{"id":"https://openalex.org/W111079477","doi":null,"title":"Developing an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinic.","display_name":"Developing an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinic.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W111079477","mag":"111079477","pmid":"https://pubmed.ncbi.nlm.nih.gov/21276410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4348040"},"language":"en","primary_location":{"id":"pmid:21276410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21276410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},"volume":null,"type":"review","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4348040","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073677610","display_name":"Rupesh Dash","orcid":"https://orcid.org/0000-0001-5740-7053","observed_orcids":["https://orcid.org/0000-0001-5740-7053"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rupesh Dash","raw_affiliation_strings":["Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, 23298, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033665986","display_name":"Belal Azab","orcid":"https://orcid.org/0000-0003-0293-6489","observed_orcids":["https://orcid.org/0000-0003-0293-6489"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Belal Azab","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112273624","display_name":"Xue\u2010Ning Shen","orcid":"https://orcid.org/0009-0001-2658-3799","observed_orcids":["https://orcid.org/0009-0001-2658-3799"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xue-Ning Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057322570","display_name":"Upneet K. Sokhi","orcid":"https://orcid.org/0000-0001-5907-5646","observed_orcids":["https://orcid.org/0000-0001-5907-5646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Upneet K Sokhi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090380865","display_name":"Siddik Sarkar","orcid":"https://orcid.org/0000-0002-3694-8915","observed_orcids":["https://orcid.org/0000-0002-3694-8915"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Siddik Sarkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967004","display_name":"Zhao-zhong Su","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhao-zhong Su","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100755827","display_name":"Xiang\u2010Yang Wang","orcid":"https://orcid.org/0000-0003-2421-5367","observed_orcids":["https://orcid.org/0000-0003-2421-5367"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiang-Yang Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015210940","display_name":"Pier Paolo Claudio","orcid":"https://orcid.org/0000-0001-7790-1622","observed_orcids":["https://orcid.org/0000-0001-7790-1622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pier Paolo Claudio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069980003","display_name":"Paul Dent","orcid":"https://orcid.org/0000-0001-6948-1875","observed_orcids":["https://orcid.org/0000-0001-6948-1875"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Dent","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036159485","display_name":"Igor P. Dmitriev","orcid":"https://orcid.org/0000-0001-9206-1975","observed_orcids":["https://orcid.org/0000-0001-9206-1975"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor P Dmitriev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022987623","display_name":"David T. Curiel","orcid":"https://orcid.org/0000-0003-3802-6014","observed_orcids":["https://orcid.org/0000-0003-3802-6014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David T Curiel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109601699","display_name":"Steven Grant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Grant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091194969","display_name":"Devanand Sarkar","orcid":"https://orcid.org/0000-0003-0973-2323","observed_orcids":["https://orcid.org/0000-0003-0973-2323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Devanand Sarkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5031490587","display_name":"Paul B. Fisher","orcid":"https://orcid.org/0000-0002-0085-4546","observed_orcids":["https://orcid.org/0000-0002-0085-4546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul B Fisher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6778,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.55652174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"11","issue":"56","first_page":"46","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.08950000256299973,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.9520000219345093},{"id":"https://openalex.org/keywords/coxsackie-adenovirus-receptor","display_name":"coxsackievirus and adenovirus receptor","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ultrasound-contrast-agents","display_name":"ultrasound contrast agents","score":0.7829999923706055},{"id":"https://openalex.org/keywords/microbubbles","display_name":"microbubbles","score":0.9390000104904175},{"id":"https://openalex.org/keywords/ultrasound-targeted-microbubble-destruction","display_name":"ultrasound-targeted microbubble destruction","score":0.9700000286102295},{"id":"https://openalex.org/keywords/targeted-gene-delivery","display_name":"targeted gene delivery","score":0.9440000057220459},{"id":"https://openalex.org/keywords/metastatic-prostate-cancer","display_name":"metastatic prostate cancer","score":0.7300000190734863},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.745141863822937},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7174292802810669},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.6625888347625732},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6483356952667236},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5047584772109985},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4906238615512848},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.48704198002815247},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.46385666728019714},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.44457748532295227},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43839094042778015},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4273533225059509},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3480764329433441},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3248140811920166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2324158251285553},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21152368187904358},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.208637535572052},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.08705025911331177},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057170","descriptor_name":"Translational Research, Biomedical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmid:21276410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21276410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3316243","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4348040","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4348040","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4348040","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Discov Med","raw_type":"Text"},{"id":"mag:111079477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21276410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3316243","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4348040","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3971002961","display_name":"Translational Applications of mda-7/IL-24 in Cancer","funder_award_id":"P01CA104177","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4918485225","display_name":"Scavenger Receptor-A and Immune Regulation","funder_award_id":"R01CA129111","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5103288897","display_name":"Pancreatic Cancer Management by Novel Gene Therapy & Dietary Agents","funder_award_id":"5r01ca127641-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8834657173","display_name":"MDA-7: Novel Cancer Therapeutic Gene","funder_award_id":"R01CA097318","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1583927081","https://openalex.org/W1624279568","https://openalex.org/W1794539469","https://openalex.org/W1800349098","https://openalex.org/W1839957286","https://openalex.org/W1964069216","https://openalex.org/W1969637872","https://openalex.org/W1970437076","https://openalex.org/W1976253176","https://openalex.org/W1979898371","https://openalex.org/W1981397338","https://openalex.org/W1989915580","https://openalex.org/W1996981135","https://openalex.org/W2000351472","https://openalex.org/W2004170517","https://openalex.org/W2004708951","https://openalex.org/W2004832301","https://openalex.org/W2005768073","https://openalex.org/W2006569353","https://openalex.org/W2010579356","https://openalex.org/W2011184161","https://openalex.org/W2012081777","https://openalex.org/W2014944687","https://openalex.org/W2017872266","https://openalex.org/W2022315435","https://openalex.org/W2022494582","https://openalex.org/W2023141450","https://openalex.org/W2029931954","https://openalex.org/W2031900842","https://openalex.org/W2035996374","https://openalex.org/W2043654385","https://openalex.org/W2044071797","https://openalex.org/W2044943819","https://openalex.org/W2047959564","https://openalex.org/W2048077855","https://openalex.org/W2052093717","https://openalex.org/W2056859858","https://openalex.org/W2057074963","https://openalex.org/W2064219151","https://openalex.org/W2071406873","https://openalex.org/W2072553587","https://openalex.org/W2074810910","https://openalex.org/W2075776905","https://openalex.org/W2078455874","https://openalex.org/W2079987784","https://openalex.org/W2080632821","https://openalex.org/W2081941885","https://openalex.org/W2085438294","https://openalex.org/W2085600315","https://openalex.org/W2087734193","https://openalex.org/W2110166030","https://openalex.org/W2123386912","https://openalex.org/W2124375652","https://openalex.org/W2139527351","https://openalex.org/W2140471620","https://openalex.org/W2140698516","https://openalex.org/W2141019354","https://openalex.org/W2141077451","https://openalex.org/W2143064142","https://openalex.org/W2156054486","https://openalex.org/W2160802204","https://openalex.org/W2170815810","https://openalex.org/W2234798757","https://openalex.org/W2329048545","https://openalex.org/W2417329899","https://openalex.org/W2443794740","https://openalex.org/W4211024301"],"related_works":["https://openalex.org/W2001522142","https://openalex.org/W7027522589","https://openalex.org/W2034316525","https://openalex.org/W4320000652","https://openalex.org/W2027619664","https://openalex.org/W2885389400","https://openalex.org/W2107965631","https://openalex.org/W2754011840","https://openalex.org/W4253387802","https://openalex.org/W2222160237"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,42,150],"is":[2,43,136],"the":[3,13,49,68,84,99,109,114,123,128,147,220,232,235],"second":[4],"leading":[5],"cause":[6],"of":[7,54,72,86,102,149,163,168,222,243],"cancer-related":[8],"deaths":[9],"in":[10,12,25,29,122,133,142,209],"men":[11],"U.S.":[14],"At":[15],"present,":[16],"no":[17],"single":[18],"or":[19,125,195],"combination":[20],"therapy":[21,95,208,224,242],"has":[22,62],"shown":[23],"efficacy":[24,221],"decreasing":[26],"disease":[27],"progression":[28],"patients":[30],"with":[31,199],"metastatic":[32],"disease.":[33],"A":[34],"potentially":[35],"viable":[36],"approach":[37,181],"for":[38,80,92,218,237],"treating":[39],"late-stage":[40],"prostate":[41,244],"gene":[44,55,94,170,223,241],"therapy.":[45],"Adenoviruses":[46],"(Ad)":[47],"are":[48,98],"most":[50],"commonly":[51],"used":[52],"mode":[53],"delivery,":[56,82],"but":[57],"progress":[58],"using":[59,96,134,177],"this":[60],"vector":[61],"been":[63],"hampered":[64],"by":[65,127,156,176],"concerns":[66],"over":[67],"safety":[69],"and":[70,83,108],"practicality":[71],"viruses":[73],"including":[74],"conditionally":[75],"replicating":[76],"Ads":[77,97,159],"(CRAds),":[78],"particularly":[79],"intravenous":[81],"inefficiency":[85],"non-viral":[87],"transfection":[88],"techniques.":[89],"Major":[90],"challenges":[91],"effective":[93,191,240],"limited":[100],"infectivity":[101],"regular":[103],"Ad":[104],"serotype":[105],"5":[106],"(Ad5)":[107],"inability":[110],"to":[111,139,189,204,229],"specifically":[112],"deliver":[113,190],"therapeutic":[115,192],"directly":[116],"into":[117,234],"diseased":[118],"tissue":[119],"without":[120],"trapping":[121],"liver":[124],"elimination":[126],"immune":[129,210],"system.":[130],"The":[131,166],"shortcoming":[132],"Ad5":[135],"mostly":[137],"attributed":[138],"a":[140,178,206,226],"reduction":[141],"Coxsackie-adenovirus":[143],"receptors":[144],"(CAR)":[145],"on":[146],"surface":[148],"cells,":[151],"which":[152],"can":[153,172],"be":[154,174],"mitigated":[155],"generating":[157],"tropism-modified":[158],"permitting":[160],"CAR-independent":[161],"infection":[162],"tumor":[164],"cells.":[165],"limitations":[167],"systemic":[169],"delivery":[171],"now":[173],"overcome":[175],"novel":[179],"targeted-delivery":[180],"such":[182],"as":[183],"ultrasound":[184],"(US)":[185],"contrast":[186],"agents":[187],"(microbubbles)":[188],"reagents,":[193],"Ads,":[194],"recombinant":[196],"proteins,":[197],"combined":[198],"ultrasound-targeted":[200],"microbubble":[201],"destruction":[202],"(UTMD),":[203],"develop":[205],"site-specific":[207],"competent":[211],"transgenic":[212],"mouse":[213],"models.":[214],"These":[215],"unique":[216],"strategies":[217],"enhancing":[219],"provide":[225],"direct":[227],"path":[228],"translation":[230],"from":[231],"laboratory":[233],"clinic":[236],"developing":[238],"an":[239],"cancer.":[245]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
