{"id":"https://openalex.org/W109728801","doi":null,"title":"PLX4032 resistance mechanisms in B-RAF V600E positive melanoma","display_name":"PLX4032 resistance mechanisms in B-RAF V600E positive melanoma","publication_year":2012,"publication_date":"2012-08-31","ids":{"openalex":"https://openalex.org/W109728801","mag":"109728801"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/254232","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/254232","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076742062","display_name":"Lennart A. Kester","orcid":"https://orcid.org/0000-0002-8259-9971","observed_orcids":["https://orcid.org/0000-0002-8259-9971"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lennart Kester","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8259-9971","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5076742062"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vemurafenib","display_name":"vemurafenib","score":0.9670000076293945},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.8999999761581421},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.6700000166893005},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.800000011920929},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6111673712730408},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.47957080602645874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42503461241722107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3419884443283081},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28120163083076477},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.101616770029068}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/254232","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl:8080/handle/1874/254232","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Master thesis"},{"id":"mag:109728801","doi":null,"is_oa":false,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/254232","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2032211985","https://openalex.org/W2323386707","https://openalex.org/W2164850852","https://openalex.org/W2314618748","https://openalex.org/W2141674733","https://openalex.org/W1560370693","https://openalex.org/W1989570273","https://openalex.org/W2129245282","https://openalex.org/W1217284267","https://openalex.org/W6990527190"],"abstract_inverted_index":{"Metastatic":[0],"melanoma":[1,111,129],"is":[2,15,61,74,120,135],"one":[3,16],"of":[4,9,17,48,79,109,114,124,138],"the":[5,18,81,85,107,110],"most":[6,19],"aggressive":[7],"forms":[8],"cancer.":[10],"The":[11],"B-RAF":[12,32,53],"V600E":[13,33,54],"mutation":[14],"common":[20],"driver":[21],"mutations":[22],"observed":[23,44],"in":[24,98],"melanoma.":[25],"Clinical":[26],"trials":[27],"with":[28],"a":[29,121,133,136,150],"recently":[30],"discovered":[31],"specific":[34],"inhibitor,":[35],"PLX4032,":[36],"yielded":[37],"great":[38],"initial":[39],"results,":[40],"however":[41],"relapses":[42],"were":[43],"after":[45],"an":[46],"average":[47],"7":[49],"months.":[50],"Understanding":[51],"how":[52,153],"positive":[55],"melanomas":[56,156],"become":[57],"resistant":[58,155],"to":[59,64,72,91,100,103],"PLX4032":[60,73,92,154],"tremendously":[62],"important":[63],"improve":[65],"therapy.":[66],"Recent":[67],"work":[68,142],"shows":[69],"cellular":[70,89],"resistance":[71,90],"often":[75],"mediated":[76],"by":[77],"hyperactivation":[78],"either":[80],"MAPK":[82],"pathway":[83],"or":[84,126],"PI3K":[86],"pathway.":[87],"Besides":[88],"cells":[93,112,125],"require":[94],"tumor":[95,115,134],"initiating":[96],"capacities":[97],"order":[99],"give":[101],"rise":[102],"relapsing":[104],"tumors.":[105],"However,":[106],"identity":[108],"capable":[113],"reinitiation":[116],"and":[117],"whether":[118,127],"this":[119,144],"rare":[122],"population":[123],"any":[128],"cell":[130],"can":[131],"reinitiate":[132],"matter":[137,145],"debate.":[139],"Here,":[140],"recent":[141],"on":[143,152],"will":[146,158],"be":[147,159],"discussed.":[148],"Finally,":[149],"model":[151],"arise":[157],"proposed.":[160]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
