{"id":"https://openalex.org/W110529162","doi":null,"title":"Bone mineral content and bone mineral metabolism: changes after growth hormone treatment in juvenile chronic arthritis.","display_name":"Bone mineral content and bone mineral metabolism: changes after growth hormone treatment in juvenile chronic arthritis.","publication_year":2000,"publication_date":"2000-04-01","ids":{"openalex":"https://openalex.org/W110529162","mag":"110529162","pmid":"https://pubmed.ncbi.nlm.nih.gov/10782840"},"language":"en","primary_location":{"id":"pmid:10782840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10782840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050091496","display_name":"Madeleine E. Rooney","orcid":"https://orcid.org/0000-0002-7369-5793","observed_orcids":["https://orcid.org/0000-0002-7369-5793"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Rooney","raw_affiliation_strings":["Centre for Paediatric and Adolescent Rheumatology, Department of Molecular Pathology, The Windeyer Institute of Medical Sciences, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Paediatric and Adolescent Rheumatology, Department of Molecular Pathology, The Windeyer Institute of Medical Sciences, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"U M Davies","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U M Davies","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060210420","display_name":"JONATHAN REEVE","orcid":"https://orcid.org/0000-0002-4364-2682","observed_orcids":["https://orcid.org/0000-0002-4364-2682","https://orcid.org/0000-0002-1609-0405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Reeve","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103344957","display_name":"Michael A. Preece","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Preece","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055219846","display_name":"Barbara M. Ansell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B M Ansell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060906323","display_name":"Patricia M. Woo","orcid":"https://orcid.org/0000-0002-3132-2665","observed_orcids":["https://orcid.org/0000-0002-3132-2665"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P M Woo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.522,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.97317399,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"4","first_page":"1073","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/juvenile-idiopathic-arthritis","display_name":"juvenile idiopathic arthritis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/growth-hormone-therapy","display_name":"growth hormone therapy","score":0.8389999866485596},{"id":"https://openalex.org/keywords/bone-mineral-content","display_name":"bone mineral content","score":0.871999979019165},{"id":"https://openalex.org/keywords/mineral-and-bone-metabolism","display_name":"bone mineral metabolism","score":0.9679999947547913},{"id":"https://openalex.org/keywords/growth-retardation","display_name":"growth retardation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.7730000019073486},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/height-velocity","display_name":"height velocity","score":0.7080000042915344},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.8259999752044678},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":1.0},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8149999976158142},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8618735074996948},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.832738995552063},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8066399693489075},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.7970844507217407},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.669856607913971},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6082895994186401},{"id":"https://openalex.org/C2778135454","wikidata":"https://www.wikidata.org/wiki/Q5611754","display_name":"Growth hormone treatment","level":4,"score":0.6036697030067444},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5985289812088013},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.5292054414749146},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.490296870470047},{"id":"https://openalex.org/C2776169692","wikidata":"https://www.wikidata.org/wiki/Q4941552","display_name":"Bone disease","level":3,"score":0.4272818863391876},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3128735423088074},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.16295894980430603},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.15403056144714355},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.14602288603782654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.074587881565094},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001171","descriptor_name":"Arthritis, Juvenile","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001171","descriptor_name":"Arthritis, Juvenile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011282","descriptor_name":"Pregnenediones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015596","descriptor_name":"Nutrition Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015675","descriptor_name":"Osteocalcin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:10782840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10782840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of rheumatology","raw_type":"Clinical Trial"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:133225","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/133225/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J RHEUMATOL , 27 (4) 1073 - 1081. (2000)","raw_type":"Article"},{"id":"mag:110529162","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10782840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2410031158","https://openalex.org/W2007475461","https://openalex.org/W114180788","https://openalex.org/W2022968795","https://openalex.org/W2333640428","https://openalex.org/W1781387059","https://openalex.org/W2128976492","https://openalex.org/W2039595430","https://openalex.org/W2109992040","https://openalex.org/W2013840081"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"whether":[3],"growth":[4,23,26,188,220],"hormone":[5,24,107,209],"(rhGH)":[6],"affects":[7],"bone":[8,12,100,127],"mineral":[9,13],"metabolism":[10],"and":[11,52,84,88,102,105,117,133,159,167,186,195,222],"content":[14],"(BMC,":[15],"g/cm)":[16],"in":[17,25,41,215,224,233],"a":[18,212],"therapeutic":[19],"trial":[20],"of":[21,56,81,97,126,218,231,236],"recombinant":[22],"retarded":[27],"children":[28,43,182,225],"with":[29,35,49,119,136,153,183,200,226],"juvenile":[30],"chronic":[31],"arthritis":[32],"(JCA)":[33],"treated":[34,48,181],"steroid.":[36],"METHODS:":[37],"BMC":[38,111],"was":[39],"measured":[40],"20":[42],"(of":[44],"whom":[45],"17":[46],"were":[47,59,79,91,150,170],"corticosteroid)":[50],"before":[51,158,177],"after":[53,130],"one":[54,74],"year":[55],"rhGH.":[57],"Children":[58],"randomized":[60],"to":[61,94],"receive":[62],"either":[63],"low":[64],"dose":[65,70,143],"(12":[66],"IU/m2/week)":[67,72],"or":[68],"high":[69,142],"(24":[71],"for":[73,140],"year.":[75],"Three":[76],"monthly":[77],"assessments":[78],"made":[80],"disease":[82,98],"activity":[83],"anthropomorphic":[85],"measurements.":[86],"Blood":[87],"urine":[89],"samples":[90],"also":[92],"obtained":[93],"measure":[95],"indicators":[96,125],"activity,":[99],"remodeling,":[101],"vitamin":[103,164,192],"D":[104],"parathyroid":[106],"(PTH)":[108],"status.":[109],"RESULTS:":[110],"increased":[112,129],"during":[113,160],"the":[114,141,216,234],"treatment":[115,132,144,199,217,235],"period":[116],"correlated":[118,134,152],"increasing":[120],"height.":[121],"Osteocalcin":[122],"levels,":[123,156],"normally":[124],"formation,":[128],"rhGH":[131,232],"significantly":[135,171],"height":[137,202],"velocity,":[138,163],"particularly":[139],"group.":[145],"In":[146],"contrast,":[147],"osteocalcin":[148,168,196],"levels":[149,169],"negatively":[151],"C-reactive":[154],"protein":[155],"both":[157,184],"treatment.":[161,178],"Height":[162],"D,":[165,193],"PTH,":[166,194],"lower":[172],"than":[173],"age":[174],"matched":[175],"controls":[176],"CONCLUSION:":[179],"Steroid":[180],"JCA":[185],"severe":[187,219],"retardation":[189,221],"have":[190],"reduced":[191],"levels.":[197],"After":[198],"rhGH,":[201],"velocity":[203],"increased,":[204],"as":[205],"did":[206],"BMC.":[207],"Growth":[208],"might":[210],"be":[211],"useful":[213],"adjunct":[214],"osteoporosis":[223,237],"JCA.":[227],"The":[228],"longterm":[229],"benefits":[230],"remain":[238],"unclear.":[239]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
