],"Cathepsin":[34],"H-specific":[35],"was":[37],"significantly":[38,147,246],"increased":[39,212,262],"(P":[47,258],"=":[48,51],"0.003;":[49],"n":[50],"77).":[52],"Highest":[53],"specific":[54,141],"activities":[55,87,127],"cancer/normal":[57],"ratios":[58,145,239,249],"(C/N)":[59],"for":[60,149,240,250],"were":[62,128,146,302],"measured":[63],"Dukes'":[65,133],"B":[66,84],"C":[68,134],"carcinomas,":[70],"involved":[72],"local":[74],"spread":[75],"invasion":[77],"lymph":[79],"nodes.":[80],"In":[81],"contrast,":[82],"L":[86],"analysed":[88,166],"same":[91],"paired":[92,164],"extracts":[93,165],"had":[94],"been":[95],"shown":[96],"be":[98],"most":[99,129,264],"frequently":[100],"elevated":[101,131,268,308],"earlier":[103],"carcinomas":[105],"(Dukes'":[106],"A":[107,160],"B),":[109],"confirming":[110],"demonstrates":[114],"a":[115,185,228,283],"distinct":[116],"pattern":[117],"during":[120],"progression.":[123],"Although":[124],"commonly":[130,265],"at":[136,189,232],"all":[137],"colon":[138,154,158],"sites,":[139],"C/N":[144,238,248],"higher":[148],"left":[153],"other":[157],"locations.":[159],"subset":[161],"43":[163],"on":[167],"Western":[168],"blots":[169],"also":[170,275,303],"revealed":[171],"consistent":[172],"changes":[173],"cancers.":[180,296],"Normal":[181],"typically":[183],"showed":[184],"strong":[186],"doublet":[188],"31":[190,204],"29":[192,252],"kDa":[193,205,234,253],"while":[194],"demonstrated":[196],"decreased":[197],"or":[199,211,225],"total":[200],"loss":[201],"(90%":[207],"cases),":[209],"equal":[210],"29-kDa":[216,271],"(67%":[218],"cases)":[220],"new":[223],"appearance":[224],"up-regulation":[226,277],"band":[231],"22":[233],"(78%":[235],"cases).":[237],"enzyme":[243],"correlated":[245],"with":[247,261,267,276],"mature":[254,289],"single-chain":[255],"form":[257],"<":[259],"0.001),":[260],"associated":[266],"but":[274],"22-kDa":[280],"band,":[281],"suggesting":[282],"shift":[284],"more":[286],"fully":[287],"processed,":[288],"active":[290],"Changes":[297],"detected":[304],"by":[305],"immunohistochemistry":[306],"as":[307],"staining":[311],"tumour":[313],"epithelial":[314],"cells.":[315]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}