{"id":"https://openalex.org/W110353352","doi":"https://doi.org/10.1023/a:1027388508570","title":"Advances in the Understanding of Cytokine Signal Transduction: The Role of Jaks and STATs in Immunoregulation and the Pathogenesis of Immunodeficiency","display_name":"Advances in the Understanding of Cytokine Signal Transduction: The Role of Jaks and STATs in Immunoregulation and the Pathogenesis of Immunodeficiency","publication_year":1997,"publication_date":"1997-11-01","ids":{"openalex":"https://openalex.org/W110353352","doi":"https://doi.org/10.1023/a:1027388508570","mag":"110353352","pmid":"https://pubmed.ncbi.nlm.nih.gov/9418183"},"language":"en","primary_location":{"id":"doi:10.1023/a:1027388508570","doi":"https://doi.org/10.1023/a:1027388508570","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1027388508570","pdf_url":null,"source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061857523","display_name":"John J. O\u2019Shea","orcid":"https://orcid.org/0000-0002-6456-9752","observed_orcids":["https://orcid.org/0000-0002-6456-9752"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. O'shea","raw_affiliation_strings":["Lymphocyte Cell Biology Section, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA","Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lymphocyte Cell Biology Section, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]},{"raw_affiliation_string":"Lymphocyte Cell Biology Section, Arthritis and Rheumatism Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029163913","display_name":"Luigi Daniele Notarangelo","orcid":"https://orcid.org/0000-0002-8335-0262","observed_orcids":["https://orcid.org/0000-0002-8335-0262"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi D. Notarangelo","raw_affiliation_strings":["Department of Pediatrics, University of Brescia, Brescia, Italy","Department of Pediatrics, University of Brescia, Brescia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]},{"raw_affiliation_string":"Department of Pediatrics, University of Brescia, Brescia","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036176344","display_name":"James A. Johnston","orcid":"https://orcid.org/0000-0002-0870-2512","observed_orcids":["https://orcid.org/0000-0002-0870-2512"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James A. Johnston","raw_affiliation_strings":["DNAX Research Institute, Palo Alto, California, 94304","DNAX Research Institute, Palo Alto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DNAX Research Institute, Palo Alto, California, 94304","institution_ids":[]},{"raw_affiliation_string":"DNAX Research Institute, Palo Alto","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062385004","display_name":"Fabio Candotti","orcid":"https://orcid.org/0000-0001-6399-6042","observed_orcids":["https://orcid.org/0000-0001-6399-6042"]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Candotti","raw_affiliation_strings":["Department of Pediatrics, University of Brescia, Brescia, Italy","Department of Pediatrics, University of Brescia, Brescia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Brescia, Brescia, Italy","institution_ids":["https://openalex.org/I79940851"]},{"raw_affiliation_string":"Department of Pediatrics, University of Brescia, Brescia","institution_ids":["https://openalex.org/I79940851"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.5542,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.63231198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"17","issue":"6","first_page":"431","last_page":"447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.9300000071525574},{"id":"https://openalex.org/keywords/janus-kinase","display_name":"Janus kinase","score":0.7519999742507935},{"id":"https://openalex.org/keywords/stat-proteins","display_name":"STAT proteins","score":0.7179999947547913},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.8349999785423279},{"id":"https://openalex.org/keywords/severe-combined-immunodeficiency","display_name":"severe combined immunodeficiency","score":0.8450000286102295},{"id":"https://openalex.org/keywords/jak3","display_name":"JAK3","score":0.9620000123977661},{"id":"https://openalex.org/keywords/receptor-phosphorylation","display_name":"receptor phosphorylation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/sh2-domain-proteins","display_name":"SH2 domain proteins","score":0.7860000133514404},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.878000020980835},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.6159999966621399},{"id":"https://openalex.org/keywords/immune-system-development","display_name":"immune system development","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.788960874080658},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.664516270160675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6000661253929138},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5785374641418457},{"id":"https://openalex.org/C112392421","wikidata":"https://www.wikidata.org/wiki/Q903451","display_name":"Janus kinase","level":3,"score":0.5696057677268982},{"id":"https://openalex.org/C154390347","wikidata":"https://www.wikidata.org/wiki/Q14914522","display_name":"Janus kinase 1","level":4,"score":0.5469433069229126},{"id":"https://openalex.org/C2775855021","wikidata":"https://www.wikidata.org/wiki/Q968436","display_name":"Cytokine receptor","level":3,"score":0.5459110736846924},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.521294355392456},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.47802552580833435},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4475121796131134},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38022011518478394},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24415844678878784},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21308568120002747}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1023/a:1027388508570","doi":"https://doi.org/10.1023/a:1027388508570","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1027388508570","pdf_url":null,"source":{"id":"https://openalex.org/S57504206","display_name":"Journal of Clinical Immunology","issn_l":"0271-9142","issn":["0271-9142","1573-2592"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:9418183","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9418183","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":219,"referenced_works":["https://openalex.org/W4553897","https://openalex.org/W23999710","https://openalex.org/W25119911","https://openalex.org/W77986286","https://openalex.org/W93069951","https://openalex.org/W151793644","https://openalex.org/W154122761","https://openalex.org/W159302622","https://openalex.org/W168754456","https://openalex.org/W175910702","https://openalex.org/W334134150","https://openalex.org/W1225996684","https://openalex.org/W1245819034","https://openalex.org/W1505115118","https://openalex.org/W1518753128","https://openalex.org/W1521367633","https://openalex.org/W1543553989","https://openalex.org/W1561293432","https://openalex.org/W1566153239","https://openalex.org/W1567604499","https://openalex.org/W1575016278","https://openalex.org/W1575865511","https://openalex.org/W1603378909","https://openalex.org/W1669690603","https://openalex.org/W1702674772","https://openalex.org/W1743711678","https://openalex.org/W1747682552","https://openalex.org/W1756978269","https://openalex.org/W1763296980","https://openalex.org/W1829424702","https://openalex.org/W1883394179","https://openalex.org/W1932261119","https://openalex.org/W1958363133","https://openalex.org/W1963635519","https://openalex.org/W1964144691","https://openalex.org/W1964220962","https://openalex.org/W1964815717","https://openalex.org/W1964973658","https://openalex.org/W1966833202","https://openalex.org/W1968177644","https://openalex.org/W1969979508","https://openalex.org/W1971500432","https://openalex.org/W1972044265","https://openalex.org/W1972254316","https://openalex.org/W1972927903","https://openalex.org/W1974607640","https://openalex.org/W1974656027","https://openalex.org/W1974968368","https://openalex.org/W1975588465","https://openalex.org/W1977176665","https://openalex.org/W1978805864","https://openalex.org/W1979676829","https://openalex.org/W1981799488","https://openalex.org/W1982051091","https://openalex.org/W1982134009","https://openalex.org/W1982186905","https://openalex.org/W1983257767","https://openalex.org/W1984339902","https://openalex.org/W1984486504","https://openalex.org/W1986763765","https://openalex.org/W1987485969","https://openalex.org/W1988928374","https://openalex.org/W1991311051","https://openalex.org/W1991348646","https://openalex.org/W1991381808","https://openalex.org/W1994584656","https://openalex.org/W1994754827","https://openalex.org/W1995204178","https://openalex.org/W1995225418","https://openalex.org/W1995297089","https://openalex.org/W1997531619","https://openalex.org/W1998051987","https://openalex.org/W2000208875","https://openalex.org/W2000652317","https://openalex.org/W2001713238","https://openalex.org/W2002186586","https://openalex.org/W2003480749","https://openalex.org/W2008313660","https://openalex.org/W2009417025","https://openalex.org/W2010462935","https://openalex.org/W2011184409","https://openalex.org/W2012219330","https://openalex.org/W2012408584","https://openalex.org/W2012628280","https://openalex.org/W2012738581","https://openalex.org/W2013036001","https://openalex.org/W2013279950","https://openalex.org/W2014215007","https://openalex.org/W2015512183","https://openalex.org/W2017072222","https://openalex.org/W2017132247","https://openalex.org/W2017515991","https://openalex.org/W2020077884","https://openalex.org/W2021820438","https://openalex.org/W2023931058","https://openalex.org/W2025656277","https://openalex.org/W2025864476","https://openalex.org/W2026708020","https://openalex.org/W2026838887","https://openalex.org/W2028467211","https://openalex.org/W2029275361","https://openalex.org/W2029312116","https://openalex.org/W2029836713","https://openalex.org/W2029860358","https://openalex.org/W2030865745","https://openalex.org/W2030922722","https://openalex.org/W2031156245","https://openalex.org/W2031501484","https://openalex.org/W2032674547","https://openalex.org/W2033222990","https://openalex.org/W2035134361","https://openalex.org/W2036500213","https://openalex.org/W2038705787","https://openalex.org/W2038829679","https://openalex.org/W2040507646","https://openalex.org/W2044673785","https://openalex.org/W2044719429","https://openalex.org/W2045427520","https://openalex.org/W2046986081","https://openalex.org/W2047153130","https://openalex.org/W2047851489","https://openalex.org/W2050013893","https://openalex.org/W2051705414","https://openalex.org/W2052172628","https://openalex.org/W2055483105","https://openalex.org/W2058706806","https://openalex.org/W2059938714","https://openalex.org/W2061037495","https://openalex.org/W2062005942","https://openalex.org/W2062222238","https://openalex.org/W2063053561","https://openalex.org/W2063814906","https://openalex.org/W2067049479","https://openalex.org/W2067194336","https://openalex.org/W2068785423","https://openalex.org/W2068871282","https://openalex.org/W2069605909","https://openalex.org/W2070242833","https://openalex.org/W2074664341","https://openalex.org/W2075590385","https://openalex.org/W2077683663","https://openalex.org/W2078105135","https://openalex.org/W2079357798","https://openalex.org/W2079721061","https://openalex.org/W2081003617","https://openalex.org/W2083685529","https://openalex.org/W2084228983","https://openalex.org/W2086715846","https://openalex.org/W2088988430","https://openalex.org/W2089262366","https://openalex.org/W2089301184","https://openalex.org/W2093184750","https://openalex.org/W2093804554","https://openalex.org/W2094111001","https://openalex.org/W2094114663","https://openalex.org/W2096245547","https://openalex.org/W2096661621","https://openalex.org/W2097765112","https://openalex.org/W2100930825","https://openalex.org/W2100938356","https://openalex.org/W2103807332","https://openalex.org/W2103858832","https://openalex.org/W2107860814","https://openalex.org/W2109389988","https://openalex.org/W2109506765","https://openalex.org/W2120464397","https://openalex.org/W2122506044","https://openalex.org/W2122702335","https://openalex.org/W2127048642","https://openalex.org/W2127434853","https://openalex.org/W2128060197","https://openalex.org/W2129362876","https://openalex.org/W2130982757","https://openalex.org/W2132521688","https://openalex.org/W2134582745","https://openalex.org/W2135055828","https://openalex.org/W2138009059","https://openalex.org/W2138807703","https://openalex.org/W2141231618","https://openalex.org/W2142928758","https://openalex.org/W2143760520","https://openalex.org/W2147028876","https://openalex.org/W2147543156","https://openalex.org/W2147766260","https://openalex.org/W2153398168","https://openalex.org/W2153449996","https://openalex.org/W2153469946","https://openalex.org/W2155449991","https://openalex.org/W2155950436","https://openalex.org/W2157376708","https://openalex.org/W2158270563","https://openalex.org/W2158602749","https://openalex.org/W2161538693","https://openalex.org/W2165513989","https://openalex.org/W2165588484","https://openalex.org/W2169649037","https://openalex.org/W2170272569","https://openalex.org/W2170615443","https://openalex.org/W2171801248","https://openalex.org/W2173560213","https://openalex.org/W2175994433","https://openalex.org/W2202501092","https://openalex.org/W2219671181","https://openalex.org/W2263174759","https://openalex.org/W2280192492","https://openalex.org/W2344807959","https://openalex.org/W2395020344","https://openalex.org/W2395212933","https://openalex.org/W2403474134","https://openalex.org/W2410814275","https://openalex.org/W2414190385","https://openalex.org/W2471626689","https://openalex.org/W2765061012","https://openalex.org/W4235751459","https://openalex.org/W4235912108","https://openalex.org/W4240759555","https://openalex.org/W4255278481","https://openalex.org/W4290751260","https://openalex.org/W6745272896"],"related_works":["https://openalex.org/W4388117573","https://openalex.org/W2131666890","https://openalex.org/W1817534450","https://openalex.org/W2150857908","https://openalex.org/W1867656969","https://openalex.org/W2002220979","https://openalex.org/W2626168880","https://openalex.org/W143828381","https://openalex.org/W2093953283","https://openalex.org/W2400329380"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
