{"id":"https://openalex.org/W111083503","doi":null,"title":"Pain intensity, illness duration, and protein catabolism in temporomandibular disorder patients with chronic muscle pain.","display_name":"Pain intensity, illness duration, and protein catabolism in temporomandibular disorder patients with chronic muscle pain.","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W111083503","mag":"111083503","pmid":"https://pubmed.ncbi.nlm.nih.gov/12836499"},"language":"en","primary_location":{"id":"pmid:12836499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12836499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orofacial pain","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020978753","display_name":"Neil McGregor","orcid":"https://orcid.org/0000-0002-2100-361X","observed_orcids":["https://orcid.org/0000-0002-2100-361X"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Neil R McGregor","raw_affiliation_strings":["Jaw Function and Orofacial Pain Research Unit, Faculty of Dentistry, University of Sydney, Westmead Centre for Oral Health, Westmead Hospital, Westmead, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jaw Function and Orofacial Pain Research Unit, Faculty of Dentistry, University of Sydney, Westmead Centre for Oral Health, Westmead Hospital, Westmead, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070368644","display_name":"Mariann Zerbes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariann Zerbes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063138233","display_name":"Suzanne H. Niblett","orcid":"https://orcid.org/0000-0003-3417-6189","observed_orcids":["https://orcid.org/0000-0003-3417-6189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suzanne H Niblett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016075912","display_name":"R. Hugh Dunstan","orcid":"https://orcid.org/0000-0002-1058-8739","observed_orcids":["https://orcid.org/0000-0002-1058-8739"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Hugh Dunstan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035343541","display_name":"Timothy K. Roberts","orcid":"https://orcid.org/0000-0002-6680-4816","observed_orcids":["https://orcid.org/0000-0002-6680-4816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy K Roberts","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108598183","display_name":"Henry L. Butt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry L Butt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086111029","display_name":"Iven J Klineberg","orcid":"https://orcid.org/0000-0002-2081-5421","observed_orcids":["https://orcid.org/0000-0002-2081-5421"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iven J Klineberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4934,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.85882353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"17","issue":"2","first_page":"112","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11282","display_name":"Fibromyalgia and Chronic Fatigue Syndrome Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/temporomandibular-disorders","display_name":"temporomandibular disorders","score":0.9539999961853027},{"id":"https://openalex.org/keywords/chronic-muscle-pain","display_name":"chronic muscle pain","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pain-intensity","display_name":"pain intensity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.9929999709129333},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.7879999876022339},{"id":"https://openalex.org/keywords/urinary-metabolites","display_name":"urinary metabolites","score":0.8109999895095825},{"id":"https://openalex.org/keywords/leucine","display_name":"leucine","score":0.6579999923706055},{"id":"https://openalex.org/keywords/succinic-acid","display_name":"succinic acid","score":0.7350000143051147},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.8560000061988831},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.8379999995231628},{"id":"https://openalex.org/keywords/metabolic-biomarkers","display_name":"metabolic biomarkers","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6101354360580444},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6056544184684753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5918738842010498},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5766823291778564},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.482636034488678},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.4811854958534241},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.4480500817298889},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.4341081976890564},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.430339515209198},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37418752908706665},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3629462718963623},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2390425205230713},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.22455841302871704},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18624013662338257},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.1776135265827179},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1413714587688446},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08801412582397461}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005157","descriptor_name":"Facial Pain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005157","descriptor_name":"Facial Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013705","descriptor_name":"Temporomandibular Joint Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013705","descriptor_name":"Temporomandibular Joint Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D019802","descriptor_name":"Succinic Acid","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12836499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12836499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orofacial pain","raw_type":"Comparative Study"},{"id":"mag:111083503","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12836499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W88010091","https://openalex.org/W100944056","https://openalex.org/W285804751","https://openalex.org/W303961334","https://openalex.org/W335533979","https://openalex.org/W1517770332","https://openalex.org/W1562301097","https://openalex.org/W1602793726","https://openalex.org/W1792389655","https://openalex.org/W1965204194","https://openalex.org/W1979971155","https://openalex.org/W1980233753","https://openalex.org/W1984254722","https://openalex.org/W1985890649","https://openalex.org/W1992618185","https://openalex.org/W2027977972","https://openalex.org/W2045402458","https://openalex.org/W2057700479","https://openalex.org/W2064395420","https://openalex.org/W2065083920","https://openalex.org/W2075956591","https://openalex.org/W2080370244","https://openalex.org/W2085294253","https://openalex.org/W2090290655","https://openalex.org/W2094483303","https://openalex.org/W2094901003","https://openalex.org/W2114508665","https://openalex.org/W2118555930","https://openalex.org/W2118767476","https://openalex.org/W2119480941","https://openalex.org/W2119813498","https://openalex.org/W2126230123","https://openalex.org/W2131714688","https://openalex.org/W2140565441","https://openalex.org/W2143230812","https://openalex.org/W2143585898","https://openalex.org/W2159712011","https://openalex.org/W2160348999","https://openalex.org/W2167872449","https://openalex.org/W2169002591","https://openalex.org/W2196857794","https://openalex.org/W2235501007","https://openalex.org/W2895037757","https://openalex.org/W2920864752","https://openalex.org/W3121638302","https://openalex.org/W3143129303"],"related_works":["https://openalex.org/W1580360160","https://openalex.org/W2895926580","https://openalex.org/W4362712562","https://openalex.org/W1562301097","https://openalex.org/W4282979345","https://openalex.org/W2161721029","https://openalex.org/W4293217964","https://openalex.org/W4224311852","https://openalex.org/W3157559124","https://openalex.org/W2123689579"],"abstract_inverted_index":{"AIMS:":[0],"To":[1],"investigate":[2],"whether":[3],"the":[4,35,118,132,192],"duration":[5,93,144,234,285],"of":[6,20,101,159,258,292],"chronic":[7],"pain":[8,28,44,74,153,160,273,300],"in":[9,58,191,211,219],"temporomandibular":[10],"disorder":[11],"(TMD)":[12],"patients":[13,32,164],"is":[14],"associated":[15,187,236,287],"with":[16,104,148,237,272,278,288,296],"a":[17,24,78,255,289],"net":[18],"depletion":[19,257],"amino":[21,62,266],"acids,":[22],"and":[23,47,50,61,114,151,155,167,171,208,218,227,243,247,275],"distinct":[25],"process":[26],"from":[27,117],"intensity.":[29,161,301],"METHODS:":[30],"Twenty-nine":[31],"defined":[33],"by":[34,65],"research":[36],"diagnostic":[37],"criteria/TMD":[38],"as":[39],"having":[40],"Type":[41],"1a":[42],"muscle":[43],"(TMD1A":[45],"group),":[46],"34":[48],"age-":[49],"sex-matched":[51],"control":[52],"subjects,":[53],"were":[54,157],"assessed":[55,76],"for":[56,299],"variation":[57],"urinary":[59,194,213,240],"organic":[60],"acid":[63,246,252,267],"excretion":[64,196,268],"gas":[66],"chromatography-mass":[67],"spectrometry.":[68],"RESULTS:":[69],"The":[70,162],"TMD1A":[71,91,141,163,232,263],"patients'":[72],"mean":[73],"intensity,":[75],"on":[77],"visual":[79],"analog":[80],"scale":[81],"(VAS),":[82],"was":[83,94,106,123,129,145,186,235,269,286],"5.4":[84],"(95%":[85],"confidence":[86],"limits:":[87],"4.5":[88],"to":[89,112],"6.3),":[90],"illness":[92,143,233,279,284],"5.0":[95,136],"+/-":[96,108,125,135],"1.2":[97],"(SD)":[98],"years,":[99],"number":[100],"body":[102,152],"areas":[103],"pain/subject":[105],"6.3":[107],"2.4":[109],"(range":[110],"0":[111],"10),":[113],"symptom":[115,149],"prevalence":[116,150],"Symptom":[119],"Check":[120],"List-90-Revised":[121],"(SCL-90-R)":[122],"25.5":[124],"11.3":[126],"symptoms/subject,":[127,137],"which":[128,180,281],"higher":[130],"than":[131],"controls":[133],"(5.2":[134],"P":[138,177],"<":[139,178,199,206,216,225,230],".001).":[140],"patient":[142],"positively":[146,270],"correlated":[147,271,277],"distribution,":[154],"all":[156],"independent":[158],"had:":[165],"(1)":[166,189,239],"increased":[168],"tyrosine:leucine":[169],"ratio;":[170],"(2)":[172,201,244],"reduced":[173,202],"leucine":[174,203],"concentrations":[175,204,242],"(both":[176],".001),":[179],"suggests":[181],"deregulated":[182],"catabolism.":[183],"Pain":[184],"intensity":[185,274],"with:":[188],"changes":[190],"multivariate":[193],"metabolite":[195,241,259],"patterns":[197],"(P":[198,205,215,224,229],".001);":[200,207],"(3)":[209],"increases":[210],"total":[212,265],"metabolites":[214],".04),":[217],"2":[220],"unidentified":[221],"molecules,":[222],"UM28":[223],".001)":[226],"CFSUM1":[228],".002).":[231],"lower":[238],"succinic":[245],"combined":[248],"glutamine":[249],"+":[250],"glutamic":[251],"levels,":[253],"suggesting":[254],"progressive":[256],"reserves.":[260],"CONCLUSION:":[261],"In":[262],"patients,":[264],"negatively":[276],"duration,":[280],"indicated":[282],"that":[283],"different":[290],"set":[291],"metabolic":[293],"anomalies":[294],"compared":[295],"those":[297],"identified":[298]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}