{"id":"https://openalex.org/W110291667","doi":null,"title":"The effect of hyperbaric oxygen on growth and chemosensitivity of metastatic prostate cancer.","display_name":"The effect of hyperbaric oxygen on growth and chemosensitivity of metastatic prostate cancer.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W110291667","mag":"110291667","pmid":"https://pubmed.ncbi.nlm.nih.gov/9568104"},"language":"en","primary_location":{"id":"pmid:9568104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9568104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061532837","display_name":"John Kalns","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Kalns","raw_affiliation_strings":["AL/AOH, Brooks Air Force Base, TX 78235-5304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AL/AOH, Brooks Air Force Base, TX 78235-5304, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084776222","display_name":"Lenz Kr\u00f6ck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Krock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027882616","display_name":"Edward H. Piepmeier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Piepmeier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.00587156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"18","issue":"1A","first_page":"363","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.08829999715089798,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperbaric-oxygen-therapy","display_name":"hyperbaric oxygen therapy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8799999952316284},{"id":"https://openalex.org/keywords/metastatic-prostate-cancer","display_name":"metastatic prostate cancer","score":0.8870000243186951},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.9139999747276306},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8930000066757202},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.781000018119812},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.5889999866485596},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/du145-cells","display_name":"DU145 cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-line-dependence","display_name":"cell line dependence","score":0.6600000262260437},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8362247943878174},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.688129186630249},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5821489095687866},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5441750288009644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5402114391326904},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5082873702049255},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.48220980167388916},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.47014477849006653},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.441805899143219},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37291771173477173},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3537771701812744},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2917320728302002}],"mesh":[{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006931","descriptor_name":"Hyperbaric Oxygenation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9568104","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9568104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:110291667","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9568104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2118288391","https://openalex.org/W2591448744","https://openalex.org/W2003642324","https://openalex.org/W2385156513","https://openalex.org/W1967973606","https://openalex.org/W2364795598","https://openalex.org/W2382667778","https://openalex.org/W1961774314","https://openalex.org/W3032799988","https://openalex.org/W2065832872"],"abstract_inverted_index":{"BACKGROUND:":[0],"Currently,":[1],"advanced":[2],"prostate":[3],"cancer":[4],"(CaP)":[5],"is":[6,15],"not":[7,77,105],"curable.":[8],"In":[9],"this":[10],"report":[11],"hyperbaric":[12],"oxygen":[13],"(HBO)":[14],"examined":[16],"as":[17,23],"an":[18],"adjuvant":[19],"to":[20,39,67,82,95,118,144],"chemotherapy":[21],"and":[22,123,141],"a":[24,69,84],"stand-alone":[25],"treatment.":[26],"MATERIALS":[27],"AND":[28],"METHODS:":[29],"CaP":[30],"cell":[31,73,151],"monolayers":[32],"grown":[33],"under":[34,47],"normoxic":[35],"conditions":[36],"were":[37],"exposed":[38],"cisplatin,":[40],"taxol":[41,96],"or":[42,53],"doxorubicin":[43,65],"for":[44],"90":[45],"minutes":[46],"HBO":[48,58,88,109,134],"(3.0":[49],"atmospheres,":[50],"100%":[51],"O2)":[52],"normal":[54],"pressure":[55],"air.":[56],"RESULTS:":[57],"reduced":[59,110],"by":[60,107],"47%":[61],"the":[62,79,90,111,137,148],"concentration":[63,80],"of":[64,92,114,139],"required":[66,81],"produce":[68,83],"20%":[70],"reduction":[71],"in":[72],"numbers,":[74],"but":[75],"did":[76],"change":[78],">":[85],"50%":[86],"reduction.":[87],"increased":[89],"sensitivity":[91,143],"PC-3":[93,124],"cells":[94],"at":[97],"all":[98],"concentrations,":[99],"(mean":[100],"1.8%).":[101],"Cisplatin":[102],"chemosensitivity":[103],"was":[104],"affected":[106],"HBO.":[108],"growth":[112],"rate":[113,138],"DU-145":[115],"8.1%":[116],"relative":[117],"control":[119],"(p":[120,126],"=":[121,127],"0.01),":[122],"2.7%":[125],"0.12).":[128],"CONCLUSIONS:":[129],"This":[130],"study":[131],"shows":[132],"that":[133],"can":[135],"decrease":[136],"growth,":[140],"increase":[142],"anticancer":[145],"agents,":[146],"however,":[147],"effects":[149],"are":[150],"line":[152],"dependent.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
