{"id":"https://openalex.org/W110826951","doi":"https://doi.org/10.1016/b978-0-12-187701-9.50115-7","title":"EXOGENOUS HEME FUNCTIONALLY RECONSTITUTES HEPATIC CYTOCHROME P-450 IN VIVO","display_name":"EXOGENOUS HEME FUNCTIONALLY RECONSTITUTES HEPATIC CYTOCHROME P-450 IN VIVO","publication_year":1980,"publication_date":"1980-01-01","ids":{"openalex":"https://openalex.org/W110826951","doi":"https://doi.org/10.1016/b978-0-12-187701-9.50115-7","mag":"110826951"},"language":"en","primary_location":{"id":"doi:10.1016/b978-0-12-187701-9.50115-7","doi":"https://doi.org/10.1016/b978-0-12-187701-9.50115-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-187701-9.50115-7","pdf_url":null,"source":{"id":"https://openalex.org/S2765034040","display_name":"Microsomes, Drug Oxidations and Chemical Carcinogenesis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microsomes, Drug Oxidations and Chemical Carcinogenesis","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W639863891","display_name":"Microsomes, Drug Oxidations and Chemical Carcinogenesis"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109955079","display_name":"Geoffrey C. Farrell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoffrey C. Farrell","raw_affiliation_strings":["Departments of Medicine and Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051826956","display_name":"Maria Almira Correia","orcid":"https://orcid.org/0000-0002-8939-2180","observed_orcids":["https://orcid.org/0000-0002-8939-2180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Almira Correia","raw_affiliation_strings":["Departments of Medicine and Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111732955","display_name":"Rudi Schmid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rudi Schmid","raw_affiliation_strings":["Departments of Medicine and Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113680078","display_name":"Paul R. Ortiz de Montellano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul R. Ortiz de Montellano","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, The Liver Center, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, The Liver Center, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111715294","display_name":"Kent L. Kunze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kent L. Kunze","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, The Liver Center, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, The Liver Center, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.08333333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"587","last_page":"590"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9269999861717224},{"id":"https://openalex.org/keywords/hepatic-mixed-function-oxidase","display_name":"hepatic mixed function oxidase","score":0.777999997138977},{"id":"https://openalex.org/keywords/allylisopropylacetamide","display_name":"allylisopropylacetamide","score":0.8600000143051147},{"id":"https://openalex.org/keywords/heme-reconstitution","display_name":"heme reconstitution","score":0.6840000152587891},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.7956579327583313},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.7939534783363342},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.723904013633728},{"id":"https://openalex.org/C2910828019","wikidata":"https://www.wikidata.org/wiki/Q6883853","display_name":"Mixed Function Oxidase","level":4,"score":0.7081853151321411},{"id":"https://openalex.org/C2778793413","wikidata":"https://www.wikidata.org/wiki/Q407241","display_name":"Phenobarbital","level":2,"score":0.6910803318023682},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6798354387283325},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.5540006160736084},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47177553176879883},{"id":"https://openalex.org/C20705724","wikidata":"https://www.wikidata.org/wiki/Q902628","display_name":"Hemeprotein","level":4,"score":0.46302834153175354},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.45886677503585815},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4533776640892029},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.4308667778968811},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3225288987159729},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21919482946395874},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21087977290153503},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19888797402381897},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18544822931289673},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-0-12-187701-9.50115-7","doi":"https://doi.org/10.1016/b978-0-12-187701-9.50115-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-0-12-187701-9.50115-7","pdf_url":null,"source":{"id":"https://openalex.org/S2765034040","display_name":"Microsomes, Drug Oxidations and Chemical Carcinogenesis","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microsomes, Drug Oxidations and Chemical Carcinogenesis","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1605233131","https://openalex.org/W1973057199","https://openalex.org/W2031705347","https://openalex.org/W2035175648","https://openalex.org/W2072797300","https://openalex.org/W2409928615"],"related_works":["https://openalex.org/W2003210267","https://openalex.org/W1575116861","https://openalex.org/W2289679195","https://openalex.org/W1605233131","https://openalex.org/W2023317081","https://openalex.org/W1578587693","https://openalex.org/W2058897016","https://openalex.org/W2079401101","https://openalex.org/W1496019889","https://openalex.org/W2035175648"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}