{"id":"https://openalex.org/W110211688","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.543.2","title":"n\u20103 fatty acids are reduced in advanced cancer patients with sarcopenia","display_name":"n\u20103 fatty acids are reduced in advanced cancer patients with sarcopenia","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W110211688","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.543.2","mag":"110211688"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.23.1_supplement.543.2","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.543.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.543.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050606354","display_name":"Rachel A. Murphy","orcid":"https://orcid.org/0000-0003-4383-5641","observed_orcids":["https://orcid.org/0000-0003-4383-5641"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Rachel A Murphy","raw_affiliation_strings":["Agricultural, Food and Nutritional Science University of Alberta Edmonton AB Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agricultural, Food and Nutritional Science University of Alberta Edmonton AB Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086743048","display_name":"Marina Mourtzakis","orcid":"https://orcid.org/0000-0001-7350-0151","observed_orcids":["https://orcid.org/0000-0001-7350-0151"]},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marina Mourtzakis","raw_affiliation_strings":["Department of Kinesiology University of Waterloo Waterloo ON Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology University of Waterloo Waterloo ON Canada","institution_ids":["https://openalex.org/I151746483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101683676","display_name":"Lisa Martin","orcid":"https://orcid.org/0000-0003-4518-7246","observed_orcids":["https://orcid.org/0000-0003-4518-7246"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lisa Martin","raw_affiliation_strings":["Agricultural, Food and Nutritional Science University of Alberta Edmonton AB Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agricultural, Food and Nutritional Science University of Alberta Edmonton AB Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059692750","display_name":"Tony Reiman","orcid":"https://orcid.org/0000-0002-2706-8764","observed_orcids":["https://orcid.org/0000-0002-2706-8764"]},"institutions":[{"id":"https://openalex.org/I4405258411","display_name":"Cross Cancer Institute","ror":"https://ror.org/00m3k3802","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405258411"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tony Reiman","raw_affiliation_strings":["Department of Oncology Cross Cancer Institute Edmonton AB Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology Cross Cancer Institute Edmonton AB Canada","institution_ids":["https://openalex.org/I4405258411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111404663","display_name":"Tom MT Clandinin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tom MT Clandinin","raw_affiliation_strings":["Agricultural, Food and Nutritional Science University of Alberta Edmonton AB Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agricultural, Food and Nutritional Science University of Alberta Edmonton AB Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085437923","display_name":"Vera Christine Mazurak","orcid":"https://orcid.org/0000-0002-7724-6354","observed_orcids":["https://orcid.org/0000-0002-7724-6354"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vera C Mazurak","raw_affiliation_strings":["Agricultural, Food and Nutritional Science University of Alberta Edmonton AB Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Agricultural, Food and Nutritional Science University of Alberta Edmonton AB Canada","institution_ids":["https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02093145,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.5449000000953674,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.43799999356269836,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.878000020980835},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/plasma-phospholipids","display_name":"plasma phospholipids","score":0.9070000052452087},{"id":"https://openalex.org/keywords/n-6-n-3-ratio","display_name":"n-6/n-3 ratio","score":0.9340000152587891},{"id":"https://openalex.org/keywords/skeletal-muscle-cross-sectional-area","display_name":"skeletal muscle area","score":0.9589999914169312},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.652999997138977},{"id":"https://openalex.org/keywords/advanced-cancer","display_name":"advanced cancer","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.9040613770484924},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5813302397727966},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5287444591522217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5228950381278992},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5188666582107544},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4826577305793762},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45935583114624023},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45802175998687744},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.43962469696998596},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.42001429200172424},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4127885699272156},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32096660137176514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28358161449432373}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.23.1_supplement.543.2","doi":"https://doi.org/10.1096/fasebj.23.1_supplement.543.2","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.23.1_supplement.543.2","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2148538398","https://openalex.org/W4311564976","https://openalex.org/W1975173686","https://openalex.org/W3170416546","https://openalex.org/W2751661695","https://openalex.org/W2036519502","https://openalex.org/W4400691640","https://openalex.org/W3088165492","https://openalex.org/W1964113171","https://openalex.org/W3139094650"],"abstract_inverted_index":{"Little":[0],"is":[1,22,45],"known":[2],"about":[3],"the":[4,35,174],"essential":[5,201],"fatty":[6,58,129,139,191,202],"acid":[7,203],"status":[8,42],"of":[9,19,49,63,128,141],"cancer":[10,44,68],"patients":[11,180],"at":[12],"diagnosis":[13],"and":[14,27,31,40,56,126,159,200],"throughout":[15],"treatment.":[16],"Sarcopenia":[17],"(depletion":[18],"skeletal":[20,71],"muscle)":[21],"associated":[23],"with":[24,155,181],"physical":[25],"disability":[26],"mortality":[28],"in":[29,43,60,166,173,186],"aging":[30],"chronic":[32],"diseases":[33],"but":[34],"relationship":[36,196],"between":[37,197],"body":[38],"composition":[39],"nutritional":[41],"unclear.":[46],"The":[47],"objective":[48],"this":[50],"study":[51],"was":[52,76],"to":[53,106],"measure":[54],"n\u20103":[55,138,190],"n\u20106":[57],"acids":[59,130,140],"plasma":[61,119],"phospholipids":[62],"advanced":[64],"non\u2010small":[65],"cell":[66],"lung":[67],"patients.":[69],"Total":[70,137],"muscle":[72,198],"cross\u2010sectional":[73],"area":[74],"(n=22)":[75],"evaluated":[77],"using":[78,121,133],"lumbar":[79],"CT":[80],"images.":[81],"Cut\u2010points":[82],"[?:":[83],"<55.4":[84],"cm":[85],"2":[86,88,92,94],"/m":[87,93],";":[89,95],"?:":[90],"<38.9cm":[91],"Mourtzakis":[96],"et":[97],"al":[98],"Appl":[99],"Physiol":[100],"Nutr":[101],"Metabol":[102],"2008]":[103],"were":[104,116,131,144],"used":[105],"classify":[107],"subjects":[108,143,148],"as":[109],"sarcopenic":[110,142,175],"(n=13)":[111],"or":[112],"non\u2010sarcopenic":[113,147,177],"(n=9).":[114],"Phospholipids":[115],"isolated":[117],"from":[118],"lipids":[120],"thin":[122],"layer":[123],"chromatography.":[124,136],"Amounts":[125],"types":[127],"determined":[132],"gas":[134],"liquid":[135],"lower":[145,157,161],"than":[146],"(16\u00b111\u00b5g/mL":[149],"versus":[150,176],"35\u00b110":[151],"\u00b5g/mL,":[152],"p":[153],"=0.001),":[154],"45%":[156],"20:5n\u20103(p=0.005)":[158],"54%":[160],"22:6n\u20103":[162],"(p=0.0098).":[163],"This":[164],"resulted":[165],"a":[167],"two\u2010fold":[168],"higher":[169],"n6:n3":[170],"ratio":[171],"(p=0.05)":[172],"subjects.":[178],"Cancer":[179],"sarcopenia":[182],"have":[183],"pronounced":[184],"alterations":[185],"lipid":[187],"metabolism,":[188],"specifically":[189],"acids,":[192],"suggesting":[193],"an":[194],"important":[195],"atrophy":[199],"metabolism.":[204],"(Supported":[205],"by":[206],"CIHR).":[207],"Grant":[208],"Funding":[209],"Source":[210],"Canadian":[211],"Institute":[212],"for":[213],"Health":[214],"Research":[215]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}