{"id":"https://openalex.org/W110127617","doi":null,"title":"STAT3 in EGF Receptor-Mediated Fibroblast and Human Prostate Cancer Cell Migration, Invasion and Apoptosis.","display_name":"STAT3 in EGF Receptor-Mediated Fibroblast and Human Prostate Cancer Cell Migration, Invasion and Apoptosis.","publication_year":2006,"publication_date":"2006-09-29","ids":{"openalex":"https://openalex.org/W110127617","mag":"110127617"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9398","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/9398/1/WeixinZhou_PhD_Dessertation_Sep2006.pdf","pdf_url":"https://d-scholarship.pitt.edu/9398/1/WeixinZhou_PhD_Dessertation_Sep2006.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068653431","display_name":"Weixin Zhou","orcid":"https://orcid.org/0000-0002-7869-1329","observed_orcids":["https://orcid.org/0000-0002-7869-1329"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Weixin Zhou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7869-1329","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068653431"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2401,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.53022324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9879999756813049},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9710000157356262},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9710000157356262},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9240000247955322},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ena-vasp","display_name":"Ena/VASP","score":0.8870000243186951},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9700000286102295},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.7300000190734863},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.8939999938011169},{"id":"https://openalex.org/keywords/dominant-negative-stat3","display_name":"dominant-negative STAT3","score":0.8059999942779541},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.6240000128746033},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.8229525685310364},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.6648451089859009},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6254604458808899},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.5522763133049011},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5369906425476074},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5304110646247864},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5051699280738831},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47433772683143616},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.4540766179561615},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.43031662702560425},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42788901925086975},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4132738709449768},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.36398306488990784},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31903788447380066},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2841329574584961},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05829739570617676},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:9398","doi":null,"is_oa":false,"landing_page_url":"https://d-scholarship.pitt.edu/9398/1/WeixinZhou_PhD_Dessertation_Sep2006.pdf","pdf_url":"https://d-scholarship.pitt.edu/9398/1/WeixinZhou_PhD_Dessertation_Sep2006.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:110127617","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/9398/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.766700029373169,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":259,"referenced_works":["https://openalex.org/W10321726","https://openalex.org/W20591230","https://openalex.org/W51995314","https://openalex.org/W68140810","https://openalex.org/W90292846","https://openalex.org/W101504470","https://openalex.org/W147424315","https://openalex.org/W148785554","https://openalex.org/W159302622","https://openalex.org/W160696900","https://openalex.org/W168754456","https://openalex.org/W198016200","https://openalex.org/W200233233","https://openalex.org/W204871574","https://openalex.org/W573858133","https://openalex.org/W1419228847","https://openalex.org/W1483520515","https://openalex.org/W1496109170","https://openalex.org/W1505887721","https://openalex.org/W1510677782","https://openalex.org/W1514463309","https://openalex.org/W1524333424","https://openalex.org/W1524954611","https://openalex.org/W1531144232","https://openalex.org/W1537655271","https://openalex.org/W1537774091","https://openalex.org/W1540744482","https://openalex.org/W1549646721","https://openalex.org/W1550156431","https://openalex.org/W1550703182","https://openalex.org/W1553277501","https://openalex.org/W1554900315","https://openalex.org/W1562699269","https://openalex.org/W1566160921","https://openalex.org/W1568614184","https://openalex.org/W1574875334","https://openalex.org/W1581824974","https://openalex.org/W1594278877","https://openalex.org/W1596261235","https://openalex.org/W1597721077","https://openalex.org/W1599507049","https://openalex.org/W1599518523","https://openalex.org/W1601571585","https://openalex.org/W1821858011","https://openalex.org/W1866851443","https://openalex.org/W1895473399","https://openalex.org/W1965234951","https://openalex.org/W1966658428","https://openalex.org/W1967265143","https://openalex.org/W1969781490","https://openalex.org/W1969974964","https://openalex.org/W1970004730","https://openalex.org/W1970174108","https://openalex.org/W1971766102","https://openalex.org/W1975514265","https://openalex.org/W1975577875","https://openalex.org/W1976206562","https://openalex.org/W1976500290","https://openalex.org/W1977635166","https://openalex.org/W1981799488","https://openalex.org/W1982757682","https://openalex.org/W1983878009","https://openalex.org/W1984530168","https://openalex.org/W1986926262","https://openalex.org/W1989992071","https://openalex.org/W1990487063","https://openalex.org/W1990896527","https://openalex.org/W1991972636","https://openalex.org/W1991982116","https://openalex.org/W1992569957","https://openalex.org/W1993016783","https://openalex.org/W1993059245","https://openalex.org/W1993805992","https://openalex.org/W1995746818","https://openalex.org/W1997169885","https://openalex.org/W1997935194","https://openalex.org/W1998052292","https://openalex.org/W1998418805","https://openalex.org/W1999468766","https://openalex.org/W2000193607","https://openalex.org/W2000630926","https://openalex.org/W2000707284","https://openalex.org/W2002930632","https://openalex.org/W2004698019","https://openalex.org/W2004759810","https://openalex.org/W2004805882","https://openalex.org/W2006077720","https://openalex.org/W2006591827","https://openalex.org/W2006778638","https://openalex.org/W2007897471","https://openalex.org/W2008061301","https://openalex.org/W2008111891","https://openalex.org/W2008940139","https://openalex.org/W2009117970","https://openalex.org/W2010174111","https://openalex.org/W2012709757","https://openalex.org/W2013121253","https://openalex.org/W2013878898","https://openalex.org/W2014718912","https://openalex.org/W2015039243","https://openalex.org/W2018317768","https://openalex.org/W2019787042","https://openalex.org/W2020011192","https://openalex.org/W2020948529","https://openalex.org/W2021430758","https://openalex.org/W2021450679","https://openalex.org/W2021538232","https://openalex.org/W2023423199","https://openalex.org/W2024282024","https://openalex.org/W2024893787","https://openalex.org/W2028317903","https://openalex.org/W2029548655","https://openalex.org/W2032674547","https://openalex.org/W2034558617","https://openalex.org/W2035134361","https://openalex.org/W2036363901","https://openalex.org/W2038086562","https://openalex.org/W2040712355","https://openalex.org/W2040774413","https://openalex.org/W2041204531","https://openalex.org/W2041688913","https://openalex.org/W2043188148","https://openalex.org/W2043471865","https://openalex.org/W2043557683","https://openalex.org/W2043911313","https://openalex.org/W2044991100","https://openalex.org/W2045630690","https://openalex.org/W2047700479","https://openalex.org/W2048499812","https://openalex.org/W2048758017","https://openalex.org/W2050085005","https://openalex.org/W2051638902","https://openalex.org/W2053222369","https://openalex.org/W2053431375","https://openalex.org/W2054410176","https://openalex.org/W2054571512","https://openalex.org/W2054821802","https://openalex.org/W2055404742","https://openalex.org/W2056862346","https://openalex.org/W2057409901","https://openalex.org/W2057458801","https://openalex.org/W2058839845","https://openalex.org/W2061671663","https://openalex.org/W2061701210","https://openalex.org/W2061761105","https://openalex.org/W2063495408","https://openalex.org/W2067894718","https://openalex.org/W2067976180","https://openalex.org/W2071442472","https://openalex.org/W2071787119","https://openalex.org/W2072493113","https://openalex.org/W2074356752","https://openalex.org/W2076932525","https://openalex.org/W2077489546","https://openalex.org/W2080448841","https://openalex.org/W2080490195","https://openalex.org/W2080908680","https://openalex.org/W2081040018","https://openalex.org/W2082454341","https://openalex.org/W2082768010","https://openalex.org/W2083162753","https://openalex.org/W2083354090","https://openalex.org/W2083802827","https://openalex.org/W2085254573","https://openalex.org/W2088094960","https://openalex.org/W2088357471","https://openalex.org/W2089109453","https://openalex.org/W2089415609","https://openalex.org/W2090217559","https://openalex.org/W2090944800","https://openalex.org/W2091549056","https://openalex.org/W2092351058","https://openalex.org/W2092970174","https://openalex.org/W2093953283","https://openalex.org/W2093986699","https://openalex.org/W2095554214","https://openalex.org/W2097617128","https://openalex.org/W2097765112","https://openalex.org/W2099708088","https://openalex.org/W2100429833","https://openalex.org/W2100794900","https://openalex.org/W2101849511","https://openalex.org/W2104206284","https://openalex.org/W2104938227","https://openalex.org/W2106000067","https://openalex.org/W2107631090","https://openalex.org/W2109145995","https://openalex.org/W2109960839","https://openalex.org/W2110425570","https://openalex.org/W2110807341","https://openalex.org/W2111620927","https://openalex.org/W2112810120","https://openalex.org/W2113901436","https://openalex.org/W2114068656","https://openalex.org/W2114445658","https://openalex.org/W2114829414","https://openalex.org/W2114934533","https://openalex.org/W2115427861","https://openalex.org/W2116555647","https://openalex.org/W2117847301","https://openalex.org/W2118310862","https://openalex.org/W2118375252","https://openalex.org/W2119529835","https://openalex.org/W2120286360","https://openalex.org/W2122782850","https://openalex.org/W2124043243","https://openalex.org/W2125255772","https://openalex.org/W2126818181","https://openalex.org/W2127170661","https://openalex.org/W2128245496","https://openalex.org/W2129895548","https://openalex.org/W2130940092","https://openalex.org/W2131711802","https://openalex.org/W2131979522","https://openalex.org/W2133638944","https://openalex.org/W2135422811","https://openalex.org/W2135547546","https://openalex.org/W2136579137","https://openalex.org/W2137330819","https://openalex.org/W2142391389","https://openalex.org/W2143536404","https://openalex.org/W2143651667","https://openalex.org/W2145269260","https://openalex.org/W2146579454","https://openalex.org/W2146889623","https://openalex.org/W2147284446","https://openalex.org/W2152869893","https://openalex.org/W2153992286","https://openalex.org/W2154189008","https://openalex.org/W2154554776","https://openalex.org/W2154799225","https://openalex.org/W2155361926","https://openalex.org/W2155653297","https://openalex.org/W2157151771","https://openalex.org/W2160459513","https://openalex.org/W2160503216","https://openalex.org/W2163046152","https://openalex.org/W2163252214","https://openalex.org/W2166229810","https://openalex.org/W2166530541","https://openalex.org/W2169290377","https://openalex.org/W2298026931","https://openalex.org/W2317698610","https://openalex.org/W2330613186","https://openalex.org/W2396070671","https://openalex.org/W2402598407","https://openalex.org/W2403474134","https://openalex.org/W2405123561","https://openalex.org/W2407535820","https://openalex.org/W2410688503","https://openalex.org/W2411965421","https://openalex.org/W2414949282","https://openalex.org/W2417161684","https://openalex.org/W2418880833","https://openalex.org/W2424913525","https://openalex.org/W2427404155","https://openalex.org/W2432513752","https://openalex.org/W2475324104","https://openalex.org/W4298355764"],"related_works":["https://openalex.org/W2146889623","https://openalex.org/W2141235890","https://openalex.org/W2006382528","https://openalex.org/W1983878009","https://openalex.org/W2053668040","https://openalex.org/W2047700479","https://openalex.org/W1481048846","https://openalex.org/W2124043243","https://openalex.org/W6977666432","https://openalex.org/W1963585816"],"abstract_inverted_index":{"Growth":[0],"factor-induced":[1],"migration":[2],"is":[3,76,161],"a":[4,53,118,136,174,186,194,205,242,264],"rate-limiting":[5],"step":[6],"in":[7,34,40,80,88,128,145,204,222,241],"tumor":[8,23,239,271,277],"invasiveness.":[9],"The":[10,139],"molecules":[11],"that":[12,63,70,159,211,232,259],"regulate":[13],"this":[14],"cellular":[15,66],"behavior":[16],"would":[17],"represent":[18],"novel":[19],"targets":[20],"for":[21,166,267],"limiting":[22,269],"cell":[24,95,122,189,228,272],"progression.":[25],"Epidermal":[26],"growth":[27],"factor":[28],"(EGF)":[29],"receptor":[30],"(EGFR)-mediated":[31],"motility,":[32,190],"present":[33],"both":[35,184,268],"autocrine":[36],"and":[37,75,82,133,191,274],"paracrine":[38],"modes":[39],"prostate":[41,85,226,270],"carcinomas,":[42],"requires":[43,213],"de":[44],"novo":[45],"transcription":[46],"to":[47,90,216,238,250,279],"persist":[48],"over":[49],"times":[50],"greater":[51],"than":[52],"few":[54],"hours.":[55],"Therefore,":[56],"we":[57],"sought":[58],"the":[59,91,146,153,180,218,223,247,253,276],"specific":[60],"signaling":[61,234,261],"pathways":[62],"directly":[64,72],"alter":[65],"transcription.":[67],"We":[68],"confirmed":[69],"STAT3":[71,108,144,160,214,233,260],"associates":[73],"with,":[74],"activated":[77,143],"by":[78,110,126,202,245],"EGFR":[79],"DU-145":[81],"PC3":[83],"human":[84,225],"carcinoma":[86],"cells":[87,248,278],"addition":[89],"model":[92],"NR6":[93],"fibroblast":[94],"line.":[96],"This":[97,230],"correlated":[98],"with":[99],"electrophoretic":[100],"motility":[101,123],"shift":[102],"of":[103,107,117,141,148,176,183,188,196,220,255],"STAT3-selective":[104],"oligonucleotides.":[105],"Inhibition":[106],"activity":[109],"antisense":[111],"or":[112,115],"siRNA":[113],"down-regulation":[114],"expression":[116,140],"dominant-negative":[119],"construct":[120],"limited":[121],"as":[124],"determined":[125],"an":[127],"vitro":[129],"wound":[130],"healing":[131],"assay":[132],"invasiveness":[134],"through":[135],"matrix":[137],"barrier.":[138],"constitutively":[142],"absence":[147],"EGF":[149,203,212],"did":[150],"not":[151,164],"increase":[152],"migration.":[154,168],"Together":[155],"these":[156,256],"data":[157,209],"indicate":[158],"necessary":[162],"but":[163],"sufficient":[165],"EGFR-mediated":[167],"An":[169],"initial":[170],"gene":[171],"array":[172],"detected":[173],"number":[175],"candidate":[177],"operative":[178],"molecules;":[179],"protein":[181],"levels":[182],"ENA/VASP,":[185],"repressor":[187],"caspase":[192],"3,":[193],"nexus":[195],"apoptotic":[197],"signaling,":[198],"were":[199],"down":[200],"regulated":[201],"STAT3-dependent":[206],"manner.":[207],"Preliminary":[208],"show":[210],"functioning":[215],"inhibit":[217],"induction":[219],"apoptosis":[221],"two":[224],"cancer":[227],"lines.":[229],"suggests":[231],"may":[235,262],"be":[236,263,280],"contributing":[237],"progression":[240],"second":[243],"manner":[244],"rendering":[246],"resistant":[249],"death.":[251],"Together,":[252],"sum":[254],"findings":[257],"suggest":[258],"new":[265],"target":[266],"invasion":[273],"enabling":[275],"killed.":[281]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
