{"id":"https://openalex.org/W109317992","doi":"https://doi.org/10.3748/wjg.v12.i26.4241","title":"Expression of angiopoietins, Tie2 and vascular endothelial growth factor in angiogenesis and progression of hepatocellular carcinoma","display_name":"Expression of angiopoietins, Tie2 and vascular endothelial growth factor in angiogenesis and progression of hepatocellular carcinoma","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W109317992","doi":"https://doi.org/10.3748/wjg.v12.i26.4241","mag":"109317992","pmid":"https://pubmed.ncbi.nlm.nih.gov/16830384","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4087383"},"language":"en","primary_location":{"id":"doi:10.3748/wjg.v12.i26.4241","doi":"https://doi.org/10.3748/wjg.v12.i26.4241","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v12.i26.4241","pdf_url":"https://www.wjgnet.com/1007-9327/full/v12/i26/4241.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.wjgnet.com/1007-9327/full/v12/i26/4241.htm","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101567793","display_name":"Zhonglin Zhang","orcid":"https://orcid.org/0000-0002-5434-0022","observed_orcids":["https://orcid.org/0000-0002-5434-0022"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhong-Lin Zhang","raw_affiliation_strings":["Department of General Surgery, Zhongnan Hospital, Wuhan University, No. 169, Donghu Road, Wuhan 430071, Hubei Province, China. zhangzhonglin221@sina.com","Department of General Surgery, Zhongnan Hospital, Wuhan University, No. 169, Donghu Road, Wuhan 430071, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Zhongnan Hospital, Wuhan University, No. 169, Donghu Road, Wuhan 430071, Hubei Province, China. zhangzhonglin221@sina.com","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210120234"]},{"raw_affiliation_string":"Department of General Surgery, Zhongnan Hospital, Wuhan University, No. 169, Donghu Road, Wuhan 430071, Hubei Province, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210120234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101567793"],"corresponding_institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210120234"],"apc_list":null,"apc_paid":null,"fwci":2.4702,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.88664399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"26","first_page":"4241","last_page":"4241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/angiopoietin-1","display_name":"angiopoietin-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tie2","display_name":"Tie2","score":0.7360000014305115},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.7509999871253967},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.7540000081062317},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.7360000014305115},{"id":"https://openalex.org/keywords/clinicopathological-features","display_name":"clinicopathological features","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C85219853","wikidata":"https://www.wikidata.org/wiki/Q4763284","display_name":"Angiopoietin receptor","level":3,"score":0.8577244877815247},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8144505023956299},{"id":"https://openalex.org/C2779094623","wikidata":"https://www.wikidata.org/wiki/Q539710","display_name":"Angiopoietin","level":4,"score":0.7926740646362305},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7510732412338257},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6500566601753235},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6169338226318359},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.5728161334991455},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4897923469543457},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42896631360054016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42249324917793274},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.4213279187679291},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3817236125469208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36430853605270386},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.1285441517829895},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12540408968925476},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.08001750707626343},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042682","descriptor_name":"Angiopoietins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042682","descriptor_name":"Angiopoietins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042683","descriptor_name":"Angiopoietin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042683","descriptor_name":"Angiopoietin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042702","descriptor_name":"Angiopoietin-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042702","descriptor_name":"Angiopoietin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042787","descriptor_name":"Receptor, TIE-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042787","descriptor_name":"Receptor, TIE-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3748/wjg.v12.i26.4241","doi":"https://doi.org/10.3748/wjg.v12.i26.4241","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v12.i26.4241","pdf_url":"https://www.wjgnet.com/1007-9327/full/v12/i26/4241.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3092683","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4087383","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4087383","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4087383","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastroenterol","raw_type":"Text"},{"id":"pmid:16830384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16830384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastroenterology","raw_type":"Journal Article"},{"id":"mag:3149516158","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/84123X/200626/22422666.html","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e16\u754c\u80c3\u80a0\u75c5\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248\uff08\u7535\u5b50\u7248\uff09","raw_type":null}],"best_oa_location":{"id":"doi:10.3748/wjg.v12.i26.4241","doi":"https://doi.org/10.3748/wjg.v12.i26.4241","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.v12.i26.4241","pdf_url":"https://www.wjgnet.com/1007-9327/full/v12/i26/4241.htm","source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320324116","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17"},{"id":"https://openalex.org/F4320329542","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79"},{"id":"https://openalex.org/F4320335642","display_name":"Institute of Hydrobiology","ror":"https://ror.org/00b4mx203"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W109317992.pdf","grobid_xml":"https://content.openalex.org/works/W109317992.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1558726098","https://openalex.org/W1868957569","https://openalex.org/W1968557245","https://openalex.org/W1970017082","https://openalex.org/W1970614272","https://openalex.org/W1977721830","https://openalex.org/W1986154258","https://openalex.org/W1998485988","https://openalex.org/W2006298485","https://openalex.org/W2008992685","https://openalex.org/W2020519615","https://openalex.org/W2024674016","https://openalex.org/W2028572934","https://openalex.org/W2029034327","https://openalex.org/W2030418468","https://openalex.org/W2048204452","https://openalex.org/W2048306047","https://openalex.org/W2050499474","https://openalex.org/W2055220513","https://openalex.org/W2058128032","https://openalex.org/W2063938081","https://openalex.org/W2066888615","https://openalex.org/W2071068908","https://openalex.org/W2079422506","https://openalex.org/W2079464218","https://openalex.org/W2086619383","https://openalex.org/W2126553185","https://openalex.org/W2130517135","https://openalex.org/W2138687800","https://openalex.org/W2152215024","https://openalex.org/W2161084513","https://openalex.org/W2319962899"],"related_works":["https://openalex.org/W2362718221","https://openalex.org/W2020519615","https://openalex.org/W2384979844","https://openalex.org/W2361050192","https://openalex.org/W2363119151","https://openalex.org/W2374568147","https://openalex.org/W2384785257","https://openalex.org/W2081557581","https://openalex.org/W2116855809","https://openalex.org/W1481008419"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"investigate":[2],"the":[3,16,80,112,141,164,246],"significance":[4,139,172],"of":[5,20,29,45,68,87,106,143,180,248,260,278],"angiopoietins,":[6],"Tie2":[7,167,223,243],"and":[8,18,31,43,51,73,79,83,94,116,126,128,147,166,189,202,222,258,276],"vascular":[9],"endothelial":[10],"growth":[11],"factor":[12],"(VEGF)":[13],"expression":[14,44,92,239],"in":[15,71,85,140,150,157,183,225,245,254,270],"angiogenesis":[17,86,275],"progress":[19],"hepatocellular":[21,264],"carcinoma":[22],"(HCC).":[23],"METHODS:":[24],"Fresh":[25],"surgically":[26],"resected":[27],"specimens":[28,76],"HCC":[30,40,72,88,151,184,272],"noncancerous":[32,261],"liver":[33,262],"(NCL)":[34],"tissue":[35,75,159],"from":[36],"38":[37],"patients":[38],"with":[39,97,207],"were":[41,89,101,131,152,191,204,229],"obtained,":[42],"angiopoietin-1":[46],"(Ang-1),":[47],"angiopoietin-2":[48],"(Ang-2),":[49],"Tie2,":[50],"VEGF":[52,125,148,190,203,249],"messenger":[53],"RNA":[54],"(mRNA)":[55],"was":[56,77,108,119,185],"examined":[57],"by":[58],"real-time":[59],"quantitative":[60],"reverse":[61],"transcription-polymerase":[62],"chain":[63],"reaction":[64],"(RT-PCR).":[65],"Expression":[66],"pattern":[67],"each":[69],"gene":[70],"NCL":[74,158],"compared":[78],"potential":[81],"role":[82,253],"interaction":[84],"analyzed.":[90],"Genes'":[91],"level":[93,179],"its":[95],"relationship":[96],"tumor's":[98,208],"clinicopathological":[99,129,209,227],"parameters":[100,210],"also":[102,132],"investigated.":[103],"Immunohistochemical":[104],"staining":[105],"CD34":[107],"performed":[109],"to":[110,136,195,263],"determine":[111],"microvessel":[113],"density":[114],"(MVD)":[115],"Ang-2/Ang-1":[117,123,187],"ratio":[118,188],"calculated.":[120],"Relationships":[121],"between":[122],"ratio,":[124,200],"MVD":[127],"features":[130],"tested":[133],"so":[134],"as":[135],"evaluate":[137],"their":[138],"progression":[142,277],"HCC.":[144,279],"RESULTS:":[145],"Ang-2":[146,201,238],"mRNAs":[149,168],"significantly":[153,231],"higher":[154],"than":[155],"those":[156],"(P":[160,173,211,218,233],"<":[161,212],"0.05),":[162,175],"whereas":[163],"Ang-1":[165,181,199,221,241],"showed":[169],"no":[170],"statistical":[171],">":[174,219,234],"though":[176],"slightly":[177],"lower":[178],"mRNA":[182],"observed.":[186],"both":[192],"positively":[193],"correlated":[194],"MVD.":[196],"The":[197],"Ang-2/":[198],"all":[205],"associated":[206],"0.05)":[213],"except":[214],"for":[215],"histological":[216],"grades":[217],"0.05).":[220,235],"levels":[224],"different":[226,232],"groups":[228],"not":[230],"CONCLUSION:":[236],"Dominant":[237],"against":[240],"through":[242],"receptor":[244],"presence":[247],"plays":[250],"a":[251],"critical":[252],"initiating":[255],"early":[256],"neovascularization":[257],"transformation":[259],"carcinoma.":[265],"Its":[266],"consequently":[267],"constant":[268],"operation":[269],"formed":[271],"induces":[273],"further":[274]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}