{"id":"https://openalex.org/W110225692","doi":null,"title":"Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis","display_name":"Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis","publication_year":2008,"publication_date":"2008-04-21","ids":{"openalex":"https://openalex.org/W110225692","mag":"110225692"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/654","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/654","pdf_url":"http://hdl.handle.net/10161/654","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10161/654","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050808615","display_name":"Yishan Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yishan Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5050808615"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac6","display_name":"HDAC6","score":0.9570000171661377},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.871999979019165},{"id":"https://openalex.org/keywords/ras-induced-transformation","display_name":"Ras-induced transformation","score":0.7170000076293945},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.9480000138282776},{"id":"https://openalex.org/keywords/anoikis","display_name":"anoikis","score":0.8429999947547913},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8169999718666077},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.9890000224113464},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.9850000143051147},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.5630000233650208},{"id":"https://openalex.org/keywords/non-histone-protein-acetylation","display_name":"non-histone protein acetylation","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C23681527","wikidata":"https://www.wikidata.org/wiki/Q18034953","display_name":"HDAC6","level":5,"score":0.8643499612808228},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6160508394241333},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5515409111976624},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5094638466835022},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.5018794536590576},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4456605315208435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4313249886035919},{"id":"https://openalex.org/C142354902","wikidata":"https://www.wikidata.org/wiki/Q18047334","display_name":"HDAC10","level":5,"score":0.4275692105293274},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.29441601037979126},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.20630982518196106},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20564386248588562},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0736469030380249}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/654","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/654","pdf_url":"http://hdl.handle.net/10161/654","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:110225692","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/bitstream/10161/654/1/D_Lee_Yishan_a_200805.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/654","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/654","pdf_url":"http://hdl.handle.net/10161/654","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W110225692.pdf","grobid_xml":"https://content.openalex.org/works/W110225692.grobid-xml"},"referenced_works_count":148,"referenced_works":["https://openalex.org/W1489973637","https://openalex.org/W1501663750","https://openalex.org/W1506966309","https://openalex.org/W1515078836","https://openalex.org/W1523601423","https://openalex.org/W1527650585","https://openalex.org/W1533191645","https://openalex.org/W1545398558","https://openalex.org/W1553935027","https://openalex.org/W1563031684","https://openalex.org/W1646199134","https://openalex.org/W1910848366","https://openalex.org/W1943173654","https://openalex.org/W1967018540","https://openalex.org/W1967169951","https://openalex.org/W1968068668","https://openalex.org/W1969268163","https://openalex.org/W1969323007","https://openalex.org/W1969342645","https://openalex.org/W1970658265","https://openalex.org/W1971407164","https://openalex.org/W1972149587","https://openalex.org/W1973023394","https://openalex.org/W1973932456","https://openalex.org/W1974090542","https://openalex.org/W1979479754","https://openalex.org/W1979832500","https://openalex.org/W1982315838","https://openalex.org/W1984690136","https://openalex.org/W1985651419","https://openalex.org/W1986242330","https://openalex.org/W1987341205","https://openalex.org/W1987899161","https://openalex.org/W1990011854","https://openalex.org/W1992740422","https://openalex.org/W1992902970","https://openalex.org/W1993510744","https://openalex.org/W1994637279","https://openalex.org/W1994659747","https://openalex.org/W1995511322","https://openalex.org/W1995676524","https://openalex.org/W1997970296","https://openalex.org/W1999781470","https://openalex.org/W1999931286","https://openalex.org/W2000929246","https://openalex.org/W2002079983","https://openalex.org/W2004980848","https://openalex.org/W2005471059","https://openalex.org/W2006299889","https://openalex.org/W2006916011","https://openalex.org/W2008054969","https://openalex.org/W2009582035","https://openalex.org/W2009899654","https://openalex.org/W2009996200","https://openalex.org/W2012593128","https://openalex.org/W2015579371","https://openalex.org/W2016567695","https://openalex.org/W2030185116","https://openalex.org/W2030205108","https://openalex.org/W2031671750","https://openalex.org/W2031954417","https://openalex.org/W2032183631","https://openalex.org/W2041959419","https://openalex.org/W2042905219","https://openalex.org/W2044578262","https://openalex.org/W2046316599","https://openalex.org/W2047219257","https://openalex.org/W2047782251","https://openalex.org/W2049763628","https://openalex.org/W2049961455","https://openalex.org/W2054848045","https://openalex.org/W2056369410","https://openalex.org/W2056913859","https://openalex.org/W2057303779","https://openalex.org/W2060128629","https://openalex.org/W2062809474","https://openalex.org/W2064247262","https://openalex.org/W2066264051","https://openalex.org/W2067839546","https://openalex.org/W2068213179","https://openalex.org/W2070089404","https://openalex.org/W2071888464","https://openalex.org/W2073423744","https://openalex.org/W2074545297","https://openalex.org/W2076368732","https://openalex.org/W2077293502","https://openalex.org/W2078901327","https://openalex.org/W2081000967","https://openalex.org/W2081774189","https://openalex.org/W2084326457","https://openalex.org/W2085615781","https://openalex.org/W2089425549","https://openalex.org/W2090381051","https://openalex.org/W2090906911","https://openalex.org/W2090926709","https://openalex.org/W2091041925","https://openalex.org/W2092349389","https://openalex.org/W2095939746","https://openalex.org/W2097360510","https://openalex.org/W2101127235","https://openalex.org/W2102458112","https://openalex.org/W2102884982","https://openalex.org/W2104261628","https://openalex.org/W2105095164","https://openalex.org/W2106357158","https://openalex.org/W2106526289","https://openalex.org/W2108230631","https://openalex.org/W2111102277","https://openalex.org/W2111447146","https://openalex.org/W2112351720","https://openalex.org/W2112678922","https://openalex.org/W2114468318","https://openalex.org/W2115232295","https://openalex.org/W2117298794","https://openalex.org/W2118650392","https://openalex.org/W2124374247","https://openalex.org/W2125007784","https://openalex.org/W2125568224","https://openalex.org/W2128151020","https://openalex.org/W2128761802","https://openalex.org/W2130441255","https://openalex.org/W2131675399","https://openalex.org/W2132403739","https://openalex.org/W2133651123","https://openalex.org/W2135830745","https://openalex.org/W2136940817","https://openalex.org/W2137022580","https://openalex.org/W2138072853","https://openalex.org/W2138369573","https://openalex.org/W2140513457","https://openalex.org/W2143591283","https://openalex.org/W2146620343","https://openalex.org/W2147723796","https://openalex.org/W2149099455","https://openalex.org/W2151445954","https://openalex.org/W2155725346","https://openalex.org/W2157293287","https://openalex.org/W2157360354","https://openalex.org/W2161552560","https://openalex.org/W2162075350","https://openalex.org/W2162787110","https://openalex.org/W2166427186","https://openalex.org/W2166907165","https://openalex.org/W2167118090","https://openalex.org/W2170501509","https://openalex.org/W2171524106","https://openalex.org/W2324328780","https://openalex.org/W2569844665"],"related_works":["https://openalex.org/W2123032057","https://openalex.org/W2071559249","https://openalex.org/W2328551301","https://openalex.org/W7101027944","https://openalex.org/W7095347842","https://openalex.org/W2892157567","https://openalex.org/W4402391027","https://openalex.org/W7100450818","https://openalex.org/W7118383681","https://openalex.org/W2101663014"],"abstract_inverted_index":{"Reversible":[0],"acetylation":[1,331],"has":[2,276],"emerged":[3],"as":[4,355],"an":[5,356],"important":[6,357],"post-translational":[7],"modification":[8],"that":[9,114,134,206,252,287,312,329,345],"rivals":[10],"phosphorylation":[11],"in":[12,104,143,155,173,182,192,200,213,226,279,336],"regulating":[13,337],"chromatin":[14],"structure":[15],"and":[16,42,47,72,97,119,128,148,164,194,222,231,275,282,296,301],"gene":[17],"expression.":[18],"Acetylation":[19],"of":[20,44,180,209,228,256,289,294,313,340,363],"histone":[21,35],"is":[22,29,58,93,122,137,217,258,268,322],"associated":[23,218],"with":[24,219],"transcriptional":[25,32,56],"activation":[26,227],"while":[27],"deacetylation":[28],"linked":[30],"to":[31,50,60,160,197,242,270,347],"repression.":[33],"Moreover,":[34],"deacetylase":[36,320],"inhibitors":[37],"induce":[38],"growth":[39,191,212],"arrest,":[40],"differentiation":[41],"apoptosis":[43],"cancer":[45,185],"cells":[46,147,216],"therefore":[48],"appear":[49],"be":[51,61,271],"promising":[52],"anti-tumor":[53,84,361],"agents.":[54],"While":[55,266],"deregulation":[57],"thought":[59],"the":[62,69,207,229,253,262,292,297,308,315,318,360],"main":[63],"mechanism":[64],"underlying":[65,359],"their":[66,83,195],"therapeutic":[67],"effects,":[68],"exact":[70],"mechanisms":[71],"targets":[73],"by":[74,273],"which":[75,78,96],"HDAC":[76,100,316,364],"inhibitors,":[77],"are":[79,102,157,239],"mostly":[80],"non-specific,":[81],"achieve":[82],"effects":[85,362],"remain":[86],"poorly":[87],"understood.":[88],"In":[89,108,303],"other":[90],"words,":[91],"it":[92],"not":[94],"known":[95,269],"how":[98],"each":[99],"members":[101],"involved":[103],"supporting":[105],"tumor":[106,129],"growth.":[107],"this":[109,177,351],"thesis,":[110],"I":[111,131,203,249,284],"have":[112,132,204,250,285],"showed":[113],"HDAC6,":[115],"a":[116,168,224,333],"cytoplasmic":[117,319,343],"localized":[118],"cytoskeleton-associated":[120],"deacetylase,":[121],"required":[123,323],"for":[124,171,324],"efficient":[125,325],"oncogenic":[126,140,162,326],"transformation":[127,142],"formation.":[130],"found":[133,286],"HDAC6":[135,156,172,181,214,236,257,274,290,321,354],"expression":[136],"induced":[138],"upon":[139],"Ras-induced":[141],"both":[144,161],"human":[145,184],"somatic":[146],"murine":[149,152],"fibroblasts.":[150],"Conversely,":[151],"fibroblasts":[153],"deficient":[154,215],"more":[158,240],"resistant":[159,241],"Ras":[163],"ErbB2-dependent":[165],"transformation,":[166,327],"indicating":[167,328],"critical":[169,334],"role":[170,335],"oncogene-induced":[174],"transformation.":[175,349],"Supporting":[176],"hypothesis,":[178],"inactivation":[179],"several":[183],"cell":[186],"lines":[187],"effectively":[188],"impairs":[189,291],"anchorage-independent":[190],"vitro":[193],"ability":[196],"form":[198],"tumors":[199],"immunocompromised":[201],"mice.":[202],"demonstrated":[205,251],"impairment":[208],"anchorage":[210],"independent":[211],"increased":[220],"anoikis":[221],"mechanistically":[223],"defect":[225],"AKT":[230],"ERK":[232],"kinase":[233],"cascades.":[234],"Additionally,":[235],"null":[237],"mice":[238],"two-stage":[243],"chemical":[244],"carcinogen-induced":[245],"skin":[246],"tumors.":[247],"Finally,":[248],"tumor-promoting":[254],"effect":[255],"probably":[259],"mediated":[260],"through":[261],"molecular":[263],"chaperon":[264],"Hsp90.":[265],"Hsp90":[267,300],"deacetylated":[272],"been":[277],"implicated":[278],"stabilizing":[280],"Raf-1":[281,295],"ErbB2,":[283],"suppression":[288],"stability":[293],"association":[298],"between":[299],"ErbB2.":[302],"conclusion,":[304],"my":[305],"work":[306,352],"provides":[307],"first":[309],"experimental":[310],"evidence":[311],"all":[314],"members,":[317],"reversible":[330],"plays":[332],"cellular":[338],"functions":[339],"non-histone":[341],"non-nuclear":[342],"proteins":[344],"contributes":[346],"malignant":[348],"Furthermore,":[350],"identifies":[353],"component":[358],"inhibitors.":[365]},"counts_by_year":[],"updated_date":"2026-09-01T08:31:24.195828","created_date":"2016-06-24T00:00:00"}
