{"id":"https://openalex.org/W10927207","doi":null,"title":"Macrophage differentiation in atherosclerosis. An in situ immunohistochemical analysis in humans.","display_name":"Macrophage differentiation in atherosclerosis. An in situ immunohistochemical analysis in humans.","publication_year":1992,"publication_date":"1992-07-01","ids":{"openalex":"https://openalex.org/W10927207","mag":"10927207","pmid":"https://pubmed.ncbi.nlm.nih.gov/1632461","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886580"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886580","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886580","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886580","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060053979","display_name":"Allard C. van der Wal","orcid":"https://orcid.org/0000-0001-5590-3758","observed_orcids":["https://orcid.org/0000-0001-5590-3758"]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A C van der Wal","raw_affiliation_strings":["Department of Cardiovascular Pathology, University of Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Pathology, University of Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111883106","display_name":"P. K. Das","orcid":"https://orcid.org/0000-0001-6023-6769","observed_orcids":["https://orcid.org/0000-0001-6023-6769","https://orcid.org/0000-0002-1578-5264"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P K Das","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086181879","display_name":"A. J. Tigges","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J Tigges","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103463445","display_name":"Anton E. Becker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A E Becker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.055,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.7560767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"141","issue":"1","first_page":"161","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-differentiation","display_name":"macrophage differentiation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/atherosclerotic-plaque","display_name":"atherosclerotic plaque","score":0.8410000205039978},{"id":"https://openalex.org/keywords/fatty-streaks","display_name":"fatty streaks","score":0.9950000047683716},{"id":"https://openalex.org/keywords/macrophage-phenotype","display_name":"macrophage phenotype","score":0.777999997138977},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.9620000123977661},{"id":"https://openalex.org/keywords/okm1","display_name":"OKM1","score":0.671999990940094},{"id":"https://openalex.org/keywords/lipid-uptake","display_name":"lipid uptake","score":0.746999979019165},{"id":"https://openalex.org/keywords/lysosomal-activity","display_name":"lysosomal activity","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.5260000228881836},{"id":"https://openalex.org/keywords/complement-receptors","display_name":"complement receptors","score":0.9589999914169312},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.8410000205039978},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.47999998927116394},{"id":"https://openalex.org/keywords/coronary-arteries","display_name":"coronary arteries","score":0.8169999718666077},{"id":"https://openalex.org/keywords/carotid-artery","display_name":"carotid artery","score":1.0}],"concepts":[{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.7095969915390015},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6365196704864502},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6347100138664246},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5452311038970947},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5287895798683167},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4564507007598877},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.45095932483673096},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.4392852485179901},{"id":"https://openalex.org/C2780806160","wikidata":"https://www.wikidata.org/wiki/Q132442","display_name":"Oil Red O","level":4,"score":0.4373953938484192},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28309863805770874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18423154950141907},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14181828498840332},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08597320318222046},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000135","descriptor_name":"Acid Phosphatase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001344","descriptor_name":"Autopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1886580","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886580","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:1632461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1632461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/65f552a6-a9bb-4245-9aa7-a6d3d3d45963","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/65f552a6-a9bb-4245-9aa7-a6d3d3d45963","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"van der Wal, A C, Das, P K, Tigges, A J & Becker, A E 1992, 'Macrophage differentiation in atherosclerosis. An in situ immunohistochemical analysis in humans', American journal of pathology, vol. 141, no. 1, pp. 161-168.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/c607f4f6-dd35-431f-9c17-2ec944e46d4c","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/macrophage-differentiation-in-atherosclerosis-an-in-situ-immunohistochemical-analysis-in-humans(c607f4f6-dd35-431f-9c17-2ec944e46d4c).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American journal of pathology, 141(1), 161 - 168. Elsevier Inc.","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:10927207","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1632461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886580","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886580","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W20509213","https://openalex.org/W82349362","https://openalex.org/W95788528","https://openalex.org/W104029063","https://openalex.org/W107727691","https://openalex.org/W152815097","https://openalex.org/W165426504","https://openalex.org/W314104006","https://openalex.org/W1924778996","https://openalex.org/W1954295490","https://openalex.org/W1962075410","https://openalex.org/W2006370688","https://openalex.org/W2013381560","https://openalex.org/W2018895320","https://openalex.org/W2020708638","https://openalex.org/W2032207767","https://openalex.org/W2038891911","https://openalex.org/W2061755142","https://openalex.org/W2077702220","https://openalex.org/W2098643663","https://openalex.org/W2100225736","https://openalex.org/W2102339257","https://openalex.org/W2123343007","https://openalex.org/W2136016201","https://openalex.org/W2151554596","https://openalex.org/W2162458714","https://openalex.org/W2168320467","https://openalex.org/W2172024457","https://openalex.org/W2265277925","https://openalex.org/W2406361801"],"related_works":["https://openalex.org/W2015182412","https://openalex.org/W2478146971","https://openalex.org/W4410088568","https://openalex.org/W2116144464","https://openalex.org/W2081287305","https://openalex.org/W1990431830","https://openalex.org/W2085069678","https://openalex.org/W1972706930","https://openalex.org/W2050965690","https://openalex.org/W2093733012"],"abstract_inverted_index":{"The":[0,151,186],"differentiation":[1,31,179],"of":[2,21,81,106,126,134,167,178,182,212,246,252],"macrophages":[3,62,184,190,220],"present":[4],"in":[5,100,110,155,160,172,222,234],"diffuse":[6],"intimal":[7,76],"thickening,":[8],"fatty":[9,85],"streaks,":[10],"and":[11,24,44,55,90,129,136,164,180,197,207,239],"atheromatous":[12,94,145],"plaques,":[13],"was":[14],"analyzed":[15],"with":[16,35,64,71,117,149,157],"immunohistochemical":[17],"methods,":[18],"using":[19],"segments":[20],"aorta,":[22],"coronary,":[23],"carotid":[25],"arteries":[26],"obtained":[27],"at":[28],"autopsy.":[29],"Various":[30],"antigens":[32],"were":[33,48,114,140],"studied":[34],"the":[36,65,72,104,107,111,144,168,183,192,210,219,244],"monoclonal":[37],"antibodies":[38],"anti-HLA-DR,":[39],"EBM-11,":[40,68],"Leu":[41,82,118,127],"M3,":[42,119],"OKM1,":[43],"OKM5.":[45,137,150],"Adjacent":[46],"sections":[47],"stained":[49,70,147],"for":[50,204],"lipids":[51],"(oil":[52],"red":[53],"O)":[54],"lysosomal":[56,165],"activity":[57,166],"(acid":[58],"phosphatase).":[59],"Almost":[60],"all":[61],"identified":[63],"pan-macrophage":[66],"antibody":[67],"also":[69,87,225],"anti-HLA-DR":[73],"antibody.":[74],"Diffuse":[75],"thickening":[77],"showed":[78,88,96,123],"a":[79,97,176,227,235],"predominance":[80],"M3+":[83],"cells;":[84],"streaks":[86],"OKM1+":[89],"OKM5+":[91],"macrophages.":[92,169],"Classical":[93],"plaques":[95],"gradual":[98],"shift":[99,171],"phenotypic":[101,152,173],"expression":[102,125,133,174],"towards":[103,199],"center":[105],"lesion.":[108],"Cells":[109,138],"superficial":[112],"layers":[113],"positive":[115],"only":[116,148],"deeper":[120],"localized":[121,141],"cells":[122,200,233],"double":[124,132],"M3":[128],"OKM1":[130,135],"or":[131],"that":[139,189,201,218],"adjacent":[142],"to":[143,229,243,257],"debris":[146],"changes":[153],"occurred":[154],"parallel":[156],"an":[158,247],"increase":[159],"both":[161],"fat":[162],"uptake":[163],"This":[170,215],"suggests":[175],"process":[177],"maturation":[181],"involved.":[185],"results":[187],"indicate":[188],"within":[191],"arterial":[193],"intima":[194],"are":[195,255],"activated":[196],"mature":[198],"express":[202],"receptors":[203],"adhesion":[205],"proteins":[206],"complement":[208],"during":[209],"development":[211],"atherosclerotic":[213,248],"plaques.":[214],"may":[216,241],"imply":[217],"involved":[221],"lipid":[223],"metabolism":[224],"have":[226],"potential":[228],"act":[230],"as":[231],"effector":[232],"chronic":[236],"inflammatory":[237],"process,":[238],"thus,":[240],"contribute":[242],"progression":[245],"plaque.":[249],"Functional":[250],"studies":[251],"macrophage":[253],"subpopulations":[254],"needed":[256],"verify":[258],"this":[259],"hypothesis.":[260]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}