{"id":"https://openalex.org/W11120151","doi":null,"title":"Disrupting FoxP2 Expression Alters Song Variability and Signal Propagation Through a Basal Ganglia Pathway Important for Learned Vocalizations","display_name":"Disrupting FoxP2 Expression Alters Song Variability and Signal Propagation Through a Basal Ganglia Pathway Important for Learned Vocalizations","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W11120151","mag":"11120151"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/8219","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/8219","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085849927","display_name":"Malavika Murugan","orcid":"https://orcid.org/0000-0003-1300-0379","observed_orcids":["https://orcid.org/0000-0003-1300-0379"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Malavika Murugan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1300-0379","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085849927"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11665","display_name":"Animal Vocal Communication and Behavior","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11665","display_name":"Animal Vocal Communication and Behavior","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10788","display_name":"Neuroscience and Music Perception","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxp2","display_name":"FOXP2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/song-variability","display_name":"song variability","score":0.7080000042915344},{"id":"https://openalex.org/keywords/zebra-finch","display_name":"zebra finch","score":0.7950000166893005},{"id":"https://openalex.org/keywords/song-control","display_name":"song control","score":0.41600000858306885},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8529999852180481},{"id":"https://openalex.org/keywords/corticostriatal-pathway","display_name":"corticostriatal pathway","score":0.859000027179718},{"id":"https://openalex.org/keywords/dopamine-d1-receptor","display_name":"dopamine D1 receptor","score":0.8349999785423279},{"id":"https://openalex.org/keywords/darpp-32","display_name":"DARPP-32","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dopaminergic-modulation","display_name":"dopaminergic modulation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/vocal-control","display_name":"vocal control","score":0.5839999914169312},{"id":"https://openalex.org/keywords/reinforcement-learning","display_name":"reinforcement learning","score":0.7200000286102295},{"id":"https://openalex.org/keywords/speech-and-language-development","display_name":"speech and language development","score":0.6660000085830688},{"id":"https://openalex.org/keywords/learned-vocalizations","display_name":"learned vocalizations","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.7252951264381409},{"id":"https://openalex.org/C207259873","wikidata":"https://www.wikidata.org/wiki/Q227241","display_name":"FOXP2","level":4,"score":0.679827094078064},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5383383631706238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37136727571487427},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.08271834254264832},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07360890507698059},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05387675762176514},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/8219","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/8219","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:11120151","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/handle/10161/8219","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":137,"referenced_works":["https://openalex.org/W17120685","https://openalex.org/W747744962","https://openalex.org/W1484755060","https://openalex.org/W1513039376","https://openalex.org/W1519902420","https://openalex.org/W1563662869","https://openalex.org/W1590482316","https://openalex.org/W1922346787","https://openalex.org/W1931794205","https://openalex.org/W1963818866","https://openalex.org/W1965587667","https://openalex.org/W1965639825","https://openalex.org/W1966014364","https://openalex.org/W1968673726","https://openalex.org/W1969366595","https://openalex.org/W1970375293","https://openalex.org/W1971341839","https://openalex.org/W1973969914","https://openalex.org/W1974528105","https://openalex.org/W1974804647","https://openalex.org/W1975348390","https://openalex.org/W1975431549","https://openalex.org/W1976862716","https://openalex.org/W1978912730","https://openalex.org/W1979500687","https://openalex.org/W1980737345","https://openalex.org/W1981147791","https://openalex.org/W1982021752","https://openalex.org/W1983398462","https://openalex.org/W1984515581","https://openalex.org/W1986382714","https://openalex.org/W1986574329","https://openalex.org/W1987170798","https://openalex.org/W1989108360","https://openalex.org/W1989605251","https://openalex.org/W1991576921","https://openalex.org/W1991600973","https://openalex.org/W1993109240","https://openalex.org/W1993663368","https://openalex.org/W1993970549","https://openalex.org/W1996739924","https://openalex.org/W1999247495","https://openalex.org/W2002151783","https://openalex.org/W2002510254","https://openalex.org/W2002859524","https://openalex.org/W2003392454","https://openalex.org/W2004132309","https://openalex.org/W2004187422","https://openalex.org/W2009444068","https://openalex.org/W2009465679","https://openalex.org/W2010016215","https://openalex.org/W2012332159","https://openalex.org/W2013700545","https://openalex.org/W2016747018","https://openalex.org/W2020841613","https://openalex.org/W2021432299","https://openalex.org/W2024613165","https://openalex.org/W2031451982","https://openalex.org/W2035171463","https://openalex.org/W2035956062","https://openalex.org/W2036497637","https://openalex.org/W2038209706","https://openalex.org/W2041319008","https://openalex.org/W2041540302","https://openalex.org/W2045488261","https://openalex.org/W2046505169","https://openalex.org/W2051235651","https://openalex.org/W2051731737","https://openalex.org/W2055523610","https://openalex.org/W2057136273","https://openalex.org/W2057874135","https://openalex.org/W2059004970","https://openalex.org/W2059498277","https://openalex.org/W2059725343","https://openalex.org/W2059863959","https://openalex.org/W2061113878","https://openalex.org/W2061691592","https://openalex.org/W2071876445","https://openalex.org/W2071969990","https://openalex.org/W2073699491","https://openalex.org/W2074669617","https://openalex.org/W2076426683","https://openalex.org/W2077842744","https://openalex.org/W2081208888","https://openalex.org/W2084336012","https://openalex.org/W2085408031","https://openalex.org/W2086130933","https://openalex.org/W2087093188","https://openalex.org/W2089664499","https://openalex.org/W2090165657","https://openalex.org/W2091594425","https://openalex.org/W2093214731","https://openalex.org/W2098952636","https://openalex.org/W2099265245","https://openalex.org/W2102224657","https://openalex.org/W2104253020","https://openalex.org/W2104548381","https://openalex.org/W2104895781","https://openalex.org/W2106437793","https://openalex.org/W2106524861","https://openalex.org/W2108558899","https://openalex.org/W2109245019","https://openalex.org/W2109603175","https://openalex.org/W2113104616","https://openalex.org/W2114366197","https://openalex.org/W2117726420","https://openalex.org/W2120422926","https://openalex.org/W2120716183","https://openalex.org/W2126957719","https://openalex.org/W2135045229","https://openalex.org/W2136104104","https://openalex.org/W2137001862","https://openalex.org/W2137233223","https://openalex.org/W2137955727","https://openalex.org/W2137987237","https://openalex.org/W2139664250","https://openalex.org/W2145462976","https://openalex.org/W2145700039","https://openalex.org/W2147712684","https://openalex.org/W2150626351","https://openalex.org/W2151370476","https://openalex.org/W2160242809","https://openalex.org/W2160603112","https://openalex.org/W2161863750","https://openalex.org/W2163956293","https://openalex.org/W2164771787","https://openalex.org/W2165535189","https://openalex.org/W2166495389","https://openalex.org/W2166626305","https://openalex.org/W2166648354","https://openalex.org/W2168021000","https://openalex.org/W2168411960","https://openalex.org/W2169622817","https://openalex.org/W2169944034","https://openalex.org/W2341624030","https://openalex.org/W2526392230","https://openalex.org/W2994863418"],"related_works":["https://openalex.org/W2165225096","https://openalex.org/W7095807080","https://openalex.org/W2049953148","https://openalex.org/W2073699491","https://openalex.org/W2981399970","https://openalex.org/W2937490865","https://openalex.org/W7095128178","https://openalex.org/W2004187422","https://openalex.org/W3011980185","https://openalex.org/W2772837579"],"abstract_inverted_index":{"Mutations":[0],"of":[1,15,38,50,87,106,121,158,176],"the":[2,16,36,85,98,173],"FOXP2":[3],"gene":[4],"impair":[5],"speech":[6,184],"and":[7,12,34,61,78,103,142,183],"language":[8],"development":[9,185],"in":[10,23,53,57,64,72,97,110,124,148,161],"humans":[11],"shRNA-mediated":[13],"suppression":[14],"avian":[17],"orthologue":[18],"FoxP2":[19,29,70,95,115,153,169],"disrupts":[20,101],"song":[21,107,130,182],"learning":[22,189],"juvenile":[24],"zebra":[25],"finches.":[26],"How":[27],"diminished":[28],"levels":[30,170],"affect":[31],"vocal":[32,76,177],"control":[33,77,86],"alter":[35],"function":[37],"neural":[39],"circuits":[40,82],"important":[41,83,128],"to":[42,129,139],"learned":[43,88],"vocalizations":[44],"remains":[45],"unclear.":[46],"Using":[47],"a":[48,125],"combination":[49],"behavioral":[51],"analysis,":[52],"vivo":[54],"intracellular":[55],"recordings":[56,63,147],"anaesthetized":[58,111],"birds,":[59,66],"pharmacology":[60],"extracellular":[62],"singing":[65,149],"I":[67,92],"addressed":[68],"how":[69],"knockdown":[71,96,116,154],"songbird":[73,99],"striatum":[74,100],"affects":[75],"signal":[79],"propagation":[80,123],"through":[81],"for":[84],"vocalizations.":[89],"In":[90],"summary,":[91],"found":[93],"that":[94,114,134,152,167],"developmental":[102],"social":[104,156],"modulation":[105,120,157,175],"variability.":[108],"Recordings":[109],"birds":[112,150],"show":[113,166],"interferes":[117],"with":[118,172],"D1R-dependent":[119],"activity":[122,160],"corticostriatal":[126],"pathway":[127],"variability,":[131,178],"an":[132],"effect":[133],"may":[135,180],"be":[136],"partly":[137],"attributable":[138],"reduced":[140,168],"D1R":[141],"DARPP-32":[143],"protein":[144],"levels.":[145],"Furthermore,":[146],"reveal":[151],"prevents":[155],"singing-related":[159],"this":[162],"pathway.":[163],"These":[164],"findings":[165],"interfere":[171],"dopaminergic":[174],"which":[179],"impede":[181],"by":[186],"disrupting":[187],"reinforcement":[188],"mechanisms.":[190]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}