{"id":"https://openalex.org/W110079774","doi":"https://doi.org/10.1007/978-1-62703-005-2_3","title":"Perspectives on Methodology for In Vitro Culture of Helicobacter pylori","display_name":"Perspectives on Methodology for In Vitro Culture of Helicobacter pylori","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W110079774","doi":"https://doi.org/10.1007/978-1-62703-005-2_3","mag":"110079774","pmid":"https://pubmed.ncbi.nlm.nih.gov/23015486","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3921885"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-62703-005-2_3","doi":"https://doi.org/10.1007/978-1-62703-005-2_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-62703-005-2_3","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4236644981","display_name":"Helicobacter Species"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3921885","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017198868","display_name":"Timothy L. Cover","orcid":"https://orcid.org/0000-0001-8503-002X","observed_orcids":["https://orcid.org/0000-0001-8503-002X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy L. Cover","raw_affiliation_strings":["Department of Medicine and Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA. timothy.l.cover@vanderbilt.edu","Department of Medicine and Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA. timothy.l.cover@vanderbilt.edu","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Medicine and Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017198868"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":16.7697,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.98862187,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"921","issue":null,"first_page":"11","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":1.0},{"id":"https://openalex.org/keywords/in-vitro-culture","display_name":"in vitro culture","score":0.984000027179718},{"id":"https://openalex.org/keywords/chemically-defined-media","display_name":"chemically defined medium","score":0.847000002861023},{"id":"https://openalex.org/keywords/microaerophilic-bacteria","display_name":"microaerophilic bacteria","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bacterial-growth-requirements","display_name":"bacterial growth requirements","score":0.6840000152587891},{"id":"https://openalex.org/keywords/bacterial-metabolism","display_name":"bacterial metabolism","score":0.777999997138977},{"id":"https://openalex.org/keywords/bacterial-physiology","display_name":"bacterial physiology","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.8521275520324707},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.8253055810928345},{"id":"https://openalex.org/C125138405","wikidata":"https://www.wikidata.org/wiki/Q548321","display_name":"Microaerophile","level":3,"score":0.72799152135849},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6951939463615417},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6440213322639465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49610862135887146},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.23862522840499878},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10465127229690552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09421062469482422}],"mesh":[{"descriptor_ui":"D000362","descriptor_name":"Agar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007753","descriptor_name":"Laboratories","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D046508","descriptor_name":"Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1007/978-1-62703-005-2_3","doi":"https://doi.org/10.1007/978-1-62703-005-2_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-62703-005-2_3","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:23015486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23015486","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2905782","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3921885","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3921885","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3921885","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Methods Mol Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2905782","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3921885","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1210968838","display_name":"Structure and function of Helicobacter pylori VacA","funder_award_id":"R01AI039657","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G283333078","display_name":"Analysis of the H. Pylori cag pathogenicity island","funder_award_id":"R01AI068009","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000895449","display_name":"H. pylori-induced Inflammation and Gastric Cancer","funder_award_id":"P01CA116087","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1519181981","https://openalex.org/W1525007623","https://openalex.org/W1536054086","https://openalex.org/W1542190884","https://openalex.org/W1965150496","https://openalex.org/W1982594309","https://openalex.org/W2015678282","https://openalex.org/W2018119252","https://openalex.org/W2027177710","https://openalex.org/W2041543306","https://openalex.org/W2054229149","https://openalex.org/W2069042155","https://openalex.org/W2081605326","https://openalex.org/W2102586400","https://openalex.org/W2105424869","https://openalex.org/W2108750208","https://openalex.org/W2119425498","https://openalex.org/W2135438086","https://openalex.org/W2137795821","https://openalex.org/W2139208404","https://openalex.org/W2140131034","https://openalex.org/W2143107875","https://openalex.org/W2143704499","https://openalex.org/W2148190806","https://openalex.org/W2148346877","https://openalex.org/W2157793061","https://openalex.org/W2167404763","https://openalex.org/W2168591421","https://openalex.org/W2171409270","https://openalex.org/W2171798710","https://openalex.org/W2256770182"],"related_works":["https://openalex.org/W3017093102","https://openalex.org/W2382287035","https://openalex.org/W166267863","https://openalex.org/W4416353672","https://openalex.org/W2949294026","https://openalex.org/W2127478904","https://openalex.org/W2139208404","https://openalex.org/W2309766759","https://openalex.org/W2392536963","https://openalex.org/W2350454318"],"abstract_inverted_index":{"Over":[0],"the":[1,48],"past":[2],"25":[3],"years,":[4],"a":[5,22],"variety":[6],"of":[7,14,36,55],"methods":[8],"have":[9],"been":[10],"developed":[11],"for":[12],"culture":[13,33],"Helicobacter":[15],"pylori":[16,20,38],"in":[17,40],"vitro.":[18],"H.":[19,37],"is":[21,28],"capnophilic":[23],"and":[24,52],"microaerophilic":[25],"organism":[26],"that":[27],"typically":[29],"cultured":[30],"using":[31],"complex":[32],"media.":[34],"Analysis":[35],"growth":[39],"chemically":[41],"defined":[42],"media":[43],"has":[44],"provided":[45],"insight":[46],"into":[47],"nutritional":[49],"requirements,":[50],"physiology,":[51],"metabolic":[53],"capacities":[54],"this":[56],"organism.":[57]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}